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Research Output 1981 2019

  • 111 Article
  • 4 Review article
  • 2 Comment/debate
  • 1 Conference contribution
2019

Pioglitazone, a PPARγ agonist, reduces cisplatin-evoked neuropathic pain by protecting against oxidative stress

Khasabova, I., Khasabov, S., Olson, J., Uhelski, M. L., Kim, A. H., Albino-Ramírez, A. M., Wagner, C. L., Seybold, V. S. & Simone, D. A., Mar 1 2019, In : Pain. 160, 3, p. 688-701 14 p.

Research output: Contribution to journalArticle

pioglitazone
Peroxisome Proliferator-Activated Receptors
Neuralgia
Cisplatin
Oxidative Stress

Sensitization of nociceptors and dorsal horn neurons contributes to pain in sickle cell disease

Uhelski, M. L. & Simone, D. A., Jul 13 2019, In : Neuroscience Letters. 705, p. 20-26 7 p.

Research output: Contribution to journalReview article

Posterior Horn Cells
Nociceptors
Sickle Cell Anemia
Chronic Pain
Pain
2 Citations (Scopus)

Sensitization of nociceptors by prostaglandin E2-glycerol contributes to hyperalgesia in mice with sickle cell disease

Khasabova, I., Uhelski, M., Khasabov, S., Gupta, K., Seybold, V. S. & Simone, D. A., May 2 2019, In : Blood. 133, 18, p. 1989-1998 10 p.

Research output: Contribution to journalArticle

Prostaglandins G
Nociceptors
Hyperalgesia
Sickle Cell Anemia
Dinoprostone
2018
3 Citations (Scopus)

Bivalent ligand MCC22 potently attenuates nociception in a murine model of sickle cell disease

Cataldo, G., Lunzer, M. M., Olson, J., Akgun, E., Belcher, J. D., Vercellotti, G. M., Portoghese, P. S. & Simone, D. A., Jul 1 2018, In : Pain. 159, 7, p. 1382-1391 10 p.

Research output: Contribution to journalArticle

Open Access
Nociception
Sickle Cell Anemia
Ligands
Pain
Morphine
Open Access
Confocal Microscopy
Pain
Skin
Collagen Type IV
Nerve Fibers

Responses of thalamic neurons to itch-and pain-producing stimuli in rats

Lipshetz, B., Khasabov, S., Truong, H., Netoff, T. I., Simone, D. A. & Giesler, G. J., Sep 1 2018, In : Journal of Neurophysiology. 120, 3, p. 1119-1134 16 p.

Research output: Contribution to journalArticle

Neurons
Pain
Ventral Thalamic Nuclei
Thalamus
Automatic Data Processing
2017
1 Citation (Scopus)

A role for neurokinin-1 receptor neurons in the rostral ventromedial medulla in the development of chronic postthoracotomy pain

Khasabov, S., Wang, J. C. F., Simone, D. A. & Strichartz, G. R., Jul 1 2017, In : Pain. 158, 7, p. 1332-1341 10 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Chronic Pain
Postoperative Pain
Neurons
Pain
5 Citations (Scopus)

Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla

Khasabov, S., Malecha, P., Noack, J., Tabakov, J., Giesler, G. J. & Simone, D. A., Nov 7 2017, In : Journal of neurophysiology. 118, 5, p. 2727-2744 18 p.

Research output: Contribution to journalArticle

Open Access
Posterior Horn Cells
Neurokinin-1 Receptors
Hyperalgesia
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine
Nociceptors
1 Citation (Scopus)

In vivo optogenetic activation of Nav1.8+ cutaneous nociceptors and their responses to natural stimuli

Uhelski, M. L., Bruce, D. J., Séguéla, P., Wilcox, G. L. & Simone, D. A., Jan 1 2017, In : Journal of neurophysiology. 117, 6, p. 2218-2223 6 p.

Research output: Contribution to journalArticle

Optogenetics
Nociceptors
Unmyelinated Nerve Fibers
Skin
Light
14 Citations (Scopus)

Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis

Uhelski, M. L., Gupta, K. & Simone, D. A., Sep 1 2017, In : Pain. 158, 9, p. 1711-1722 12 p.

Research output: Contribution to journalArticle

Unmyelinated Nerve Fibers
Nociceptors
Sickle Cell Anemia
Hyperalgesia
Hydrolysis
2015
5 Citations (Scopus)

Activation of rostral ventromedial medulla neurons by noxious stimulation of Cutaneous and deep craniofacial tissues

Khasabov, S., Malecha, P., Noack, J., Tabakov, J., Okamoto, K., Bereiter, D. A. & Simone, D. A., Jan 1 2015, In : Journal of neurophysiology. 113, 1, p. 14-22 9 p.

