Deborah A Ferrington

Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: A peroxynitrite-mediated process?

Viner, R. I., Ferrington, D. A., Hühmer, A. F. R., Bigelow, D. J. & Schöneich, C., Feb 5 1996, In: FEBS Letters. 379, 3, p. 286-290 5 p.

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Activating the AKT2–nuclear factor-κB–lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration

Ghosh, S., Shang, P., Yazdankhah, M., Bhutto, I., Hose, S., Montezuma, S. R., Luo, T., Chattopadhyay, S., Qian, J., Lutty, G. A., Ferrington, D. A., Zigler, J. S. & Sinha, D., Apr 1 2017, In: Journal of Pathology. 241, 5, p. 583-588 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Activation of the sarcoplasmic reticulum Ca²⁺-ATPase induced by exercise

Ferrington, D. A., Reijneveld, J. C., Bär, P. R. & Bigelow, D. J., Mar 13 1996, In: Biochimica et Biophysica Acta - Biomembranes. 1279, 2, p. 203-213 11 p.

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Adaptive changes in lipid composition of skeletal sarcoplasmic reticulum membranes associated with aging

Krainev, A. G., Ferrington, D. A., Williams, T. D., Squier, T. C. & Bigelow, D. J., May 4 1995, In: BBA - Biomembranes. 1235, 2, p. 406-418 13 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Age-dependent effects of treadmill exercise during a period of inactivity

Arora, P., Husom, A. D., Ferrington, D. A. & Thompson, L. V., Jul 2008, In: Experimental Gerontology. 43, 7, p. 668-673 6 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Age-dependent inhibition of proteasome chymotrypsin-like activity in the retina

Kapphahn, R. J., Bigelow, E. J. & Ferrington, D. A., Apr 2007, In: Experimental Eye Research. 84, 4, p. 646-654 9 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Age-related chemical modification of the skeletal muscle sarcoplasmic reticulum Ca-ATPase of the rat

Schöneich, C., Viner, R. I., Ferrington, D. A. & Bigelow, D. J., Mar 15 1999, In: Mechanisms of Ageing and Development. 107, 3, p. 221-231 11 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Age-related differences in the adaptive potential of type I skeletal muscle fibers

Husom, A. D., Ferrington, D. A. & Thompson, L. D. V., Mar 2005, In: Experimental Gerontology. 40, 3, p. 227-235 9 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal

Ethen, C. M., Reilly, C., Feng, X., Olsen, T. W. & Ferrington, D. A., Aug 2007, In: Investigative Ophthalmology and Visual Science. 48, 8, p. 3469-3479 11 p.

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress

Chen, C. N., Brown-Borg, H. M., Rakoczy, S. G., Ferrington, D. A. & Thompson, L. V., 2010, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65, 2, p. 129-137 9 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration

Ferrington, D. A., Ebeling, M. C., Kapphahn, R. J., Terluk, M. R., Fisher, C. R., Polanco, J. R., Roehrich, H., Leary, M. M., Geng, Z., Dutton, J. R. & Montezuma, S. R., Oct 2017, In: Redox Biology. 13, p. 255-265 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Altered proteasome function and subunit composition in aged muscle

Husom, A. D., Peters, E. A., Kolling, E. A., Fugere, N. A., Thompson, L. D. V. & Ferrington, D. A., Jan 1 2004, In: Archives of Biochemistry and Biophysics. 421, 1, p. 67-76 10 p.

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Altered proteasome structure, function, and oxidation in aged muscle

Ferrington, D. A., Husom, A. D. & Thompson, L. D. V., Apr 2005, In: FASEB Journal. 19, 6, p. 644-646 3 p.

Research output: Contribution to journal › Article › peer-review

179 Scopus citations

Altered turnover of calcium regulatory proteins of the sarcoplasmic reticulum in aged skeletal muscle

Ferrington, D. A., Krainev, A. G. & Bigelow, D. J., Mar 6 1998, In: Journal of Biological Chemistry. 273, 10, p. 5885-5891 7 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

A novel role for the immunoproteasome in retinal function

Hussong, S. A., Roehrich, H., Kapphahn, R. J., Maldonado, M., Pardue, M. T. & Ferrington, D. A., Feb 2011, In: Investigative Ophthalmology and Visual Science. 52, 2, p. 714-723 10 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Hytti, M., Korhonen, E., Hyttinen, J. M. T., Roehrich, H., Kaarniranta, K., Ferrington, D. A. & Kauppinen, A., 2019, In: Oxidative medicine and cellular longevity. 2019, 1583656.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Automating Human Induced Pluripotent Stem Cell Culture and Differentiation of iPSC-Derived Retinal Pigment Epithelium for Personalized Drug Testing

Truong, V., Viken, K., Geng, Z., Barkan, S., Johnson, B., Ebeling, M. C., Montezuma, S. R., Ferrington, D. A. & Dutton, J. R., Jun 2021, In: SLAS Technology. 26, 3, p. 287-299 13 p.

