If you made any changes in Pure, your changes will be visible here soon.

Research Output 1981 2019

  • 112 Article
  • 4 Review article
  • 2 Comment/debate
  • 1 Conference contribution
2007
44 Citations (Scopus)

Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer pain

Khasabova, I., Stucky, C. L., Harding-Rose, C. A., Eikmeier, L., Beitz, A. J., Coicou, L. G., Hanson, A. E., Simone, D. A. & Seybold, V. S., Sep 19 2007, In : Journal of Neuroscience. 27, 38, p. 10289-10298 10 p.

Research output: Contribution to journalArticle

Fibrosarcoma
Sensory Receptor Cells
CC Chemokines
Neoplasms
Ligands
32 Citations (Scopus)

NK-1 receptors modulate the excitability of on cells in the rostral ventromedial medulla

Budai, D., Khasabov, S., Mantyh, P. W. & Simone, D. A., Feb 1 2007, In : Journal of Neurophysiology. 97, 2, p. 1388-1395 8 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
N-Methylaspartate
Capsaicin
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine
Substance P
169 Citations (Scopus)

The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons

Davidson, S., Zhang, X., Yoon, C. H., Khasabov, S., Simone, D. A. & Giesler, G. J., Sep 12 2007, In : Journal of Neuroscience. 27, 37, p. 10007-10014 8 p.

Research output: Contribution to journalArticle

Spinothalamic Tracts
Histamine Agents
Primates
Neurons
Histamine
38 Citations (Scopus)

Tumor-evoked hyperalgesia and sensitization of nociceptive dorsal horn neurons in a murine model of cancer pain

Khasabov, S., Hamamoto, D. T., Harding-Rose, C. A. & Simone, D. A., Nov 14 2007, In : Brain Research. 1180, 1, p. 7-19 13 p.

Research output: Contribution to journalArticle

Posterior Horn Cells
Nociceptors
Hyperalgesia
Hot Temperature
Neurons
2005
15 Citations (Scopus)

Cannabinoid agonist, CP 55,940, prevents capsaicin-induced sensitization of spinal cord dorsal horn neurons

Johanek, L. M. & Simone, D. A., Feb 1 2005, In : Journal of Neurophysiology. 93, 2, p. 989-997 9 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Posterior Horn Cells
Capsaicin
Cannabinoids
Neurons
39 Citations (Scopus)

Nociceptive characteristics of tumor necrosis factor-α in naive and tumor-bearing mice

Wacnik, P. W., Eikmeier, L. J., Simone, D. A., Wilcox, G. L. & Beitz, A. J., Jan 1 2005, In : Neuroscience. 132, 2, p. 479-491 13 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Neoplasms
Hyperalgesia
Fibrosarcoma
Hypersensitivity
52 Citations (Scopus)

Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer pain

Gilchrist, L. S., Cain, D. M., Harding-Rose, C. A., Kov, A. N., Wendelschafer-Crabb, G., Kennedy, W. R. & Simone, D. A., May 24 2005, In : Brain Research. 1044, 2, p. 197-205 9 p.

Research output: Contribution to journalArticle

Purinergic P2X3 Receptors
Nerve Fibers
Neoplasms
Purinergic P2 Receptors
Bone Neoplasms
35 Citations (Scopus)

Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus

Khasabov, S., Ghilardi, J. R., Mantyh, P. W. & Simone, D. A., Feb 1 2005, In : Journal of Neurophysiology. 93, 2, p. 998-1006 9 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Posterior Horn Cells
Neurons
Nociceptors
Hot Temperature
2004
64 Citations (Scopus)

Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury

Johanek, L. M. & Simone, D. A., Jun 1 2004, In : Pain. 109, 3, p. 432-442 11 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Hyperalgesia
Hot Temperature
Skin
Wounds and Injuries
69 Citations (Scopus)

Comparison of Responses of Primate Spinothalamic Tract Neurons to Pruritic and Algogenic Stimuli

Simone, D. A., Zhang, X., Li, J., Zhang, J. M., Honda, C. N., LaMotte, R. H. & Giesler, G. J., Jan 1 2004, In : Journal of Neurophysiology. 91, 1, p. 213-222 10 p.

