1991 …2023
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Research Output 1991 2019

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104 Citations (Scopus)

Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: A peroxynitrite-mediated process?

Viner, R. I., Ferrington, D. A., Hühmer, A. F. R., Bigelow, D. J. & Schöneich, C., Feb 5 1996, In : FEBS Letters. 379, 3, p. 286-290 5 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Nitration
Adenosine Triphosphatases
Muscle
Rats
11 Citations (Scopus)

Activating the AKT2–nuclear factor-κB–lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration

Ghosh, S., Shang, P., Yazdankhah, M., Bhutto, I., Hose, S., Montezuma, S. R., Luo, T., Chattopadhyay, S., Qian, J., Lutty, G. A., Ferrington, D. A., Zigler, J. S. & Sinha, D., Apr 1 2017, In : Journal of Pathology. 241, 5, p. 583-588 6 p.

Research output: Contribution to journalArticle

Open Access
Macular Degeneration
Lysosomes
Retina
Immune System
Epithelium
41 Citations (Scopus)

Activation of the sarcoplasmic reticulum Ca2+-ATPase induced by exercise

Ferrington, D. A., Reijneveld, J. C., Bär, P. R. & Bigelow, D. J., Mar 13 1996, In : Biochimica et Biophysica Acta - Biomembranes. 1279, 2, p. 203-213 11 p.

Research output: Contribution to journalArticle

Calcium-Transporting ATPases
Sarcoplasmic Reticulum
Chemical activation
Calcium
Membranes
32 Citations (Scopus)

Adaptive changes in lipid composition of skeletal sarcoplasmic reticulum membranes associated with aging

Krainev, A. G., Ferrington, D. A., Williams, T. D., Squier, T. C. & Bigelow, D. J., May 4 1995, In : BBA - Biomembranes. 1235, 2, p. 406-418 13 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Aging of materials
Membranes
Lipids
Calcium-Transporting ATPases
5 Citations (Scopus)

Age-dependent effects of treadmill exercise during a period of inactivity

Arora, P., Husom, A. D., Ferrington, D. A. & Thompson, L. V., Jul 1 2008, In : Experimental Gerontology. 43, 7, p. 668-673 6 p.

Research output: Contribution to journalArticle

Bearings (structural)
Exercise equipment
Exercise
Weight-Bearing
Rats
41 Citations (Scopus)

Age-dependent inhibition of proteasome chymotrypsin-like activity in the retina

Kapphahn, R. J., Bigelow, E. J. & Ferrington, D. A., Apr 1 2007, In : Experimental Eye Research. 84, 4, p. 646-654 9 p.

Research output: Contribution to journalArticle

Chymotrypsin
Proteasome Endopeptidase Complex
Retina
Cysteine
Caseins
32 Citations (Scopus)

Age-related chemical modification of the skeletal muscle sarcoplasmic reticulum Ca-ATPase of the rat

Schöneich, C., Viner, R. I., Ferrington, D. A. & Bigelow, D. J., Mar 15 1999, In : Mechanisms of Ageing and Development. 107, 3, p. 221-231 11 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Adenosine Triphosphatases
Skeletal Muscle
Peroxynitrous Acid
Protein Isoforms
15 Citations (Scopus)

Age-related differences in the adaptive potential of type I skeletal muscle fibers

Husom, A. D., Ferrington, D. A. & Thompson, L. V., Jan 1 2005, In : Experimental Gerontology. 40, 3, p. 227-235 9 p.

Research output: Contribution to journalArticle

Slow-Twitch Muscle Fibers
Skeletal Muscle Fibers
Muscle
Skeletal Muscle
Fibers
63 Citations (Scopus)

Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal

Ethen, C. M., Reilly, C., Feng, X., Olsen, T. W. & Ferrington, D. A., Aug 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 8, p. 3469-3479 11 p.

Research output: Contribution to journalArticle

Macular Degeneration
Proteins
4-hydroxy-2-nonenal
Lipid Peroxidation
2-nonenal
22 Citations (Scopus)

Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress

Chen, C. N., Brown-Borg, H. M., Rakoczy, S. G., Ferrington, D. A. & Thompson, L. V., Apr 9 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65, 2, p. 129-137 9 p.

