1991 …2023
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1991 2019

Filter
Article
2019

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Hytti, M., Korhonen, E., Hyttinen, J. M. T., Roehrich, H., Kaarniranta, K., Ferrington, D. A. & Kauppinen, A., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 1583656.

Research output: Contribution to journalArticle

Open Access
Antimycin A
Retinal Pigments
Retinal Pigment Epithelium
Autophagy
Cell death

Increased serum proteins in non-exudative AMD retinas

Schultz, H., Song, Y., Baumann, B. H., Kapphahn, B., Montezuma, S. R., Ferrington, D. A. & Dunaief, J. L., Sep 1 2019, In : Experimental Eye Research. 186, 107686.

Research output: Contribution to journalArticle

Macular Degeneration
Retina
Blood-Retinal Barrier
Blood Proteins
Albumins
2 Citations (Scopus)

Lipid-derived and other oxidative modifications of retinal proteins in a rat model of Smith-Lemli-Opitz syndrome

Kapphahn, B., Richards, M. J., Ferrington, D. A. & Fliesler, S. J., Jan 1 2019, In : Experimental Eye Research. 178, p. 247-254 8 p.

Research output: Contribution to journalArticle

Open Access
trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
Smith-Lemli-Opitz Syndrome
Lipids
Retina
Proteins
9 Citations (Scopus)

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S., Viiri, J., Paterno, J. J., Hyttinen, J. M. T., Koskela, A., Chen, M., Leinonen, H., Tanila, H., Kivinen, N., Koistinen, A., Toropainen, E., Amadio, M., Smedowski, A., Reinisalo, M., Winiarczyk, M., Mackiewicz, J., Mutikainen, M., Ruotsalainen, A. K., Kettunen, M., Jokivarsi, K. & 16 others, Sinha, D., Kinnunen, K., Petrovski, G., Blasiak, J., Bjørkøy, G., Koskelainen, A., Skottman, H., Urtti, A., Salminen, A., Kannan, R., Ferrington, D. A., Xu, H., Levonen, A. L., Tavi, P., Kauppinen, A. & Kaarniranta, K., Jan 1 2019, In : Redox Biology. 20, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
Retinal Pigments
Retinal Pigment Epithelium
Macular Degeneration
Genes
Epithelial Cells
Open Access
Retinal Pigments
Macular Degeneration
Acetylcysteine
Epithelial Cells
Retinal Pigment Epithelium

“Genetic variants regulating retinal transcriptome (GREx) identify genes underlying age-related macular degeneration”.

Montezuma, S. R., Ratnapriya, R., Sosina, O. A., Starostik, M. R., Kwicklis, M., Kapphahn, B., Fritsche, L. G., Walton, A., Arvanitis, M., Gieser, L., Pietraszkiewicz, A., Chew, E. Y., Battle, A., Abecasis, G. R., Ferrington, D. A., Chatterjee, N. & Swaroop, A., Apr 2019, In : Nature Genetics. p. 606-610

Research output: Contribution to journalArticle

2018
4 Citations (Scopus)

Downhill exercise alters immunoproteasome content in mouse skeletal muscle

Baumann, C. W., Kwak, D., Ferrington, D. A. & Thompson, L. D. V., Jul 1 2018, In : Cell Stress and Chaperones. 23, 4, p. 507-517 11 p.

Research output: Contribution to journalArticle

Open Access
Muscle
Skeletal Muscle
Muscles
Proteasome Endopeptidase Complex
Running

Immunoproteasomes as a novel antiviral mechanism in rhinovirus-infected airways

Dimasuay, K. G., Sanchez, A., Schaefer, N., Polanco, J., Ferrington, D. A. & Chu, H. W., Aug 1 2018, In : Clinical science. 132, 15, p. 1711-1723 13 p.

Research output: Contribution to journalArticle

Rhinovirus
Antiviral Agents
Epithelial Cells
Infection
Interferons
6 Citations (Scopus)

Perspective on AMD pathobiology: A bioenergetic crisis in the RPE

Fisher, C. R. & Ferrington, D. A., Mar 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 4, p. AMD41-AMD47

Research output: Contribution to journalArticle

Open Access
Energy Metabolism
Mitochondria
Pathology
Mitochondrial Proteins
Blindness
2017
11 Citations (Scopus)

Activating the AKT2–nuclear factor-κB–lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration

Ghosh, S., Shang, P., Yazdankhah, M., Bhutto, I., Hose, S., Montezuma, S. R., Luo, T., Chattopadhyay, S., Qian, J., Lutty, G. A., Ferrington, D. A., Zigler, J. S. & Sinha, D., Apr 1 2017, In : Journal of Pathology. 241, 5, p. 583-588 6 p.

