DeWayne Townsend

19982020

Research output per year

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2020

In situ expansion, differentiation, and electromechanical coupling of human cardiac muscle in a 3D bioprinted, chambered organoid

Kupfer, M. E., Lin, W-H., Ravikumar, V., Qiu, K., Wang, L., Gao, L., Bhuiyan, D. B., Lenz, M., Ai, J., Mahutga, R. R., Townsend, D., Zhang, J., McAlpine, M., Tolkacheva, E. & Ogle, B. M., 2020, In : Circulation Research.

Research output: Contribution to journalArticle

Stem Cell–Derived Cardiomyocytes and Beta-Adrenergic Receptor Blockade in Duchenne Muscular Dystrophy Cardiomyopathy

Kamdar, F., Das, S., Gong, W., Klaassen Kamdar, A., Meyers, T. A., Shah, P., Ervasti, J. M., Townsend, D. W., Kamp, T. J., Wu, J. C., Garry, M. G., Zhang, J. & Garry, D. J., Mar 17 2020, In : Journal of the American College of Cardiology. 75, 10, p. 1159-1174 16 p.

Research output: Contribution to journalArticle

2019

Acute AT 1 R blockade prevents isoproterenol-induced injury in mdx hearts

Meyers, T. A., Heitzman, J. A., Krebsbach, A. M., Aufdembrink, L. M., Hughes, R., Bartolomucci, A. & Townsend, D., Mar 2019, In : Journal of Molecular and Cellular Cardiology. 128, p. 51-61 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Hyperbaric therapy provides no benefit for skeletal muscle and respiratory function and accelerates cardiac injury in mdx mice

Fischer, K. D., Heitzman, J. A. & Townsend, D., Dec 1 2019, In : Scientific reports. 9, 1, 12306.

Research output: Contribution to journalArticle

Open Access
2018

CRABP1 protects the heart from isoproterenol-induced acute and chronic remodeling

Park, S. W., Persaud, S. D., Ogokeh, S., Meyers, T. A., Townsend, D. & Wei, L-N., Jan 1 2018, In : Journal of Endocrinology. 236, 3, p. 151-165 15 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Integrative effects of dystrophin loss on metabolic function of the mdx mouse

Strakova, J., Kamdar, F., Kulhanek, D., Razzoli, M., Garry, D. J., Ervasti, J. M., Bartolomucci, A. & Townsend, D. W., Dec 1 2018, In : Scientific reports. 8, 1, 13624.

Research output: Contribution to journalArticle

Open Access
2016

Hypoxia-induced cardiac injury in dystrophic mice

Stelter, Z., Strakova, J., Yellamilli, A., Fischer, K., Sharpe, K. M. & Townsend, D., Apr 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 7, p. H938-H948

Research output: Contribution to journalArticle

2 Scopus citations

Measuring pressure volume loops in the mouse

Townsend, D. W., May 2 2016, In : Journal of Visualized Experiments. 2016, 111, e53810.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Diastolic dysfunction precedes hypoxia-induced mortality in dystrophic mice

Townsend, D. W., Jan 1 2015, In : Physiological Reports. 3, 8, e12513.

Research output: Contribution to journalArticle

2 Scopus citations

Early detection of myocardial bioenergetic deficits: A 9.4 tesla complete non invasive 31P MR spectroscopy study in mice with muscular dystrophy

Cui, W., Jang, A., Zhang, P., Thompson, B., Townsend, D., Metzger, J. M. & Zhang, J., Aug 11 2015, In : PloS one. 10, 8, e0135000.

Research output: Contribution to journalArticle

5 Scopus citations
19 Scopus citations

Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment

Barnabei, M. S., Sjaastad, F. V., Townsend, D., Bedada, F. B. & Metzger, J. M., Jul 1 2015, In : Science Translational Medicine. 7, 294, 294ra106.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Dystrobrevin increases dystrophin's binding to the dystrophin-glycoprotein complex and provides protection during cardiac stress

Strakova, J., Dean, J. D., Sharpe, K. M., Meyers, T. A., Odom, G. L. & Townsend, D. W., Nov 1 2014, In : Current Therapeutic Research - Clinical and Experimental. 76, p. 106-115 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Finding the sweet spot: Assembly and glycosylation of the dystrophin-associated glycoprotein complex

Townsend, D. W., Sep 2014, In : Anatomical Record. 297, 9, p. 1694-1705 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Alterations of dystrophin-associated glycoproteins in the heart lacking dystrophin or dystrophin and utrophin

Sharpe, K. M., Premsukh, M. D. & Townsend, D., Dec 1 2013, In : Journal of muscle research and cell motility. 34, 5-6, p. 395-405 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2011