Research output: Contribution to journalArticle

Spinothalamic Tracts
Primates
Histamine
Hyperalgesia
Neurons
59 Citations (Scopus)

Differential Effects of CB1 and Opioid Agonists on Two Populations of Adult Rat Dorsal Root Ganglion Neurons

Khasabova, I., Harding-Rose, C. A., Simone, D. A. & Seybold, V. S., Feb 18 2004, In : Journal of Neuroscience. 24, 7, p. 1744-1753 10 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Opioid Analgesics
Cannabinoid Receptor CB1
Diagnosis-Related Groups
Neurons
2003
94 Citations (Scopus)

A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain

Kehl, L. J., Hamamoto, D. T., Wacnik, P. W., Croft, D. L., Norsted, B. D., Wilcox, G. L. & Simone, D. A., Jan 1 2003, In : Pain. 103, 1-2, p. 175-186 12 p.

Research output: Contribution to journalArticle

Muscle Neoplasms
Cannabinoid Receptor Agonists
Myalgia
Hyperalgesia
Animal Models
20 Citations (Scopus)

Characterization of cutaneous primary afferent fibers excited by acetic acid in a model of nociception in frogs

Hamamoto, D. T. & Simone, D. A., Aug 1 2003, In : Journal of neurophysiology. 90, 2, p. 566-577 12 p.

Research output: Contribution to journalArticle

Nociception
Acetic Acid
Anura
Skin
Unmyelinated Nerve Fibers
27 Citations (Scopus)

More severe neurologic deficits in SJL/J male than female mice following Theiler's virus-induced CNS demyelination

Alley, J., Khasabov, S., Simone, D. A., Beitz, A. J., Rodriguez, M. & Njenga, M. K., Mar 1 2003, In : Experimental Neurology. 180, 1, p. 14-24 11 p.

Research output: Contribution to journalArticle

Theilovirus
Demyelinating Diseases
Neurologic Manifestations
Multiple Sclerosis
Paralysis
10 Citations (Scopus)

SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia

Turner, M. S., Hamamoto, D. T., Hodges, J. S., Maccecchini, M. L. & Simone, D. A., May 30 2003, In : Brain Research. 973, 2, p. 252-264 13 p.

Research output: Contribution to journalArticle

Kainic Acid Receptors
Capsaicin
Hyperalgesia
Hot Temperature
Excitatory Amino Acids
2002

Antinocicepción opiácea periférica y preventiva en un modelo de dolor visceral en ratón

Translated title of the contribution: Peripheral and preemptive opiod anticocieption in a mouse visceral pain modelReichert, J. A., Daughters, R. S., Rivard, R. & Simone, D. A., Oct 1 2002, In : Revista de la Sociedad Espanola del Dolor. 9, 7, p. 423-431 9 p.

Research output: Contribution to journalArticle

Visceral Pain
Acetic Acid
Opioid Analgesics
Morphine
Loperamide
46 Citations (Scopus)

Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats

Khasabova, I., Simone, D. A. & Seybold, V. S., Dec 20 2002, In : Neuroscience. 115, 2, p. 613-625 13 p.

Research output: Contribution to journalArticle

Afferent Neurons
Cannabinoids
Cannabinoid Receptor CB1
Neurons
Calcium Channels
178 Citations (Scopus)

Spinal neurons that possess the substance P receptor are required for the development of central sensitization

Khasabov, S., Rogers, S. D., Ghilardi, J. R., Peters, C. M., Mantyh, P. W. & Simone, D. A., Oct 15 2002, In : Journal of Neuroscience. 22, 20, p. 9086-9098 13 p.

Research output: Contribution to journalArticle

Central Nervous System Sensitization
Neurokinin-1 Receptors
Capsaicin
Neurons
Hyperalgesia
2001
13 Citations (Scopus)

Animal models of cancer pain may reveal novel approaches to palliative care

Cain, D. M., Wacnik, P. W. & Simone, D. A., Apr 18 2001, In : Pain. 91, 1-2, p. 1-4 4 p.

