20062021
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Research Output 2006 2019

2019
Immunophenotyping
lymphatic diseases
lymphoma
cell biology
diagnostic techniques
2 Citations (Scopus)

Reprogramming responsiveness to checkpoint blockade in dysfunctional CD8 T cells

Nelson, C. E., Mills, L. J., McCurtain, J. L., Thompson, E., Seelig, D., Bhela, S., Quarnstrom, C. F., Fife, B. T. & Vezys, V., Feb 12 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 7, p. 2640-2645 6 p.

Research output: Contribution to journalArticle

Open Access
T-Lymphocytes
Autoimmunity
Antigens
Neoplasms
Sirolimus

Robust Iterative Stimulation with Self-Antigens Overcomes CD8+ T Cell Tolerance to Self- and Tumor Antigens

Nelson, C. E., Thompson, E. A., Quarnstrom, C. F., Fraser, K. A., Seelig, D. M., Bhela, S., Burbach, B. J., Masopust, D. & Vezys, V., Sep 17 2019, In : Cell reports. 28, 12, p. 3092-3104.e5

Research output: Contribution to journalArticle

Open Access
T-cells
Autoantigens
Neoplasm Antigens
T-Lymphocytes
Tumors

Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice

Grant, M. K. O., Seelig, D., Sharkey, L. C., Choi, W. S. V., Abdelgawad, I. Y. & Zordoky, B., Feb 1 2019, In : PloS one. 14, 2, e0212486.

Research output: Contribution to journalArticle

Open Access
nephrotoxicity
doxorubicin
Sex Characteristics
sexual dimorphism
Doxorubicin
1 Citation (Scopus)

The utility of diagnostic tests for immune-mediated hemolytic anemia

Members of the Veterinary and Comparative Clinical Immunology Society Diagnostic Task Force, Oct 1 2019, In : Veterinary Clinical Pathology. 48, S1, p. 7-16 10 p.

Research output: Contribution to journalReview article

hemolytic anemia
Hemolytic Anemia
Routine Diagnostic Tests
diagnostic techniques
anemia
2018
9 Citations (Scopus)

Anticancer effects of resveratrol in canine hemangiosarcoma cell lines

Carlson, A., Alderete, K. S., Grant, M. K. O., Seelig, D., Sharkey, L. C. & Zordoky, B., Jun 1 2018, In : Veterinary and Comparative Oncology. 16, 2, p. 253-261 9 p.

Research output: Contribution to journalArticle

Open Access
hemangiosarcoma
Hemangiosarcoma
resveratrol
Canidae
cell lines

Assessment of eosinophils in gastrointestinal inflammatory disease of dogs

Bastan, I., Rendahl, A., Seelig, D., Day, M. J., Hall, E. J., Rao, S. P., Washabau, VMD, PhD, R. J. & Rao, S., Nov 1 2018, In : Journal of veterinary internal medicine. 32, 6, p. 1911-1917 7 p.

Research output: Contribution to journalArticle

Open Access
dog diseases
Gastrointestinal Diseases
eosinophils
Eosinophils
Dogs
5 Citations (Scopus)

Blocking interleukin-4 enhances efficacy of vaccines for treatment of opioid abuse and prevention of opioid overdose

Laudenbach, M., Baruffaldi, F., Robinson, C., Carter, P., Seelig, D., Baehr, C. & Pravetoni, M., Dec 1 2018, In : Scientific reports. 8, 1, 5508.

Research output: Contribution to journalArticle

Open Access
Interleukin-4
Opioid Analgesics
Vaccines
Oxycodone
Immunologic Factors

Diagnostic utility of renal fine-needle aspirate cytology and ultrasound in the cat

McAloney, C. A., Sharkey, L. C., Feeney, D. A. & Seelig, D. M., Jun 1 2018, In : Journal of Feline Medicine and Surgery. 20, 6, p. 544-553 10 p.

