Accepting PhD Students

PhD projects

meningitis epidemiology, prevention, diagnostics, treatment, clinical trials

20032024

Research output per year

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Research Output

2020

B cell compartmentalization in blood and cerebrospinal fluid of HIV-infected ugandans with cryptococcal meningitis

Okurut, S., Meya, D. B., Bwanga, F., Olobo, J., Eller, M. A., Cham-Jallow, F., Bohjanen, P. R., Pratap, H., Palmer, B. E., Hullsiek, K. H., Manabe, Y. C., Boulware, D. R. & Janoff, E. N., Mar 1 2020, In : Infection and immunity. 88, 3, e00779-19.

Research output: Contribution to journalArticle

Open Access

Change in plasma cryptococcal antigen titer is not associated with survival among human immunodeficiency virus-infected persons receiving preemptive therapy for asymptomatic cryptococcal antigenemia

Pullen, M. F., Kakooza, F., Nalintya, E., Kiragga, A. N., Morawski, B. M., Rajasingham, R., Mubiru, A., Manabe, Y. C., Kaplan, J. E., Meya, D. B. & Boulware, D. R., Jan 15 2020, In : Clinical Infectious Diseases. 70, 2, p. 353-355 3 p.

Research output: Contribution to journalLetter

1 Scopus citations

Cryptococcosis in pregnancy and the postpartum period: Case series and systematic review with recommendations for management

Pastick, K. A., Nalintya, E., Tugume, L., Ssebambulidde, K., Stephens, N., Evans, E. E., Ndyetukira, J. F., Nuwagira, E., Skipper, C., Muzoora, C., Meya, D. B., Rhein, J., Boulware, D. R. & Rajasingham, R., Apr 1 2020, In : Medical mycology. 58, 3, p. 282-292 11 p.

Research output: Contribution to journalArticle

Efficacy of cerebrospinal fluid beta-D-glucan diagnostic testing for fungal meningitis: A systematic review

Davis, C., Joseph Wheat, L., Myint, T., Boulware, D. R. & Bahr, N. C., Jan 1 2020, In : Journal of clinical microbiology. 58, 4, e02094-19.

Research output: Contribution to journalReview article

Evaluation of serum cryptococcal antigen testing using two novel semiquantitative lateral flow assays in persons with cryptococcal antigenemia

Skipper, C., Tadeo, K., Martyn, E., Nalintya, E., Rajasingham, R., Meya, D. B., Kafufu, B., Rhein, J. & Boulware, D. R., Jan 1 2020, In : Journal of clinical microbiology. 58, 4, e02046-19.

Research output: Contribution to journalArticle

Review: Hydroxychloroquine and chloroquine for treatment of SARS-CoV-2 (COVID-19)

Pastick, K. A., Okafor, E. C., Wang, F., Lofgren, S. M., Skipper, C. P., Nicol, M. R., Pullen, M. F., Rajasingham, R., McDonald, E. G., Lee, T. C., Schwartz, I. S., Kelly, L. E., Lother, S. A., Mitjà, O., Letang, E., Abassi, M. & Boulware, D. R., Mar 16 2020, In : Open Forum Infectious Diseases. 7, 4, ofaa130.

Research output: Contribution to journalReview article

Open Access

Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2

Ingraham, N. E., Boulware, D., Sparks, M. A., Schacker, T., Benson, B., Sparks, J. A., Murray, T., Connett, J., Chipman, J. G., Charles, A. & Tignanelli, C. J., Apr 28 2020, In : Critical Care. 24, 1, 182.

Research output: Contribution to journalComment/debate

Open Access

Should we perform the serum cryptococcal antigen test in people living with HIV hospitalized due to a community-acquired pneumonia episode?

Silva, A. P., Zenatti, C. T., Figueiredo-Mello, C., Negra, M. D., Levin, A. S., Boulware, D. R. & Vidal, J. E., Mar 1 2020, In : International Journal of STD and AIDS. 31, 4, p. 345-350 6 p.

