Personal profile

Research interests

Dr. David Boulware is an infectious disease physician-scientist with formal training in public health, clinical trials, and tropical medicine.  As a translational researcher, Dr. Boulware combines his clinical research training with basic science investigations into disease pathogenesis. His primary research interests are in meningitis in resource-limited areas including diagnosis, prevention, treatment, and quality improvement initiatives incorporating cost-effectiveness analyses in order to translate knowledge into improved care.

Dr. Boulware’s current research is focused on improving the clinical outcomes of HIV-infected persons with meningitis.  Cryptococcal meningitis is the second most common AIDS-defining opportunistic infection in Sub-Saharan Africa and the most common cause of adult meningitis. Why Cryptococcus?  During 2016, cryptococcal meningitis accounts for ~70% of adult meningitis in Uganda. Even in the U.S., the estimated incidence of 1.1 hospitalizations for cryptococcal meningitis makes this more common than all causes of bacterial meningitis combined. Prevention with targeted cryptococcal antigen screening and preemptive therapy for early disseminated Cryptococcus infection is of great interest with ongoing clinical studies and trials. Diagnostics for TB meningitis have become an emerging area of interest and research.  Dr. Boulware has active research collaborations in Uganda, South Africa, Tanzania, and Ethiopia leading a multidisciplinary, international research team which is highly collaborative in working with others.

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Cryptococcal Meningitis Medicine & Life Sciences
HIV Medicine & Life Sciences
Cerebrospinal Fluid Medicine & Life Sciences
Antigens Medicine & Life Sciences
Immune Reconstitution Inflammatory Syndrome Medicine & Life Sciences
Mortality Medicine & Life Sciences
Meningitis Medicine & Life Sciences
Uganda Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2021

Research Output 2003 2017

1 Citations

Acridine orange fluorescent microscopy is more sensitive than India ink light microscopy in the rapid detection of cryptococcosis among CrAg positive HIV patients

Kwizera, R., Akampurira, A., Williams, D., Boulware, D. R., Meya, D. B. & ASTRO-CM Study Team Jul 1 2017 In : PLoS ONE. 12, 7, e0182108

Research output: Contribution to journalArticle

HIV Antigens
Cryptococcosis
Acridine Orange
Ink
Microscopy

Case 8-2017: A 39-year-old zimbabwean man with a severe headache

Boulware, D. R. & Makadzange, A. T. Mar 16 2017 In : New England Journal of Medicine. 376, 11, p. 1065-1071 7 p.

Research output: Contribution to journalArticle

CD4+ T-cell count may not be a useful strategy to monitor antiretroviral therapy response in HTLV-1/HIV co-infected patients

Vandormael, A., Rego, F., Danaviah, S., Alcantara, L. C. J., Boulware, D. & de Oliveira, T. 2017 In : Current HIV Research. 15, 3, p. 225-231 7 p.

Research output: Contribution to journalArticle

Human T-lymphotropic virus 1
CD4 Lymphocyte Count
HIV
T-Lymphocytes
Viral Load

Cryptococcal meningitis: A neglected NTD?

Molloy, S. F. , Chiller, T. , Greene, G. S. , Burry, J. , Govender, N. P. , Kanyama, C. , Mfinanga, S. , Lesikari, S. , Mapoure, Y. N. , Kouanfack, C. , Sini, V. , Temfack, E. , Boulware, D. R. , Dromer, F. , Denning, D. W. , Day, J. , Stone, N. R. H. , Bicanic, T. , Jarvis, J. N. , Lortholary, O. & 3 others Harrison, T. S., Jaffar, S. & Loyse, A. Jun 29 2017 In : PLoS Neglected Tropical Diseases. 11, 6, e0005575

Research output: Contribution to journalArticle

Differences in immunologic factors among patients presenting with altered mental status during cryptococcal meningitis

Lofgren, S., Hullsiek, K. H., Morawski, B. M., Nabeta, H. W., Kiggundu, R., Taseera, K., Musubire, A., Schutz, C., Abassi, M., Bahr, N. C., Tugume, L., Muzoora, C., Williams, D. A., Rolfes, M. A., Velamakanni, S. S., Rajasingham, R., Meintjes, G., Rhein, J., Meya, D. B. & Boulware, D. R. 2017 In : Journal of Infectious Diseases. 215, 5, p. 693-697 5 p.

Research output: Contribution to journalArticle

Cryptococcal Meningitis
Cryptococcus
Immunologic Factors
Chemokines
Interleukin-10