Projects per year
Personal profile
Research interests
Nanotherapeutics and Nanotheranostics for personalised medicine: I am interested in developing and understanding the properties of nano/bio-materials and engineering the surface chemistry for various biomedical applications. The primary focus is on engineering polymeric and or metallic/metal oxide nanoparticles, and composites for cancer targeting, drug/molecular delivery, tissue engineering, bone regeneration, diagnostics and dental applications.
Publications
2023
- Polyphosphate metabolism under nutrient stimuli and potential inhibitor in dental caries associated Lacticaseibacillus, Subhrangshu Mandal, Beverely E. Flood, Mark Lunzer, Dhiraj Kumar, Robert S. Jones, Jake V. Bailey. 2023 (mSphere ASM, IF-), DOI: under preparation).
- High atomic number-based theranostics nanoparticles in the realm of spectral CT imaging, Isha Mutreja, Nabil Maalej, Dhiraj Kumar*, Aamir Raja*. 2023 (Materials Advances RSC, IF-), DOI: under review).
- MARS for molecular imaging and preclinical studies, Mahdieh Moghiseh, Jennifer A Clark, Maya R Amma, Krishna M Chapagain, Devyani Dixit, Chiara Lowe, Aysouda Matanaghi, Emily Searle, Yann Sayous, Dhiraj Kumar, Anthony P H Butler, and MARS Collaboration 2023 (Springer book chapter), DOI: under review).
- Lipid nanoparticle-based formulations for high-performance Dentistry Applications, Isha Mutreja, Dhiraj Kumar, Ajeet Kaushik and Yogendra Mishra 2023 (Journal of Materials Chemistry B RSC, IF-7.571), DOI: 10.1039/D3TB00431G).
- Recent advances in noble metal nanoparticles for cancer nanotheranostics, Isha Mutreja, Ajeet Kaushik, Dhiraj Kumar. 2023 (Nanotheranostics MDPI, IF:), DOI: 10.3390/jnt4020008).
- LHRH conjugated gold nanoparticles assisted efficient ovarian cancer targeting evaluated via spectral photon-counting CT imaging: A proof-of-concept research, Dhiraj Kumar*, Mahdieh Moghiseh*, Kenny Chitcholtan, Chiara Lowe, Isha Mutreja, Ajeet Kaushik, Anthony Butler, Nigel Anderson, Peter Sykes, Aamir Raja 2023 (Journal of Materials Chemistry B RSC, IF-7.571), DOI: 10.1039/D2TB02416K).
- Fluoride and Gallein Inhibit Polyphosphate Accumulation by Oral Pathogen Rothia dentocariosa, Dhiraj Kumar, Subhrangshu Mandal, Jake V. Bailey, Beverly E. Flood, Robert S. Jones 2023 (Letters in Applied Microbiology, IF-2.813), DOI: 10.1093/lambio/ovad017).
2022
- Gelatin methacryloyl hydrogels for musculoskeletal tissue regeneration, Yang-Hee Kim, Jonathan I Dawson, Richard O.C. Oreffo, Yasuhiko Tabata, Dhiraj Kumar, Conrado Aparicio, Isha Mutreja 2022 (Bioengineering, MDPI), DOI: 10.3390/bioengineering9070332).
- Methacrylate Polymers with 'Flipped External' Ester Groups: A Review, Dhiraj Kumar, Robert D Bolskar, Isha Mutreja, and Robert S Jones, 2022 (Frontiers in Dental Medicine (IF–), DOI: 10.3389/fdmed.2022.923780).
- Emerging Nanostructures in Dental Applications, Debarati Ghose* and Dhiraj Kumar* 2022 (Book Chapter), DOI: https://link.springer.com/chapter/10.1007/978-981-19-1312-9_8).
2021
- Strontium- and peptide-modified silicate nanostructures for dual osteogenic and antimicrobial activity, Isha Mutreja, Dhiraj Kumar, Kami Hogan, Emily Campbell, Kim Mansky, Conrado Aparicio, 2021 (Biomaterials Advances (IF–7.328), DOI: 10.1016/j.bioadv.2022.212735).
- Utilizing a degradation prediction pathway system to understand how a novel methacrylate derivative polymer with flipped external ester groups retains physico-mechanical properties following esterase exposure, Dhiraj Kumar, Debarati Ghose, Robert D Bolskar, Isha Mutreja, Conrado Aparicio, and Robert S Jones. 2021 (Dental Materials (IF–5.304), DOI: 10.1016/j.dental.2021.12.008).
