1985 …2023
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1985 2019

Filter
Article
2019
1 Citation (Scopus)

A Cinchona Alkaloid Antibiotic That Appears to Target ATP Synthase in Streptococcus pneumoniae

Wang, X., Zeng, Y., Sheng, L., Larson, P., Liu, X., Zou, X., Wang, S., Guo, K., Ma, C., Zhang, G., Cui, H., Ferguson, D. M., Li, Y., Zhang, J. & Aldrich, C. C., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2305-2332 28 p.

Research output: Contribution to journalArticle

Cinchona Alkaloids
Quinuclidines
Streptococcus pneumoniae
Adenosine Triphosphate
Anti-Bacterial Agents
1 Citation (Scopus)

Combination of Sunitinib and PD-L1 Blockade Enhances Anticancer Efficacy of TLR7/8 Agonist-Based Nanovaccine

Kim, H., Khanna, V., Kucaba, T. A., Zhang, W., Ferguson, D. M., Griffith, T. S. & Panyam, J., Mar 4 2019, In : Molecular pharmaceutics. 16, 3, p. 1200-1210 11 p.

Research output: Contribution to journalArticle

Cancer Vaccines
Ligands
T-Lymphocytes
Tumor Microenvironment
Nanoparticles
1 Citation (Scopus)

Investigation of (S)-(-)-acidomycin: A selective antimycobacterial natural product that inhibits biotin synthase

Bockman, M. R., Engelhart, C. A., Cramer, J. D., Howe, M. D., Mishra, N. K., Zimmerman, M., Larson, P., Alvarez-Cabrera, N., Park, S. W., Boshoff, H. I. M., Bean, J. M., Young, V. G., Ferguson, D. M., Dartois, V., Jarrett, J. T., Schnappinger, D. & Aldrich, C., Apr 12 2019, In : ACS Infectious Diseases. 5, 4, p. 598-617 20 p.

Research output: Contribution to journalArticle

Biological Products
Microbial Sensitivity Tests
Biotin
Tuberculosis
Multidrug-Resistant Tuberculosis
2018
9 Citations (Scopus)

Acidic pH-responsive polymer nanoparticles as a TLR7/8 agonist delivery platform for cancer immunotherapy

Kim, H., Sehgal, D., Kucaba, T. A., Ferguson, D. M., Griffith, T. S. & Panyam, J., Nov 28 2018, In : Nanoscale. 10, 44, p. 20851-20862 12 p.

Research output: Contribution to journalArticle

Polymers
Nanoparticles
T-cells
Gases
Antigens
6 Citations (Scopus)

Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification

Bockman, M. R., Engelhart, C. A., Dawadi, S., Larson, P., Tiwari, D., Ferguson, D. M., Schnappinger, D. & Aldrich, C. C., Jul 13 2018, In : ACS Infectious Diseases. 4, 7, p. 1102-1113 12 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Nucleosides
Anti-Bacterial Agents
Ligases
Biotin
27 Citations (Scopus)

Polymeric nanoparticles encapsulating novel TLR7/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy

Kim, H., Niu, L., Larson, P., Kucaba, T. A., Murphy, K. A., James, B. R., Ferguson, D. M., Griffith, T. S. & Panyam, J., May 1 2018, In : Biomaterials. 164, p. 38-53 16 p.

Research output: Contribution to journalArticle

T-cells
Immunotherapy
Nanoparticles
Vaccines
Tumors
2017
12 Citations (Scopus)
Open Access
Toll-Like Receptor 8
Toll-Like Receptor 7
Chemical activation
Cytokines
Transcription
2015
1 Citation (Scopus)

Targeting topoisomerase II activity in NSCLC with 9-aminoacridine derivatives

Ferguson, D. M., Jacobson, B. A., Jay-Dixon, J., Patel, M. R., Kratzke, R. A. & Raza, A., Jan 1 2015, In : Anticancer Research. 35, 10, p. 5211-5218 8 p.

Research output: Contribution to journalArticle

Aminacrine
Acridines
Type II DNA Topoisomerase
Non-Small Cell Lung Carcinoma
Poisons
2014
31 Citations (Scopus)

Structure-activity relationship analysis of imidazoquinolines with toll-like receptors 7 and 8 selectivity and enhanced cytokine induction

Schiaffo, C. E., Shi, C., Xiong, Z., Olin, M. R., Ohlfest, J. R., Aldrich, C. & Ferguson, D. M., Jan 23 2014, In : Journal of Medicinal Chemistry. 57, 2, p. 339-347 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 8
Toll-Like Receptor 7
Structure-Activity Relationship
Cytokines
Interleukin-12
16 Citations (Scopus)

Synthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity

Benoit, A. R., Schiaffo, C., Salomon, C., Goodell, J. R., Hiasa, H. & Ferguson, D. M., Jul 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 14, p. 3014-3017 4 p.

