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meningitis epidemiology, prevention, diagnostics, treatment, clinical trials

20032024

Research output per year

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Article
2020

B cell compartmentalization in blood and cerebrospinal fluid of HIV-infected ugandans with cryptococcal meningitis

Okurut, S., Meya, D. B., Bwanga, F., Olobo, J., Eller, M. A., Cham-Jallow, F., Bohjanen, P. R., Pratap, H., Palmer, B. E., Hullsiek, K. H., Manabe, Y. C., Boulware, D. R. & Janoff, E. N., Mar 1 2020, In : Infection and immunity. 88, 3, e00779-19.

Research output: Contribution to journalArticle

Open Access

Cryptococcosis in pregnancy and the postpartum period: Case series and systematic review with recommendations for management

Pastick, K. A., Nalintya, E., Tugume, L., Ssebambulidde, K., Stephens, N., Evans, E. E., Ndyetukira, J. F., Nuwagira, E., Skipper, C., Muzoora, C., Meya, D. B., Rhein, J., Boulware, D. R. & Rajasingham, R., Apr 1 2020, In : Medical mycology. 58, 3, p. 282-292 11 p.

Research output: Contribution to journalArticle

Evaluation of serum cryptococcal antigen testing using two novel semiquantitative lateral flow assays in persons with cryptococcal antigenemia

Skipper, C., Tadeo, K., Martyn, E., Nalintya, E., Rajasingham, R., Meya, D. B., Kafufu, B., Rhein, J. & Boulware, D. R., Jan 1 2020, In : Journal of clinical microbiology. 58, 4, e02046-19.

Research output: Contribution to journalArticle

Open Access

Prophylaxie post-exposition ou traitement préventif pour le syndrome respiratoire aigu sévère du coronavirus 2 (SARS-CoV-2) : protocole d’étude pour une étude randomisée contrôlée pragmatique

Translated title of the contribution: Post-exposure prophylaxis or pre-emptive therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): study protocol for a pragmatic randomized-controlled trialLother, S. A., Abassi, M., Agostinis, A., Bangdiwala, A. S., Cheng, M. P., Drobot, G., Engen, N., Hullsiek, K. H., Kelly, L. E., Lee, T. C., Lofgren, S. M., MacKenzie, L. J., Marten, N., McDonald, E. G., Okafor, E. C., Pastick, K. A., Pullen, M. F., Rajasingham, R., Schwartz, I., Skipper, C. P. & 3 others, Turgeon, A. F., Zarychanski, R. & Boulware, D. R., Jan 1 2020, (Accepted/In press) In : Canadian Journal of Anesthesia.

Research output: Contribution to journalArticle

Open Access

Should we perform the serum cryptococcal antigen test in people living with HIV hospitalized due to a community-acquired pneumonia episode?

Silva, A. P., Zenatti, C. T., Figueiredo-Mello, C., Negra, M. D., Levin, A. S., Boulware, D. R. & Vidal, J. E., Mar 1 2020, In : International Journal of STD and AIDS. 31, 4, p. 345-350 6 p.

Research output: Contribution to journalArticle

Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study

ASTRO-CM Team, Mar 2020, In : The Lancet Infectious Diseases. 20, 3, p. 308-317 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial

ASTRO-CM Team, Aug 2019, In : The Lancet Infectious Diseases. 19, 8, p. 843-851 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

AMBIsome Therapy Induction OptimisatioN (AMBITION): High dose AmBisome for cryptococcal meningitis induction therapy in sub-Saharan Africa: Economic evaluation protocol for a randomised controlled trial-based equivalence study

Ponatshego, P. L., Lawrence, D. S., Youssouf, N., Molloy, S. F., Alufandika, M., Bango, F., Boulware, D. R., Chawinga, C., Dziwani, E., Gondwe, E., Hlupeni, A., Hosseinipour, M. C., Kanyama, C., Meya, D. B., Mosepele, M., Muthoga, C., Muzoora, C. K., Mwandumba, H., Ndhlovu, C. E., Rajasingham, R. & 18 others, Sayed, S., Shamu, S., Tsholo, K., Tugume, L., Williams, D., Maheswaran, H., Shiri, T., Boyer-Chammard, T., Loyse, A., Chen, T., Wang, D., Lortholary, O., Lalloo, D. G., Meintjes, G., Jaffar, S., Harrison, T. S., Jarvis, J. N. & Niessen, L. W., Apr 1 2019, In : BMJ open. 9, 4, e026288.

