20052023
If you made any changes in Pure, your changes will be visible here soon.

Research Output 2005 2019

2019
1 Citation (Scopus)

Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors

Hassler, T., Urmann, E., Teschner, S., Federle, C., Dileepan, T., Schober, K., Jenkins, M. K., Busch, D. H., Hinterberger, M. & Klein, L., Sep 10 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18537-18543 7 p.

Research output: Contribution to journalArticle

Open Access
T-Cell Antigen Receptor
Regulatory T-Lymphocytes
T-Lymphocytes
Equipment and Supplies
Cell Differentiation
2018

Cutting edge: Allograft rejection is associated with weak t-cell responses to many different graft leukocyte-derived peptides

Burrack, A. L., Malhotra, D., Dileepan, T., Osum, K. C., Swanson, L. A., Fife, B. T. & Jenkins, M. K., Apr 1 2018, In : Transplantation. 102, 4, 1 p.

Research output: Contribution to journalComment/debate

Allografts
Leukocytes
Transplants
Peptides
14 Citations (Scopus)

Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM + and Transient IgG + Memory B Cells

Pape, K. A., Maul, R. W., T, D., Paustian, A. S., Gearhart, P. J. & Jenkins, M., Jun 19 2018, In : Immunity. 48, 6, p. 1135-1143.e4

Research output: Contribution to journalArticle

Open Access
Antigen Receptors
Phycoerythrin
Immunoglobulin M
B-Lymphocytes
Immunoglobulin G
15 Citations (Scopus)

Regulatory CD4+ T cells recognize major histocompatibility complex class II molecule-restricted peptide epitopes of apolipoprotein B

Kimura, T., Kobiyama, K., Winkels, H., Tse, K., Miller, J., Vassallo, M., Wolf, D., Ryden, C., Orecchioni, M., Dileepan, T., Jenkins, M. K., James, E. A., Kwok, W. W., Hanna, D. B., Kaplan, R. C., Strickler, H. D., Durkin, H. G., Kassaye, S. G., Karim, R., Tien, P. C. & 5 others, Landay, A. L., Gange, S. J., Sidney, J., Sette, A. & Ley, K., Jan 1 2018, In : Circulation. 138, 11, p. 1130-1143 14 p.

Research output: Contribution to journalArticle

Open Access
Apolipoproteins B
Regulatory T-Lymphocytes
Major Histocompatibility Complex
Epitopes
Peptides
3 Citations (Scopus)

Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells

Goldberg, M. F., Roeske, E. K., Ward, L. N., Pengo, T., T, D., Kotov, D. I. & Jenkins, M., Dec 18 2018, In : Immunity. 49, 6, p. 1090-1102.e7

Research output: Contribution to journalArticle

Open Access
Th1 Cells
Salmonella enterica
Granuloma
Salmonella
Macrophages
2017
1 Citation (Scopus)

Cutting Edge: Allograft Rejection is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides

Burrack, A. L., Malhotra, D., Dileepan, T., Osum, K. C., Swanson, L. A., Fife, B. T. & Jenkins, M. K., Dec 1 2017, In : Journal of Immunology. 200, 2, p. 477-482 6 p.

Research output: Contribution to journalArticle

Open Access
Allografts
Leukocytes
T-Lymphocytes
Transplants
Peptides

Cutting Edge: Allograft Rejection is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides

Burrack, A. L., Malhotra, D., T, D., Osum, K. C., Swanson, L. A., Fife, B. T. & Jenkins, M., Dec 1 2017, In : Journal of Immunology. 200, 2, p. 477-482 6 p.

Research output: Contribution to journalArticle

Allografts
Leukocytes
T-Lymphocytes
Transplants
Peptides

Enzyme-linked immunosorbent assay for group A Streptococcal anti-DNase B in human sera, using recombinant proteins - Comparison to the DNA methyl green micromethod

Das, S., T, D., Johnson, D. R., Kaplan, E. L. & Patrick Cleary, P., Dec 1 2017, In : Journal of Immunological Methods. 451, p. 111-117 7 p.