Research output: Contribution to journalArticle

Aminacrine
Acridines
Methicillin Resistance
Methicillin
Structure-Activity Relationship
2013
5 Citations (Scopus)

Efficacy of substituted 9-aminoacridine derivatives in small cell lung cancer

Ryan, E., Jacobson, B. A., Benoit, A., Ferguson, D. M. & Robert, A. K., Apr 1 2013, In : Investigational New Drugs. 31, 2, p. 285-292 8 p.

Research output: Contribution to journalArticle

Aminacrine
Small Cell Lung Carcinoma
Poisons
Cell Proliferation
Psidium
19 Citations (Scopus)

Structure and Stability of Human Telomeric G-Quadruplex with Preclinical 9-Amino Acridines

Ferreira, R., Artali, R., Benoit, A., Gargallo, R., Eritja, R., Ferguson, D. M., Sham, Y. Y. & Mazzini, S., Mar 15 2013, In : PloS one. 8, 3, e57701.

Research output: Contribution to journalArticle

acridines
G-Quadruplexes
Acridines
DNA
Nuclear magnetic resonance
2012
10 Citations (Scopus)

9-Amino acridine pharmacokinetics, brain distribution, and in vitro/in vivo efficacy against malignant glioma

Teitelbaum, A. M., Gallardo, J. L., Bedi, J., Giri, R., Benoit, A. R., Olin, M. R., Morizio, K. M., Ohlfest, J. R., Remmel, R. P. & Ferguson, D. M., Jun 1 2012, In : Cancer chemotherapy and pharmacology. 69, 6, p. 1519-1527 9 p.

Research output: Contribution to journalArticle

Acridines
Pharmacokinetics
Glioma
Brain
Biological Availability
17 Citations (Scopus)

Discovery of imidazoquinolines with toll-like receptor 7/8 independent cytokine induction

Shi, C., Xiong, Z., Chittepu, P., Aldrich, C., Ohlfest, J. R. & Ferguson, D. M., May 14 2012, In : ACS Medicinal Chemistry Letters. 3, 6, p. 501-504 4 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 8
Toll-Like Receptor 7
imiquimod
resiquimod
Cytokines
11 Citations (Scopus)
Topoisomerase II Inhibitors
Acridines
Mesothelioma
Cell Proliferation
Apoptosis
2010
60 Citations (Scopus)

Synthesis and cancer cell cytotoxicity of substituted xanthenes

Giri, R., Goodell, J. R., Xing, C., Benoit, A., Kaur, H., Hiasa, H. & Ferguson, D. M., Feb 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 4, p. 1456-1463 8 p.

Research output: Contribution to journalArticle

Xanthenes
Cytotoxicity
Cells
Cell growth
Acridines
2009
59 Citations (Scopus)

Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II

Oppegard, L. M., Ougolkov, A. V., Luchini, D. N., Schoon, R. A., Goodell, J. R., Kaur, H., Billadeau, D. D., Ferguson, D. M. & Hiasa, H., Jan 14 2009, In : European Journal of Pharmacology. 602, 2-3, p. 223-229 7 p.

Research output: Contribution to journalArticle

Topoisomerase II Inhibitors
Acridines
Type II DNA Topoisomerase
Pancreatic Neoplasms
Amsacrine
14 Citations (Scopus)

On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents

Gálvez-Peralta, M., Hackbarth, J. S., Flatten, K. S., Kaufmann, S. H., Hiasa, H., Xing, C. & Ferguson, D. M., Aug 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 15, p. 4459-4462 4 p.

Research output: Contribution to journalArticle

Aminacrine
Type I DNA Topoisomerase
Cytotoxicity
Antineoplastic Agents
Cells
2008
86 Citations (Scopus)

Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis

Goodell, J. R., Ougolkov, A. V., Hiasa, H., Kaur, H., Remmel, R. P., Billadeau, D. D. & Ferguson, D. M., Jan 24 2008, In : Journal of Medicinal Chemistry. 51, 2, p. 179-182 4 p.

Research output: Contribution to journalArticle

Acridines
Type II DNA Topoisomerase
Pancreatic Neoplasms
Aminacrine
Cell Proliferation
17 Citations (Scopus)
Adenosine Monophosphate
Antitubercular Agents
Ligands
Acids
Enzymes
26 Citations (Scopus)
xanomeline
Muscarinic Receptors
Hydrophobic and Hydrophilic Interactions
Binding Sites
Ligands
36 Citations (Scopus)

Toward a structure-based model of salvinorin A recognition of the κ-opioid receptor

Kane, B. E., McCurdy, C. R. & Ferguson, D. M., Mar 27 2008, In : Journal of Medicinal Chemistry. 51, 6, p. 1824-1830 7 p.

Research output: Contribution to journalArticle

salvinorin A
Opioid Receptors
Opiate Alkaloids
Ligands
Mutagenesis
2006
39 Citations (Scopus)
salvinorin A
kappa Opioid Receptor
Drug Design
G-Protein-Coupled Receptors
drugs
34 Citations (Scopus)

A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist

Kane, B. E., Nieto, M. J., McCurdy, C. R. & Ferguson, D. M., May 1 2006, In : FEBS Journal. 273, 9, p. 1966-1974 9 p.

