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Research Output 1993 2019

2019

Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength

Collins, B. C., Laakkonen, E. K. & Lowe, D. A., Jun 1 2019, In : Bone. 123, p. 137-144 8 p.

Research output: Contribution to journalArticle

Musculoskeletal System
Muscle Strength
Estrogens
Skeletal Muscle
Sarcopenia

Distinct mechanical properties in homologous spectrin-like repeats of utrophin

Rajaganapathy, S., McCourt, J. L., Ghosal, S., Lindsay, A., McCourt, P. M., Lowe, D. A., Ervasti, J. M. & Salapaka, M. V., Dec 1 2019, In : Scientific reports. 9, 1, 5210.

Research output: Contribution to journalArticle

Open Access
Utrophin
Spectrin
Dystrophin
Dystroglycans
Connectin
1 Citation (Scopus)

Dystrophinopathy-associated dysfunction of Krebs cycle metabolism

Lindsay, A., Chamberlain, C. M., Witthuhn, B. A., Lowe, D. A. & Ervasti, J. M., Jan 1 2019, In : Human molecular genetics. 28, 6, p. 942-951 10 p.

Research output: Contribution to journalArticle

Citric Acid Cycle
Succinic Acid
Dystrophin
Muscles
Inbred mdx Mouse
2 Citations (Scopus)

Effects of ovarian hormones and estrogen receptor α on physical activity and skeletal muscle fatigue in female mice

Cabelka, C. A., Baumann, C. W., Collins, B. C., Nash, N., Le, G. C., Lindsay, A., Spangenburg, E. E. & Lowe, D. A., Jan 1 2019, In : Experimental Gerontology. 115, p. 155-164 10 p.

Research output: Contribution to journalArticle

Muscle Fatigue
Estrogen Receptors
Muscle
Skeletal Muscle
Fatigue of materials

Estrogen Regulates the Satellite Cell Compartment in Females

Collins, B. C., Arpke, R. W., Larson, A. A., Baumann, C. W., Xie, N., Cabelka, C. A., Nash, N. L., Juppi, H. K., Laakkonen, E. K., Sipilä, S., Kovanen, V., Spangenburg, E. E., Kyba, M. & Lowe, D. A., Jul 9 2019, In : Cell reports. 28, 2, p. 368-381.e6

Research output: Contribution to journalArticle

Open Access
Muscle
Estrogens
Muscle Cells
Satellites
Stem Cells
1 Citation (Scopus)

Isometric resistance training increases strength and alters histopathology of dystrophin-deficient mouse skeletal muscle

Lindsay, A., Larson, A. A., Verma, M., Ervasti, J. M. & Lowe, D. A., Feb 1 2019, In : Journal of applied physiology. 126, 2, p. 363-375 13 p.

Research output: Contribution to journalArticle

Open Access
Dystrophin
Resistance Training
Duchenne Muscular Dystrophy
Skeletal Muscle
Muscles

Variable cytoplasmic actin expression impacts the sensitivity of different dystrophin-deficient mdx skeletal muscles to eccentric contraction

Lindsay, A., Southern, W. M., McCourt, P. M., Larson, A. A., Hodges, J. S., Lowe, D. A. & Ervasti, J. M., Jul 1 2019, In : FEBS Journal. 286, 13, p. 2562-2576 15 p.

Research output: Contribution to journalArticle

Utrophin
Dystrophin
Muscle
Actins
Skeletal Muscle
2018
22 Citations (Scopus)

17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle

Torres, M. J., Kew, K. A., Ryan, T. E., Pennington, E. R., Lin, C. T., Buddo, K. A., Fix, A. M., Smith, C. A., Gilliam, L. A., Karvinen, S., Lowe, D. A., Spangenburg, E. E., Zeczycki, T. N., Shaikh, S. R. & Neufer, P. D., Jan 9 2018, In : Cell Metabolism. 27, 1, p. 167-179.e7

Research output: Contribution to journalArticle

Mitochondrial Membranes
Energy Metabolism
Estradiol
Skeletal Muscle
Metabolic Diseases
1 Citation (Scopus)

Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice

Phung, L. A., Karvinen, S. M., Colson, B. A., Thomas, D. D. & Lowe, D. A., Sep 1 2018, In : PloS one. 13, 9, e0199062.

Research output: Contribution to journalArticle

Skeletal Muscle Fibers
Myosins
myosin
Muscle
Fibers
5 Citations (Scopus)

A moderate oestradiol level enhances neutrophil number and activity in muscle after traumatic injury but strength recovery is accelerated

Le, G. C., Novotny, S. A., Mader, T. L., Greising, S., Chan, S., Kyba, M., Lowe, D. A. & Warren, G. L., Oct 1 2018, In : Journal of Physiology. 596, 19, p. 4665-4680 16 p.