Research output: Contribution to journalArticle

Glutamate-Cysteine Ligase
Catalytic Domain
Skeletal Muscle
Extremities
Muscles
17 Citations (Scopus)

Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration

Ferrington, D. A., Ebeling, M. C., Kapphahn, R. J., Terluk, M. R., Fisher, C. R., Polanco, J. R., Roehrich, H., Leary, M. M., Geng, Z., Dutton, J. R. & Montezuma, S. R., Oct 1 2017, In : Redox Biology. 13, p. 255-265 11 p.

Research output: Contribution to journalArticle

Open Access
Oxidative stress
Retinal Pigments
Retinal Pigment Epithelium
Macular Degeneration
Energy Metabolism
137 Citations (Scopus)

Altered proteasome function and subunit composition in aged muscle

Husom, A. D., Peters, E. A., Kolling, E. A., Fugere, N. A., Thompson, L. V. & Ferrington, D. A., Jan 1 2004, In : Archives of Biochemistry and Biophysics. 421, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Muscle
Muscles
Chemical analysis
Muscular Atrophy
162 Citations (Scopus)

Altered proteasome structure, function, and oxidation in aged muscle

Ferrington, D. A., Husom, A. D. & Thompson, L. V., Apr 1 2005, In : FASEB Journal. 19, 6, p. 644-646 3 p.

Research output: Contribution to journalArticle

dithiothreitol
muscle protein
proteasome endopeptidase complex
calmodulin
skeletal muscle
70 Citations (Scopus)

Altered turnover of calcium regulatory proteins of the sarcoplasmic reticulum in aged skeletal muscle

Ferrington, D. A., Krainev, A. G. & Bigelow, D. J., Mar 6 1998, In : Journal of Biological Chemistry. 273, 10, p. 5885-5891 7 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Muscle
Skeletal Muscle
Calcium
Leucine
20 Citations (Scopus)

A novel role for the immunoproteasome in retinal function

Hussong, S. A., Roehrich, H., Kapphahn, R. J., Maldonado, M., Pardue, M. T. & Ferrington, D. A., Feb 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 2, p. 714-723 10 p.

Research output: Contribution to journalArticle

Knockout Mice
Catalytic Domain
Electroretinography
Proteasome Endopeptidase Complex
Retina

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Hytti, M., Korhonen, E., Hyttinen, J. M. T., Roehrich, H., Kaarniranta, K., Ferrington, D. A. & Kauppinen, A., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 1583656.

Research output: Contribution to journalArticle

Open Access
Antimycin A
Retinal Pigments
Retinal Pigment Epithelium
Autophagy
Cell death

Body Composition And Plasma Lipoprotein Profile Of Male And Female Swimming And Track Athletes

Schneider, C. M., Klish, W. J., Insull, W. & Ferrington, D. A., Oct 1 1991, In : Sports Medicine, Training and Rehabilitation. 3, 1, p. 13-18 6 p.

Research output: Contribution to journalArticle

Body Composition
Athletes
Lipoproteins
Adipose Tissue
Cholesterol
15 Citations (Scopus)

Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading

Chen, C. N., Ferrington, D. A. & Thompson, L. V., Nov 1 2008, In : Journal of applied physiology. 105, 5, p. 1554-1561 8 p.

Research output: Contribution to journalArticle

Carbonic Anhydrase III
Muscles
Proteins
Hindlimb Suspension
Muscle Proteins
94 Citations (Scopus)

Catalytic site-specific inhibition of the 20S proteasome by 4-hydroxynonenal

Ferrington, D. A. & Kapphahn, R. J., Dec 17 2004, In : FEBS Letters. 578, 3, p. 217-223 7 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Catalytic Domain
Chymotrypsin
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Electrophoresis, Gel, Two-Dimensional
106 Citations (Scopus)

Changes in Select Redox Proteins of the Retinal Pigment Epithelium in Age-related Macular Degeneration

Decanini, A., Nordgaard, C. L., Feng, X., Ferrington, D. A. & Olsen, T. W., Jan 1 2007, In : American journal of ophthalmology. 143, 4

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Macular Degeneration
Oxidation-Reduction
Proteins
Eye Diseases
16 Citations (Scopus)

Closer proximity between opposing domains of vertebrate calmodulin following deletion of Met145-Lys148

Yin, D., Sun, H., Ferrington, D. A. & Squier, T. C., Aug 22 2000, In : Biochemistry. 39, 33, p. 10255-10268 14 p.