Research output: Contribution to journalArticle

Open Access
Macular Degeneration
Lysosomes
Retina
Immune System
Epithelium
16 Citations (Scopus)

Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration

Ferrington, D. A., Ebeling, M. C., Kapphahn, R. J., Terluk, M. R., Fisher, C. R., Polanco, J. R., Roehrich, H., Leary, M. M., Geng, Z., Dutton, J. R. & Montezuma, S. R., Oct 1 2017, In : Redox Biology. 13, p. 255-265 11 p.

Research output: Contribution to journalArticle

Open Access
Oxidative stress
Retinal Pigments
Retinal Pigment Epithelium
Macular Degeneration
Energy Metabolism
8 Citations (Scopus)

Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration

Geng, Z., Walsh, P. J., Truong, V., Hill, C., Ebeling, M., Kapphahn, R. J., Montezuma, S. R., Yuan, C., Roehrich, H., Ferrington, D. A. & Dutton, J. R., Mar 1 2017, In : PloS one. 12, 3, e0173575.

Research output: Contribution to journalArticle

Open Access
conjunctiva
Conjunctiva
Macular Degeneration
Stem cells
epithelium
2016
3 Citations (Scopus)

Denervation-induced activation of the standard proteasome and immunoproteasome

Liu, H. M., Ferrington, D. A., Baumann, C. W. & Thompson, L. V., Nov 2016, In : PloS one. 11, 11, e0166831.

Research output: Contribution to journalArticle

proteasome endopeptidase complex
Denervation
Proteasome Endopeptidase Complex
Muscular Atrophy
Muscle
19 Citations (Scopus)

Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration

Ferrington, D. A., Kapphahn, R. J., Leary, M. M., Atilano, S. R., Terluk, M. R., Karunadharma, P., Chen, G. K. J., Ratnapriya, R., Swaroop, A., Montezuma, S. R. & Kenney, M. C., Apr 1 2016, In : Experimental Eye Research. 145, p. 269-277 9 p.

Research output: Contribution to journalArticle

Macular Degeneration
Mitochondrial DNA
Retinal Pigment Epithelium
Alleles
Tissue Donors
4 Citations (Scopus)

Lactoferrin Expression in Human and Murine Ocular Tissue

Rageh, A. A., Ferrington, D. A., Roehrich, H., Yuan, C., Terluk, M. R., Nelson, E. F. & Montezuma, S. R., Jul 2 2016, In : Current Eye Research. 41, 7, p. 883-889 7 p.

Research output: Contribution to journalArticle

Lactoferrin
Retinal Pigment Epithelium
Cornea
Retina
Iris
10 Citations (Scopus)
Macular Degeneration
Tandem Mass Spectrometry
Liquid Chromatography
DNA
Retinal Pigment Epithelium
2015
8 Citations (Scopus)

Immunoproteasome deficiency protects in the retina after optic nerve crush

Schuld, N. J., Hussong, S. A., Kapphahn, B., Lehmann, U., Roehrich, H., Rageh, A. A., Heuss, N. D., Bratten, W., Gregerson, D. S. & Ferrington, D. A., May 15 2015, In : PloS one. 10, 5, e0126768.