Research output: Contribution to journalArticle

Open Access
Estradiol
Estrogens
Neutrophils
Muscles
Wounds and Injuries
8 Citations (Scopus)

Deletion of estrogen receptor α in skeletal muscle results in impaired contractility in female mice

Collins, B. C., Mader, T. L., Cabelka, C. A., Iñigo, M. R., Spangenburg, E. E. & Lowe, D. A., Apr 1 2018, In : Journal of applied physiology. 124, 4, p. 980-992 13 p.

Research output: Contribution to journalArticle

Open Access
Estrogen Receptors
Skeletal Muscle
Estradiol
Muscle Strength
Myosin Light Chains
Dystrophin
Medical Genetics
Microtubules
Molecular Biology
Phenotype
Open Access
HTML
Organized Financing
pathology
Pathology
muscles
5 Citations (Scopus)

Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms

O'Rourke, A. R., Lindsay, A. J., Tarpey, M. D., Yuen, S., McCourt, P., Nelson, D. M., Perrin, B. J., Thomas, D. D., Spangenburg, E. E., Lowe, D. A. & Ervasti, J. M., Feb 1 2018, In : FEBS Journal. 285, 3, p. 481-500 20 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Muscle Relaxation
Ablation
Muscle
Actins
3 Citations (Scopus)

Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle

Olthoff, J. T., Lindsay, A., Abo-Zahrah, R., Baltgalvis, K. A., Patrinostro, X., Belanto, J. J., Yu, D. Y., Perrin, B. J., Garry, D. J., Rodney, G. G., Lowe, D. A. & Ervasti, J. M., Dec 1 2018, In : Nature communications. 9, 1, 5104.

Research output: Contribution to journalArticle

Peroxiredoxins
Dystrophin
eccentrics
muscles
contraction
5 Citations (Scopus)

Mouse models of two missense mutations in actin-binding domain 1 of dystrophin associated with duchenne or becker muscular dystrophy

McCourt, J. L., Talsness, D. M., Lindsay, A., Arpke, R. W., Chatterton, P. D., Nelson, D. M., Chamberlain, C. M., Olthoff, J. T., Belanto, J. J., McCourt, P. M., Kyba, M., Lowe, D. A. & Ervasti, J. M., Feb 1 2018, In : Human molecular genetics. 27, 3, p. 451-462 12 p.

Research output: Contribution to journalArticle

Open Access
Dystrophin
Duchenne Muscular Dystrophy
Missense Mutation
Actins
Proteasome Endopeptidase Complex
8 Citations (Scopus)

Neopterin/7,8-dihydroneopterin is elevated in Duchenne muscular dystrophy patients and protects mdx skeletal muscle function

Lindsay, A., Schmiechen, A., Chamberlain, C. M., Ervasti, J. M. & Lowe, D. A., Jul 1 2018, In : Experimental Physiology. 103, 7, p. 995-1009 15 p.

Research output: Contribution to journalArticle

Open Access
Neopterin
Duchenne Muscular Dystrophy
Skeletal Muscle
Creatinine
Muscles
2 Citations (Scopus)

Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

Levy, Y., Ross, J. A., Niglas, M., Snetkov, V. A., Lynham, S., Liao, C. Y., Puckelwartz, M. J., Hsu, Y. M., McNally, E. M., Alsheimer, M., Harridge, S. D., Young, S. G., Fong, L. G., Español, Y., Lopez-Otin, C., Kennedy, B. K., Lowe, D. A. & Ochala, J., Oct 4 2018, In : JCI Insight. 3, 19

Research output: Contribution to journalArticle

Open Access
Muscle Weakness
Premature Aging
Muscles
Nuclear Envelope
Myosins
12 Citations (Scopus)

Variable rescue of microtubule and physiological phenotypes in mdx muscle expressing different miniaturized dystrophins

Nelson, D. M., Lindsay, A., Judge, L. M., Duan, D., Chamberlain, J. S., Lowe, D. A. & Ervasti, J. M., Jun 15 2018, In : Human molecular genetics. 27, 12, p. 2090-2100 11 p.

Research output: Contribution to journalArticle

Open Access
Dystrophin
Microtubules
Phenotype
Muscles
Inbred mdx Mouse
4 Citations (Scopus)

Xanthine oxidase is hyper-active in Duchenne muscular dystrophy

Lindsay, A., McCourt, P. M., Karachunski, P. I., Lowe, D. A. & Ervasti, J. M., Dec 1 2018, In : Free Radical Biology and Medicine. 129, p. 364-371 8 p.