Age-dependent Dystrophin Loss and Genetic Reconstitution Establish a Molecular Link between Dystrophin and Heart Performance during Aging

Townsend, D., Daly, M., Chamberlain, J. S. & Metzger, J. M., Oct 2011, In : Molecular Therapy. 19, 10, p. 1821-1825 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex

Townsend, D., Yasuda, S., McNally, E. & Metzger, J. M., Sep 1 2011, In : FASEB Journal. 25, 9, p. 3106-3114 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Exercise and muscular dystrophy: Implications and analysis of effects on musculoskeletal and cardiovascular systems

Barnabei, M. S., Martindale, J. M., Townsend, D. & Metzger, J. M., Jul 1 2011, In : Comprehensive Physiology. 1, 3, p. 1353-1363 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2010

Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs

Townsend, D. W., Turner, I., Yasuda, S., Martindale, J., Davis, J., Shillingford, M., Kornegay, J. N. & Metzger, J. M., Apr 1 2010, In : Journal of Clinical Investigation. 120, 4, p. 1140-1150 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Heparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodeling

Adhikari, N., Basi, D. L., Townsend, D. W., Rusch, M., Mariash, A., Mullegama, S., Watson, A., Larson, J., Tan, S., Lerman, B., Esko, J. D., Selleck, S. B. & Hall, J. L., Aug 1 2010, In : Journal of Molecular and Cellular Cardiology. 49, 2, p. 287-293 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2009

Artificial selection for whole animal low intrinsic aerobic capacity co-segregates with hypoxia-induced cardiac pump failure

Palpant, N. J., Szatkowski, M. L., Wang, W., Townsend, D., Bedada, F. B., Koch, L. G., Britton, S. L. & Metzger, J. M., Jul 1 2009, In : PloS one. 4, 7, e6117.

Research output: Contribution to journalArticle

8 Scopus citations

Cardiac consequences to skeletal muscle-centric therapeutics for Duchenne muscular dystrophy.

Townsend, D., Yasuda, S., Chamberlain, J. & Metzger, J. M., Feb 1 2009, In : Trends in Cardiovascular Medicine. 19, 2, p. 50-55 6 p.

Research output: Contribution to journalArticle

2008

Cardiac involvement in the dystrophinopathies

Russell, M. W., Townsend, D. W. & Metzger, J. M., Jan 1 2008, In : Journal of Pediatric Rehabilitation Medicine. 1, 3, p. 211-223 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Emergent dilated cardiomyopathy caused by targeted repair of dystrophic skeletal muscle

Townsend, D. W., Yasuda, S., Li, S., Chamberlain, J. S. & Metzger, J. M., May 2008, In : Molecular Therapy. 16, 5, p. 832-835 4 p.

Research output: Contribution to journalArticle

87 Scopus citations
2007

Dystrophin-deficient mdx mice display a reduced life span and are susceptible to spontaneous rhabdomyosarcoma

Chamberlain, J. S., Metzger, J., Reyes, M., Townsend, D. & Faulkner, J. A., Jul 1 2007, In : FASEB Journal. 21, 9, p. 2195-2204 10 p.

Research output: Contribution to journalArticle

189 Scopus citations

Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure

Townsend, D. W., Blankinship, M. J., Allen, J. M., Gregorevic, P., Chamberlain, J. S. & Metzger, J. M., Jun 1 2007, In : Molecular Therapy. 15, 6, p. 1086-1092 7 p.

Research output: Contribution to journalArticle

100 Scopus citations
2005

Dystrophic heart failure blocked by membrane sealant poloxamer

Yasuda, S., Townsend, D. W., Michele, D. E., Favre, E. G., Day, S. M. & Metzger, J. M., Aug 18 2005, In : Nature. 436, 7053, p. 1025-1029 5 p.

Research output: Contribution to journalArticle

217 Scopus citations

Mediation of neurogenic ion transport by acetylcholine, prostanoids and 5-hydroxytryptamine in porcine ileum

Townsend, D., Casey, M. A. & Brown, D. R., Sep 20 2005, In : European Journal of Pharmacology. 519, 3, p. 285-289 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
2004
9 Scopus citations
2003
1 Scopus citations
3 Scopus citations
2002
12 Scopus citations
2001

Pharmaconeuroimmunology in the intestinal tract: Opioid and cannabinoid receptors, enteric neurons and mucosal defense

Brown, D. R., Green, B. T., Kulkarni-Narla, A., Poonyachoti, S. & Townsend IV, D., Jan 1 2001, In : Advances in experimental medicine and biology. 493, p. 197-205 9 p.

Research output: Contribution to journalArticle

1998
52 Scopus citations