Research output: Contribution to journalReview article

Animal Disease Models
Palliative Care
Animal Models
Pain
Neoplasms
71 Citations (Scopus)

Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms

Johanek, L. M., Heitmiller, D. R., Turner, M., Nader, N., Hodges, J. S. & Simone, D. A., Aug 29 2001, In : Pain. 93, 3, p. 303-315 13 p.

Research output: Contribution to journalArticle

Cannabinoids
Capsaicin
Hyperalgesia
rimonabant
Injections
50 Citations (Scopus)
Spinal Ganglia
Neurons
TRPV Cation Channels
Capsaicin
Hyperalgesia
32 Citations (Scopus)

Enhanced responses of spinal dorsal horn neurons to heat and cold stimuli following mild freeze injury to the skin

Khasabov, S., Cain, D. M., Thong, D., Mantyh, P. W. & Simone, D. A., Aug 22 2001, In : Journal of Neurophysiology. 86, 2, p. 986-996 11 p.

Research output: Contribution to journalArticle

Posterior Horn Cells
Hot Temperature
Neurons
Skin
Wounds and Injuries
1 Citation (Scopus)

Epidermal nerve fibers: Observations on structure and function

Kennedy, W. R., Khalili, N., Wendelschafer-Crabb, G., Nolano, M. & Simone, D. A., Dec 1 2001, In : Neurological Sciences. 22, SUPPL. 1

Research output: Contribution to journalArticle

Nerve Degeneration
Nerve Fibers
Skin
94 Citations (Scopus)

Functional interactions between tumor and peripheral nerve: Changes in excitability and morphology of primary afferent fibers in a murine model of cancer pain

Cain, D. M., Wacnik, P. W., Turner, M., Wendelschafer-Crabb, G., Kennedy, W. R., Wilcox, G. L. & Simone, D. A., Dec 1 2001, In : Journal of Neuroscience. 21, 23, p. 9367-9376 10 p.

Research output: Contribution to journalArticle

Peripheral Nervous System Neoplasms
Unmyelinated Nerve Fibers
Neoplasms
Nerve Fibers
Skin
41 Citations (Scopus)

Functional interactions between tumor and peripheral nerve in a model of cancer pain in the mouse

Cain, D. M., Wacnik, P. W., Eikmeier, L., Beitz, A. J., Wilcox, G. L. & Simone, D. A., Jan 1 2001, In : Pain Medicine. 2, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

Peripheral Nervous System Neoplasms
Neuralgia
Pain
Neoplasms
Opioid Analgesics
42 Citations (Scopus)

Influence of thermode size for detecting heat pain dysfunction in a capsaicin model of epidermal nerve fiber loss

Khalili, N., Wendelschafer-Crabb, G., Kennedy, W. R. & Simone, D. A., Apr 5 2001, In : Pain. 91, 3, p. 241-250 10 p.

Research output: Contribution to journalArticle

Capsaicin
Nerve Fibers
Hot Temperature
Pain
Pain Threshold
104 Citations (Scopus)

Peripheral and preemptive opioid antinociception in a mouse visceral pain model

Reichert, J. A., Daughters, R. S., Rivard, R. & Simone, D. A., Feb 22 2001, In : Pain. 89, 2-3, p. 221-227 7 p.

Research output: Contribution to journalArticle

Visceral Pain
Acetic Acid
Opioid Analgesics
Morphine
Loperamide
128 Citations (Scopus)

Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: An in vivo study

Cain, D. M., Khasabov, S. & Simone, D. A., Apr 19 2001, In : Journal of Neurophysiology. 85, 4, p. 1561-1574 14 p.

Research output: Contribution to journalArticle

Nociceptors
Mechanoreceptors
Unmyelinated Nerve Fibers
Hot Temperature
Myelinated Nerve Fibers
2000
1 Citation (Scopus)

Cannabinoids: Worthwhile analgesics?

Simone, D. A. & Seybold, V. S., Jan 1 2000, In : Journal of Pain. 1, 1, p. 18-19 2 p.