Research output: Contribution to journalArticle

Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study

ASTRO-CM Team, Mar 2020, In : The Lancet Infectious Diseases. 20, 3, p. 308-317 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial

ASTRO-CM Team, Aug 2019, In : The Lancet Infectious Diseases. 19, 8, p. 843-851 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

AMBIsome Therapy Induction OptimisatioN (AMBITION): High dose AmBisome for cryptococcal meningitis induction therapy in sub-Saharan Africa: Economic evaluation protocol for a randomised controlled trial-based equivalence study

Ponatshego, P. L., Lawrence, D. S., Youssouf, N., Molloy, S. F., Alufandika, M., Bango, F., Boulware, D. R., Chawinga, C., Dziwani, E., Gondwe, E., Hlupeni, A., Hosseinipour, M. C., Kanyama, C., Meya, D. B., Mosepele, M., Muthoga, C., Muzoora, C. K., Mwandumba, H., Ndhlovu, C. E., Rajasingham, R. & 18 others, Sayed, S., Shamu, S., Tsholo, K., Tugume, L., Williams, D., Maheswaran, H., Shiri, T., Boyer-Chammard, T., Loyse, A., Chen, T., Wang, D., Lortholary, O., Lalloo, D. G., Meintjes, G., Jaffar, S., Harrison, T. S., Jarvis, J. N. & Niessen, L. W., Apr 1 2019, In : BMJ open. 9, 4, e026288.

Research output: Contribution to journalArticle

Burden of Depression in Outpatient HIV-Infected adults in Sub-Saharan Africa; Systematic Review and Meta-analysis

Lofgren, S. M., Bond, D. J., Nakasujja, N. & Boulware, D. R., Jan 1 2019, (Accepted/In press) In : AIDS and Behavior. 24, 6, p. 1752-1764 13 p.

Research output: Contribution to journalReview article

Case report: Three's a crowd: A case report examining the diagnostic and pharmacokinetic challenges in hiv-tuberculous meningitis-malaria co-infection [version 2; referees: 2 approved]

Ellis, J., Eneh, P. C., Ssebambulidde, K., Rutakingirwa, M. K., Lamorde, M., Rhein, J., Cresswell, F. V., Boulware, D. R. & Nicol, M. R., Jan 1 2019, In : Wellcome Open Research. 3, 111.

Research output: Contribution to journalArticle

Open Access

Cerebrospinal Fluid and Brain Tissue Penetration of Tenofovir, Lamivudine, and Efavirenz in Postmortem Tissues with Cryptococcal Meningitis

Nicol, M. R., Pastick, K. A., Taylor, J., Namuju, O. C., Rhein, J., Williams, D. A., Meya, D. B., Boulware, D. R. & Lukande, R., Sep 1 2019, In : Clinical and translational science. 12, 5, p. 445-449 5 p.

Research output: Contribution to journalArticle

Open Access

Checklists to guide the supportive and critical care of tuberculous meningitis [version 1; peer review: 2 approved]

Tuberculous Meningitis International Research Consortium, Jan 1 2019, In : Wellcome Open Research. 4, 163.

Research output: Contribution to journalArticle

Open Access

Correction: AMBIsome Therapy Induction OptimisatioN (AMBITION): High dose AmBisome for cryptococcal meningitis induction therapy in sub-Saharan Africa: Study protocol for a phase 3 randomised controlled non-inferiority trial (Trials (2018) 19 (649) DOI: 10.1186/s13063-018-3026-4)

Lawrence, D. S., Youssouf, N., Molloy, S. F., Alanio, A., Alufandika, M., Boulware, D. R., Boyer-Chammard, T., Chen, T., Dromer, F., Hlupeni, A., Hope, W., Hosseinipour, M. C., Kanyama, C., Lortholary, O., Loyse, A., Meya, D. B., Mosepele, M., Muzoora, C., Mwandumba, H. C., Ndhlovu, C. E. & 9 others, Niessen, L., Schutz, C., Stott, K. E., Wang, D., Lalloo, D. G., Meintjes, G., Jaffar, S., Harrison, T. S. & Jarvis, J. N., Jan 14 2019, In : Trials. 20, 1, 48.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Cryptococcal meningitis diagnostics and screening in the era of point-of-care laboratory testing

Rajasingham, R., Wake, R. M., Beyene, T., Katende, A., Letang, E. & Boulware, D. R., Jan 2019, In : Journal of clinical microbiology. 57, 1, e01238.

Research output: Contribution to journalReview article

Open Access
8 Scopus citations

Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma, anti-Coccidioides and anti-Blastomyces antibodies

Bahr, N. C., Panackal, A. A., Durkin, M. M., Smedema, M. L., Keown, W., Davis, T. E., Raymond-Guillen, L., Park, Y. D., Marr, K. A., Fries, B. C., Williamson, P. R., Boulware, D. R. & Wheat, L. J., Mar 1 2019, In : Mycoses. 62, 3, p. 268-273 6 p.