Research output: Contribution to journalArticle

Neurons
Skin
Temporomandibular Joint
Adenosine Triphosphate
Facial Pain
13 Citations (Scopus)
Endocannabinoids
Nociceptors
Peripheral Nervous System Diseases
Hydrolysis
Drug Therapy
11 Citations (Scopus)

Inhibition of inactive states of tetrodotoxin-sensitive sodium channels reduces spontaneous firing of C-fiber nociceptors and produces analgesia in formalin and complete freund's adjuvant models of pain

Matson, D. J., Hamamoto, D. T., Bregman, H., Cooke, M., DiMauro, E. F., Huang, L., Johnson, D., Li, X., McDermott, J., Morgan, C., Wilenkin, B., Malmberg, A. B., McDonough, S. I. & Simone, D. A., Sep 17 2015, In : PloS one. 10, 9, e0138140.

Research output: Contribution to journalArticle

tetrodotoxin
Unmyelinated Nerve Fibers
Nociceptors
sodium channels
Freund's Adjuvant
5 Citations (Scopus)

Molecular mechanism for opioid dichotomy: bidirectional effect of μ-opioid receptors on P2X3 receptor currents in rat sensory neurones

Chizhmakov, I., Kulyk, V., Khasabova, I., Khasabov, S., Simone, D. A., Bakalkin, G., Gordienko, D., Verkhratsky, A. & Krishtal, O., Jun 1 2015, In : Purinergic Signalling. 11, 2, p. 171-181 11 p.

Research output: Contribution to journalArticle

Purinergic P2X3 Receptors
Opioid Receptors
Sensory Receptor Cells
Opioid Analgesics
Pertussis Toxin
46 Citations (Scopus)

Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease

Cataldo, G., Rajput, S., Gupta, K. & Simone, D. A., Apr 1 2015, In : Pain. 156, 4, p. 722-730 9 p.

Research output: Contribution to journalArticle

Nociceptors
Sickle Cell Anemia
Pain
Chronic Pain
Posterior Horn Cells
2014
27 Citations (Scopus)

A quantitative sensory analysis of peripheral neuropathy in colorectal cancer and its exacerbation by oxaliplatin chemotherapy

De Carvalho Barbosa, M., Kosturakis, A. K., Eng, C., Wendelschafer-Crabb, G., Kennedy, W. R., Simone, D. A., Wang, X. S., Cleeland, C. S. & Dougherty, P. M., Nov 1 2014, In : Cancer Research. 74, 21, p. 5955-5962 8 p.

Research output: Contribution to journalArticle

oxaliplatin
Peripheral Nervous System Diseases
Colorectal Neoplasms
Drug Therapy
Healthy Volunteers
11 Citations (Scopus)

JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy

Khasabova, I., Yao, X., Paz, J., Lewandowski, C. T., Lindberg, A. E., Coicou, L., Burlakova, N., Simone, D. A. & Seybold, V. S., Jan 1 2014, In : Pharmacological Research. 90, p. 67-75 9 p.

Research output: Contribution to journalArticle

Peripheral Nervous System Diseases
Cisplatin
Hyperalgesia
Spinal Ganglia
Cannabinoid Receptor CB2
19 Citations (Scopus)

Subclinical peripheral neuropathy in patients with multiple myeloma before chemotherapy is correlated with decreased fingertip innervation density

Kosturakis, A. K., He, Z., Li, Y., Boyette-Davis, J. A., Shah, N., Thomas, S. K., Zhang, H., Vichaya, E. G., Wang, X. S., Wendelschafer-Crabb, G., Kennedy, W. R., Simone, D. A., Cleeland, C. S. & Dougherty, P. M., Oct 1 2014, In : Journal of Clinical Oncology. 32, 28, p. 3156-3162 7 p.

Research output: Contribution to journalArticle

Peripheral Nervous System Diseases
Multiple Myeloma
Drug Therapy
Mechanoreceptors
Confocal Microscopy
2013
13 Citations (Scopus)

Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain

Khasabova, I., Holman, M., Morse, T., Burlakova, N., Coicou, L., Harding-Rose, C. A., Simone, D. A. & Seybold, V. S., Oct 1 2013, In : Neurobiology of Disease. 58, p. 19-28 10 p.