Research output: Contribution to journalArticle

Case report: Three's a crowd: A case report examining the diagnostic and pharmacokinetic challenges in hiv-tuberculous meningitis-malaria co-infection [version 2; referees: 2 approved]

Ellis, J., Eneh, P. C., Ssebambulidde, K., Rutakingirwa, M. K., Lamorde, M., Rhein, J., Cresswell, F. V., Boulware, D. R. & Nicol, M. R., Jan 1 2019, In : Wellcome Open Research. 3, 111.

Research output: Contribution to journalArticle

Open Access

Cerebrospinal Fluid and Brain Tissue Penetration of Tenofovir, Lamivudine, and Efavirenz in Postmortem Tissues with Cryptococcal Meningitis

Nicol, M. R., Pastick, K. A., Taylor, J., Namuju, O. C., Rhein, J., Williams, D. A., Meya, D. B., Boulware, D. R. & Lukande, R., Sep 1 2019, In : Clinical and translational science. 12, 5, p. 445-449 5 p.

Research output: Contribution to journalArticle

Open Access

Checklists to guide the supportive and critical care of tuberculous meningitis [version 1; peer review: 2 approved]

Tuberculous Meningitis International Research Consortium, Jan 1 2019, In : Wellcome Open Research. 4, 163.

Research output: Contribution to journalArticle

Open Access

Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma, anti-Coccidioides and anti-Blastomyces antibodies

Bahr, N. C., Panackal, A. A., Durkin, M. M., Smedema, M. L., Keown, W., Davis, T. E., Raymond-Guillen, L., Park, Y. D., Marr, K. A., Fries, B. C., Williamson, P. R., Boulware, D. R. & Wheat, L. J., Mar 1 2019, In : Mycoses. 62, 3, p. 268-273 6 p.

Research output: Contribution to journalArticle

Epidemiology of non-traumatic spinal cord injury in Uganda: A single center, prospective study with MRI evaluation

Musubire, A. K., Meya, D. B., Katabira, E. T., Meyer, A. C. L., Bohjanen, P. R., Boulware, D. R. & Minja, F., Jan 15 2019, In : BMC neurology. 19, 1, 10.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Etiology of Sepsis in Uganda Using a Quantitative Polymerase Chain Reaction-based TaqMan Array Card

Moore, C. C., Jacob, S. T., Banura, P., Zhang, J., Stroup, S., Boulware, D. R., Scheld, W. M., Houpt, E. R. & Liu, J., Jan 7 2019, In : Clinical Infectious Diseases. 68, 2, p. 266-272 7 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Evaluation of a national cryptococcal antigen screening program for HIV-infected patients in Uganda: A cost-effectiveness modeling analysis

Rajasingham, R., Meya, D. B., Greene, G. S., Jordan, A., Nakawuka, M., Chiller, T. M., Boulware, D. R. & Larson, B. A., Jan 2019, In : PloS one. 14, 1, e0210105.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Heterogeneity in neurocognitive change trajectories among people with HIV starting antiretroviral therapy in Rakai, Uganda

Rubin, L. H., Saylor, D., Nakigozi, G., Nakasujja, N., Robertson, K., Kisakye, A., Batte, J., Mayanja, R., Anok, A., Lofgren, S. M., Boulware, D. R., Dastgheyb, R., Reynolds, S. J., Quinn, T. C., Gray, R. H., Wawer, M. J. & Sacktor, N., Dec 1 2019, In : Journal of neurovirology. 25, 6, p. 800-813 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hiv-associated cryptococcal immune reconstitution inflammatory syndrome is associated with aberrant t cell function and increased cytokine responses

Meya, D. B., Okurut, S., Zziwa, G., Cose, S., Boulware, D. R. & Janoff, E. N., Jun 2019, In : Journal of Fungi. 5, 2, 42.

