Deborah A Ferrington

Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: A peroxynitrite-mediated process?

Viner, R. I., Ferrington, D. A., Hühmer, A. F. R., Bigelow, D. J. & Schöneich, C., Feb 5 1996, In : FEBS Letters. 379, 3, p. 286-290 5 p.

Research output: Contribution to journal › Article

Peroxynitrous Acid

Nitration

Adenosine Triphosphatases

Muscle

Rats

11 Citations (Scopus)

Activating the AKT2–nuclear factor-κB–lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration

Ghosh, S., Shang, P., Yazdankhah, M., Bhutto, I., Hose, S., Montezuma, S. R., Luo, T., Chattopadhyay, S., Qian, J., Lutty, G. A., Ferrington, D. A., Zigler, J. S. & Sinha, D., Apr 1 2017, In : Journal of Pathology. 241, 5, p. 583-588 6 p.

Research output: Contribution to journal › Article

Open Access

Macular Degeneration

Lysosomes

Retina

Immune System

Epithelium

41 Citations (Scopus)

Activation of the sarcoplasmic reticulum Ca²⁺-ATPase induced by exercise

Ferrington, D. A., Reijneveld, J. C., Bär, P. R. & Bigelow, D. J., Mar 13 1996, In : Biochimica et Biophysica Acta - Biomembranes. 1279, 2, p. 203-213 11 p.

Research output: Contribution to journal › Article

Calcium-Transporting ATPases

Sarcoplasmic Reticulum

Chemical activation

Calcium

Membranes

32 Citations (Scopus)

Adaptive changes in lipid composition of skeletal sarcoplasmic reticulum membranes associated with aging

Krainev, A. G., Ferrington, D. A., Williams, T. D., Squier, T. C. & Bigelow, D. J., May 4 1995, In : BBA - Biomembranes. 1235, 2, p. 406-418 13 p.

Research output: Contribution to journal › Article

Sarcoplasmic Reticulum

Aging of materials

Membranes

Lipids

Calcium-Transporting ATPases

5 Citations (Scopus)

Age-dependent effects of treadmill exercise during a period of inactivity

Arora, P., Husom, A. D., Ferrington, D. A. & Thompson, L. V., Jul 1 2008, In : Experimental Gerontology. 43, 7, p. 668-673 6 p.

Research output: Contribution to journal › Article

Bearings (structural)

Exercise equipment

Exercise

Weight-Bearing

Rats

41 Citations (Scopus)

Age-dependent inhibition of proteasome chymotrypsin-like activity in the retina

Kapphahn, R. J., Bigelow, E. J. & Ferrington, D. A., Apr 1 2007, In : Experimental Eye Research. 84, 4, p. 646-654 9 p.

Research output: Contribution to journal › Article

Chymotrypsin

Proteasome Endopeptidase Complex

Retina

Cysteine

Caseins

32 Citations (Scopus)

Age-related chemical modification of the skeletal muscle sarcoplasmic reticulum Ca-ATPase of the rat

Schöneich, C., Viner, R. I., Ferrington, D. A. & Bigelow, D. J., Mar 15 1999, In : Mechanisms of Ageing and Development. 107, 3, p. 221-231 11 p.

Research output: Contribution to journal › Article

Sarcoplasmic Reticulum

Adenosine Triphosphatases

Skeletal Muscle

Peroxynitrous Acid

Protein Isoforms

15 Citations (Scopus)

Age-related differences in the adaptive potential of type I skeletal muscle fibers

Husom, A. D., Ferrington, D. A. & Thompson, L. V., Jan 1 2005, In : Experimental Gerontology. 40, 3, p. 227-235 9 p.

Research output: Contribution to journal › Article

Slow-Twitch Muscle Fibers

Skeletal Muscle Fibers

Muscle

Skeletal Muscle

Fibers

63 Citations (Scopus)

Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal

Ethen, C. M., Reilly, C., Feng, X., Olsen, T. W. & Ferrington, D. A., Aug 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 8, p. 3469-3479 11 p.

