20012020

Research output per year

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Research Output

2020

A randomized evaluation of on-site monitoring nested in a multinational randomized trial

Wyman Engen, N., Huppler Hullsiek, K., Belloso, W. H., Finley, E., Hudson, F., Denning, E., Carey, C., Pearson, M. & Kagan, J., Feb 1 2020, In : Clinical Trials. 17, 1, p. 3-14 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019
Open Access
6 Scopus citations
2018

Increased indoleamine-2,3-dioxygenase activity is associated with poor clinical outcome in adults hospitalized with influenza in the INSIGHT FLU003Plus study

Pett, S. L., Kunisaki, K. M., Wentworth, D., Griffin, T. J., Kalomenidis, I., Nahra, R., Sanchez, R. M., Hodgson, S. W., Ruxrungtham, K., Dwyer, D., Davey, R. T., Wendt, C. H., Lundgren, J., Jansson, P., Pearson, M., Aagaard, B., Hudson, F., Bennet, R., Pacciarini, F., Angus, B. & 31 others, Paton, N., Collaco Moraes, Y., Cooper, D., Pett, S., Emery, S., Courtney-Rogers, D., Robson, R., Gordin, F., Sanchez, A., Standridge, B., Vjecha, M., Moricz, A., Delfino, M., Belloso, W., Losso, M., Tillmann, K., Touloumi, G., Gioukari, V., Anagnostou, O., La Rosa, A., Saenz, M. J., Lopez, P., Herrero, P., Portas, B., Avihingsanon, A., Ruxrungtham, K., Kaewon, P., Denning, E., Engen, N., Neaton, J. D. & For the INSIGHT FLU003 Plus Study Group, Jan 1 2018, In : Open Forum Infectious Diseases. 5, 1, ofx228.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2017

A randomized trial comparing concise and standard consent forms in the START trial

Grady, C., Touloumi, G., Walker, A. S., Smolskis, M., Sharma, S., Babiker, A. G., Pantazis, N., Tavel, J., Florence, E., Sanchez, A., Hudson, F., Papadopoulos, A., Emanuel, E., Clewett, M., Munroe, D. & Denning, E., Apr 2017, In : PloS one. 12, 4, e0172607.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Effect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per μL: secondary outcome results from a randomised controlled trial

O'Connor, J., Vjecha, M. J., Phillips, A. N., Angus, B., Cooper, D., Grinsztejn, B., Lopardo, G., Das, S., Wood, R., Wilkin, A., Klinker, H., Kantipong, P., Klingman, K. L., Jilich, D., Herieka, E., Denning, E., Abubakar, I., Gordin, F., Lundgren, J. D. & INSIGHT START study group, Mar 1 2017, In : The Lancet HIV. 4, 3, p. e105-e112

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Improved quality of life with immediate versus deferred initiation of antiretroviral therapy in early asymptomatic HIV infection

Lifson, A. R., Grund, B., Gardner, E. M., Kaplan, R., Denning, E., Engen, N., Carey, C. L., Chen, F., Dao, S., Florence, E., Sanz, J., Emery, S. & on behalf of INSIGHT START Study Group, Apr 24 2017, In : AIDS. 31, 7, p. 953-963 11 p.

Research output: Contribution to journalReview article

Open Access
26 Scopus citations
2016

INSIGHT FLU005: An anti-influenza virus hyperimmune intravenous immunoglobulin pilot study

Davey, R. T., Markowitz, N., Beigel, J., Wentworth, D., Babiker, A., Rehman, T., Dewar, R., Metcalf, J., Uyeki, T. M., Finley, E. B., Standridge, B., Riska, P., Lane, H. C., Gordin, F., Neaton, J. D., Denning, E., Duchene, A., Engen, N., Harrison, M., Quan, K. & 27 others, Thompson, G., Sanchez, A., Hoover, M., Natarajan, V., Holley, H. P., Tierney, J., Voell, J., Baxter, J., Bigley, D., Coburn, P., Faber, L., Gardner, E., Harlow, L., Jain, M., Makohon, L., Mcconnell, R., Moghe, J., Nahra, R., Omotosho, B., Petersen, T., Polenakovik, H., Rizza, S., Scott, J., Shoen, A., Solorzano, C., Temesgen, Z. & Whitaker, J., Feb 15 2016, In : Journal of Infectious Diseases. 213, 4, p. 574-578 5 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Challenges, successes and patterns of enrolment in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial

