Projects per year
Personal profile
Research interests
Dr. David Boulware is an infectious disease physician-scientist with formal training in public health, clinical trials, and tropical medicine. As a translational researcher, Dr. Boulware combines his clinical research training with basic science investigations into disease pathogenesis. His primary research interests are in meningitis in resource-limited areas including diagnosis, prevention, treatment, and quality improvement initiatives incorporating cost-effectiveness analyses in order to translate knowledge into improved care.
Dr. Boulware’s current research is focused on improving the clinical outcomes of HIV-infected persons with meningitis. Cryptococcal meningitis is the second most common AIDS-defining opportunistic infection in Sub-Saharan Africa and the most common cause of adult meningitis. Why Cryptococcus? During 2016, cryptococcal meningitis accounts for ~70% of adult meningitis in Uganda. Even in the U.S., the estimated incidence of 1.1 hospitalizations for cryptococcal meningitis makes this more common than all causes of bacterial meningitis combined. Prevention with targeted cryptococcal antigen screening and preemptive therapy for early disseminated Cryptococcus infection is of great interest with ongoing clinical studies and trials. Diagnostics for TB meningitis have become an emerging area of interest and research. Dr. Boulware has active research collaborations in Uganda, South Africa, Tanzania, and Ethiopia leading a multidisciplinary, international research team which is highly collaborative in working with others.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Network
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11th International Conference on Cryptococcus and Cryptococcosis (ICCC)
NIH Nat'l Inst of Allergy & Infect Dis
2/1/22 → 1/31/23
Project: Research project
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An Enhanced Package of Care to Reduce Mortality in Persons with Advanced HIV Disease
Rajasingham, R., Boulware, D. R. & Huppler Hullsiek, K.
NIH Nat'l Inst of Allergy & Infect Dis
8/23/21 → 7/31/26
Project: Research project
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TB Meningitis: Evaluating CSF Immunology to Discover Hidden Disease and Potential Immunomodulatory Therapies
NIH Nat'l Inst of Allergy & Infect Dis
8/1/21 → 7/31/26
Project: Research project
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A randomized clinical trial of early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa
9/18/20 → 6/30/25
Project: Research project
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Infectious Disease Training in Clinical Investigation
National Institutes of Health (NIH)
7/1/20 → 6/30/25
Project: Research project
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Determinants of cryptococcal antigen (CrAg) screening uptake in Kampala, Uganda: An assessment of health center characteristics
Srishyla, D., Saemisch, G., Turya, F., Nalintya, E., Jjunju, S., Kagimu, E., Rutakingirwa, M. K., Skipper, C. P., Boulware, D. R., Meya, D. B. & Rajasingham, R., Apr 1 2022, In: Medical mycology. 60, 4, myac013.Research output: Contribution to journal › Article › peer-review
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Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization: A Systematic Review and Meta-analysis
Lee, T. C., Vigod, S., Bortolussi-Courval, É., Hanula, R., Boulware, D. R., Lenze, E. J., Reiersen, A. M. & McDonald, E. G., Apr 6 2022, In: JAMA Network Open. 5, 4, p. E226269Research output: Contribution to journal › Review article › peer-review
Open Access -
Fluvoxamine for the treatment of COVID-19
Boulware, D. R. & Abassi, M., Mar 2022, In: The Lancet Global Health. 10, 3, p. e329Research output: Contribution to journal › Letter › peer-review
Open Access -
Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics
Ramachandran, P. S., Ramesh, A., Creswell, F. V., Wapniarski, A., Narendra, R., Quinn, C. M., Tran, E. B., Rutakingirwa, M. K., Bangdiwala, A. S., Kagimu, E., Kandole, K. T., Zorn, K. C., Tugume, L., Kasibante, J., Ssebambulidde, K., Okirwoth, M., Bahr, N. C., Musubire, A. K., Skipper, C. P., Fouassier, C. & 11 others, , Dec 2022, In: Nature communications. 13, 1, 1675.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis
Ambition Study Group, Mar 24 2022, In: New England Journal of Medicine. 386, 12, p. 1109-1120 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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COAT Trial Public Dataset
Boulware, D. R., investigator, Jul 1 2015
https://www.researchgate.net/publication/280156939_COAT_Trial_Public_Dataset_03December2013
Dataset
Press / Media
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The Strange and Twisted Tale of Hydroxychloroquine
11/11/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
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Trump pushes FDA to quickly clear coronavirus antibody treatments, erroneously calling them a "cure"
10/9/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
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Trump’s age, health woes raise his risk for COVID-19 illness
10/2/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
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Hydroxychloroquine didn't prevent Covid-19 among health care workers in new study
9/30/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
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Twitter deletes video promoted by Trump on hydroxychloroquine use for coronavirus
7/28/20
1 item of Media coverage
Press/Media: Expert Comment or Interview