Research output: Contribution to journalArticle

Nerve Crush
Optic Nerve
optics
retina
Retina
77 Citations (Scopus)

Investigating mitochondria as a target for treating age-related macular degeneration

Terluk, M. R., Kapphahn, B., Soukup, L. M., Gong, H., Gallardo, C., Montezuma, S. R. & Ferrington, D. A., May 6 2015, In : Journal of Neuroscience. 35, 18, p. 7304-7311 8 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Macular Degeneration
Mitochondrial DNA
Mitochondria
Retina
4 Citations (Scopus)

Lactoferrin Reduces Chorioretinal Damage in the Murine Laser Model of Choroidal Neovascularization

Montezuma, S. R., Dolezal, L. D., Rageh, A. A., Mar, K., Jordan, M. & Ferrington, D. A., Sep 2 2015, In : Current Eye Research. 40, 9, p. 946-953 8 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Lactoferrin
Lasers
Knockout Mice
Fluorescein Angiography
2014
11 Citations (Scopus)

Immunoproteasome in animal models of Duchenne muscular dystrophy

Chen, C. N. J., Graber, T. G., Bratten, W. M., Ferrington, D. A. & Thompson, L. V., Jan 1 2014, In : Journal of muscle research and cell motility. 35, 2, p. 191-201 11 p.

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
Muscle
Proteasome Endopeptidase Complex
Animals
Animal Models
10 Citations (Scopus)

Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice

Heuss, N. D., Pierson, M. J., Montaniel, K. R. C., McPherson, S. W., Lehmann, U., Hussong, S. A., Ferrington, D. A., Low, W. C. & Gregerson, D. S., Aug 13 2014, In : Journal of Neuroinflammation. 11, 1, 143.

Research output: Contribution to journalArticle

Dendritic Cells
Nerve Crush
Retinal Ganglion Cells
Microglia
Optic Nerve
2013
9 Citations (Scopus)

Corneal Wound Healing Is Compromised by Immunoproteasome Deficiency

Ferrington, D. A., Roehrich, H., Chang, A. A., Huang, C. W., Maldonado, M., Bratten, W., Rageh, A. A., Heuss, N. D., Gregerson, D. S., Nelson, E. F. & Yuan, C., Jan 30 2013, In : PloS one. 8, 1, e54347.

Research output: Contribution to journalArticle

Immune system
cornea
tissue repair
Cell culture
Wound Healing
15 Citations (Scopus)

Immunoproteasome Deficiency Modifies the Alternative Pathway of NFκB Signaling

Maldonado, M., Kapphahn, R. J., Terluk, M. R., Heuss, N. D., Yuan, C., Gregerson, D. S. & Ferrington, D. A., Feb 14 2013, In : PloS one. 8, 2, e56187.

Research output: Contribution to journalArticle

Transcription Factor RelA
Transcription Factors
Genes
Chemical activation
Retinal Pigments
2011
20 Citations (Scopus)

A novel role for the immunoproteasome in retinal function

Hussong, S. A., Roehrich, H., Kapphahn, R. J., Maldonado, M., Pardue, M. T. & Ferrington, D. A., Feb 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 2, p. 714-723 10 p.

Research output: Contribution to journalArticle

Knockout Mice
Catalytic Domain
Electroretinography
Proteasome Endopeptidase Complex
Retina
2010
21 Citations (Scopus)

Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress

Chen, C. N., Brown-Borg, H. M., Rakoczy, S. G., Ferrington, D. A. & Thompson, L. V., Apr 9 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65, 2, p. 129-137 9 p.

Research output: Contribution to journalArticle

Glutamate-Cysteine Ligase
Catalytic Domain
Skeletal Muscle
Extremities
Muscles
60 Citations (Scopus)

Immunoproteasome deficiency alters retinal proteasome's response to stress

Hussong, S. A., Kapphahn, B., Phillips, S. L., Maldonado, M. & Ferrington, D. A., Jun 1 2010, In : Journal of Neurochemistry. 113, 6, p. 1481-1490 10 p.

Research output: Contribution to journalArticle

Retinal Pigments
Proteasome Endopeptidase Complex
Retina
Oxidative stress
Up-Regulation
104 Citations (Scopus)

Mitochondrial DNA damage as a potential mechanism for Age-Related macular Degeneration

Karunadharma, P. P., Nordgaard, C. L., Olsen, T. W. & Ferrington, D. A., Nov 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 11, p. 5470-5479 10 p.

Research output: Contribution to journalArticle

Macular Degeneration
Mitochondrial DNA
DNA Damage
Mitochondrial Genome
Retinal Pigment Epithelium
2009
27 Citations (Scopus)

Site-specific methionine oxidation initiates calmodulin degradation by the 20S proteasome

Balog, E. M., Lockamy, E. L., Thomas, D. D. & Ferrington, D. A., Apr 7 2009, In : Biochemistry. 48, 13, p. 3005-3016 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Calmodulin
Methionine
Proteolysis
Degradation
2008
5 Citations (Scopus)

Age-dependent effects of treadmill exercise during a period of inactivity

Arora, P., Husom, A. D., Ferrington, D. A. & Thompson, L. V., Jul 1 2008, In : Experimental Gerontology. 43, 7, p. 668-673 6 p.