Research output: Contribution to journalArticle

Calmodulin
Vertebrates
Cell membranes
Adenosine Triphosphatases
Cell Membrane
42 Citations (Scopus)

Comparable levels of Ca-ATPase inhibition by phospholamban in slow-twitch skeletal and cardiac sarcoplasmic reticulum

Ferrington, D. A., Yao, Q., Squier, T. C. & Bigelow, D. J., Nov 5 2002, In : Biochemistry. 41, 44, p. 13289-13296 8 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Adenosine Triphosphatases
Calcium
Phosphorylation
phospholamban
9 Citations (Scopus)

Corneal Wound Healing Is Compromised by Immunoproteasome Deficiency

Ferrington, D. A., Roehrich, H., Chang, A. A., Huang, C. W., Maldonado, M., Bratten, W., Rageh, A. A., Heuss, N. D., Gregerson, D. S., Nelson, E. F. & Yuan, C., Jan 30 2013, In : PloS one. 8, 1, e54347.

Research output: Contribution to journalArticle

Immune system
cornea
tissue repair
Cell culture
Wound Healing
100 Citations (Scopus)
Fatty Acid-Binding Proteins
Antioxidants
Proteins
Lipids
Ionization
20 Citations (Scopus)

Declines in arrestin and rhodopsin in the macula with progression of age-related macular degeneration

Ethen, C. M., Feng, X., Olsen, T. W. & Ferrington, D. A., Mar 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 3, p. 769-775 7 p.

Research output: Contribution to journalArticle

Arrestin
Rhodopsin
Macular Degeneration
Retinal Rod Photoreceptor Cells
Proteins
24 Citations (Scopus)

Decreased conformational stability of the sarcoplasmic reticulum Ca- ATPase in aged skeletal muscle

Ferrington, D. A., Jones, T. E., Qin, Z., Miller-Schlyer, M., Squier, T. C. & Bigelow, D. J., Dec 4 1997, In : Biochimica et Biophysica Acta - Biomembranes. 1330, 2, p. 233-247 15 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Adenosine Triphosphatases
Muscle
Skeletal Muscle
Muscles
3 Citations (Scopus)

Denervation-induced activation of the standard proteasome and immunoproteasome

Liu, H. M., Ferrington, D. A., Baumann, C. W. & Thompson, L. V., Nov 2016, In : PloS one. 11, 11, e0166831.

Research output: Contribution to journalArticle

proteasome endopeptidase complex
Denervation
Proteasome Endopeptidase Complex
Muscular Atrophy
Muscle
156 Citations (Scopus)

Diastereoselective reduction of protein-bound methionine sulfoxide by methionine sulfoxide reductase

Sharov, V. S., Ferrington, D. A., Squier, T. C. & Schöneich, C., Jul 23 1999, In : FEBS Letters. 455, 3, p. 247-250 4 p.

Research output: Contribution to journalArticle

Calmodulin
sulfoxide
Proteins
Oxidative stress
Liver
30 Citations (Scopus)

Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells

Ferrington, D. A., Tran, T. N., Lew, K. L., Van Remmen, H. & Gregerson, D. S., Sep 1 2006, In : Experimental Eye Research. 83, 3, p. 638-650 13 p.

Research output: Contribution to journalArticle

Retinal Pigments
Caspases
Epithelial Cells
Oxidants
Apoptosis
4 Citations (Scopus)

Downhill exercise alters immunoproteasome content in mouse skeletal muscle

Baumann, C. W., Kwak, D., Ferrington, D. A. & Thompson, L. D. V., Jul 1 2018, In : Cell Stress and Chaperones. 23, 4, p. 507-517 11 p.

Research output: Contribution to journalArticle

Open Access
Muscle
Skeletal Muscle
Muscles
Proteasome Endopeptidase Complex
Running
8 Citations (Scopus)

Effects of dietary protein on enzyme activity following exercise- induced muscle injury

Hayward, R., Ferrington, D. A., Kochanowski, L. A., Miller, L. M., Jaworsky, G. M. & Schneider, C. M., Jan 1 1999, In : Medicine and Science in Sports and Exercise. 31, 3, p. 414-420 7 p.