Research output: Contribution to journalArticle

Hyperalgesia
Sensory Receptor Cells
Spinal Ganglia
Cannabinoid Receptors
Neurons
14 Citations (Scopus)
Neurokinin-1 Receptors
Hyperalgesia
Neurons
Capsaicin
Freund's Adjuvant
86 Citations (Scopus)

Mast cell activation contributes to sickle cell pathobiology and pain in mice

Vincent, L., Vang, D., Nguyen, J., Gupta, M., Luk, K., Ericson, M. E., Simone, D. A. & Gupta, K., Jan 1 2013, In : Blood. 122, 11, p. 1853-1862 10 p.

Research output: Contribution to journalArticle

Mast Cells
Chemical activation
Pain
Morphine
Skin
17 Citations (Scopus)

The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain

Uhelski, M. L., Cain, D. M., Harding-Rose, C. A. & Simone, D. A., Sep 5 2013, In : Neuroscience. 247, p. 84-94 11 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Unmyelinated Nerve Fibers
Nociceptors
Hyperalgesia
Cannabinoid Receptor CB2
2012
55 Citations (Scopus)

Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy

Khasabova, I., Khasabov, S., Paz, J., Harding-Rose, C. A., Simone, D. A. & Seybold, V. S., May 16 2012, In : Journal of Neuroscience. 32, 20, p. 7091-7101 11 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Cisplatin
Drug Therapy
Pain
Hyperalgesia
16 Citations (Scopus)

Changes in response properties of rostral ventromedial medulla neurons during prolonged inflammation: Modulation by neurokinin-1 receptors

Khasabov, S., Brink, T. S., Schupp, M., Noack, J. & Simone, D. A., Nov 8 2012, In : Neuroscience. 224, p. 235-248 14 p.

Research output: Contribution to journalArticle

3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine
Neurokinin-1 Receptors
Inflammation
Neurons
Hyperalgesia
21 Citations (Scopus)

Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors

Brink, T. S., Pacharinsak, C., Khasabov, S., Beitz, A. J. & Simone, D. A., Feb 1 2012, In : Journal of neurophysiology. 107, 4, p. 1210-1221 12 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Capsaicin
Neurons
Injections
Hyperalgesia
49 Citations (Scopus)

Mouse models for studying pain in sickle disease: Effects of strain, age, and acuteness

Cain, D. M., Vang, D., Simone, D. A., Hebbel, R. P. & Gupta, K., Feb 1 2012, In : British Journal of Haematology. 156, 4, p. 535-544 10 p.

Research output: Contribution to journalArticle

Nociceptive Pain
Pain
Sickle Cell Anemia
Hyperalgesia
Hot Temperature
66 Citations (Scopus)

Pruriceptive spinothalamic tract neurons: Physiological properties and projection targets in the primate

Davidson, S., Zhang, X., Khasabov, S., Moser, H. R., Honda, C. N., Simone, D. A. & Giesler, G. J., Sep 15 2012, In : Journal of neurophysiology. 108, 6, p. 1711-1723 13 p.

Research output: Contribution to journalArticle

Spinothalamic Tracts
Primates
Neurons
Histamine
Ventral Thalamic Nuclei
26 Citations (Scopus)

Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy

Boyette-Davis, J. A., Eng, C., Wang, X. S., Cleeland, C. S., Wendelschafer-Crabb, G., Kennedy, W. R., Simone, D. A., Zhang, H. & Dougherty, P. M., Jun 1 2012, In : Clinical Cancer Research. 18, 11, p. 3180-3187 8 p.

Research output: Contribution to journalArticle

Peripheral Nervous System Diseases
Colorectal Neoplasms
Touch
Drug Therapy
Hot Temperature
2011
15 Citations (Scopus)

A new device to quantify tactile sensation in neuropathy

Kennedy, W. R., Selim, M. M., Brink, T. S., Hodges, J. S., Wendelschafer-Crabb, G., Foster, S. X. Y. L., Nolano, M., Provitera, V. & Simone, D. A., May 10 2011, In : Neurology. 76, 19, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

Touch
Fingers
Equipment and Supplies
Mechanoreceptors
Peripheral Nervous System Diseases
21 Citations (Scopus)

CB1 and CB2 receptor agonists promote analgesia through synergy in a murine model of tumor pain

Khasabova, I., Gielissen, J., Chandiramani, A., Harding-Rose, C. A., Odeh, D. A., Simone, D. A. & Seybold, V. S., Sep 1 2011, In : Behavioural Pharmacology. 22, 5-6, p. 607-616 10 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB2
Cannabinoid Receptor CB1
Analgesia
Hyperalgesia
Cannabinoid Receptor Agonists

Changes in response properties of nociceptors and dorsal horn neurons in a murine model of cancer pain.