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
Xanthine Oxidase
Inbred mdx Mouse
Dystrophin
Muscle
2017
10 Citations (Scopus)

Chemical End Group Modified Diblock Copolymers Elucidate Anchor and Chain Mechanism of Membrane Stabilization

Houang, E. M., Haman, K. J., Kim, M., Zhang, W., Lowe, D. A., Sham, Y. Y., Lodge, T. P., Hackel, B. J., Bates, F. S. & Metzger, J. M., Jul 3 2017, In : Molecular pharmaceutics. 14, 7, p. 2333-2339 7 p.

Research output: Contribution to journalArticle

Open Access
Membranes
Poloxamer
Ethylene Oxide
Muscular Dystrophies
Molecular Dynamics Simulation
3 Citations (Scopus)
Vibration
Bone and Bones
Muscles
Lower Extremity
Duchenne Muscular Dystrophy
5 Citations (Scopus)

Female reproductive factors are associated with objectively measured physical activity in middle-aged women

Laakkonen, E. K., Kulmala, J., Aukee, P., Hakonen, H., Kujala, U. M., Lowe, D. A., Kovanen, V., Tammelin, T. & Sipilä, S., Feb 1 2017, In : PloS one. 12, 2, e0172054.

Research output: Contribution to journalArticle

Open Access
middle-aged adults
physical activity
Exercise
Health
menopause
16 Citations (Scopus)

Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model

Bosnakovski, D., Chan, S., Recht, O. O., Hartweck, L. M., Gustafson, C. J., Athman, L. L., Lowe, D. A. & Kyba, M., Dec 1 2017, In : Nature communications. 8, 1, 550.

Research output: Contribution to journalArticle

Open Access
Facioscapulohumeral Muscular Dystrophy
pathology
Pathology
muscles
mice
2016
5 Citations (Scopus)

Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats

Wang, H., Alencar, A., Lin, M., Sun, X., Sudo, R. T., Zapata-Sudo, G., Lowe, D. A. & Groban, L., Jun 17 2016, In : Biochemical and Biophysical Research Communications. 475, 1, p. 81-86 6 p.

Research output: Contribution to journalArticle

Muscle Strength
Muscle
Rats
Skeletal Muscle
Chemical activation
3 Citations (Scopus)

Eccentric contraction-induced muscle injury: Reproducible, quantitative, physiological models to impair skeletal muscle’s capacity to generate force

Call, J. A. & Lowe, D. A., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 3-18 16 p. (Methods in Molecular Biology; vol. 1460).

Research output: Chapter in Book/Report/Conference proceedingChapter

Muscle Contraction
Skeletal Muscle
Wounds and Injuries
Muscles
Regeneration
17 Citations (Scopus)

Estradiol modulates myosin regulatory light chain phosphorylation and contractility in skeletal muscle of female mice

Lai, S., Collins, B. C., Colson, B. A., Kararigas, G. & Lowe, D. A., May 1 2016, In : American Journal of Physiology - Endocrinology and Metabolism. 310, 9, p. E724-E733

Research output: Contribution to journalArticle

Myosin Light Chains
Estradiol
Skeletal Muscle
Phosphorylation
Muscles
5 Citations (Scopus)

Freeze injury of the tibialis anterior muscle

Le, G. C., Lowe, D. A. & Kyba, M., Jan 1 2016, In : Methods in Molecular Biology. 1460, p. 33-41 9 p.

Research output: Contribution to journalArticle

Muscles
Wounds and Injuries
Muscle Cells
Skeletal Muscle
6 Citations (Scopus)

High frequency hearing loss and hyperactivity in DUX4 transgenic mice

Dandapat, A., Perrin, B. J., Cabelka, C., Razzoli, M., Ervasti, J. M., Bartolomucci, A., Lowe, D. A. & Kyba, M., Mar 1 2016, In : PloS one. 11, 3, e0151467.

Research output: Contribution to journalArticle

High-Frequency Hearing Loss
Audition
hearing
Transgenic Mice
Doxycycline
16 Citations (Scopus)

Independent variability of microtubule perturbations associated with dystrophinopathy

Belanto, J. J., Olthoff, J. T., Mader, T. L., Chamberlain, C. M., Nelson, D. M., McCourt, P. M., Talsness, D. M., Gundersen, G. G., Lowe, D. A. & Ervasti, J. M., Nov 15 2016, In : Human molecular genetics. 25, 22, p. 4951-4961 11 p.

