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David R Boulware

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David R Boulware

 https://orcid.org/0000-0002-4715-0060

Accepting PhD Students

PhD projects

meningitis epidemiology, prevention, diagnostics, treatment, clinical trials

20032026

Research activity per year

Personal profile

Research interests

Dr. David Boulware is an infectious disease physician-scientist with formal training in public health, clinical trials, and tropical medicine.  As a translational researcher, Dr. Boulware combines his clinical research training with basic science investigations into disease pathogenesis. His primary research interests are in meningitis including diagnosis, prevention, and treatment. The overall objective is to translate knowledge into improved care and updated US and international guidelines.

Dr. Boulware leads a Platform Trial on cryptococcal meningitis (PLATFORM-CM) investigating new antifungal therapies with the objective to bring new antifungal therapies forward to FDA approval, thereby making these new antifungal therapies available for Americans. Cryptococcal meningitis, a fungal infection in and around the brain, is the most common cause of meningitis in Africa. This also occurs in the US with an estimated incidence of 1.1 per 100,000 Americans. While progress has been made, the mortality through 4-months remains ~30% with current first-line therapy.  

A second focus is on clinical research for TB meningitis, which is the second most common cause of meningitis in Africa.  His team has worked on diagnostics for TB meningitis, changing first-line recommended diagnostics. Still more work needs to be done to improve diagnosis.  His collaborative team also conducts clinical trials for TB meningitis, investigating new therapies to improve upon the ~45% mortality rate.     

Dr. Boulware has active research collaborations in Uganda, South Africa, Ethiopia, Indonesia, Brazil, United Kingdom, and The Netherlands, leading a multidisciplinary, international research team which is highly collaborative in working with others.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 1 - No Poverty
    SDG 1 No Poverty
  2. SDG 2 - Zero Hunger
    SDG 2 Zero Hunger
  3. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being
  4. SDG 4 - Quality Education
    SDG 4 Quality Education
  5. SDG 5 - Gender Equality
    SDG 5 Gender Equality
  6. SDG 6 - Clean Water and Sanitation
    SDG 6 Clean Water and Sanitation
  7. SDG 8 - Decent Work and Economic Growth
    SDG 8 Decent Work and Economic Growth
  8. SDG 9 - Industry, Innovation, and Infrastructure
    SDG 9 Industry, Innovation, and Infrastructure
  9. SDG 10 - Reduced Inequalities
    SDG 10 Reduced Inequalities
  10. SDG 12 - Responsible Consumption and Production
    SDG 12 Responsible Consumption and Production
  11. SDG 16 - Peace, Justice and Strong Institutions
    SDG 16 Peace, Justice and Strong Institutions
  12. SDG 17 - Partnerships for the Goals
    SDG 17 Partnerships for the Goals

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View all 47 projects and grants
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