- Hybrid nanocoatings of antimicrobial peptides and silver nanoparticles for preservation of implant infections, Zhou Ye, Ting Sang, Kun Li, Nicholas G. Fisher, Isha Mutreja, Constanza Echeverria, Dhiraj Kumar, Zhen Tang, Conrado Aparicio. 2021 (Acta Biomaterialia (IF–8.947), DOI: 10.1016/j.actbio.2021.12.008).
- A novel methacrylate derivative polymer that resists bacterial cell-mediated biodegradation, Dhiraj Kumar, Debarati Ghose, Robert D Bolskar, Isha Mutreja, and Robert S Jones. 2021 (Journal of Biomedical Materials Research B (IF–3.368), DOI: 10.1002/jbm.b.34972).
2020
- A novel dental polymer with a flipped external ester group design that resists degradation via polymer backbone preservation, Dhiraj Kumar, Robert D Bolskar, Sydney Malone, Isha Mutreja, Conrado Aparicio, and Robert S Jones. 2020 (ACS, Biomaterials Science & Engineering (IF–4.152), DOI: 10.1021/acsbiomaterials.0c00947).
- Design and characterization of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity, Cesar R. Alcala-Orozco, Isha Mutreja, Xiaolin Cui, Dhiraj Kumar, Gary J. Hooper, Khoon S. Lim, Tim B.F. Woodfield. 2020 (Bioprinting (IF – 5.88), DOI: 10.1016/j.bprint.2019.e00073).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Co-functionalized gold nanoparticles for drug delivery application, Ulster University
Sep 1 2009 → Oct 21 2012
Award Date: May 6 2013
Masters, Nanobiotechnology - Surface modified alumina nanotubes for controlled drug release and Silica NPs as Nanocarrier, Amity University
2007 → 2009
MSc, Physical Chemistry, Department of Chemistry, Delhi University
2004 → 2006
BS, Chemistry Honors, Hindu College, Delhi University
2001 → 2004
External Positions
Research Fellow, Department of Obstetrics and Gynecology, University of Otago at Christchurch
Jan 2014 → Jun 2018
Visiting Postdoc, School of Engineering, University of Canterbury
2013 → 2015
Research Interest Keywords
- Nanotherapeutics
- nanoparticle
- Nanotheranostics
- Nanomedicine
- nanomaterials
- Nano-contrast agent
- biomedical imaging
- biomaterials
- Drug Delivery
- molecular delivery
- Cancer targeting
- nanoparticle-polymer composites
- nanobioengineering
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Network
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Utilizing a degradation prediction pathway system to understand how a novel methacrylate derivative polymer with flipped external ester groups retains physico-mechanical properties following esterase exposure
Kumar, D., Ghose, D., Mutreja, I., Bolskar, R. D., Aparicio, C. & Jones, R. S., Dec 18 2021, In: Dental Materials.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Spectral Photon-Counting Molecular Imaging for Quantification of Monoclonal Antibody-Conjugated Gold Nanoparticles Targeted to Lymphoma and Breast Cancer: An In Vitro Study
Moghiseh, M., Lowe, C., Lewis, J. G., Kumar, D., Butler, A., Anderson, N. & Raja, A., Dec 18 2018, In: Contrast Media and Molecular Imaging.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Design and characterisation of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity
Alcala-Orozco, C. R., Mutreja, I., Cui, X., Kumar, D., Hooper, G. J., Lim, K. S. & Woodfield, T. B. F., Dec 2019, In: Bioprinting.Research output: Contribution to journal › Article › peer-review
48 Scopus citations -
Cytotoxicity and cellular uptake of different sized gold nanoparticles in ovarian cancer cells
Kumar, D., Mutreja, I., Chitcholtan, K. & Sykes, P., Nov 3 2017, In: Nanotechnology. 28, 47, 475101.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
A novel methacrylate derivative polymer that resists bacterial cell-mediated biodegradation
Kumar, D., Ghose, D., Bolskar, R. D., Mutreja, I. & Jones, R. S., Dec 2 2021, In: Journal of Biomedical Materials Research - Part B Applied Biomaterials.Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Datasets
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A Novel Methacrylate Derivative Polymer That Resists Bacterial Cell-Mediated Biodegradation Data Sharing Archive
Kumar, D., Ghose, D., Mutreja, I., Bolskar, R. D. & Jones, R. S., Data Repository for the University of Minnesota, Nov 22 2021
DOI: 10.13020/jms8-pq47, https://hdl.handle.net/11299/225348
Dataset
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Investigating the Cytocompatibility of a Novel Flipped Ester Group Design Polymer Composites against Oral Keratinocytes
Kumar, D., Bolskar, R. D., Mutreja, I. & Jones, R. S., Data Repository for the University of Minnesota, May 9 2022
https://hdl.handle.net/11299/227293
Dataset