Research output: Contribution to journalArticle

Dietary Proteins
Muscles
Protein-Restricted Diet
Wounds and Injuries
Enzymes
17 Citations (Scopus)

Electron paramagnetic resonance: A high-resolution tool for muscle physiology

Thompson, L. V., Lowe, D. A., Ferrington, D. A. & Thomas, D. D., Jan 1 2001, In : Exercise and Sport Sciences Reviews. 29, 1, p. 3-6 4 p.

Research output: Contribution to journalArticle

Electron Spin Resonance Spectroscopy
Muscles
Muscle Relaxation
Myosins
Adenosine Triphosphatases
67 Citations (Scopus)

Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers

Prochniewicz, E., Lowe, D. A., Spakowicz, D. J., Higgins, L., O'Conor, K., Thompson, L. V., Ferrington, D. A. & Thomas, D. D., Feb 1 2008, In : American Journal of Physiology - Cell Physiology. 294, 2

Research output: Contribution to journalArticle

Skeletal Muscle Fibers
Myosins
Hydrogen Peroxide
Peroxides
Myofibrils
8 Citations (Scopus)

Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration

Geng, Z., Walsh, P. J., Truong, V., Hill, C., Ebeling, M., Kapphahn, R. J., Montezuma, S. R., Yuan, C., Roehrich, H., Ferrington, D. A. & Dutton, J. R., Mar 2017, In : PloS one. 12, 3, e0173575.

Research output: Contribution to journalArticle

Open Access
conjunctiva
Conjunctiva
Macular Degeneration
Stem cells
epithelium
55 Citations (Scopus)

Human retinal pigment epithelium proteome changes in early diabetes

Decanini, A., Karunadharma, P. R., Nordgaard, C. L., Feng, X., Olsen, T. W. & Ferrington, D. A., Jun 1 2008, In : Diabetologia. 51, 6, p. 1051-1061 11 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Proteome
Diabetic Retinopathy
Proteins
Mass Spectrometry
13 Citations (Scopus)

Identification of a novel phosphorylation site in ataxin-1

Vierra-Green, C. A., Orr, H. T., Zoghbi, H. Y. & Ferrington, D. A., May 15 2005, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1744, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Serine
Phosphorylation
Alanine
Transgenic Mice
60 Citations (Scopus)

Immunoproteasome deficiency alters retinal proteasome's response to stress

Hussong, S. A., Kapphahn, B., Phillips, S. L., Maldonado, M. & Ferrington, D. A., Jun 1 2010, In : Journal of Neurochemistry. 113, 6, p. 1481-1490 10 p.

Research output: Contribution to journalArticle

Retinal Pigments
Proteasome Endopeptidase Complex
Retina
Oxidative stress
Up-Regulation
15 Citations (Scopus)

Immunoproteasome Deficiency Modifies the Alternative Pathway of NFκB Signaling

Maldonado, M., Kapphahn, R. J., Terluk, M. R., Heuss, N. D., Yuan, C., Gregerson, D. S. & Ferrington, D. A., Feb 14 2013, In : PloS one. 8, 2, e56187.

Research output: Contribution to journalArticle

Transcription Factor RelA
Transcription Factors
Genes
Chemical activation
Retinal Pigments
8 Citations (Scopus)

Immunoproteasome deficiency protects in the retina after optic nerve crush

Schuld, N. J., Hussong, S. A., Kapphahn, R. J., Lehmann, U., Roehrich, H., Rageh, A. A., Heuss, N. D., Bratten, W., Gregerson, D. S. & Ferrington, D. A., May 15 2015, In : PloS one. 10, 5, e0126768.

Research output: Contribution to journalArticle

Nerve Crush
Optic Nerve
optics
retina
Retina
11 Citations (Scopus)

Immunoproteasome in animal models of Duchenne muscular dystrophy

Chen, C. N. J., Graber, T. G., Bratten, W. M., Ferrington, D. A. & Thompson, L. V., Jan 1 2014, In : Journal of muscle research and cell motility. 35, 2, p. 191-201 11 p.

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
Muscle
Proteasome Endopeptidase Complex
Animals
Animal Models
50 Citations (Scopus)

Immunoproteasome responds to injury in the retina and brain

Ferrington, D. A., Hussong, S. A., Roehrich, H., Kapphahn, B., Kavanaugh, S. M., Heuss, N. D. & Gregerson, D. S., Jul 1 2008, In : Journal of Neurochemistry. 106, 1, p. 158-169 12 p.