Research output: Contribution to journalArticle

cell biology
Needles
Cell Biology
Cats
kidneys
Needles
kidneys
Dogs
Kidney
dogs
12 Citations (Scopus)
Open Access
Idiopathic Pulmonary Fibrosis
Cell Death
Fibroblasts
Radiation
Pulmonary Fibrosis

Indolent T-cell-rich small B-cell hepatic lymphoma in a Golden Retriever

Rout, E. D., Hughes, K. L., Boostrom, B. O., Seelig, D., Avery, A. C. & Avery, P. R., Aug 1 2018, In : Clinical Case Reports. 6, 8, p. 1436-1444 9 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
T-Lymphocytes
Liver
B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
2 Citations (Scopus)
Carboxymethylcellulose Sodium
Microspheres
Rabbits
Kidney
Infarction
2017
1 Citation (Scopus)

A double blinded, placebo-controlled pilot study to examine reduction of CD34+/CD117+/CD133+ lymphoma progenitor cells and duration of remission induced by neoadjuvant valspodar in dogs with large B-cell lymphoma

Modiano, J., Ito, D., Childress, M., Mason, N., Winter, A., O'Brien, T., Henson, M., Borgatti, A., Lewellen, M., Krick, E., Stewart, J., Lahrman, S., Rajwa, B., Scott, M. C., Seelig, D., Koopmeiners, J. & Ruetz, S., Jan 1 2017, In : F1000Research. 4, 42.

Research output: Contribution to journalArticle

Open Access
Lymphoid Progenitor Cells
B-Cell Lymphoma
Lymphoma
Stem Cells
Placebos
2 Citations (Scopus)

A double blinded, placebo-controlled pilot study to examine reduction of CD34+ /CD117+ /CD133+ lymphoma progenitor cells and duration of remission induced by neoadjuvant valspodar in dogs with large B-cell lymphoma

Ito, D., Childress, M., Mason, N., Winter, A., O'Brien, T., Henson, M., Borgatti, A., Lewellen, M., Krick, E., Stewart, J., Lahrman, S., Rajwa, B., Scott, M. C., Seelig, D., Koopmeiners, J., Ruetz, S. & Modiano, J., Jan 1 2017, In : F1000Research. 4, 42.

Research output: Contribution to journalArticle

Lymphoid Progenitor Cells
B-Cell Lymphoma
Lymphoma
Stem Cells
Placebos
1 Citation (Scopus)

Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies

Seelig, D. M., Ito, D., Forster, C. L., Yoon, U. A., Breen, M., Burns, L. J., Bachanova, V., Lindblad-Toh, K., O’Brien, T. D., Schmechel, S. C., Rizzardi, A. E., Modiano, J. F. & Linden, M. A., Jul 3 2017, In : Leukemia and Lymphoma. 58, 7, p. 1702-1710 9 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
NF-kappa B
Canidae
Cell Survival
Neoplasms
2 Citations (Scopus)

Early assessment of dosimetric and biological differences of total marrow irradiation versus total body irradiation in rodents

Hui, S., Takahashi, Y., Holtan, S. G., Azimi, R., Seelig, D., Yagi, M., Ingvalson, J., Alaei, P., Sharkey, L., Kodal, B., Peterson, N., Meyer, C., Godin, L., Ehrhardt, M., Storme, G., Zhou, D. & Panoskaltsis-Mortari, A., Sep 1 2017, In : Radiotherapy and Oncology. 124, 3, p. 468-474 7 p.

Research output: Contribution to journalArticle

Open Access
Whole-Body Irradiation
Rodentia
Bone Marrow
Cell Transplantation
Histology
2 Citations (Scopus)

Establishment of a Patient-Derived Xenograft of Canine Enteropathy-Associated T-Cell Lymphoma, Large Cell Type

Im, K. S., Kim, J. H., Graef, A. J., Cornax, I., Seelig, D. M., O'Sullivan, M. G., Kovi, R. C. & Modiano, J. F., Jan 1 2017, In : Journal of Comparative Pathology. 156, 1, p. 37-41 5 p.

Research output: Contribution to journalArticle

Enteropathy-Associated T-Cell Lymphoma
digestive system diseases
lymphoma
Heterografts
Canidae
4 Citations (Scopus)
Open Access
Doxorubicin
Cytochrome P-450 Enzyme System
induction
Gene Expression
cause
6 Citations (Scopus)

The use, publication and future directions of immunocytochemistry in veterinary medicine: a consensus of the Oncology-Pathology Working Group

Priest, H. L., Hume, K. R., Killick, D., Kozicki, A., Rizzo, V. L., Seelig, D., Snyder, L. A., Springer, N. L., Wright, Z. M. & Robat, C., Sep 1 2017, In : Veterinary and Comparative Oncology. 15, 3, p. 868-880 13 p.

Research output: Contribution to journalArticle

Veterinary Medicine
immunocytochemistry
veterinary medicine
Publications
Consensus
2016
5 Citations (Scopus)

Central nervous system injury - A newly observed bystander effect of radiation

Feiock, C., Yagi, M., Maidman, A., Rendahl, A., Hui, S. & Seelig, D., Sep 1 2016, In : PloS one. 11, 9, e0163233.