Research output: Contribution to journalArticle

Methyl Green
Recombinant Proteins
Enzyme-Linked Immunosorbent Assay
DNA
Serum
19 Citations (Scopus)

Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen

Leonard, J. D., Gilmore, D. C., T, D., Nawrocka, W. I., Chao, J. L., Schoenbach, M. H., Jenkins, M., Adams, E. J. & Savage, P. A., Jul 18 2017, In : Immunity. 47, 1, p. 107-117.e8

Research output: Contribution to journalArticle

Open Access
T-Lymphocyte Epitopes
Autoantigens
Regulatory T-Lymphocytes
Autoimmunity
Prostate
13 Citations (Scopus)

Increased effector memory insulin-specific CD4+ T cells correlate with insulin autoantibodies in patients with recent-onset type 1 diabetes

Spanier, J. A., Sahli, N. L., Wilson, J. C., Martinov, T., T, D., Burrack, A. L., Finger, E. B., Blazar, B. R., Michels, A. W., Moran, A., Jenkins, M. & Fife, B. T., Dec 1 2017, In : Diabetes. 66, 12, p. 3051-3060 10 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Autoantibodies
Insulin
T-Lymphocytes
Phenotype
2016
34 Citations (Scopus)

Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells

Dileepan, T., Smith, E. D., Knowland, D., Hsu, M., Platt, M., Bittner-Eddy, P., Cohen, B., Southern, P., Latimer, E., Harley, E., Agalliu, D. & Cleary, P. P., Jan 4 2016, In : Journal of Clinical Investigation. 126, 1, p. 303-317 15 p.

Research output: Contribution to journalArticle

Th17 Cells
Streptococcal Infections
Streptococcus
Blood-Brain Barrier
Olfactory Bulb
12 Citations (Scopus)

Gut microbial membership modulates CD4 T cell reconstitution and function after sepsis

Cabrera-Perez, J., Babcock, J. C., Dileepan, T., Murphy, K. A., Kucaba, T. A., Badovinac, V. P. & Griffith, T. S., Sep 1 2016, In : Journal of Immunology. 197, 5, p. 1692-1698 7 p.

Research output: Contribution to journalArticle

Sepsis
T-Lymphocytes
Bacteria
Punctures
Ligation
68 Citations (Scopus)

Tolerance is established in polyclonal CD4 + T cells by distinct mechanisms, according to self-peptide expression patterns

Malhotra, D., Linehan, J. L., Dileepan, T., Lee, Y. J., Purtha, W. E., Lu, J. V., Nelson, R. W., Fife, B. T., Orr, H. T., Anderson, M. S., Hogquist, K. A. & Jenkins, M. K., Feb 1 2016, In : Nature immunology. 17, 2, p. 187-195 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Peptides
Clonal Deletion
Self Tolerance
T-Lymphocyte Epitopes
2015

Erratum to T Cell Receptor Cross-Reactivity between Similar Foreign and Self Peptides Influences Naive Cell Population Size and Autoimmunity (Immunity 42, 95-107, 2015)

Nelson, R. W., Beisang, D., Tubo, N. J., Dileepan, T., Wiesner, D. L., Nielsen, K., Wüthrich, M., Klein, B. S., Kotov, D. I., Spanier, J. A., Fife, B. T., Moon, J. J. & Jenkins, M. K., Jun 16 2015, In : Immunity. 42, 6, p. 1212-1213 2 p.

Research output: Contribution to journalComment/debate

T-Cell Antigen Receptor
Population Density
Autoimmunity
Cell Size
Immunity
27 Citations (Scopus)

Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells

Linehan, J. L., T, D., Kashem, S. W., Kaplan, D. H., Cleary, P. & Jenkins, M., Oct 13 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 41, p. 12782-12787 6 p.

Research output: Contribution to journalArticle

Th17 Cells
Streptococcus pyogenes
Dendritic Cells
Interleukin-6
Infection
2 Citations (Scopus)

In situ peptide-MHC-II tetramer staining of antigen-specific CD4+ T cells in tissues

Dileepan, T., Kim, H. O., Cleary, P. P. & Skinner, P. J., Jun 11 2015, In : PloS one. 10, 6, e0128862.

Research output: Contribution to journalArticle

CD4 Antigens
T-cells
T-lymphocytes
peptides
Tissue
68 Citations (Scopus)

T Cell Receptor Cross-Reactivity between Similar Foreign and Self Peptides Influences Naive Cell Population Size and Autoimmunity

Nelson, R. W., Beisang, D., Tubo, N. J., Dileepan, T., Wiesner, D. L., Nielsen, K., Wüthrich, M., Klein, B. S., Kotov, D. I., Spanier, J. A., Fife, B. T., Moon, J. J. & Jenkins, M. K., Jan 20 2015, In : Immunity. 42, 1, p. 95-107 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Population Density
Autoimmunity
Cell Size
Peptides
2011
54 Citations (Scopus)

Robust antigen specific th17 t cell response to group a streptococcus is dependent on il-6 and intranasal route of infection

Dileepan, T., Linehan, J. L., Moon, J. J., Pepper, M., Jenkins, M. K. & Cleary, P. P., Sep 1 2011, In : PLoS pathogens. 7, 9, e1002252.