Simone, D. A., Khasabov, S., Cain, D. M., Hamamoto, D. T. & Khasabova, I., Jan 1 2011, In : Fiziolohichnyǐ zhurnal (Kiev, Ukraine : 1994). 57, 5, p. 75-77 3 p.

Research output: Contribution to journalArticle

Drug Dose Response Relationship
Experimental Neoplasms
Morpholines
Naphthalenes
Benzoxazines
44 Citations (Scopus)

Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain

Khasabova, I., Chandiramani, A., Harding-Rose, C. A., Simone, D. A. & Seybold, V. S., Jul 1 2011, In : Pharmacological Research. 64, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Hyperalgesia
Cannabinoid Receptor CB2
Endocannabinoids
Cannabinoid Receptor CB1
2010
113 Citations (Scopus)

A Randomized, Controlled, Open-Label Study of the Long-Term Effects of NGX-4010, a High-Concentration Capsaicin Patch, on Epidermal Nerve Fiber Density and Sensory Function in Healthy Volunteers

Kennedy, W. R., Vanhove, G. F., Lu, S. P., Tobias, J., Bley, K. R., Walk, D., Wendelschafer-Crabb, G., Simone, D. A. & Selim, M. M., Jun 1 2010, In : Journal of Pain. 11, 6, p. 579-587 9 p.

Research output: Contribution to journalArticle

Capsaicin
Nerve Fibers
Healthy Volunteers
Touch
Pain
91 Citations (Scopus)

Mechanisms of cancer pain

Schmidt, B. L., Hamamoto, D. T., Simone, D. A. & Wilcox, G. L., Jun 1 2010, In : Molecular interventions. 10, 3, p. 164-178 15 p.

Research output: Contribution to journalReview article

Central Nervous System Sensitization
Neoplasms
Nociceptors
Pain Perception
Animal Models

Microfabricated structures for evaluation of tactile sensitivity

Cibuzar, G., Von Dissen, L., Fisher, M., Kennedy, W. R., Selim, M., Brink, T., Wendelschafer-Crabb, G., Simone, D. A., Foster, S., Nolano, M. & Provitera, V., Aug 24 2010, 2010 18th Biennial University/Government/Industry Micro-Nano Symposium, UGIM 2010 - Proceedings. 5508926. (Biennial University/Government/Industry Microelectronics Symposium - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dry etching
Microfabrication
Lithography
Skin
92 Citations (Scopus)

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: Modulation by cannabinoids

Kohli, D. R., Li, Y., Khasabov, S., Gupta, P., Kehl, L. J., Ericson, M. E., Nguyen, J., Gupta, V., Hebbel, R. P., Simone, D. A. & Gupta, K., Jul 22 2010, In : Blood. 116, 3, p. 456-465 10 p.

Research output: Contribution to journalArticle

Sickle Hemoglobin
Cannabinoids
Modulation
Cannabinoid Receptor Agonists
Hyperalgesia
26 Citations (Scopus)

Variation in quantitative sensory testing and epidermal nerve fiber density in repeated measurements

Selim, M. M., Wendelschafer-Crabb, G., Hodges, J. S., Simone, D. A., Foster, S. X. Y. L., Vanhove, G. F. & Kennedy, W. R., Dec 1 2010, In : Pain. 151, 3, p. 575-581 7 p.

Research output: Contribution to journalArticle

Nerve Fibers
Touch
Pain
Hot Temperature
Pain Threshold
2009
17 Citations (Scopus)

Excitation of cutaneous C nociceptors by intraplantar administration of anandamide

Potenzieri, C., Brink, T. S. & Simone, D. A., May 1 2009, In : Brain Research. 1268, p. 38-47 10 p.