Research output: Contribution to journalArticle

Open Access

HIV-Associated cryptococcal meningitis occurring at relatively higher CD4 counts

Tugume, L., Rhein, J., Hullsiek, K. H., Mpoza, E., Kiggundu, R., Ssebambulidde, K., Schutz, C., Taseera, K., Williams, D. A., Abassi, M., Muzoora, C., Musubire, A. K., Meintjes, G., Meya, D. B., Boulware, D. R., Nabeta, H. W., Ndyetukira, J. F., Ahimbisibwe, C., Kugonza, F., Namuju, C. & 28 others, Sadiq, A., Namudde, A., Mwesigye, J., Kandole, T. K., Kwizera, R., Kirumira, P., Okirwoth, M., Akampurira, A., Luggya, T., Kaboggoza, J., Laker, E., Atwine, L., Muganzi, D., Evans, E. E., Bridge, S. C., Velamakanni, S. S., Rajasingham, R., Pastick, K., Stadelman, A., Flynn, A., Fujita, A. W., Mukaremera, L., Lofgren, S. M., Morawski, B. M., Bangdiwala, A., Nielsen, K., Bohjanen, P. R. & Kambugu, A., Feb 23 2019, In : Journal of Infectious Diseases. 219, 6, p. 877-883 7 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Identification of pathogen genomic differences that impact human immune response and disease during cryptococcus neoformans infection

Gerstein, A. C., Jackson, K. M., McDonald, T. R., Wang, Y., Lueck, B. D., Bohjanen, S., Smith, K. D., Akampurira, A., Meya, D. B., Xue, C., Boulware, D. R. & Nielsen, K., Jan 1 2019, In : mBio. 10, 4, e01440-19.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Improved detection of group A: Streptococcus during thermal contrast amplification vs. visual reading of clinical rapid diagnostic tests

Wang, Y., Louwagie, E., Larkin, D., Sankey, S., Boulware, D. R. & Bischof, J. C., Apr 21 2019, In : Analytical Methods. 11, 15, p. 2013-2017 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Inadequate diagnostics: The case to move beyond the bacilli for detection of meningitis due to mycobacterium tuberculosis

Bahr, N. C., Meintjes, G. & Boulware, D. R., May 2019, In : Journal of medical microbiology. 68, 5, p. 755-760 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Laboratory-reflex cryptococcal antigen screening is associated with a survival benefit in tanzania

Faini, D., Kalinjuma, A. V., Katende, A., Mbwaji, G., Mnzava, D., Nyuri, A., Glass, T. R., Furrer, H., Hatz, C., Boulware, D. R. & Letang, E., Feb 1 2019, In : Journal of Acquired Immune Deficiency Syndromes. 80, 2, p. 205-213 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Longitudinal changes in cd4+, cd8+ t cell phenotype and activation marker expression following antiretroviral therapy initiation among patients with cryptococcal meningitis

Bayiyana, A., Okurut, S., Nabatanzi, R., Zziwa, G., Boulware, D. R., Lutwama, F. & Meya, D., Sep 2019, In : Journal of Fungi. 5, 3, 63.

Research output: Contribution to journalArticle

Open Access

Management of amphotericin-induced phlebitis among HIV patients with cryptococcal meningitis in a resource-limited setting: A prospective cohort study

Ahimbisibwe, C., Kwizera, R., Ndyetukira, J. F., Kugonza, F., Sadiq, A., Hullsiek, K. H., Williams, D. A., Rhein, J., Boulware, D. R. & Meya, D. B., Jun 26 2019, In : BMC infectious diseases. 19, 1, 558.

Research output: Contribution to journalArticle

Open Access

Management of intracranial tuberculous mass lesions: How long should we treat for? [version 2; peer review: 1 approved, 2 approved with reservations]

Tuberculous Meningitis International Research Consortium, Jan 1 2019, In : Wellcome Open Research. 4, 158.