Research output: Contribution to journal › Article › peer-review

Body Composition And Plasma Lipoprotein Profile Of Male And Female Swimming And Track Athletes

Schneider, C. M., Klish, W. J., Insull, W. & Ferrington, D. A., Oct 1 1991, In: Sports Medicine, Training and Rehabilitation. 3, 1, p. 13-18 6 p.

Research output: Contribution to journal › Article › peer-review

Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading

Chen, C. N., Ferrington, D. A. & Thompson, L. V., Nov 2008, In: Journal of applied physiology. 105, 5, p. 1554-1561 8 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Catalytic site-specific inhibition of the 20S proteasome by 4-hydroxynonenal

Ferrington, D. A. & Kapphahn, R. J., Dec 17 2004, In: FEBS Letters. 578, 3, p. 217-223 7 p.

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Changes in Select Redox Proteins of the Retinal Pigment Epithelium in Age-related Macular Degeneration

Decanini, A., Nordgaard, C. L., Feng, X., Ferrington, D. A. & Olsen, T. W., Apr 2007, In: American journal of ophthalmology. 143, 4, p. 607-615.e2

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Closer proximity between opposing domains of vertebrate calmodulin following deletion of Met¹⁴⁵-Lys¹⁴⁸

Yin, D., Sun, H., Ferrington, D. A. & Squier, T. C., Aug 22 2000, In: Biochemistry. 39, 33, p. 10255-10268 14 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Comparable levels of Ca-ATPase inhibition by phospholamban in slow-twitch skeletal and cardiac sarcoplasmic reticulum

Ferrington, D. A., Yao, Q., Squier, T. C. & Bigelow, D. J., Nov 5 2002, In: Biochemistry. 41, 44, p. 13289-13296 8 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Corneal Wound Healing Is Compromised by Immunoproteasome Deficiency

Ferrington, D. A., Roehrich, H., Chang, A. A., Huang, C. W., Maldonado, M., Bratten, W., Rageh, A. A., Heuss, N. D., Gregerson, D. S., Nelson, E. F. & Yuan, C., Jan 30 2013, In: PloS one. 8, 1, e54347.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Covalent modification of epithelial fatty acid-binding protein by 4-hydroxynonenal in vitro and in vivo: Evidence for a role in antioxidant biology

Bennaars-Eiden, A., Higgins, L. A., Hertzel, A. V., Kapphahn, R. J., Ferrington, D. A. & Bernlohr, D. A., Dec 27 2002, In: Journal of Biological Chemistry. 277, 52, p. 50693-50702 10 p.

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Declines in arrestin and rhodopsin in the macula with progression of age-related macular degeneration

Ethen, C. M., Feng, X., Olsen, T. W. & Ferrington, D. A., Mar 2005, In: Investigative Ophthalmology and Visual Science. 46, 3, p. 769-775 7 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Decreased conformational stability of the sarcoplasmic reticulum Ca- ATPase in aged skeletal muscle

Ferrington, D. A., Jones, T. E., Qin, Z., Miller-Schlyer, M., Squier, T. C. & Bigelow, D. J., Dec 4 1997, In: Biochimica et Biophysica Acta - Biomembranes. 1330, 2, p. 233-247 15 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Denervation-induced activation of the standard proteasome and immunoproteasome

Liu, H. M., Ferrington, D. A., Baumann, C. W. & Thompson, L. V., Nov 2016, In: PloS one. 11, 11, e0166831.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Diastereoselective reduction of protein-bound methionine sulfoxide by methionine sulfoxide reductase

Sharov, V. S., Ferrington, D. A., Squier, T. C. & Schöneich, C., Jul 23 1999, In: FEBS Letters. 455, 3, p. 247-250 4 p.

Research output: Contribution to journal › Article › peer-review

160 Scopus citations

Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells

Ferrington, D. A., Tran, T. N., Lew, K. L., Van Remmen, H. & Gregerson, D. S., Sep 2006, In: Experimental Eye Research. 83, 3, p. 638-650 13 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Downhill exercise alters immunoproteasome content in mouse skeletal muscle

Baumann, C. W., Kwak, D., Ferrington, D. A. & Thompson, L. D. V., Jul 1 2018, In: Cell Stress and Chaperones. 23, 4, p. 507-517 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Effects of dietary protein on enzyme activity following exercise- induced muscle injury

Hayward, R., Ferrington, D. A., Kochanowski, L. A., Miller, L. M., Jaworsky, G. M. & Schneider, C. M., Jan 1 1999, In: Medicine and science in sports and exercise. 31, 3, p. 414-420 7 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Electron paramagnetic resonance: A high-resolution tool for muscle physiology