Research output: Contribution to journalArticle

Cannabinoids
Analgesics
26 Citations (Scopus)

The role of pH and osmolarity in evoking the acetic acid-induced wiping response in a model of nociception in frogs

Hamamoto, D. T., Forkey, M. W., Davis, W. L., Kajander, K. C. & Simone, D. A., Apr 17 2000, In : Brain Research. 862, 1-2, p. 217-229 13 p.

Research output: Contribution to journalArticle

Nociception
Acetic Acid
Anura
Osmolar Concentration
Buffers
1999
70 Citations (Scopus)

Primary afferent fibers that contribute to increased substance P receptor internalization in the spinal cord after injury

Allen, B. J., Li, J., Menning, P. M., Rogers, S. D., Ghilardi, J., Mantyh, P. W. & Simone, D. A., Jan 1 1999, In : Journal of neurophysiology. 81, 3, p. 1379-1390 12 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Spinal Cord Injuries
Myelinated Nerve Fibers
Inflammation
Unmyelinated Nerve Fibers
81 Citations (Scopus)

The cannabinoid receptor agonist WIN 55,212-2 mesylate blocks the development of hyperalgesia produced by capsaicin in rats

Li, J., Daughters, R. S., Bullis, C., Bengiamin, R., Stucky, M. W., Brennan, J. & Simone, D. A., May 1 1999, In : Pain. 81, 1-2, p. 25-33 9 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Mesylates
Capsaicin
Hyperalgesia
Cannabinoids
333 Citations (Scopus)

Topical capsaicin in humans: Parallel loss of epidermal nerve fibers and pain sensation

Nolano, M., Simone, D. A., Wendelschafer-Crabb, G., Johnson, T., Hazen, E. & Kennedy, W. R., May 1 1999, In : Pain. 81, 1-2, p. 135-145 11 p.

Research output: Contribution to journalArticle

Capsaicin
Neuralgia
Nerve Fibers
Nociceptors
Blister
334 Citations (Scopus)

Transmission of chronic nociception by spinal neurons expressing the substance P receptor

Nichols, M. L., Allen, B. J., Rogers, S. D., Ghilardi, J. R., Honore, P., Luger, N. M., Finke, M. P., Li, J., Lappi, D. A., Simone, D. A. & Mantyh, P. W., Nov 19 1999, In : Science. 286, 5444, p. 1558-1561 4 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Nociception
Hyperalgesia
Neuralgia
Neurons
240 Citations (Scopus)

Windup leads to characteristics of central sensitization

Li, J., Simone, D. A. & Larson, A. A., Jan 1 1999, In : Pain. 79, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

Central Nervous System Sensitization
Unmyelinated Nerve Fibers
Posterior Horn Cells
Myelinated Nerve Fibers
Nociceptors
1998
277 Citations (Scopus)

Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: Correlation with sensory function

Simone, D. A., Nolano, M., Johnson, T., Wendelschafer-Crabb, G. & Kennedy, W. R., Nov 1 1998, In : Journal of Neuroscience. 18, 21, p. 8947-8959 13 p.

Research output: Contribution to journalArticle

Intradermal Injections
Capsaicin
Nerve Fibers
Skin
Epidermis
1997
471 Citations (Scopus)

Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor

Mantyh, P. W., Rogers, S. D., Honore, P., Allen, B. J., Ghilardi, J. R., Li, J., Daughters, R. S., Lappi, D. A., Wiley, R. G. & Simone, D. A., Oct 10 1997, In : Science. 278, 5336, p. 275-279 5 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Hyperalgesia
Spinal Cord
Neurons
Substance P
132 Citations (Scopus)

Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: Imaging peptide action in vivo

Allen, B. J., Rogers, S. D., Ghilardi, J. R., Menning, P. M., Kuskowski, M. A., Basbaum, A. I., Simone, D. A. & Mantyh, P. W., Aug 1 1997, In : Journal of Neuroscience. 17, 15, p. 5921-5927 7 p.

Research output: Contribution to journalArticle

Substance P
Spinal Cord
Hot Temperature
Neurons
Skin
13 Citations (Scopus)

Primary afferent nerve fibers that contribute to muscle pain sensation in humans

Simone, D. A., Marchettini, P. & Ochoa, J. L., Dec 1 1997, In : Pain Forum. 6, 4, p. 207-212 6 p.