Research output: Contribution to journalArticle

Dystrophin
Microtubules
Inbred mdx Mouse
Utrophin
Tubulin
4 Citations (Scopus)

The presence of the ovary prevents hepatic mitochondrial oxidative stress in young and aged female mice through glutathione peroxidase 1

Valencia, A. P., Schappal, A. E., Matthew Morris, E., Thyfault, J. P., Lowe, D. A. & Spangenburg, E. E., Jan 1 2016, In : Experimental Gerontology. 73, p. 14-22 9 p.

Research output: Contribution to journalArticle

Oxidative stress
Ovary
Oxidative Stress
Liver
Tissue
2015
4 Citations (Scopus)

Influence of ovarian hormones on strength loss in healthy and dystrophic female mice

Kosir, A. M., Mader, T. L., Greising, A. G., Novotny, S. A., Baltgalvis, K. A. & Lowe, D. A., Jun 4 2015, In : Medicine and science in sports and exercise. 47, 6, p. 1177-1187 11 p.

Research output: Contribution to journalArticle

Hormones
Inbred mdx Mouse
Torque
Wounds and Injuries
Leg
15 Citations (Scopus)
Skeletal Muscle
Poloxamer
Duchenne Muscular Dystrophy
Membranes
Sarcolemma
10 Citations (Scopus)

The myosin super-relaxed state is disrupted by estradiol deficiency

Colson, B. A., Petersen, K. J., Collins, B. C., Lowe, D. A. & Thomas, D. D., Jan 2 2015, In : Biochemical and Biophysical Research Communications. 456, 1, p. 151-155 5 p.

Research output: Contribution to journalArticle

Myosins
Muscle
Estradiol
Adenosine Triphosphate
Muscles
2014
5 Citations (Scopus)

CCR2 Elimination in Mice Results in Larger and Stronger Tibial Bones but Bone Loss is not Attenuated Following Ovariectomy or Muscle Denervation

Mader, T. L., Novotny, S. A., Lin, A. S., Guldberg, R. E., Lowe, D. A. & Warren, G. L., Oct 8 2014, In : Calcified Tissue International. 95, 5, p. 457-466 10 p.

Research output: Contribution to journalArticle

CCR2 Receptors
Muscle Denervation
Ovariectomy
Bone and Bones
Tibia
38 Citations (Scopus)

Dominant Lethal Pathologies in Male Mice Engineered to Contain an X-Linked DUX4 Transgene

Dandapat, A., Bosnakovski, D., Hartweck, L. M., Arpke, R. W., Baltgalvis, K. A., Vang, D., Baik, J., Darabi, R., Perlingeiro, R. C. R., Hamra, F. K., Gupta, K., Lowe, D. A. & Kyba, M., Jan 1 2014, In : Cell Reports. 8, 5, p. 1484-1496 13 p.

Research output: Contribution to journalArticle

Facioscapulohumeral Muscular Dystrophy
Doxycycline
Pathology
Transgenes
Retinal Vessels
12 Citations (Scopus)

Exercise increases utrophin protein expression in the mdx mouse model of Duchenne muscular dystrophy

Gordon, B. S., Lowe, D. A. & Kostek, M. C., Jan 1 2014, In : Muscle and Nerve. 49, 6, p. 915-918 4 p.

Research output: Contribution to journalArticle

Utrophin
Inbred mdx Mouse
Duchenne Muscular Dystrophy
Exercise
Muscles
5 Citations (Scopus)

Low intensity, high frequency vibration training to improve musculoskeletal function in a mouse model of duchenne muscular dystrophy

Novotny, S. A., Mader, T. L., Greising, A. G., Lin, A. S., Guldberg, R. E., Warren, G. L. & Lowe, D. A., Aug 14 2014, In : PloS one. 9, 8, e104339.

Research output: Contribution to journalArticle

Open Access
muscular dystrophy
Duchenne Muscular Dystrophy
Vibration
vibration
Muscle
54 Citations (Scopus)

Microtubule binding distinguishes dystrophin from utrophin

Belanto, J. J., Mader, T. L., Eckhoff, M. D., Strandjord, D. M., Banks, G. B., Gardner, M. K., Lowe, D. A. & Ervasti, J. M., Apr 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5723-5728 6 p.

Research output: Contribution to journalArticle

Utrophin
Dystrophin
Microtubules
Inbred mdx Mouse
Duchenne Muscular Dystrophy
2013
16 Citations (Scopus)

Acute failure of action potential conduction in mdx muscle reveals new mechanism of contraction-induced force loss

Call, J. A., Warren, G. L., Verma, M. & Lowe, D. A., Aug 1 2013, In : Journal of Physiology. 591, 15, p. 3765-3776 12 p.

