Personal profile

Research interests

Dr. David Boulware is an infectious disease physician-scientist with formal training in public health, clinical trials, and tropical medicine.  As a translational researcher, Dr. Boulware combines his clinical research training with basic science investigations into disease pathogenesis. His primary research interests are in meningitis in resource-limited areas including diagnosis, prevention, treatment, and quality improvement initiatives incorporating cost-effectiveness analyses in order to translate knowledge into improved care.

Dr. Boulware’s current research is focused on improving the clinical outcomes of HIV-infected persons with meningitis.  Cryptococcal meningitis is the second most common AIDS-defining opportunistic infection in Sub-Saharan Africa and the most common cause of adult meningitis. Why Cryptococcus?  During 2016, cryptococcal meningitis accounts for ~70% of adult meningitis in Uganda. Even in the U.S., the estimated incidence of 1.1 hospitalizations for cryptococcal meningitis makes this more common than all causes of bacterial meningitis combined. Prevention with targeted cryptococcal antigen screening and preemptive therapy for early disseminated Cryptococcus infection is of great interest with ongoing clinical studies and trials. Diagnostics for TB meningitis have become an emerging area of interest and research.  Dr. Boulware has active research collaborations in Uganda, South Africa, Tanzania, and Ethiopia leading a multidisciplinary, international research team which is highly collaborative in working with others.

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Cryptococcal Meningitis Medicine & Life Sciences
HIV Medicine & Life Sciences
Immune Reconstitution Inflammatory Syndrome Medicine & Life Sciences
Cerebrospinal Fluid Medicine & Life Sciences
Uganda Medicine & Life Sciences
Antigens Medicine & Life Sciences
Meningitis Medicine & Life Sciences
Meningeal Tuberculosis Medicine & Life Sciences

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Projects 2009 2021

Research Output 2003 2018

Absence of cerebrospinal fluid pleocytosis in tuberculous meningitis is a common occurrence in HIV co-infection and a predictor of poor outcomes

Cresswell, F. V., Bangdiwala, A. S., Meya, D. B., Bahr, N. C., Vidal, J. E., Török, M. E., Thao, L. T. P., Thwaites, G. E. & Boulware, D. R. Mar 1 2018 In : International Journal of Infectious Diseases. 68, p. 77-78 2 p.

Research output: Contribution to journalLetter

Meningeal Tuberculosis
Leukocytosis
Coinfection
HIV Infections
Cerebrospinal Fluid

Antimicrobial drug resistance in blood culture isolates at a tertiary hospital, Uganda

Kajumbula, H., Fujita, A. W., Mbabazi, O., Najjuka, C., Izale, C., Akampurira, A., Aisu, S., Lamorde, M., Walwema, R., Bahr, N. C., Meya, D. B., Boulware, D. R. & Manabe, Y. C. Jan 1 2018 In : Emerging infectious diseases. 24, 1, p. 174-175 2 p.

Research output: Contribution to journalLetter

Uganda
Microbial Drug Resistance
Tertiary Care Centers
Africa South of the Sahara
Microbiology
11 Citations

Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study

Bahr, N. C., Nuwagira, E., Evans, E. E., Cresswell, F. V., Bystrom, P. V., Byamukama, A., Bridge, S. C., Bangdiwala, A. S., Meya, D. B., Denkinger, C. M., Muzoora, C. & Boulware, D. R. Jan 1 2018 In : The Lancet Infectious Diseases. 18, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

Meningeal Tuberculosis
Cohort Studies
HIV
Prospective Studies
Cerebrospinal Fluid

Evaluation of a point-of-care immunoassay test kit ‘StrongStep’ for cryptococcal antigen detection

Mpoza, E., Mukaremera, L., Kundura, D. A., Akampurira, A., Luggya, T., Tadeo, K. K., Pastick, K. A., Bridge, S. C., Tugume, L., Kiggundu, R., Musubire, A. K., Williams, D. A., Muzoora, C., Nalintya, E., Rajasingham, R., Rhein, J., Boulware, D. R., Meya, D. B. & Abassi, M. Jan 1 2018 In : PLoS ONE. 13, 1, e0190652

Research output: Contribution to journalArticle

fungal antigens
Fungal Antigens
middle-aged adults
Point-of-Care Systems
Cryptococcus

Performance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in HIV-infected patients with culture-proven cryptococcal meningitis admitted at a Brazilian referral center

Vidal, J. E., Toniolo, C., Paulino, A., Colombo, A. L., Martins, M. D. A., Meira, C. D. S., Azevedo, R. G. S., Pereira-Chioccola, V. L., Gomes, H. R., Lazera, M. D. S., de Oliveira, A. C. P. & Boulware, D. R. Jan 1 2018 In : Revista do Instituto de Medicina Tropical de Sao Paulo. 60, e1

Research output: Contribution to journalArticle

Cryptococcal Meningitis
Cerebrospinal Fluid
Referral and Consultation
HIV
Urine