Grarup, J., Rappoport, C., Engen, N., Carey, C., Hudson, F., Denning, E., Sharma, S., Florence, E., Vjecha, M. & International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) START Study Group, Apr 1 2015, In : HIV Medicine. 16, S1, p. 14-23 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Murray, D. D., Suzuki, K., Law, M., Trebicka, J., Wentworth, D., Johnson, M., Vjecha, M. J., Kelleher, A. D., Emery, S., Aagaard, B., Aragon, E., Arnaiz, J., Borup, L., Clotet, B., Dragsted, U., Fau, A., Gey, D., Grarup, J., Hengge, U., Herrero, P. & 30 others, Jansson, P., Jensen, B., Jensen, K., Juncher, H., Lopez, P., Lundgren, J., Matthews, C., Mollerup, D., Pearson, M., Phillips, A., Reilev, S., Tillmann, K., Varea, S., Angus, B., Babiker, A., Cordwell, B., Darbyshire, J., Dodds, W., Fleck, S., Collins, G., Denning, E., Neaton, J., Wentworth, D., Wyman, N., Lifson, A., Grund, B., Neuhaus, J., Duprez, D., Henry, W. K. & INSIGHT ESPRIT and SMART Study Groups, Oct 14 2015, In : PloS one. 10, 10, e0139981.

Research output: Contribution to journalArticle

7 Scopus citations

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Mocroft, A., Lundgren, J. D., Ross, M., Law, M., Reiss, P., Kirk, O., Smith, C., Wentworth, D., Neuhaus, J., Fux, C. A., Moranne, O., Morlat, P., Johnson, M. A., Ryom, L., Lundgren, J. D., Powderly, B., Shortman, N., Moecklinghoff, C., Reilly, G., Franquet, X. & 31 others, Sabin, C. A., Phillips, A., Kirk, O., Reiss, P., Weber, R., Pradier, C., Law, M., d'Arminio Monforte, A., Dabis, F., El-Sadr, W. M., De Wit, S., Powderly, B., Shortman, N., Moecklinghoff, C., Reilly, G., Franquet, X., Ryom, L., Sabin, C. A., Kamara, D., Smith, C., Phillips, A., Mocroft, A., Tverland, J., Mansfeld, M., Nielsen, J., Raben, D., Lundgren, J. D., DuChene, A., Bartsch, G., Hoy, J. & D:A:D study group, the Royal Free Hospital Clinic Cohort, and the INSIGHT, SMART, and ESPRIT study groups, Mar 1 2015, In : PLoS medicine. 12, 3, e1001809.

Research output: Contribution to journalArticle

67 Scopus citations

Investigating the Efficacy of Clinical Trial Monitoring Strategies: Design and Implementation of the Cluster Randomized START Monitoring Substudy

Hullsiek, K. H., Kagan, J. M., Engen, N., Grarup, J., Hudson, F., Denning, E. T., Carey, C., Courtney-Rodgers, D., Finley, E. B., Jansson, P. O., Pearson, M. T., Peavy, D. E. & Belloso, W. H., Mar 15 2015, In : Therapeutic Innovation and Regulatory Science. 49, 2, p. 225-233 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Reported consent processes and demographics: A substudy of the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial

International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) START Study Group, Apr 1 2015, In : HIV Medicine. 16, S1, p. 24-29 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Why START? Reflections that led to the conduct of this large long-term strategic HIV trial

Lundgren, J., Babiker, A., Gordin, F., Emery, S., Fätkenheuer, G., Molina, J. M., Wood, R., Neaton, J. D., Agan, B. K., Alston-Smith, B., Arenas-Pinto, A., Arribas, J. R., Baker, J. V., Baxter, J., Belloso, W. H., Brekke, K., Brew, B., Brobst, S. W., Burman, W., Carey, C. & 53 others, Clark, R., Cooper, D. A., Davey, R. T., De La Rosa, G., Denning, E. T., Dolan, M., Dore, G., Duprez, D., Emanuel, E., Grady, C., Grund, B., Hirschel, B., Hoen, B., Hudson, F., Johnson, M. A., Kambili, C., Klingman, K., Kunisaki, K. M., Landay, A., Ledergerber, B., Lehrman, S. N., Martinez, A., Meger, S., Misar, K., Mitsuyasu, R. T., Mocroft, A., Munroe, D., Norton, M., Palmer, R. C., Pett, S. L., Phillips, A., Pillay, D., Porter, D., Price, R. W., Proschan, M., Rappoport, C., Reiss, P., Renjifo, B., Robertson, K., Rockstroh, J., Rodriguez, G., Rooney, J. F., Ross, M. J., Schechter, M., Schwarze, S., Seekins, D., Sharma, S., Snowden, W., Telenti, A., Tryon, J., van Wyk, J., Vjecha, M. J. & Wright, E., Apr 1 2015, In : HIV Medicine. 16, S1, p. 1-9 9 p.