Research output: Contribution to journalArticle

Nociceptors
Skin
Injections
anandamide
Hot Temperature
106 Citations (Scopus)

Hematopoietic colony-stimulating factors mediate tumor-nerve interactions and bone cancer pain

Schweizerhof, M., Stösser, S., Kurejova, M., Njoo, C., Gangadharan, V., Agarwal, N., Schmelz, M., Bali, K. K., Michalski, C. W., Brugger, S., Dickenson, A., Simone, D. A. & Kuner, R., Jul 1 2009, In : Nature Medicine. 15, 7, p. 802-807 6 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factors
Bone Neoplasms
Granulocyte-Macrophage Colony-Stimulating Factor
Tumors
Bone
10 Citations (Scopus)

P2X receptors in sensory neurons co-cultured with cancer cells exhibit a decrease in opioid sensitivity

Chizhmakov, I., Mamenko, N., Volkova, T., Khasabova, I., Simone, D. A. & Krishtal, O., Jan 1 2009, In : European Journal of Neuroscience. 29, 1, p. 76-86 11 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Opioid Analgesics
Neurons
Neoplasms
Fibrosarcoma
96 Citations (Scopus)

Relief of itch by scratching: State-dependent inhibition of primate spinothalamic tract neurons

Davidson, S., Zhang, X., Khasabov, S., Simone, D. A. & Giesler, G. J., May 1 2009, In : Nature Neuroscience. 12, 5, p. 544-546 3 p.

Research output: Contribution to journalArticle

Spinothalamic Tracts
Primates
Neurons
Histamine
Spinal Cord
2008
64 Citations (Scopus)

A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain

Khasabova, I., Khasabov, S., Harding-Rose, C. A., Coicou, L. G., Seybold, B. A., Lindberg, A. E., Steevens, C. D., Simone, D. A. & Seybold, V. S., Oct 29 2008, In : Journal of Neuroscience. 28, 44, p. 11141-11152 12 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Hyperalgesia
Spinal Ganglia
Cannabinoid Receptor CB1
Maintenance
23 Citations (Scopus)

Cannabinoid modulation of cutaneous Aδ nociceptors during inflammation

Potenzieri, C., Brink, T. S., Pacharinsak, C. & Simone, D. A., Nov 1 2008, In : Journal of Neurophysiology. 100, 5, p. 2794-2806 13 p.

Research output: Contribution to journalArticle

Nociceptors
Cannabinoids
Hyperalgesia
Cannabinoid Receptor CB1
Inflammation
14 Citations (Scopus)

Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer pain

Simone, D. A., Khasabov, S. G. & Hamamoto, D. T., Oct 25 2008, In : Sheng li xue bao : [Acta physiologica Sinica]. 60, 5, p. 635-644 10 p.

Research output: Contribution to journalArticle

Posterior Horn Cells
Nociceptors
Neurons
Hot Temperature
Hyperalgesia
21 Citations (Scopus)

NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin

Pacharinsak, C., Khasabov, S., Beitz, A. J. & Simone, D. A., Sep 30 2008, In : Pain. 139, 1, p. 34-46 13 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Capsaicin
Hyperalgesia
Hot Temperature
Injections
11 Citations (Scopus)

Termination zones of functionally characterized spinothalamic tract neurons within the primate posterior thalamus

Davidson, S., Zhang, X., Khasabov, S., Simone, D. A. & Giesler, G. J., Oct 1 2008, In : Journal of neurophysiology. 100, 4, p. 2026-2037 12 p.

Research output: Contribution to journalArticle

Spinothalamic Tracts
Thalamus
Primates
Neurons
Posterior Thalamic Nuclei
34 Citations (Scopus)

The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms

Potenzieri, C., Harding-Rose, C. A. & Simone, D. A., Jun 18 2008, In : Brain Research. 1215, p. 69-75 7 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Cannabinoids
Hyperalgesia
Neoplasms
Injections
27 Citations (Scopus)

Tumor-evoked sensitization of C nociceptors: A role for endothelin

Hamamoto, D. T., Khasabov, S., Cain, D. M. & Simone, D. A., Oct 1 2008, In : Journal of neurophysiology. 100, 4, p. 2300-2311 12 p.

Research output: Contribution to journalArticle

Nociceptors
Endothelins
Endothelin-1
Neoplasms
Hot Temperature
2007
35 Citations (Scopus)

Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesia

Hamamoto, D. T., Giridharagopalan, S. & Simone, D. A., Mar 8 2007, In : European Journal of Pharmacology. 558, 1-3, p. 73-87 15 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Hyperalgesia
Neoplasms
Catalepsy
Spiperone
44 Citations (Scopus)

Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer pain

Khasabova, I., Stucky, C. L., Harding-Rose, C. A., Eikmeier, L., Beitz, A. J., Coicou, L. G., Hanson, A. E., Simone, D. A. & Seybold, V. S., Sep 19 2007, In : Journal of Neuroscience. 27, 38, p. 10289-10298 10 p.

Research output: Contribution to journalArticle

Fibrosarcoma
Sensory Receptor Cells
CC Chemokines
Neoplasms
Ligands