Personal profile

Research interests

Dr. David Boulware is an infectious disease physician-scientist with formal training in public health, clinical trials, and tropical medicine.  As a translational researcher, Dr. Boulware combines his clinical research training with basic science investigations into disease pathogenesis. His primary research interests are in meningitis in resource-limited areas including diagnosis, prevention, treatment, and quality improvement initiatives incorporating cost-effectiveness analyses in order to translate knowledge into improved care.

Dr. Boulware’s current research is focused on improving the clinical outcomes of HIV-infected persons with meningitis.  Cryptococcal meningitis is the second most common AIDS-defining opportunistic infection in Sub-Saharan Africa and the most common cause of adult meningitis. Why Cryptococcus?  During 2016, cryptococcal meningitis accounts for ~70% of adult meningitis in Uganda. Even in the U.S., the estimated incidence of 1.1 hospitalizations for cryptococcal meningitis makes this more common than all causes of bacterial meningitis combined. Prevention with targeted cryptococcal antigen screening and preemptive therapy for early disseminated Cryptococcus infection is of great interest with ongoing clinical studies and trials. Diagnostics for TB meningitis have become an emerging area of interest and research.  Dr. Boulware has active research collaborations in Uganda, South Africa, Tanzania, and Ethiopia leading a multidisciplinary, international research team which is highly collaborative in working with others.

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 5 Similar Profiles
HIV Medicine & Life Sciences
Cryptococcal Meningitis Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Cerebrospinal Fluid Medicine & Life Sciences
Antigens Medicine & Life Sciences
Mortality Medicine & Life Sciences
Immune Reconstitution Inflammatory Syndrome Medicine & Life Sciences
Meningitis Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2021

Research Output 2003 2018

Antimicrobial drug resistance in blood culture isolates at a tertiary hospital, Uganda

Kajumbula, H., Fujita, A. W., Mbabazi, O., Najjuka, C., Izale, C., Akampurira, A., Aisu, S., Lamorde, M., Walwema, R., Bahr, N. C., Meya, D. B., Boulware, D. R. & Manabe, Y. C. Jan 1 2018 In : Emerging Infectious Diseases. 24, 1, p. 174-175 2 p.

Research output: Research - peer-reviewLetter

Uganda
Microbial Drug Resistance
Tertiary Care Centers
Blood Culture
Africa South of the Sahara

Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study

Bahr, N. C., Nuwagira, E., Evans, E. E., Cresswell, F. V., Bystrom, P. V., Byamukama, A., Bridge, S. C., Bangdiwala, A. S., Meya, D. B., Denkinger, C. M., Muzoora, C. & Boulware, D. R. Jan 1 2018 In : The Lancet Infectious Diseases. 18, 1, p. 68-75 8 p.

Research output: Research - peer-reviewArticle

Meningeal Tuberculosis
Cohort Studies
HIV
Prospective Studies
Cerebrospinal Fluid

Evaluation of a point-of-care immunoassay test kit ‘StrongStep’ for cryptococcal antigen detection

Mpoza, E., Mukaremera, L., Kundura, D. A., Akampurira, A., Luggya, T., Tadeo, K. K., Pastick, K. A., Bridge, S. C., Tugume, L., Kiggundu, R., Musubire, A. K., Williams, D. A., Muzoora, C., Nalintya, E., Rajasingham, R., Rhein, J., Boulware, D. R., Meya, D. B. & Abassi, M. Jan 1 2018 In : PLoS ONE. 13, 1, e0190652

Research output: Research - peer-reviewArticle

antigen detection
analytical kits
immunoassays
antigens
Point-of-Care Systems

Poor specificity of urinary cryptococcal antigen testing: Reply to Drain et al. Prevalence of cryptococcal antigenuria at initial HIV diagnosis in KwaZulu-Natal

Tenforde, M. W., Longley, N., Meya, D. B., Boulware, D. R., Meintjes, G., Goercke, I., Harrison, T. S. & Jarvis, J. N. Feb 1 2018 In : HIV Medicine. 19, 2, p. e47-e48

Research output: Research - peer-reviewLetter

HIV
Antigens

Systematic Review of Interventions for Depression for People Living with HIV in Africa

Lofgren, S. M., Nakasujja, N. & Boulware, D. R. Jan 1 2018 In : AIDS and Behavior. 22, 1

Research output: Research - peer-reviewReview article

HIV
Depression
MEDLINE
Psychotherapy
Antidepressive Agents