Projects per year
Personal profile
Research interests
Dr. David Boulware is an infectious disease physician-scientist with formal training in public health, clinical trials, and tropical medicine. As a translational researcher, Dr. Boulware combines his clinical research training with basic science investigations into disease pathogenesis. His primary research interests are in meningitis in resource-limited areas including diagnosis, prevention, treatment, and quality improvement initiatives incorporating cost-effectiveness analyses in order to translate knowledge into improved care.
Dr. Boulware’s current research is focused on improving the clinical outcomes of HIV-infected persons with meningitis. Cryptococcal meningitis is the second most common AIDS-defining opportunistic infection in Sub-Saharan Africa and the most common cause of adult meningitis. Why Cryptococcus? During 2016, cryptococcal meningitis accounts for ~70% of adult meningitis in Uganda. Even in the U.S., the estimated incidence of 1.1 hospitalizations for cryptococcal meningitis makes this more common than all causes of bacterial meningitis combined. Prevention with targeted cryptococcal antigen screening and preemptive therapy for early disseminated Cryptococcus infection is of great interest with ongoing clinical studies and trials. Diagnostics for TB meningitis have become an emerging area of interest and research. Dr. Boulware has active research collaborations in Uganda, South Africa, Tanzania, and Ethiopia leading a multidisciplinary, international research team which is highly collaborative in working with others.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Cerebral Hemodynamics and Stroke in HIV-associated TB Meningitis
NIH NAT INST OF NEURO DISORDERS & STROKE
8/1/23 → 7/31/25
Project: Research project
-
Enhanced Antifungal Therapy to Improve Survival in Early Disseminated Cryptococcal Infection
Rajasingham, R., Boulware, D. R. & Huppler Hullsiek, K.
NIH Nat'l Inst of Allergy & Infect Dis
4/21/23 → 3/31/24
Project: Research project
-
Encochleated Oral Amphotericin for HIV-related Cryptococcal Meningitis Trial: Phase 3 Trial
Boulware, D. R., Abassi, M., Huppler Hullsiek, K., Nicol, M. R. & Skipper, C. P.
NIH NAT INST OF NEURO DISORDERS & STROKE
2/15/23 → 1/31/24
Project: Research project
-
Immune profiling to detect viral hepatitis-related liver cancer in HIV-infected patients
Debes, J. D., Boulware, D. R. & Koopmeiners, J.
NIH FIC JOHN E FOGARTY INTL CT
7/1/22 → 6/30/24
Project: Research project
-
Adherence of health workers to guidelines for screening and management of cryptococcal meningitis in Uganda
Namuju, O. C., Namuwenge, P. M., Kwizera, R., Obuya, E., Kirumira, P., Naluyima, R., Ahimbisibwe, C., Ndyetukira, J. F., Nakato, H., Kirungi, R., Gakuru, J., Junju, S., Nuwagira, E., Rutakagirwa, M., Nsibirwa, S., Nabitaka, V., Nalintya, E., Mpoza, E., Muzoora, C. K., Musubire, A. K., & 2 others , Apr 2023, In: PloS one. 18, 4 April, e0284165.Research output: Contribution to journal › Article › peer-review
Open Access -
Differences in Reasons for Late Presentation to HIV Care in Uganda Among Men and Women
Lofgren, S. M., Tsui, S., Natala, N., Nakasujja, N., Sebuliba, R., Ndyetukira, J. F., Arinda, A., Akinyange, V., Hullsiek, K. H., Nalintya, E., Sadiq, A., Pastick, K., Stadleman, A., Meya, D. B. & Boulware, D. R., Jan 2023, In: AIDS and Behavior. 27, 1, p. 303-313 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Disseminated Cryptococcosis Is a Common Finding among Human Immunodeficiency Virus-Infected Patients with Suspected Sepsis and Is Associated with Higher Mortality Rates
Tufa, T. B., Orth, H. M., Wienemann, T., Jensen, B. E. O., Mackenzie, C. R., Boulware, D. R., Luedde, T. & Feldt, T., Aug 2023, In: Journal of Fungi. 9, 8, 836.Research output: Contribution to journal › Article › peer-review
Open Access -
Early Treatment with Fluvoxamine among Patients with COVID-19: A Cost-Consequence Model
TOGETHER Investigators, Jan 2023, In: American Journal of Tropical Medicine and Hygiene. 108, 1, p. 101-106 6 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Effect of Coronavirus Disease 2019 Lockdowns on Identification of Advanced Human Immunodeficiency Virus Disease in Outpatient Clinics in Uganda
Nalintya, E., Sekar, P., Kavuma, P., Kigozi, J., Ssuna, M., Kirumira, P., Naluyima, R., Namuli, T., Musa, F. T., Skipper, C. P., Huppler Hullsiek, K., Ellis, J., Boulware, D. R., Meya, D. B. & Rajasingham, R., Jun 1 2023, In: Clinical Infectious Diseases. 76, 11, p. 2014-2017 4 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Datasets
-
COAT Trial Public Dataset
Boulware, D. R., investigator, Jul 1 2015
https://www.researchgate.net/publication/280156939_COAT_Trial_Public_Dataset_03December2013
Dataset
Press/Media
-
The Strange and Twisted Tale of Hydroxychloroquine
11/11/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
-
Trump pushes FDA to quickly clear coronavirus antibody treatments, erroneously calling them a "cure"
10/9/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
-
Trump’s age, health woes raise his risk for COVID-19 illness
10/2/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
-
Hydroxychloroquine didn't prevent Covid-19 among health care workers in new study
9/30/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
-
Twitter deletes video promoted by Trump on hydroxychloroquine use for coronavirus
7/28/20
1 item of Media coverage
Press/Media: Expert Comment or Interview