Research output: Contribution to journalReview article

Myalgia
Nerve Fibers
Nociceptors
Muscles
Pain
130 Citations (Scopus)

Responses of cutaneous A-fiber nociceptors to noxious cold

Simone, D. A. & Kajander, K. C., Jan 1 1997, In : Journal of neurophysiology. 77, 4, p. 2049-2060 12 p.

Research output: Contribution to journalArticle

Myelinated Nerve Fibers
Nociceptors
Skin
Mechanoreceptors
Temperature
1996
168 Citations (Scopus)

Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of Capsaicin in rats

Gilchrist, H. D., Allard, B. L. & Simone, D. A., Jan 1 1996, In : Pain. 67, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

Capsaicin
Hyperalgesia
Hot Temperature
Injections
Pharmacology
78 Citations (Scopus)

Excitation of rat cutaneous nociceptors by noxious cold

Simone, D. A. & Kajander, K. C., Jul 26 1996, In : Neuroscience Letters. 213, 1, p. 53-56 4 p.

Research output: Contribution to journalArticle

Nociceptors
Skin
Unmyelinated Nerve Fibers
Temperature
140 Citations (Scopus)

Pain from excitation of identified muscle nociceptors in humans

Marchettini, P., Simone, D. A., Caputi, G. & Ochoa, J. L., Nov 18 1996, In : Brain Research. 740, 1-2, p. 109-116 8 p.

Research output: Contribution to journalArticle

Nociceptors
Myalgia
Pain
Muscles
Microelectrodes
1995
408 Citations (Scopus)

Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation

Mantyh, P. W., DeMaster, E., Malhotra, A., Ghilardi, J. R., Rogers, S. D., Mantyh, C. R., Liu, H., Basbaum, A. I., Vigna, S. R., Maggio, J. E. & Simone, D. A., Jan 1 1995, In : Science. 268, 5217, p. 1629-1632 4 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Dendrites
Endocytosis
Neurons
Spinal Cord
1994
124 Citations (Scopus)

Identification of muscle afferents subserving sensation of deep pain in humans

Simone, D. A., Marchettini, P., Caputi, G. & Ochoa, J. L., Jan 1 1994, In : Journal of neurophysiology. 72, 2, p. 883-889 7 p.

Research output: Contribution to journalArticle

Nociceptors
Pain
Muscles
Tendons
Mechanoreceptors
1993
2 Citations (Scopus)

Allodynia, hyperalgesia, and excitability of dorsal horn neurons

Simone, D. A., Jan 1 1993, In : APS Journal. 2, 1, p. 34-36 3 p.

Research output: Contribution to journalComment/debate

Posterior Horn Cells
Hyperalgesia

Mediators of spinal hyperexcitability and hyperalgesia

Simone, D. A., Jan 1 1993, In : APS Journal. 2, 4, p. 283-286 4 p.

Research output: Contribution to journalComment/debate

Hyperalgesia
16 Citations (Scopus)

Nociceptive neurons of the raccoon lateral thalamus

Simone, D. A., Hanson, M. E., Bernau, N. A. & Pubols, B. H., Jan 1 1993, In : Journal of Neurophysiology. 69, 2, p. 318-328 11 p.

Research output: Contribution to journalArticle

Raccoons
Nociceptors
Thalamus
Neurons
Hot Temperature
1992
28 Citations (Scopus)

Neural mechanisms of hyperalgesia

Simone, D. A., Jan 1 1992, In : Current Opinion in Neurobiology. 2, 4, p. 479-483 5 p.

Research output: Contribution to journalArticle

Hyperalgesia
Central Nervous System Sensitization
Pain
Inflammation
Neurons
85 Citations (Scopus)

Single C nociceptor responses and psychophysical parameters of evoked pain: effect of rate of rise of heat stimuli in humans.

Yarnitsky, D., Simone, D. A., Dotson, R. M., Cline, M. A. & Ochoa, J. L., May 1 1992, In : The Journal of Physiology. 450, 1, p. 581-592 12 p.

Research output: Contribution to journalArticle

Nociceptors
Hot Temperature
Pain
Temperature
Architectural Accessibility