Research output: Contribution to journalArticle

Open Access
Open Access
2 Scopus citations

Performance of lipoarabinomannan assay using cerebrospinal fluid for the diagnosis of tuberculous meningitis among HIV patients [version 1; peer review: 2 approved]

Kwizera, R., Cresswell, F. V., Mugumya, G., Okirwoth, M., Kagimu, E., Bangdiwala, A. S., Williams, D. A., Rhein, J., Boulware, D. R. & Meya, D. B., Jan 1 2019, In : Wellcome Open Research. 4, 123.

Research output: Contribution to journalArticle

Open Access

Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis

ASTRO-CM Study Team, Dec 1 2019, In : Journal of Pharmacokinetics and Pharmacodynamics. 46, 6, p. 565-576 12 p.

Research output: Contribution to journalArticle

Reflexive laboratory-based cryptococcal antigen screening and preemptive fluconazole therapy for cryptococcal antigenemia in HIV-Infected Individuals with CD4 <100 Cells/μL: A Stepped-Wedge, Cluster-Randomized Trial

Meya, D. B., Kiragga, A. N., Nalintya, E., Morawski, B. M., Rajasingham, R., Park, B. J., Mubiru, A., Kaplan, J. E., Manabe, Y. C. & Boulware, D. R., Feb 1 2019, In : Journal of Acquired Immune Deficiency Syndromes. 80, 2, p. 182-189 8 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Short-course amphotericin B in addition to sertraline and fluconazole for treatment of HIV-associated cryptococcal meningitis in rural Tanzania

the KIULARCO Study Group, Dec 1 2019, In : Mycoses. 62, 12, p. 1127-1132 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Southern African HIV Clinicians Society guideline for the prevention, diagnosis and management of cryptococcal disease among HIV-infected persons: 2019 update

Govender, N. P., Meintjes, G., Mangena, P., Nel, J., Potgieter, S., Reddy, D., Rabie, H., Wilson, D., Black, J., Boulware, D., Boyles, T., Chiller, T., Dawood, H., Dlamini, S., Harrison, T. S., Ive, P., Jarvis, J., Karstaedt, A., Madua, M. C., Menezes, C. & 9 others, Moosa, M. Y. S., Motlekar, Z., Shroufi, A., Stacey, S. L., Tsitsi, M., van Cutsem, G., Variava, E., Venter, M. & Wake, R., Jan 1 2019, In : Southern African Journal of HIV Medicine. 20, 1

Research output: Contribution to journalArticle

Open Access

Symptomatic Cryptococcal Antigenemia Presenting as Early Cryptococcal Meningitis with Negative Cerebral Spinal Fluid Analysis

For the Adjunctive Sertraline for Treatment of HIV-associated Cryptococcal Meningitis Team, Jun 2019, In : Clinical Infectious Diseases. 68, 12, p. 2094-2098 5 p., ciy817.

Research output: Contribution to journalArticle

7 Scopus citations

The conundrum of clinical trials and standard of care in sub-Saharan Africa – the research nurse perspective

Frances Ndyetukira, J., Kwizera, R., Kugonza, F., Ahimbisibwe, C., Namujju, C., Sadiq, A., Namudde, A., Williams, D., Abassi, M., Rhein, J., Boulware, D. R. & Meya, D. B., Dec 1 2019, In : Journal of Research in Nursing. 24, 8, p. 649-660 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

The mouse inhalation model of Cryptococcus neoformans infection recapitulates strain virulence in humans and shows that closely related strains can possess differential virulence

Mukaremera, L., McDonald, T. R., Nielsen, J. N., Molenaar, C. J., Akampurira, A., Schutz, C., Taseera, K., Muzoora, C., Meintjes, G., Meya, D. B., Boulware, D. R. & Nielsen, K., May 1 2019, In : Infection and immunity. 87, 5, e00046-19.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Tuberculosis at the animal-human interface in the Ugandan cattle corridor using a third-generation sequencing platform: A cross-sectional analysis study

Pullen, M. F., Boulware, D. R., Sreevatsan, S. & Bazira, J., Apr 1 2019, In : BMJ open. 9, 4, e024221.