Research output: Contribution to journalArticle

Th17 Cells
Streptococcus
Interleukin-17
T-Lymphocytes
Antigens
2010
200 Citations (Scopus)

Different routes of bacterial infection induce long-lived T H 1 memory cells and short-lived T H 17 cells

Pepper, M., Linehan, J. L., Pagán, A. J., Zell, T., T, D., Cleary, P. P. & Jenkins, M., Jan 1 2010, In : Nature immunology. 11, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

Th1 Cells
Bacterial Infections
Infection
Major Histocompatibility Complex
Interleukin-15 Receptors
57 Citations (Scopus)

Induction of TGF-β1 and TGF-β1-dependent predominant Th17 differentiation by group A streptococcal infection

Wang, B., Dileepan, T., Briscoe, S., Hyland, K. A., Kang, J., Khoruts, A. & Cleary, P. P., Mar 30 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 13, p. 5937-5942 6 p.

Research output: Contribution to journalArticle

Streptococcal Infections
Streptococcus
Interleukin-17
Lymphoid Tissue
Nose
2007
43 Citations (Scopus)

Human CD18 is the functional receptor for Aggregatibacter actinomycetemcomitans leukotoxin

Dileepan, T., Kachlany, S. C., Balashova, N. V., Patel, J. & Maheswaran, S. K., Oct 1 2007, In : Infection and immunity. 75, 10, p. 4851-4856 6 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Lymphocyte Function-Associated Antigen-1
Integrins
Gingival Diseases
Aggressive Periodontitis
11 Citations (Scopus)

Integrin-EGF-3 domain of bovine CD18 is critical for Mannheimia haemolytica leukotoxin species-specific susceptibility

T, D., Kannan, M. S., Walcheck, B. & Maheswaran, S. K., Sep 1 2007, In : FEMS Microbiology Letters. 274, 1, p. 67-72 6 p.

Research output: Contribution to journalArticle

Mannheimia haemolytica
Epidermal Growth Factor
Integrins
Amino Acids
Pneumonic Pasteurellosis
2005
16 Citations (Scopus)

Characterization of Mannheimia (Pasteurella) haemolytica leukotoxin interaction with bovine alveolar macrophage β2 integrins

Thumbikat, P., Dileepan, T., Kannan, M. S. & Maheswaran, S. K., Sep 1 2005, In : Veterinary research. 36, 5-6, p. 771-786 16 p.

Research output: Contribution to journalArticle

Mannheimia
Mannheimia haemolytica
leukotoxins
Lymphocyte Function-Associated Antigen-1
integrins
15 Citations (Scopus)

Mapping of the binding site for Mannheimia haemolytica leukotoxin within bovine CD18

T, D., Kannan, M. S., Walcheck, B., Thumbikat, P. & Maheswaran, S. K., Aug 1 2005, In : Infection and Immunity. 73, 8, p. 5233-5237 5 p.

Research output: Contribution to journalArticle

Mannheimia haemolytica
Binding Sites
Lymphocyte Function-Associated Antigen-1
K562 Cells
Amino Acids
34 Citations (Scopus)

Mechanisms underlying Mannheimia haemolytica leukotoxin-induced oncosis and apoptosis of bovine alveolar macrophages

Thumbikat, P., T, D., Kannan, M. S. & Maheswaran, S. K., Jan 1 2005, In : Microbial Pathogenesis. 38, 4, p. 161-172 12 p.

Research output: Contribution to journalArticle

Mannheimia haemolytica
Lymphocyte Function-Associated Antigen-1
Alveolar Macrophages
Apoptosis
Caspase 1
22 Citations (Scopus)

Recombinant expression of bovine LFA-1 and characterization of its role as a receptor for Mannheimia haemolytica leukotoxin

Dileepan, T., Thumbikat, P., Walcheck, B., Kannan, M. S. & Maheswaran, S. K., May 1 2005, In : Microbial Pathogenesis. 38, 5-6, p. 249-257 9 p.

Research output: Contribution to journalArticle

Mannheimia haemolytica
Lymphocyte Function-Associated Antigen-1
Cell Line
K562 Cells
Lung Injury