Elizabeth A Ambrose

20012020
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Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

Molecular modeling Chemical Compounds
Zinc Chemical Compounds
Ligands Chemical Compounds
Molecules Chemical Compounds
Cytotoxicity Chemical Compounds
Bacilli Chemical Compounds
Geometry Chemical Compounds
Charge distribution Chemical Compounds

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Projects 2007 2020

Research Output 2001 2019

7-methylation of chenodeoxycholic acid derivatives yields a substantial increase in TGR5 receptor potency

Nakhi, A., Mcdermott, C. M., Stoltz, K. L., John, K., Hawkinson, J. E., Ambrose, E. A., Khoruts, A., Sadowsky, M. J. & Dosa, P. I., Jul 25 2019, In : Journal of Medicinal Chemistry. 62, 14, p. 6824-6830 7 p.

Research output: Contribution to journalArticle

Chenodeoxycholic Acid
Methylation
Inflammatory Bowel Diseases
Hydroxyl Radical
Type 2 Diabetes Mellitus

Botulinum neurotoxin, tetanus toxin, and anthrax lethal factor countermeasures

Ambrose, E. A., Jul 1 2017, Topics in Medicinal Chemistry. Springer- Verlag, p. 47-67 21 p. (Topics in Medicinal Chemistry; vol. 22).

Research output: Chapter in Book/Report/Conference proceedingChapter

Tetanus Toxin
Neurotoxins
Bioterrorism
Biological Warfare
Biological Warfare Agents
4 Citations (Scopus)

Erratum: Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria (Cell Chemical Biology (2017) 24(10) (1259–1275.e6) (S2451945617302830)(10.1016/j.chembiol.2017.08.009))

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, 1 p.

Research output: Contribution to journalComment/debate

Biguanides
Mitochondria
Heme
Cytochrome P-450 Enzyme System
Cell Biology
3 Citations (Scopus)

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, p. 1259-1275.e6

Research output: Contribution to journalArticle

Open Access
Biguanides
Cytochrome P-450 CYP3A
Mitochondria
Heme
Cytochrome P-450 Enzyme System
5 Citations (Scopus)
inhibitors
Support vector machines
Bacilli
Bacillus
Cell signaling