Thompson, L. D. V., Lowe, D. A., Ferrington, D. A. & Thomas, D. D., Jan 2001, In: Exercise and sport sciences reviews. 29, 1, p. 3-6 4 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Family-based exome sequencing identifies rare coding variants in age-related macular degeneration

Ratnapriya, R., Acar, I. E., Geerlings, M. J., Branham, K., Kwong, A., Saksens, N. T. M., Pauper, M., Corominas, J., Kwicklis, M., Zipprer, D., Starostik, M. R., Othman, M., Yashar, B., Abecasis, G. R., Chew, E. Y., Ferrington, D. A., Hoyng, C. B., Swaroop, A. & den Hollander, A. I., Jul 29 2020, In: Human molecular genetics. 29, 12, p. 2022-2034 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers

Prochniewicz, E., Lowe, D. A., Spakowicz, D. J., Higgins, L., O'Conor, K., Thompson, L. V., Ferrington, D. A. & Thomas, D. D., Feb 2008, In: American Journal of Physiology - Cell Physiology. 294, 2, p. C613-C626

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration

Geng, Z., Walsh, P. J., Truong, V., Hill, C., Ebeling, M., Kapphahn, R. J., Montezuma, S. R., Yuan, C., Roehrich, H., Ferrington, D. A. & Dutton, J. R., Mar 2017, In: PloS one. 12, 3, e0173575.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Human retinal pigment epithelium proteome changes in early diabetes

Decanini, A., Karunadharma, P. R., Nordgaard, C. L., Feng, X., Olsen, T. W. & Ferrington, D. A., Jun 2008, In: Diabetologia. 51, 6, p. 1051-1061 11 p.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Identification of a novel phosphorylation site in ataxin-1

Vierra-Green, C. A., Orr, H. T., Zoghbi, H. Y. & Ferrington, D. A., May 15 2005, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1744, 1, p. 11-18 8 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Immunoproteasome deficiency alters retinal proteasome's response to stress

Hussong, S. A., Kapphahn, R. J., Phillips, S. L., Maldonado, M. & Ferrington, D. A., Jun 2010, In: Journal of Neurochemistry. 113, 6, p. 1481-1490 10 p.

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Immunoproteasome Deficiency Modifies the Alternative Pathway of NFκB Signaling

Maldonado, M., Kapphahn, R. J., Terluk, M. R., Heuss, N. D., Yuan, C., Gregerson, D. S. & Ferrington, D. A., Feb 14 2013, In: PloS one. 8, 2, e56187.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Immunoproteasome deficiency protects in the retina after optic nerve crush

Schuld, N. J., Hussong, S. A., Kapphahn, R. J., Lehmann, U., Roehrich, H., Rageh, A. A., Heuss, N. D., Bratten, W., Gregerson, D. S. & Ferrington, D. A., May 15 2015, In: PloS one. 10, 5, e0126768.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Immunoproteasome in animal models of Duchenne muscular dystrophy

Chen, C. N. J., Graber, T. G., Bratten, W. M., Ferrington, D. A. & Thompson, L. V., Apr 2014, In: Journal of muscle research and cell motility. 35, 2, p. 191-201 11 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Immunoproteasome responds to injury in the retina and brain

Ferrington, D. A., Hussong, S. A., Roehrich, H., Kapphahn, R. J., Kavanaugh, S. M., Heuss, N. D. & Gregerson, D. S., Jul 2008, In: Journal of Neurochemistry. 106, 1, p. 158-169 12 p.

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Immunoproteasomes as a novel antiviral mechanism in rhinovirus-infected airways

Dimasuay, K. G., Sanchez, A., Schaefer, N., Polanco, J., Ferrington, D. A. & Chu, H. W., Aug 1 2018, In: Clinical science. 132, 15, p. 1711-1723 13 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Impaired Mitochondrial Function in iPSC-Retinal Pigment Epithelium with the Complement Factor H Polymorphism for Age-Related Macular Degeneration

Ebeling, M. C., Geng, Z., Kapphahn, R. J., Roehrich, H., Montezuma, S. R., Dutton, J. R. & Ferrington, D. A., Apr 2 2021, In: Cells. 10, 4

Research output: Contribution to journal › Article › peer-review

Open Access

Improving retinal mitochondrial function as a treatment for age-related macular degeneration

Ebeling, M. C., Polanco, J. R., Qu, J., Tu, C., Montezuma, S. R. & Ferrington, D. A., Jul 2020, In: Redox Biology. 34, 101552.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration

Ferrington, D. A., Kapphahn, R. J., Leary, M. M., Atilano, S. R., Terluk, M. R., Karunadharma, P., Chen, G. K. J., Ratnapriya, R., Swaroop, A., Montezuma, S. R. & Kenney, M. C., Apr 1 2016, In: Experimental Eye Research. 145, p. 269-277 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access