Research output: Contribution to journalArticle

Detection of Cryptococcus DNA by Metagenomic Next-generation Sequencing in Symptomatic Cryptococcal Antigenemia

Ramachandran, P. S., Cresswell, F. V., Meya, D. B., Langelier, C., Crawford, E. D., Derisi, J. L., Boulware, D. R. & Wilson, M. R., May 17 2019, In : Clinical Infectious Diseases. 68, 11, p. 1978-1979 2 p.

Research output: Contribution to journalLetter

1 Scopus citations
Open Access
2 Scopus citations

Epidemiology of non-traumatic spinal cord injury in Uganda: A single center, prospective study with MRI evaluation

Musubire, A. K., Meya, D. B., Katabira, E. T., Meyer, A. C. L., Bohjanen, P. R., Boulware, D. R. & Minja, F., Jan 15 2019, In : BMC neurology. 19, 1, 10.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access

Essential in vitro diagnostics for advanced HIV and serious fungal diseases: international experts’ consensus recommendations

Bongomin, F., Govender, N. P., Chakrabarti, A., Robert-Gangneux, F., Boulware, D. R., Zafar, A., Oladele, R. O., Richardson, M. D., Gangneux, J. P., Alastruey-Izquierdo, A., Bazira, J., Boyles, T. H., Sarcarlal, J., Nacher, M., Obayashi, T., Worodria, W., Pasqualotto, A. C., Meya, D. B., Cheng, B., Sriruttan, C. & 6 others, Muzoora, C., Kambugu, A., Rodriguez Tudela, J. L., Jordan, A., Chiller, T. M. & Denning, D. W., Sep 1 2019, In : European Journal of Clinical Microbiology and Infectious Diseases. 38, 9, p. 1581-1584 4 p.

Research output: Contribution to journalEditorial

Open Access
4 Scopus citations

Etiology of Sepsis in Uganda Using a Quantitative Polymerase Chain Reaction-based TaqMan Array Card

Moore, C. C., Jacob, S. T., Banura, P., Zhang, J., Stroup, S., Boulware, D. R., Scheld, W. M., Houpt, E. R. & Liu, J., Jan 7 2019, In : Clinical Infectious Diseases. 68, 2, p. 266-272 7 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Evaluation of a national cryptococcal antigen screening program for HIV-infected patients in Uganda: A cost-effectiveness modeling analysis

Rajasingham, R., Meya, D. B., Greene, G. S., Jordan, A., Nakawuka, M., Chiller, T. M., Boulware, D. R. & Larson, B. A., Jan 2019, In : PloS one. 14, 1, e0210105.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Heterogeneity in neurocognitive change trajectories among people with HIV starting antiretroviral therapy in Rakai, Uganda

Rubin, L. H., Saylor, D., Nakigozi, G., Nakasujja, N., Robertson, K., Kisakye, A., Batte, J., Mayanja, R., Anok, A., Lofgren, S. M., Boulware, D. R., Dastgheyb, R., Reynolds, S. J., Quinn, T. C., Gray, R. H., Wawer, M. J. & Sacktor, N., Dec 1 2019, In : Journal of neurovirology. 25, 6, p. 800-813 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hiv-associated cryptococcal immune reconstitution inflammatory syndrome is associated with aberrant t cell function and increased cytokine responses

Meya, D. B., Okurut, S., Zziwa, G., Cose, S., Boulware, D. R. & Janoff, E. N., Jun 2019, In : Journal of Fungi. 5, 2, 42.

Research output: Contribution to journalArticle

Open Access

HIV-Associated cryptococcal meningitis occurring at relatively higher CD4 counts

Tugume, L., Rhein, J., Hullsiek, K. H., Mpoza, E., Kiggundu, R., Ssebambulidde, K., Schutz, C., Taseera, K., Williams, D. A., Abassi, M., Muzoora, C., Musubire, A. K., Meintjes, G., Meya, D. B., Boulware, D. R., Nabeta, H. W., Ndyetukira, J. F., Ahimbisibwe, C., Kugonza, F., Namuju, C. & 28 others, Sadiq, A., Namudde, A., Mwesigye, J., Kandole, T. K., Kwizera, R., Kirumira, P., Okirwoth, M., Akampurira, A., Luggya, T., Kaboggoza, J., Laker, E., Atwine, L., Muganzi, D., Evans, E. E., Bridge, S. C., Velamakanni, S. S., Rajasingham, R., Pastick, K., Stadelman, A., Flynn, A., Fujita, A. W., Mukaremera, L., Lofgren, S. M., Morawski, B. M., Bangdiwala, A., Nielsen, K., Bohjanen, P. R. & Kambugu, A., Feb 23 2019, In : Journal of Infectious Diseases. 219, 6, p. 877-883 7 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Identification of pathogen genomic differences that impact human immune response and disease during cryptococcus neoformans infection