Research output: Contribution to journalEditorial

26 Scopus citations
2010

Effects of intermittent IL-2 alone or with peri-cycle antiretroviral therapy in early HIV infection: The STALWART study

Tavel, J. A., Babiker, A., Carey, C., Fisher, M., Fox, L., Gey, D., Lopardo, G. D., Lopez, J. C., Markowitz, N., Munroe, D., Paton, N., Ruxrungtham, K., Standridge, B., Wentworth, D., Wyman, N., Aagaard, B., Borup, L., Grarup, J., Jansson, P. O., Jensen, K. & 94 others, Lundgren, J., Mollerup, D., Reilev, S., Braimah, N., Darbyshire, J., Horton, J., King, E., Smith, N., Van Hooff, F., Cooper, D. A., Courtney-Rodgers, D., Emery, S., Finley, E., Gordin, F., Sánchez, A., Thomas, D., Bebchuk, J., Bollenbeck, P., Denning, E., DuChene, A. G., Fosdick, L., Harrison, M., Krum, E., Larson, G., Neaton, J. D., Nelson, R., Quan, K., Quan, S. F. L., Schultz, T., Thompson, G., Collins, S., Haerry, D. H., Meulbroek, M., Peavy, D., Rappoport, C., Schwarze, S., Valdez, M., Watson, J., Belloso, W. H., Davey, R., Duprez, D., Gatell, J. M., Hoy, J., Lifson, A., Pederson, C., Perez, G., Price, R., Prineas, R., Rhame, F., Sampson, J. H., Worley, J., Modlin, J. F., Beral, V., Chaisson, R. E., Fleming, T. R., Hill, C., Kim, K., Murray, B. E., Pick, B., Seligmann, M., Weller, I., Luzar, M. A., Martinez, A., Costas, V., Eckstrand, J., Brown, S., Lupo, S. H., Losso, M. H., Anderson, J., Chuah, J., Kelly, M., Orth, D., Wolff, M. J., Rusconi, S., Tambussi, G., Horban, A., Antunes, F., Mansinho, K., Da Conceicao Vera, J. A. V., Himmich, H., Chetchotisakd, P., Kantipong, P., Orkin, C., Portsmouth, S., Winston, A., Wiselka, M. J., Anstead, G. M., Arduino, R. C., Goetz, M. B., Hennessey, K., El-Sadr, W., Labriola, A. M., Nixon, D. E. & Rodriguez-Barradas, M. C., Feb 23 2010, In : PloS one. 5, 2, e9334.

Research output: Contribution to journalArticle

12 Scopus citations

Regulatory impediments jeopardizing the conduct of clinical trials in Europe funded by the National Institutes of Health

Neaton, J. D., Babiker, A., Bohnhorst, M., Darbyshire, J., Denning, E., Frishman, A., Grarup, J., Larson, G. & Lundgren, J., Dec 1 2010, In : Clinical Trials. 7, 6, p. 705-718 14 p.

Research output: Contribution to journalArticle

21 Scopus citations
2002

Randomized, open-label study of the impact of two doses of subcutaneous recombinant interleukin-2 on viral burden in patients with HIV-1 infection and CD4+ cell counts of ≥300/mm3: CPCRA 059

Abrams, D. I., Bebchuk, J. D., Denning, E. T., Davey, R. T., Fox, L., Lane, H. C., Sampson, J., Verheggen, R., Zeh, D. & Markowitz, N. P., Mar 1 2002, In : Journal of Acquired Immune Deficiency Syndromes. 29, 3, p. 221-231 11 p.

Research output: Contribution to journalArticle

45 Scopus citations
2001

A review of efficacy studies of 6-month short-course therapy for tuberculosis among patients infected with human immunodeficiency virus: Differences in study outcomes

El-Sadr, W. M., Perlman, D. C., Denning, E., Matts, J. P. & Cohn, D. L., Feb 15 2001, In : Clinical Infectious Diseases. 32, 4, p. 623-632 10 p.

Research output: Contribution to journalArticle

76 Scopus citations