Research output: Contribution to journal › Article

Macular Degeneration

Proteins

4-hydroxy-2-nonenal

Lipid Peroxidation

2-nonenal

21 Citations (Scopus)

Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress

Chen, C. N., Brown-Borg, H. M., Rakoczy, S. G., Ferrington, D. A. & Thompson, L. V., Apr 9 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65, 2, p. 129-137 9 p.

Research output: Contribution to journal › Article

Glutamate-Cysteine Ligase

Catalytic Domain

Skeletal Muscle

Extremities

Muscles

17 Citations (Scopus)

Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration

Ferrington, D. A., Ebeling, M. C., Kapphahn, R. J., Terluk, M. R., Fisher, C. R., Polanco, J. R., Roehrich, H., Leary, M. M., Geng, Z., Dutton, J. R. & Montezuma, S. R., Oct 1 2017, In : Redox Biology. 13, p. 255-265 11 p.

Research output: Contribution to journal › Article

Open Access

Oxidative stress

Retinal Pigments

Retinal Pigment Epithelium

Macular Degeneration

Energy Metabolism

137 Citations (Scopus)

Altered proteasome function and subunit composition in aged muscle

Husom, A. D., Peters, E. A., Kolling, E. A., Fugere, N. A., Thompson, L. V. & Ferrington, D. A., Jan 1 2004, In : Archives of Biochemistry and Biophysics. 421, 1, p. 67-76 10 p.

Research output: Contribution to journal › Article

Proteasome Endopeptidase Complex

Muscle

Muscles

Chemical analysis

Muscular Atrophy

162 Citations (Scopus)

Altered proteasome structure, function, and oxidation in aged muscle

Ferrington, D. A., Husom, A. D. & Thompson, L. V., Apr 1 2005, In : FASEB Journal. 19, 6, p. 644-646 3 p.

Research output: Contribution to journal › Article

dithiothreitol

muscle protein

proteasome endopeptidase complex

calmodulin

skeletal muscle

70 Citations (Scopus)

Altered turnover of calcium regulatory proteins of the sarcoplasmic reticulum in aged skeletal muscle

Ferrington, D. A., Krainev, A. G. & Bigelow, D. J., Mar 6 1998, In : Journal of Biological Chemistry. 273, 10, p. 5885-5891 7 p.

Research output: Contribution to journal › Article

Sarcoplasmic Reticulum

Muscle

Skeletal Muscle

Calcium

Leucine

20 Citations (Scopus)

A novel role for the immunoproteasome in retinal function

Hussong, S. A., Roehrich, H., Kapphahn, R. J., Maldonado, M., Pardue, M. T. & Ferrington, D. A., Feb 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 2, p. 714-723 10 p.

Research output: Contribution to journal › Article

Knockout Mice

Catalytic Domain

Electroretinography

Proteasome Endopeptidase Complex

Retina

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Hytti, M., Korhonen, E., Hyttinen, J. M. T., Roehrich, H., Kaarniranta, K., Ferrington, D. A. & Kauppinen, A., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 1583656.

Research output: Contribution to journal › Article

Open Access

Antimycin A

Retinal Pigments

Retinal Pigment Epithelium

Autophagy

Cell death

Body Composition And Plasma Lipoprotein Profile Of Male And Female Swimming And Track Athletes

Schneider, C. M., Klish, W. J., Insull, W. & Ferrington, D. A., Oct 1 1991, In : Sports Medicine, Training and Rehabilitation. 3, 1, p. 13-18 6 p.

Research output: Contribution to journal › Article

Body Composition

Athletes

Lipoproteins

Adipose Tissue

Cholesterol

15 Citations (Scopus)

Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading

Chen, C. N., Ferrington, D. A. & Thompson, L. V., Nov 1 2008, In : Journal of applied physiology. 105, 5, p. 1554-1561 8 p.