Research output: Contribution to journalArticle

Bystander Effect
Nervous System Trauma
Neurology
central nervous system
Brain

Clinical challenge

Linden, M. A., Williams, S. A., Forster, C., Croonquist, P., Braido, J., Danneman, S., Beckel, M., Callahan, M. & Seelig, D., Sep 1 2016, In : Journal of Zoo and Wildlife Medicine. 47, 3, p. 948-951 4 p.

Research output: Contribution to journalArticle

Soft Tissue Neoplasms
sarcoma
wolves
Sarcoma
animals
4 Citations (Scopus)

Potential approaches for heterologous prion protein treatment of prion diseases

Seelig, D. M., Goodman, P. A. & Skinner, P. J., Jan 2 2016, In : Prion. 10, 1, p. 18-24 7 p.

Research output: Contribution to journalComment/debate

Prion Diseases
Prions
PrPC Proteins
Peptide Hydrolases
Neurodegenerative diseases
5 Citations (Scopus)
Disintegrins
Neutrophil Infiltration
Metalloproteases
Sepsis
Leukocytes
19 Citations (Scopus)

The comparative diagnostic features of canine and human lymphoma

Seelig, D. M., Avery, A. C., Ehrhart, E. J. & Linden, M. A., Jun 1 2016, In : Veterinary Sciences. 3, 2, 11.

Research output: Contribution to journalReview article

lymphoma
Canidae
Lymphoma
dogs
non-Hodgkin lymphoma
2015
11 Citations (Scopus)

Calibrated bioresorbable microspheres as an embolic agent: An experimental study in a rabbit renal model

Weng, L., Seelig, D., Rostamzadeh, P. & Golzarian, J., Dec 1 2015, In : Journal of Vascular and Interventional Radiology. 26, 12, p. 1887-1894.e1

Research output: Contribution to journalArticle

Microspheres
Rabbits
Kidney
Angiography
Inflammation
5 Citations (Scopus)

Lesion Profiling and Subcellular Prion Localization of Cervid Chronic Wasting Disease in Domestic Cats

Seelig, D., Nalls, A. V., Flasik, M., Frank, V., Eaton, S., Mathiason, C. K. & Hoover, E. A., Jan 29 2015, In : Veterinary pathology. 52, 1, p. 107-119 13 p.

Research output: Contribution to journalArticle

Chronic Wasting Disease
chronic wasting disease
Prions
prions
Felidae
1 Citation (Scopus)

Pathology in practice

Benson, C. J., Stiller, A. T., Corbin, E. E. & Seelig, D. M., Jan 1 2015, In : Journal of the American Veterinary Medical Association. 246, 9, p. 973-975 3 p.

Research output: Contribution to journalArticle

kidney neoplasms
Dog Diseases
dog diseases
Kidney Neoplasms
Leukocytosis
6 Citations (Scopus)

Treatment of prion disease with heterologous prion proteins

Skinner, P. J., Kim, H. O., Bryant, D., Kinzel, N. J., Reilly, C., Priola, S. A., Ward, A. E., Goodman, P. A., Olson, K. & Seelig, D. M., Jul 2 2015, In : PloS one. 10, 7, e0131993.

Research output: Contribution to journalArticle

Prion Diseases
prion diseases
Prions
prions
Cricetinae
2014
3 Citations (Scopus)

All lesions great and small, part 1: Diagnostic cytology in veterinary medicine

Sharkey, L. C., Seelig, D. & Overmann, J., Jan 1 2014, In : Diagnostic Cytopathology. 42, 6, p. 535-543 9 p.

Research output: Contribution to journalReview article

Veterinary Medicine
Cell Biology
Molecular Diagnostic Techniques
Medicine
Azure Stains
1 Citation (Scopus)

All lesions great and small, part 2. Diagnostic cytology in veterinary medicine

Sharkey, L. C., Seelig, D. & Overmann, J. A., Jan 1 2014, In : Diagnostic Cytopathology. 42, 6, p. 544-552 9 p.

Research output: Contribution to journalReview article

Veterinary Medicine
Cell Biology
Medicine
Nerve Tissue
Manuscripts
42 Citations (Scopus)

Canine t-zone lymphoma: Unique immunophenotypic features, outcome, and population characteristics

Seelig, D., Avery, P., Webb, T., Yoshimoto, J., Bromberek, J., Ehrhart, E. J. & Avery, A. C., Jan 1 2014, In : Journal of Veterinary Internal Medicine. 28, 3, p. 878-886 9 p.