Research output: Contribution to journalArticle

Retina
Brain
T-cells
Cytotoxic T-Lymphocytes
Wounds and Injuries

Immunoproteasomes as a novel antiviral mechanism in rhinovirus-infected airways

Dimasuay, K. G., Sanchez, A., Schaefer, N., Polanco, J., Ferrington, D. A. & Chu, H. W., Aug 1 2018, In : Clinical science. 132, 15, p. 1711-1723 13 p.

Research output: Contribution to journalArticle

Rhinovirus
Antiviral Agents
Epithelial Cells
Infection
Interferons
19 Citations (Scopus)

Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration

Ferrington, D. A., Kapphahn, R. J., Leary, M. M., Atilano, S. R., Terluk, M. R., Karunadharma, P., Chen, G. K. J., Ratnapriya, R., Swaroop, A., Montezuma, S. R. & Kenney, M. C., Apr 1 2016, In : Experimental Eye Research. 145, p. 269-277 9 p.

Research output: Contribution to journalArticle

Macular Degeneration
Mitochondrial DNA
Retinal Pigment Epithelium
Alleles
Tissue Donors

Increased serum proteins in non-exudative AMD retinas

Schultz, H., Song, Y., Baumann, B. H., Kapphahn, B., Montezuma, S. R., Ferrington, D. A. & Dunaief, J. L., Sep 1 2019, In : Experimental Eye Research. 186, 107686.

Research output: Contribution to journalArticle

Macular Degeneration
Retina
Blood-Retinal Barrier
Blood Proteins
Albumins
25 Citations (Scopus)
Epithelial Cells
T-Lymphocytes
Major Histocompatibility Complex
Antigens
Coculture Techniques
79 Citations (Scopus)

Investigating mitochondria as a target for treating age-related macular degeneration

Terluk, M. R., Kapphahn, B., Soukup, L. M., Gong, H., Gallardo, C., Montezuma, S. R. & Ferrington, D. A., May 6 2015, In : Journal of Neuroscience. 35, 18, p. 7304-7311 8 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Macular Degeneration
Mitochondrial DNA
Mitochondria
Retina
36 Citations (Scopus)

In vivo aging of rat skeletal muscle sarcoplasmic reticulum Ca-ATPase. Chemical analysis and quantitative simulation by exposure to low levels of peroxyl radicals

Viner, R. I., Ferrington, D. A., Aced, G. I., Miller-Schlyer, M., Bigelow, D. J. & Schöneich, C., Oct 23 1997, In : Biochimica et Biophysica Acta - Biomembranes. 1329, 2, p. 321-335 15 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Adenosine Triphosphatases
Muscle
Rats
Skeletal Muscle
4 Citations (Scopus)

Lactoferrin Expression in Human and Murine Ocular Tissue

Rageh, A. A., Ferrington, D. A., Roehrich, H., Yuan, C., Terluk, M. R., Nelson, E. F. & Montezuma, S. R., Jul 2 2016, In : Current Eye Research. 41, 7, p. 883-889 7 p.

Research output: Contribution to journalArticle

Lactoferrin
Retinal Pigment Epithelium
Cornea
Retina
Iris
4 Citations (Scopus)

Lactoferrin Reduces Chorioretinal Damage in the Murine Laser Model of Choroidal Neovascularization

Montezuma, S. R., Dolezal, L. D., Rageh, A. A., Mar, K., Jordan, M. & Ferrington, D. A., Sep 2 2015, In : Current Eye Research. 40, 9, p. 946-953 8 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Lactoferrin
Lasers
Knockout Mice
Fluorescein Angiography
2 Citations (Scopus)

Lipid-derived and other oxidative modifications of retinal proteins in a rat model of Smith-Lemli-Opitz syndrome

Kapphahn, B., Richards, M. J., Ferrington, D. A. & Fliesler, S. J., Jan 1 2019, In : Experimental Eye Research. 178, p. 247-254 8 p.

Research output: Contribution to journalArticle

Open Access
trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
Smith-Lemli-Opitz Syndrome
Lipids
Retina
Proteins