Research output: Contribution to journal › Article

Carbonic Anhydrase III

Muscles

Proteins

Hindlimb Suspension

Muscle Proteins

94 Citations (Scopus)

Catalytic site-specific inhibition of the 20S proteasome by 4-hydroxynonenal

Ferrington, D. A. & Kapphahn, R. J., Dec 17 2004, In : FEBS Letters. 578, 3, p. 217-223 7 p.

Research output: Contribution to journal › Article

Proteasome Endopeptidase Complex

Catalytic Domain

Chymotrypsin

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry

Electrophoresis, Gel, Two-Dimensional

106 Citations (Scopus)

Changes in Select Redox Proteins of the Retinal Pigment Epithelium in Age-related Macular Degeneration

Decanini, A., Nordgaard, C. L., Feng, X., Ferrington, D. A. & Olsen, T. W., Jan 1 2007, In : American journal of ophthalmology. 143, 4

Research output: Contribution to journal › Article

Retinal Pigment Epithelium

Macular Degeneration

Oxidation-Reduction

Proteins

Eye Diseases

16 Citations (Scopus)

Closer proximity between opposing domains of vertebrate calmodulin following deletion of Met¹⁴⁵-Lys¹⁴⁸

Yin, D., Sun, H., Ferrington, D. A. & Squier, T. C., Aug 22 2000, In : Biochemistry. 39, 33, p. 10255-10268 14 p.

Research output: Contribution to journal › Article

Calmodulin

Vertebrates

Cell membranes

Adenosine Triphosphatases

Cell Membrane

42 Citations (Scopus)

Comparable levels of Ca-ATPase inhibition by phospholamban in slow-twitch skeletal and cardiac sarcoplasmic reticulum

Ferrington, D. A., Yao, Q., Squier, T. C. & Bigelow, D. J., Nov 5 2002, In : Biochemistry. 41, 44, p. 13289-13296 8 p.

Research output: Contribution to journal › Article

Sarcoplasmic Reticulum

Adenosine Triphosphatases

Calcium

Phosphorylation

phospholamban

9 Citations (Scopus)

Corneal Wound Healing Is Compromised by Immunoproteasome Deficiency

Ferrington, D. A., Roehrich, H., Chang, A. A., Huang, C. W., Maldonado, M., Bratten, W., Rageh, A. A., Heuss, N. D., Gregerson, D. S., Nelson, E. F. & Yuan, C., Jan 30 2013, In : PloS one. 8, 1, e54347.

Research output: Contribution to journal › Article

Immune system

cornea

tissue repair

Cell culture

Wound Healing

100 Citations (Scopus)

Covalent modification of epithelial fatty acid-binding protein by 4-hydroxynonenal in vitro and in vivo: Evidence for a role in antioxidant biology

Bennaars-Eiden, A., Higgins, L., Hertzel, A. M., Kapphahn, B., Ferrington, D. A. & Bernlohr, D. A., Dec 27 2002, In : Journal of Biological Chemistry. 277, 52, p. 50693-50702 10 p.

Research output: Contribution to journal › Article

Fatty Acid-Binding Proteins

Antioxidants

Proteins

Lipids

Ionization

20 Citations (Scopus)

Declines in arrestin and rhodopsin in the macula with progression of age-related macular degeneration

Ethen, C. M., Feng, X., Olsen, T. W. & Ferrington, D. A., Mar 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 3, p. 769-775 7 p.

Research output: Contribution to journal › Article

Arrestin

Rhodopsin

Macular Degeneration

Retinal Rod Photoreceptor Cells

Proteins

24 Citations (Scopus)

Decreased conformational stability of the sarcoplasmic reticulum Ca- ATPase in aged skeletal muscle

Ferrington, D. A., Jones, T. E., Qin, Z., Miller-Schlyer, M., Squier, T. C. & Bigelow, D. J., Dec 4 1997, In : Biochimica et Biophysica Acta - Biomembranes. 1330, 2, p. 233-247 15 p.