Research output: Contribution to journalArticle

population characteristics
Population Characteristics
lymphoma
Canidae
T-Cell Lymphoma
25 Citations (Scopus)

Flow cytometric characterization and clinical outcome of CD4+ T-cell lymphoma in dogs: 67 cases

Avery, P. R., Burton, J., Bromberek, J. L., Seelig, D. M., Elmslie, R., Correa, S., Ehrhart, E. J., Morley, P. S. & Avery, A. C., Jan 1 2014, In : Journal of veterinary internal medicine. 28, 2, p. 538-546 9 p.

Research output: Contribution to journalArticle

T-Cell Lymphoma
lymphoma
T-lymphocytes
Dogs
dogs
2013
43 Citations (Scopus)

Aerosol transmission of chronic wasting disease in white-tailed deer

Denkers, N. D., Hayes-Klug, J., Anderson, K. R., Seelig, D. M., Haley, N. J., Dahmes, S. J., Osborn, D. A., Miller, K. V., Warren, R. J., Mathiason, C. K. & Hoover, E. A., Feb 1 2013, In : Journal of virology. 87, 3, p. 1890-1892 3 p.

Research output: Contribution to journalArticle

Chronic Wasting Disease
chronic wasting disease
Deer
Prions
prions
31 Citations (Scopus)

Mother to Offspring Transmission of Chronic Wasting Disease in Reeves' Muntjac Deer

Nalls, A. V., McNulty, E., Powers, J., Seelig, D. M., Hoover, C., Haley, N. J., Hayes-Klug, J., Anderson, K., Stewart, P., Goldmann, W., Hoover, E. A. & Mathiason, C. K., Aug 14 2013, In : PloS one. 8, 8, e71844.

Research output: Contribution to journalArticle

Muntjacs
Chronic Wasting Disease
Muntiacus
chronic wasting disease
Deer
23 Citations (Scopus)

Prion-seeding activity in cerebrospinal fluid of deer with chronic wasting disease

Haley, N. J., Van De Motter, A., Carver, S., Henderson, D., Davenport, K., Seelig, D. M., Mathiason, C. & Hoover, E., Nov 25 2013, In : PloS one. 8, 11, e81488.

Research output: Contribution to journalArticle

Chronic Wasting Disease
chronic wasting disease
Cerebrospinal fluid
Deer
Prions
22 Citations (Scopus)

Susceptibility of domestic cats to chronic wasting disease

Mathiason, C. K., Nalls, A. V., Seelig, D. M., Kraft, S. L., Carnes, K., Anderson, K. R., Hayes-Klug, J. & Hoovera, E. A., Feb 1 2013, In : Journal of virology. 87, 4, p. 1947-1956 10 p.

Research output: Contribution to journalArticle

Chronic Wasting Disease
chronic wasting disease
Cats
cats
Felidae

WE‐E‐108‐08: Dosimetric and Biological Benchmarking of a Murine Total Marrow Irradiation Platform

Azimi, R., Alaei, P., Takahashi, Y., Spezi, E., Yagi, M., Arentsen, L., Sharkey, L., Seelig, D., Schappa, J. & Hui, S., Jan 1 2013, In : Medical Physics. 40, 6, 1 p.

Research output: Contribution to journalArticle

Benchmarking
Bone Marrow
Radiation
Brain
Film Dosimetry
2012
23 Citations (Scopus)

Genetic depletion of complement receptors CD21/35 prevents terminal prion disease in a mouse model of chronic wasting disease

Michel, B., Ferguson, A., Johnson, T., Bender, H., Meyerett-Reid, C., Pulford, B., Von Teichman, A., Seelig, D., Weis, J. H., Telling, G. C., Aguzzi, A. & Zabel, M. D., Nov 1 2012, In : Journal of Immunology. 189, 9, p. 4520-4527 8 p.

Research output: Contribution to journalArticle

Chronic Wasting Disease
Complement Receptors
Prion Diseases
Prions
Scrapie
2011
21 Citations (Scopus)

Alteration of the chronic wasting disease species barrier by in vitro prion amplification

Kurt, T. D., Seelig, D. M., Schneider, J. R., Johnson, C. J., Telling, G. C., Heisey, D. M. & Hoover, E. A., Sep 1 2011, In : Journal of virology. 85, 17, p. 8528-8537 10 p.

Research output: Contribution to journalArticle

Chronic Wasting Disease
chronic wasting disease
Prions
prions
Arvicolinae
15 Citations (Scopus)

Chronic wasting disease prion trafficking via the autonomic nervous system

Seelig, D., Mason, G. L., Telling, G. C. & Hoover, E. A., Sep 1 2011, In : American Journal of Pathology. 179, 3, p. 1319-1328 10 p.