Research output: Contribution to journalArticle

Bearings (structural)
Exercise equipment
Exercise
Weight-Bearing
Rats
14 Citations (Scopus)

Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading

Chen, C. N., Ferrington, D. A. & Thompson, L. V., Nov 1 2008, In : Journal of applied physiology. 105, 5, p. 1554-1561 8 p.

Research output: Contribution to journalArticle

Carbonic Anhydrase III
Muscles
Proteins
Hindlimb Suspension
Muscle Proteins
67 Citations (Scopus)

Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers

Prochniewicz, E., Lowe, D. A., Spakowicz, D. J., Higgins, L., O'Conor, K., Thompson, L. V., Ferrington, D. A. & Thomas, D. D., Feb 1 2008, In : American Journal of Physiology - Cell Physiology. 294, 2

Research output: Contribution to journalArticle

Skeletal Muscle Fibers
Myosins
Hydrogen Peroxide
Peroxides
Myofibrils
54 Citations (Scopus)

Human retinal pigment epithelium proteome changes in early diabetes

Decanini, A., Karunadharma, P. R., Nordgaard, C. L., Feng, X., Olsen, T. W. & Ferrington, D. A., Jun 1 2008, In : Diabetologia. 51, 6, p. 1051-1061 11 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Proteome
Diabetic Retinopathy
Proteins
Mass Spectrometry
50 Citations (Scopus)

Immunoproteasome responds to injury in the retina and brain

Ferrington, D. A., Hussong, S. A., Roehrich, H., Kapphahn, B., Kavanaugh, S. M., Heuss, N. D. & Gregerson, D. S., Jul 1 2008, In : Journal of Neurochemistry. 106, 1, p. 158-169 12 p.

Research output: Contribution to journalArticle

Retina
Brain
T-cells
Cytotoxic T-Lymphocytes
Wounds and Injuries
100 Citations (Scopus)

Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration

Nordgaard, C. L., Karunadharma, P. P., Feng, X., Olsen, T. W. & Ferrington, D. A., Jul 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 7, p. 2848-2855 8 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Macular Degeneration
Proteomics
Mitochondrial Proteins
Mitochondria
2007
41 Citations (Scopus)

Age-dependent inhibition of proteasome chymotrypsin-like activity in the retina

Kapphahn, B., Bigelow, E. J. & Ferrington, D. A., Apr 1 2007, In : Experimental Eye Research. 84, 4, p. 646-654 9 p.

Research output: Contribution to journalArticle

Chymotrypsin
Proteasome Endopeptidase Complex
Retina
Cysteine
Caseins
63 Citations (Scopus)

Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal

Ethen, C. M., Reilly, C. S., Feng, X., Olsen, T. W. & Ferrington, D. A., Aug 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 8, p. 3469-3479 11 p.

Research output: Contribution to journalArticle

Macular Degeneration
Proteins
4-hydroxy-2-nonenal
Lipid Peroxidation
2-nonenal
106 Citations (Scopus)

Changes in Select Redox Proteins of the Retinal Pigment Epithelium in Age-related Macular Degeneration

Decanini, A., Nordgaard, C. L., Feng, X., Ferrington, D. A. & Olsen, T. W., Jan 1 2007, In : American journal of ophthalmology. 143, 4

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Macular Degeneration
Oxidation-Reduction
Proteins
Eye Diseases
25 Citations (Scopus)
Epithelial Cells
T-Lymphocytes
Major Histocompatibility Complex
Antigens
Coculture Techniques
59 Citations (Scopus)

Transformation of the proteasome with age-related macular degeneration

Ethen, C. M., Hussong, S. A., Reilly, C. S., Feng, X., Olsen, T. W. & Ferrington, D. A., Mar 6 2007, In : FEBS Letters. 581, 5, p. 885-890 6 p.