Research output: Contribution to journal › Article

Sarcoplasmic Reticulum

Adenosine Triphosphatases

Muscle

Skeletal Muscle

Muscles

3 Citations (Scopus)

Denervation-induced activation of the standard proteasome and immunoproteasome

Liu, H. M., Ferrington, D. A., Baumann, C. W. & Thompson, L. V., Nov 2016, In : PloS one. 11, 11, e0166831.

Research output: Contribution to journal › Article

proteasome endopeptidase complex

Denervation

Proteasome Endopeptidase Complex

Muscular Atrophy

Muscle

156 Citations (Scopus)

Diastereoselective reduction of protein-bound methionine sulfoxide by methionine sulfoxide reductase

Sharov, V. S., Ferrington, D. A., Squier, T. C. & Schöneich, C., Jul 23 1999, In : FEBS Letters. 455, 3, p. 247-250 4 p.

Research output: Contribution to journal › Article

Calmodulin

sulfoxide

Proteins

Oxidative stress

Liver

30 Citations (Scopus)

Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells

Ferrington, D. A., Tran, T. N., Lew, K. L., Van Remmen, H. & Gregerson, D. S., Sep 1 2006, In : Experimental Eye Research. 83, 3, p. 638-650 13 p.

Research output: Contribution to journal › Article

Retinal Pigments

Caspases

Epithelial Cells

Oxidants

Apoptosis

4 Citations (Scopus)

Downhill exercise alters immunoproteasome content in mouse skeletal muscle

Baumann, C. W., Kwak, D., Ferrington, D. A. & Thompson, L. D. V., Jul 1 2018, In : Cell Stress and Chaperones. 23, 4, p. 507-517 11 p.

Research output: Contribution to journal › Article

Open Access

Muscle

Skeletal Muscle

Muscles

Proteasome Endopeptidase Complex

Running

8 Citations (Scopus)

Effects of dietary protein on enzyme activity following exercise- induced muscle injury

Hayward, R., Ferrington, D. A., Kochanowski, L. A., Miller, L. M., Jaworsky, G. M. & Schneider, C. M., Jan 1 1999, In : Medicine and Science in Sports and Exercise. 31, 3, p. 414-420 7 p.

Research output: Contribution to journal › Article

Dietary Proteins

Muscles

Protein-Restricted Diet

Wounds and Injuries

Enzymes

17 Citations (Scopus)

Electron paramagnetic resonance: A high-resolution tool for muscle physiology

Thompson, L. V., Lowe, D. A., Ferrington, D. A. & Thomas, D. D., Jan 1 2001, In : Exercise and Sport Sciences Reviews. 29, 1, p. 3-6 4 p.

Research output: Contribution to journal › Article

Electron Spin Resonance Spectroscopy

Muscles

Muscle Relaxation

Myosins

Adenosine Triphosphatases

67 Citations (Scopus)

Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers

Prochniewicz, E., Lowe, D. A., Spakowicz, D. J., Higgins, L., O'Conor, K., Thompson, L. V., Ferrington, D. A. & Thomas, D. D., Feb 1 2008, In : American Journal of Physiology - Cell Physiology. 294, 2

Research output: Contribution to journal › Article

Skeletal Muscle Fibers

Myosins

Hydrogen Peroxide

Peroxides

Myofibrils

8 Citations (Scopus)

Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration

Geng, Z., Walsh, P. J., Truong, V., Hill, C., Ebeling, M., Kapphahn, R. J., Montezuma, S. R., Yuan, C., Roehrich, H., Ferrington, D. A. & Dutton, J. R., Mar 2017, In : PloS one. 12, 3, e0173575.