Research output: Contribution to journalArticle

Chronic Wasting Disease
Prions
Autonomic Nervous System
Enteric Nervous System
Peptide Hydrolases
6 Citations (Scopus)

Monoclonal immunoglobulin protein production in two dogs with secretory B-cell lymphoma with Mott cell differentiation

Seelig, D. M., Perry, J. A., Zaks, K., Avery, A. C. & Avery, P. R., Dec 1 2011, In : Journal of the American Veterinary Medical Association. 239, 11, p. 1477-1482 6 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
lymphoma
cell differentiation
immunoglobulins
B-lymphocytes
12 Citations (Scopus)

Transmission of chronic wasting disease identifies a prion strain causing cachexia and heart infection in hamsters

Bessen, R. A., Robinson, C. J., Seelig, D. M., Watschke, C. P., Lowe, D., Shearin, H., Martinka, S. & Babcock, A. M., Dec 14 2011, In : PloS one. 6, 12, e28026.

Research output: Contribution to journalArticle

Chronic Wasting Disease
chronic wasting disease
cachexia
Cachexia
Prions
2010
40 Citations (Scopus)

Aerosol and nasal transmission of chronic wasting disease in cervidized mice

Denkers, N. D., Seelig, D. M., Telling, G. C. & Hoover, E. A., Jun 1 2010, In : Journal of General Virology. 91, 6, p. 1651-1658 8 p.

Research output: Contribution to journalArticle

Chronic Wasting Disease
Nasal Sprays
PrPC Proteins
Prions
Aerosols
13 Citations (Scopus)

Monoclonal gammopathy without hyperglobulinemia in 2 dogs with IgA secretory neoplasms

Seelig, D. M., Perry, J. A., Avery, A. C. & Avery, P. R., Dec 1 2010, In : Veterinary Clinical Pathology. 39, 4, p. 447-453 7 p.

Research output: Contribution to journalArticle

Secretory Immunoglobulin A
Paraproteinemias
Dogs
myeloma
neoplasms
11 Citations (Scopus)

Pathogenesis of chronic wasting disease in cervidized transgenic mice

Seelig, D. M., Mason, G. L., Telling, G. C. & Hoover, E. A., Jan 1 2010, In : American Journal of Pathology. 176, 6, p. 2785-2797 13 p.

Research output: Contribution to journalArticle

Chronic Wasting Disease
Transgenic Mice
Prion Diseases
Islets of Langerhans
PrPC Proteins
2009
144 Citations (Scopus)

Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassay

Haley, N. J., Seelig, D. M., Zabel, M. D., Telling, G. C. & Hoover, E. A., Mar 18 2009, In : PloS one. 4, 3, e4848.

Research output: Contribution to journalArticle

Chronic Wasting Disease
Peromyscus
chronic wasting disease
Bioassay
Prions
2008
10 Citations (Scopus)

Goitrous hypothyroidism associated with treatment with trimethoprim- sulfamethoxazole in a young dog

Seelig, D. M., Whittemore, J. C., Lappin, M. R., Myers, A. M. & Avery, P. R., Apr 15 2008, In : Journal of the American Veterinary Medical Association. 232, 8, p. 1181-1185 5 p.

Research output: Contribution to journalArticle

sulfamethoxazole
hypothyroidism
trimethoprim
Sulfamethoxazole Drug Combination Trimethoprim
Hypothyroidism
1 Citation (Scopus)

What is your diagnosis? Pancytopenia in a dog

Williams, M. J., Gardiner, D., Seelig, D. & Olver, C. S., Dec 1 2008, In : Veterinary Clinical Pathology. 37, 4, p. 429-433 5 p.

Research output: Contribution to journalArticle

Pancytopenia
Dogs
dogs
cells
bone marrow
2006
317 Citations (Scopus)

Infectious prions in the saliva and blood of deer with chronic wasting disease

Mathiason, C. K., Powers, J. G., Dahmes, S. J., Osborn, D. A., Miller, K. V., Warren, R. J., Mason, G. L., Hays, S. A., Hayes-Klug, J., Seelig, D. M., Wild, M. A., Wolfe, L. L., Spraker, T. R., Miller, M. W., Sigurdson, C. J., Telling, G. C. & Hoover, E. A., Oct 6 2006, In : Science. 314, 5796, p. 133-136 4 p.

Research output: Contribution to journalArticle

Chronic Wasting Disease
Deer
Prions
Saliva
Body Fluids