Research output: Contribution to journalArticle

Oxidative stress
Macular Degeneration
Proteasome Endopeptidase Complex
Retina
Chymotrypsin
2006
30 Citations (Scopus)

Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells

Ferrington, D. A., Tran, T. N., Lew, K. L., Van Remmen, H. & Gregerson, D. S., Sep 1 2006, In : Experimental Eye Research. 83, 3, p. 638-650 13 p.

Research output: Contribution to journalArticle

Retinal Pigments
Caspases
Epithelial Cells
Oxidants
Apoptosis
53 Citations (Scopus)

Myosin and actin expression and oxidation in aging muscle

Thompson, L. V., Durand, D., Fugere, N. A. & Ferrington, D. A., Dec 1 2006, In : Journal of Applied Physiology. 101, 6, p. 1581-1587 7 p.

Research output: Contribution to journalArticle

Myosins
Actins
Muscles
Skeletal Muscle
Proteins
44 Citations (Scopus)

Protein nitration with aging in the rat semimembranosus and soleus muscles

Fugere, N. A., Ferrington, D. A. & Thompson, L. V., Jan 1 2006, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 61, 8, p. 806-812 7 p.

Research output: Contribution to journalArticle

Skeletal Muscle
Muscles
Proteins
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Triose-Phosphate Isomerase
92 Citations (Scopus)

Proteomics of the retinal pigment epithelium reveals altered protein expression at progressive stages of age-related macular degeneration

Nordgaard, C. L., Berg, K. M., Kapphahn, B., Reilly, C. S., Feng, X., Olsen, T. W. & Ferrington, D. A., Mar 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 3, p. 815-822 8 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Macular Degeneration
Proteomics
Proteins
Geographic Atrophy
65 Citations (Scopus)

Retinal proteins modified by 4-hydroxynonenal: Identification of molecular targets

Kapphahn, B., Giwa, B. M., Berg, K. M., Roehrich, H., Feng, X., Olsen, T. W. & Ferrington, D. A., Jul 1 2006, In : Experimental Eye Research. 83, 1, p. 165-175 11 p.

Research output: Contribution to journalArticle

Proteins
Triose-Phosphate Isomerase
Phosphopyruvate Hydratase
Electrophoresis, Gel, Two-Dimensional
Retina
12 Citations (Scopus)
Cytotoxic T-Lymphocytes
Epithelial Cells
Antigens
Antigen Presentation
Major Histocompatibility Complex
86 Citations (Scopus)

The proteome of central and peripheral retina with progression of age-related macular degeneration

Ethen, C. M., Reilly, C. S., Feng, X., Olsen, T. W. & Ferrington, D. A., Jun 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 6, p. 2280-2290 11 p.

Research output: Contribution to journalArticle

Macular Degeneration
Proteome
Retina
Proteins
Proteomics
2005
15 Citations (Scopus)

Age-related differences in the adaptive potential of type I skeletal muscle fibers

Husom, A. D., Ferrington, D. A. & Thompson, L. V., Jan 1 2005, In : Experimental Gerontology. 40, 3, p. 227-235 9 p.

Research output: Contribution to journalArticle

Slow-Twitch Muscle Fibers
Skeletal Muscle Fibers
Muscle
Skeletal Muscle
Fibers
161 Citations (Scopus)

Altered proteasome structure, function, and oxidation in aged muscle

Ferrington, D. A., Husom, A. D. & Thompson, L. V., Apr 1 2005, In : FASEB Journal. 19, 6, p. 644-646 3 p.

Research output: Contribution to journalArticle

dithiothreitol
Muscle Proteins
Dithiothreitol
Inbred F344 Rats
muscle protein
20 Citations (Scopus)

Declines in arrestin and rhodopsin in the macula with progression of age-related macular degeneration

Ethen, C. M., Feng, X., Olsen, T. W. & Ferrington, D. A., Mar 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 3, p. 769-775 7 p.

Research output: Contribution to journalArticle

Arrestin
Rhodopsin
Macular Degeneration
Retinal Rod Photoreceptor Cells
Proteins
13 Citations (Scopus)

Identification of a novel phosphorylation site in ataxin-1

Vierra-Green, C. A., Orr, H. T., Zoghbi, H. Y. & Ferrington, D. A., May 15 2005, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1744, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Serine
Phosphorylation
Alanine
Transgenic Mice