Research output: Contribution to journal › Article

Open Access

conjunctiva

Conjunctiva

Macular Degeneration

Stem cells

epithelium

55 Citations (Scopus)

Human retinal pigment epithelium proteome changes in early diabetes

Decanini, A., Karunadharma, P. R., Nordgaard, C. L., Feng, X., Olsen, T. W. & Ferrington, D. A., Jun 1 2008, In : Diabetologia. 51, 6, p. 1051-1061 11 p.

Research output: Contribution to journal › Article

Retinal Pigment Epithelium

Proteome

Diabetic Retinopathy

Proteins

Mass Spectrometry

13 Citations (Scopus)

Identification of a novel phosphorylation site in ataxin-1

Vierra-Green, C. A., Orr, H. T., Zoghbi, H. Y. & Ferrington, D. A., May 15 2005, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1744, 1, p. 11-18 8 p.

Research output: Contribution to journal › Article

Spinocerebellar Ataxias

Serine

Phosphorylation

Alanine

Transgenic Mice

60 Citations (Scopus)

Immunoproteasome deficiency alters retinal proteasome's response to stress

Hussong, S. A., Kapphahn, B., Phillips, S. L., Maldonado, M. & Ferrington, D. A., Jun 1 2010, In : Journal of Neurochemistry. 113, 6, p. 1481-1490 10 p.

Research output: Contribution to journal › Article

Retinal Pigments

Proteasome Endopeptidase Complex

Retina

Oxidative stress

Up-Regulation

15 Citations (Scopus)

Immunoproteasome Deficiency Modifies the Alternative Pathway of NFκB Signaling

Maldonado, M., Kapphahn, R. J., Terluk, M. R., Heuss, N. D., Yuan, C., Gregerson, D. S. & Ferrington, D. A., Feb 14 2013, In : PloS one. 8, 2, e56187.

Research output: Contribution to journal › Article

Transcription Factor RelA

Transcription Factors

Genes

Chemical activation

Retinal Pigments

8 Citations (Scopus)

Immunoproteasome deficiency protects in the retina after optic nerve crush

Schuld, N. J., Hussong, S. A., Kapphahn, R. J., Lehmann, U., Roehrich, H., Rageh, A. A., Heuss, N. D., Bratten, W., Gregerson, D. S. & Ferrington, D. A., May 15 2015, In : PloS one. 10, 5, e0126768.

Research output: Contribution to journal › Article

Nerve Crush

Optic Nerve

optics

retina

Retina

11 Citations (Scopus)

Immunoproteasome in animal models of Duchenne muscular dystrophy

Chen, C. N. J., Graber, T. G., Bratten, W. M., Ferrington, D. A. & Thompson, L. V., Jan 1 2014, In : Journal of muscle research and cell motility. 35, 2, p. 191-201 11 p.

Research output: Contribution to journal › Article

Duchenne Muscular Dystrophy

Muscle

Proteasome Endopeptidase Complex

Animals

Animal Models

50 Citations (Scopus)

Immunoproteasome responds to injury in the retina and brain

Ferrington, D. A., Hussong, S. A., Roehrich, H., Kapphahn, B., Kavanaugh, S. M., Heuss, N. D. & Gregerson, D. S., Jul 1 2008, In : Journal of Neurochemistry. 106, 1, p. 158-169 12 p.

Research output: Contribution to journal › Article

Retina

Brain

T-cells

Cytotoxic T-Lymphocytes

Wounds and Injuries

Immunoproteasomes as a novel antiviral mechanism in rhinovirus-infected airways

Dimasuay, K. G., Sanchez, A., Schaefer, N., Polanco, J., Ferrington, D. A. & Chu, H. W., Aug 1 2018, In : Clinical science. 132, 15, p. 1711-1723 13 p.

Research output: Contribution to journal › Article

Rhinovirus

Antiviral Agents

Epithelial Cells

Infection

Interferons

19 Citations (Scopus)

Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration

Ferrington, D. A., Kapphahn, R. J., Leary, M. M., Atilano, S. R., Terluk, M. R., Karunadharma, P., Chen, G. K. J., Ratnapriya, R., Swaroop, A., Montezuma, S. R. & Kenney, M. C., Apr 1 2016, In : Experimental Eye Research. 145, p. 269-277 9 p.