Gerstein, A. C., Jackson, K. M., McDonald, T. R., Wang, Y., Lueck, B. D., Bohjanen, S., Smith, K. D., Akampurira, A., Meya, D. B., Xue, C., Boulware, D. R. & Nielsen, K., Jan 1 2019, In : mBio. 10, 4, e01440-19.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Improved detection of group A: Streptococcus during thermal contrast amplification vs. visual reading of clinical rapid diagnostic tests

Wang, Y., Louwagie, E., Larkin, D., Sankey, S., Boulware, D. R. & Bischof, J. C., Apr 21 2019, In : Analytical Methods. 11, 15, p. 2013-2017 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Inadequate diagnostics: The case to move beyond the bacilli for detection of meningitis due to mycobacterium tuberculosis

Bahr, N. C., Meintjes, G. & Boulware, D. R., May 2019, In : Journal of medical microbiology. 68, 5, p. 755-760 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Knowledge gaps and research priorities in tuberculous meningitis

Tuberculous Meningitis International Research Consortium, Jan 1 2019, In : Wellcome Open Research. 4, 188.

Research output: Contribution to journalLetter

Open Access

Laboratory-reflex cryptococcal antigen screening is associated with a survival benefit in tanzania

Faini, D., Kalinjuma, A. V., Katende, A., Mbwaji, G., Mnzava, D., Nyuri, A., Glass, T. R., Furrer, H., Hatz, C., Boulware, D. R. & Letang, E., Feb 1 2019, In : Journal of Acquired Immune Deficiency Syndromes. 80, 2, p. 205-213 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries

Loyse, A., Burry, J., Cohn, J., Ford, N., Chiller, T., Ribeiro, I., Koulla-Shiro, S., Mghamba, J., Ramadhani, A., Nyirenda, R., Aliyu, S. H., Wilson, D., Le, T., Oladele, R., Lesikari, S., Muzoora, C., Kalata, N., Temfack, E., Mapoure, Y., Sini, V. & 35 others, Chanda, D., Shimwela, M., Lakhi, S., Ngoma, J., Gondwe-Chunda, L., Perfect, C., Shroufi, A., Andrieux-Meyer, I., Chan, A., Schutz, C., Hosseinipour, M., Van der Horst, C., Klausner, J. D., Boulware, D. R., Heyderman, R., Lalloo, D., Day, J., Jarvis, J. N., Rodrigues, M., Jaffar, S., Denning, D., Migone, C., Doherty, M., Lortholary, O., Dromer, F., Stack, M., Molloy, S. F., Bicanic, T., van Oosterhout, J., Mwaba, P., Kanyama, C., Kouanfack, C., Mfinanga, S., Govender, N. & Harrison, T. S., Apr 2019, In : The Lancet Infectious Diseases. 19, 4, p. e143-e147

Research output: Contribution to journalReview article

10 Scopus citations

Longitudinal changes in cd4+, cd8+ t cell phenotype and activation marker expression following antiretroviral therapy initiation among patients with cryptococcal meningitis

Bayiyana, A., Okurut, S., Nabatanzi, R., Zziwa, G., Boulware, D. R., Lutwama, F. & Meya, D., Sep 2019, In : Journal of Fungi. 5, 3, 63.

Research output: Contribution to journalArticle

Open Access

Management of amphotericin-induced phlebitis among HIV patients with cryptococcal meningitis in a resource-limited setting: A prospective cohort study

Ahimbisibwe, C., Kwizera, R., Ndyetukira, J. F., Kugonza, F., Sadiq, A., Hullsiek, K. H., Williams, D. A., Rhein, J., Boulware, D. R. & Meya, D. B., Jun 26 2019, In : BMC infectious diseases. 19, 1, 558.

Research output: Contribution to journalArticle

Open Access

Management of intracranial tuberculous mass lesions: How long should we treat for? [version 2; peer review: 1 approved, 2 approved with reservations]

Tuberculous Meningitis International Research Consortium, Jan 1 2019, In : Wellcome Open Research. 4, 158.