Research output: Contribution to journalArticle

Open Access
2018

AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial 11 Medical and Health Sciences 1103 Clinical Sciences

Lawrence, D. S., Youssouf, N., Molloy, S. L. F., Alanio, A., Alufandika, M., Boulware, D. R., Boyer-Chammard, T., Chen, T., Dromer, F., Hlupeni, A., Hope, W., Hosseinipour, M. C., Kanyama, C., Lortholary, O., Loyse, A., Meya, D. B., Mosepele, M., Muzoora, C., Mwandumba, H. C., Ndhlovu, C. E. & 9 others, Niessen, L., Schutz, C., Stott, K. E., Wang, D., Lalloo, D. G., Meintjes, G., Jaffar, S., Harrison, T. S. & Jarvis, J. N., Nov 23 2018, In : Trials. 19, 1, 649.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access
7 Scopus citations
Open Access
1 Scopus citations

Blood neutrophil counts in HIV-infected patients with cryptococcal meningitis: Association with mortality

the COAT and ASTRO trial teams, Dec 2018, In : PloS one. 13, 12, e0209337.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Cerebral oximetry for detecting high-mortality risk patients with cryptococcal meningitis

ASTRO-CM Trial Team, Jan 1 2018, In : Open Forum Infectious Diseases. 5, 6

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Cryptococcal Disease in the Era of "test and Treat": Is There Cause for Concern?

Abassi, M., Rhein, J., Meya, D. B. & Boulware, D. R., Jan 1 2018, In : Open Forum Infectious Diseases. 5, 1, ofx274.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

Ellis, J., Cresswell, F. V., Rhein, J., Ssebambulidde, K. & Boulware, D. R., Jan 1 2018, In : Open Forum Infectious Diseases. 5, 8

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Delta-like 1 protein, Vitamin D binding protein and fetuin for detection of Mycobacterium tuberculosis meningitis

Bahr, N. C., Halupnick, R., Linder, G., Kiggundu, R., Nabeta, H. W., Williams, D. A., Musubire, A. K., Morawski, B. M., Sreevatsan, S., Meya, D. B., Rhein, J. R. & Boulware, D. R., Jul 2018, In : Biomarkers in Medicine. 12, 7, p. 707-716 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Detection of Mycobacterium tuberculosis in urine by Xpert MTB/RIF Ultra: A useful adjunctive diagnostic tool in HIV-associated tuberculosis

Atherton, R. R., Cresswell, F. V., Ellis, J., Skipper, C., Tadeo, K. K., Mugumya, G., Wadda, V., Meya, D. B. & Boulware, D. R., Oct 2018, In : International Journal of Infectious Diseases. 75, p. 92-94 3 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Detrimental outcomes of unmasking cryptococcal meningitis with recent ARt initiation

ASTRO-CM Study Team, Jan 1 2018, In : Open Forum Infectious Diseases. 5, 8

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study

Bahr, N. C., Nuwagira, E., Evans, E. E., Cresswell, F. V., Bystrom, P. V., Byamukama, A., Bridge, S. C., Bangdiwala, A. S., Meya, D. B., Denkinger, C. M., Muzoora, C. & Boulware, D. R., Jan 2018, In : The Lancet Infectious Diseases. 18, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

Open Access
100 Scopus citations

Evaluation of a point-of-care immunoassay test kit ‘StrongStep’ for cryptococcal antigen detection

Mpoza, E., Mukaremera, L., Kundura, D. A., Akampurira, A., Luggya, T., Tadeo, K. K., Pastick, K. A., Bridge, S. C., Tugume, L., Kiggundu, R., Musubire, A. K., Williams, D. A., Muzoora, C., Nalintya, E., Rajasingham, R., Rhein, J., Boulware, D. R., Meya, D. B. & Abassi, M., Jan 2018, In : PloS one. 13, 1, e0190652.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
Open Access
3 Scopus citations