Research output: Contribution to journal › Article

Macular Degeneration

Mitochondrial DNA

Retinal Pigment Epithelium

Alleles

Tissue Donors

Increased serum proteins in non-exudative AMD retinas

Schultz, H., Song, Y., Baumann, B. H., Kapphahn, B., Montezuma, S. R., Ferrington, D. A. & Dunaief, J. L., Sep 1 2019, In : Experimental Eye Research. 186, 107686.

Research output: Contribution to journal › Article

Macular Degeneration

Retina

Blood-Retinal Barrier

Blood Proteins

Albumins

25 Citations (Scopus)

Interaction of retinal pigmented epithelial cells and CD4 T cells Leads to T-cell anergy

Gregerson, D. S., Heuss, N. D., Lew, K. L., McPherson, S. W. & Ferrington, D. A., Oct 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 10, p. 4654-4663 10 p.

Research output: Contribution to journal › Article

Epithelial Cells

T-Lymphocytes

Major Histocompatibility Complex

Antigens

Coculture Techniques

77 Citations (Scopus)

Investigating mitochondria as a target for treating age-related macular degeneration

Terluk, M. R., Kapphahn, B., Soukup, L. M., Gong, H., Gallardo, C., Montezuma, S. R. & Ferrington, D. A., May 6 2015, In : Journal of Neuroscience. 35, 18, p. 7304-7311 8 p.

Research output: Contribution to journal › Article

Retinal Pigment Epithelium

Macular Degeneration

Mitochondrial DNA

Mitochondria

Retina

36 Citations (Scopus)

In vivo aging of rat skeletal muscle sarcoplasmic reticulum Ca-ATPase. Chemical analysis and quantitative simulation by exposure to low levels of peroxyl radicals

Viner, R. I., Ferrington, D. A., Aced, G. I., Miller-Schlyer, M., Bigelow, D. J. & Schöneich, C., Oct 23 1997, In : Biochimica et Biophysica Acta - Biomembranes. 1329, 2, p. 321-335 15 p.

Research output: Contribution to journal › Article

Sarcoplasmic Reticulum

Adenosine Triphosphatases

Muscle

Rats

Skeletal Muscle

4 Citations (Scopus)

Lactoferrin Expression in Human and Murine Ocular Tissue

Rageh, A. A., Ferrington, D. A., Roehrich, H., Yuan, C., Terluk, M. R., Nelson, E. F. & Montezuma, S. R., Jul 2 2016, In : Current Eye Research. 41, 7, p. 883-889 7 p.

Research output: Contribution to journal › Article

Lactoferrin

Retinal Pigment Epithelium

Cornea

Retina

Iris

4 Citations (Scopus)

Lactoferrin Reduces Chorioretinal Damage in the Murine Laser Model of Choroidal Neovascularization

Montezuma, S. R., Dolezal, L. D., Rageh, A. A., Mar, K., Jordan, M. & Ferrington, D. A., Sep 2 2015, In : Current Eye Research. 40, 9, p. 946-953 8 p.

Research output: Contribution to journal › Article

Choroidal Neovascularization

Lactoferrin

Lasers

Knockout Mice

Fluorescein Angiography

2 Citations (Scopus)

Lipid-derived and other oxidative modifications of retinal proteins in a rat model of Smith-Lemli-Opitz syndrome

Kapphahn, B., Richards, M. J., Ferrington, D. A. & Fliesler, S. J., Jan 1 2019, In : Experimental Eye Research. 178, p. 247-254 8 p.

Research output: Contribution to journal › Article

Open Access

trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

Smith-Lemli-Opitz Syndrome

Lipids

Retina

Proteins