Research output: Contribution to journalArticle

Open Access
Open Access
2 Scopus citations
1 Scopus citations

Performance of lipoarabinomannan assay using cerebrospinal fluid for the diagnosis of tuberculous meningitis among HIV patients [version 1; peer review: 2 approved]

Kwizera, R., Cresswell, F. V., Mugumya, G., Okirwoth, M., Kagimu, E., Bangdiwala, A. S., Williams, D. A., Rhein, J., Boulware, D. R. & Meya, D. B., Jan 1 2019, In : Wellcome Open Research. 4, 123.

Research output: Contribution to journalArticle

Open Access

Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis

ASTRO-CM Study Team, Dec 1 2019, In : Journal of Pharmacokinetics and Pharmacodynamics. 46, 6, p. 565-576 12 p.

Research output: Contribution to journalArticle

Reflexive laboratory-based cryptococcal antigen screening and preemptive fluconazole therapy for cryptococcal antigenemia in HIV-Infected Individuals with CD4 <100 Cells/μL: A Stepped-Wedge, Cluster-Randomized Trial

Meya, D. B., Kiragga, A. N., Nalintya, E., Morawski, B. M., Rajasingham, R., Park, B. J., Mubiru, A., Kaplan, J. E., Manabe, Y. C. & Boulware, D. R., Feb 1 2019, In : Journal of Acquired Immune Deficiency Syndromes. 80, 2, p. 182-189 8 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Short-course amphotericin B in addition to sertraline and fluconazole for treatment of HIV-associated cryptococcal meningitis in rural Tanzania

the KIULARCO Study Group, Dec 1 2019, In : Mycoses. 62, 12, p. 1127-1132 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Southern African HIV Clinicians Society guideline for the prevention, diagnosis and management of cryptococcal disease among HIV-infected persons: 2019 update

Govender, N. P., Meintjes, G., Mangena, P., Nel, J., Potgieter, S., Reddy, D., Rabie, H., Wilson, D., Black, J., Boulware, D., Boyles, T., Chiller, T., Dawood, H., Dlamini, S., Harrison, T. S., Ive, P., Jarvis, J., Karstaedt, A., Madua, M. C., Menezes, C. & 9 others, Moosa, M. Y. S., Motlekar, Z., Shroufi, A., Stacey, S. L., Tsitsi, M., van Cutsem, G., Variava, E., Venter, M. & Wake, R., Jan 1 2019, In : Southern African Journal of HIV Medicine. 20, 1

Research output: Contribution to journalArticle

Open Access

Symptomatic Cryptococcal Antigenemia Presenting as Early Cryptococcal Meningitis with Negative Cerebral Spinal Fluid Analysis

For the Adjunctive Sertraline for Treatment of HIV-associated Cryptococcal Meningitis Team, Jun 2019, In : Clinical Infectious Diseases. 68, 12, p. 2094-2098 5 p., ciy817.

Research output: Contribution to journalArticle

7 Scopus citations

The conundrum of clinical trials and standard of care in sub-Saharan Africa – the research nurse perspective

Frances Ndyetukira, J., Kwizera, R., Kugonza, F., Ahimbisibwe, C., Namujju, C., Sadiq, A., Namudde, A., Williams, D., Abassi, M., Rhein, J., Boulware, D. R. & Meya, D. B., Dec 1 2019, In : Journal of Research in Nursing. 24, 8, p. 649-660 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

The current global situation for tuberculous meningitis: Epidemiology, diagnostics, treatment and outcomes

Tuberculous Meningitis International Research Consortium, Jan 1 2019, In : Wellcome Open Research. 4, 167.

Research output: Contribution to journalReview article

Open Access

The mouse inhalation model of Cryptococcus neoformans infection recapitulates strain virulence in humans and shows that closely related strains can possess differential virulence

Mukaremera, L., McDonald, T. R., Nielsen, J. N., Molenaar, C. J., Akampurira, A., Schutz, C., Taseera, K., Muzoora, C., Meintjes, G., Meya, D. B., Boulware, D. R. & Nielsen, K., May 1 2019, In : Infection and immunity. 87, 5, e00046-19.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Tuberculosis at the animal-human interface in the Ugandan cattle corridor using a third-generation sequencing platform: A cross-sectional analysis study

Pullen, M. F., Boulware, D. R., Sreevatsan, S. & Bazira, J., Apr 1 2019, In : BMJ open. 9, 4, e024221.

Research output: Contribution to journalArticle

Open Access