Research output: Contribution to journalArticle

Action Potentials
Muscles
Inbred mdx Mouse
Dystrophin
Duchenne Muscular Dystrophy
15 Citations (Scopus)

Adaptations of mouse skeletal muscle to low-intensity vibration training

McKeehen, J. N., Novotny, S. A., Baltgalvis, K. A., Call, J. A., Nuckley, D. J. & Lowe, D. A., Jan 1 2013, In : Medicine and Science in Sports and Exercise. 45, 6, p. 1051-1059 9 p.

Research output: Contribution to journalArticle

Vibration
Skeletal Muscle
Muscles
Hindlimb
Leg
47 Citations (Scopus)

A new immuno-, dystrophin-deficient model, the NSG-mdx4Cv mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation

Arpke, R. W., Darabi, R., Mader, T. L., Zhang, Y., Toyama, A., Lonetree, C. L., Nash, N., Lowe, D. A., Perlingeiro, R. C. R. & Kyba, M., Aug 1 2013, In : STEM CELLS. 31, 8, p. 1611-1620 10 p.

Research output: Contribution to journalArticle

Dystrophin
Cell Transplantation
Muscle Cells
Muscular Dystrophies
Muscles
35 Citations (Scopus)

Estrogen replacement and skeletal muscle: Mechanisms and population health

Tiidus, P. M., Lowe, D. A. & Brown, M., Sep 1 2013, In : Journal of Applied Physiology. 115, 5, p. 569-578 10 p.

Research output: Contribution to journalArticle

Estrogen Replacement Therapy
Skeletal Muscle
Hormones
Health
Population

Influence of ovarian hormones on skeletal muscle contractility

Lowe, D. A. & Greising, S. M., Dec 1 2013, Integrative Biology of Women's Health. Springer New York, p. 1-15 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Muscle Strength
Skeletal Muscle
Hormones
Estradiol
Muscle Weakness
5 Citations (Scopus)

Musculoskeletal response of dystrophic mice to short term, low intensity, high frequency vibration

Novotny, S. A., Eckhoff, M. D., Eby, B. C., Call, J. A., Nuckley, D. & Lowe, D. A., Dec 1 2013, In : Journal of Musculoskeletal Neuronal Interactions. 13, 4, p. 418-429 12 p.

Research output: Contribution to journalArticle

Vibration
Muscles
Torque
Utrophin
Gene Expression
3 Citations (Scopus)

Vibration platform for mice to deliver precise, low intensity mechanical signals to the musculoskeleton

Novotny, S. A., Mehta, H., Lowe, D. A. & Nuckley, D. J., Dec 1 2013, In : Journal of Musculoskeletal Neuronal Interactions. 13, 4, p. 412-417 6 p.

Research output: Contribution to journalArticle

Vibration
Equipment and Supplies
2012
37 Citations (Scopus)

Exercise training improves plantar flexor muscle function in mdx Mice

Baltgalvis, K. A., Call, J. A., Cochrane, G. D., Laker, R. C., Yan, Z. & Lowe, D. A., Sep 1 2012, In : Medicine and science in sports and exercise. 44, 9, p. 1671-1679 9 p.

Research output: Contribution to journalArticle

Inbred mdx Mouse
Exercise
Muscles
Torque
Running
10 Citations (Scopus)

Prednisolone treatment and restricted physical activity further compromise bone of mdx mice

Novotny, S. A., Warren, G. L., Lin, A. S., Guldberg, R. E., Baltgalvis, K. A. & Lowe, D. A., Mar 1 2012, In : Journal of Musculoskeletal Neuronal Interactions. 12, 1, p. 16-23 8 p.

Research output: Contribution to journalArticle

Inbred mdx Mouse
Prednisolone
Bone and Bones
Bone Density
Tomography

Reduced compliance in patellar tendons from a mouse model of muscular dystrophy

Wagner, H., Lowe, D. A. & Barocas, V. H., Dec 1 2012, ASME 2012 Summer Bioengineering Conference, SBC 2012. p. 381-382 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tendons
Compliance
17 Citations (Scopus)

Regulation of physiological and metabolic function of muscle by female sex steroids

Spangenburg, E. E., Geiger, P. C., Leinwand, L. A. & Lowe, D. A., Sep 1 2012, In : Medicine and science in sports and exercise. 44, 9, p. 1653-1662 10 p.

Research output: Contribution to journalArticle

Striated Muscle
Steroids
Muscles
Estrogens
Aptitude