Research output: Contribution to journalArticle

salvinorin A
kappa Opioid Receptor
Epitopes
Ligands
Opioid Analgesics
117 Citations (Scopus)

Identification of compounds with anti-West Nile virus activity

Goodell, J. R., Puig-Basagoiti, F., Forshey, B. M., Shi, P. Y. & Ferguson, D. M., Mar 23 2006, In : Journal of Medicinal Chemistry. 49, 6, p. 2127-2137 11 p.

Research output: Contribution to journalArticle

West Nile virus
West Nile Fever
Quinolines
RNA Helicases
Small Molecule Libraries
67 Citations (Scopus)

Molecular recognition of opioid receptor ligands

Kane, B. E., Svensson, B. & Ferguson, D. M., Mar 10 2006, In : AAPS Journal. 8, 1, 15.

Research output: Contribution to journalArticle

Opioid Receptors
Ligands
Opiate Alkaloids
Recombinant DNA
Site-Directed Mutagenesis
10 Citations (Scopus)
Acridines
Hydrolysis
Aminacrine
energy
Aminoacridines
114 Citations (Scopus)

Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity

Goodell, J. R., Madhok, A. A., Hiasa, H. & Ferguson, D. M., Aug 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 16, p. 5467-5480 14 p.

Research output: Contribution to journalArticle

Acridines
Type II DNA Topoisomerase
Viruses
Amsacrine
Herpes Simplex
100 Citations (Scopus)

Triaryl pyrazoline compound inhibits flavivirus RNA replication

Puig-Basagoiti, F., Tilgner, M., Forshey, B. M., Philpott, S. M., Espina, N. G., Wentworth, D. E., Goebel, S. J., Masters, P. S., Falgout, B., Ren, P., Ferguson, D. M. & Shi, P. Y., Apr 1 2006, In : Antimicrobial agents and chemotherapy. 50, 4, p. 1320-1329 10 p.

Research output: Contribution to journalArticle

Flavivirus
West Nile virus
Replicon
Viral RNA
Dengue Virus
2005
82 Citations (Scopus)

High-throughput assays using a luciferase-expressing replicon, virus-like particles, and full-length virus for West Nile virus drug discovery

Puig-Basagoiti, F., Deas, T. S., Ren, P., Tilgner, M., Ferguson, D. M. & Shi, P. Y., Dec 1 2005, In : Antimicrobial agents and chemotherapy. 49, 12, p. 4980-4988 9 p.

Research output: Contribution to journalArticle

Flavivirus
West Nile virus
Replicon
Drug Discovery
High-Throughput Screening Assays
2002
10 Citations (Scopus)

4 Molecular Modeling of Opioid Receptor-Ligand Complexes

McFadyen, I., Metzger, T., Subramanian, G., Poda, G., Jorvig, E. & Ferguson, D. M., Jan 1 2002, In : Progress in Medicinal Chemistry. 40, C, p. 107-135 29 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

Cation-π interactions: An energy decomposition analysis and its implication in δ-opioid receptor-ligand binding

Mo, Y., Subramanian, G., Gao, J. & Ferguson, D. M., May 1 2002, In : Journal of the American Chemical Society. 124, 17, p. 4832-4837 6 p.

Research output: Contribution to journalArticle

Opioid Receptors
Cations
Positive ions
Ligands
Decomposition
2001
7 Citations (Scopus)

Exploring the unique pharmacology of a novel opioid receptor, ZFOR1, using molecular modeling and the 'message-address' concept

McFadyen, I. J., Metzger, T. G., Paterlini, M. G. & Ferguson, D. M., Dec 1 2001, In : Protein Engineering. 14, 12, p. 953-960 8 p.

Research output: Contribution to journalArticle

Molecular modeling
Opioid Receptors
Ligands
Pharmacology
Opioid Analgesics
77 Citations (Scopus)
Oxymorphone
Naltrexone
Opioid Receptors
Site-Directed Mutagenesis
naltrindole
45 Citations (Scopus)

Transformation of a κ-opioid receptor antagonist to a κ-agonist by transfer of a guanidinium group from the 5′- to 6′-position of naltrindole

Kumar Sharma, S., Jones, R. M., Metzger, T. G., Ferguson, D. M. & Portoghese, P. S., Jun 21 2001, In : Journal of Medicinal Chemistry. 44, 13, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

naltrindole
Narcotic Antagonists
Guanidine
Opioid Receptors
Site-Directed Mutagenesis
2000
8 Citations (Scopus)

Conformational landscape of selective μ-opioid agonists in gas phase and in aqueous solution: The fentanyl series

Subramanian, G. & Ferguson, D. M., Jul 8 2000, In : Drug Design and Discovery. 17, 1, p. 55-67 13 p.

Research output: Contribution to journalArticle

Fentanyl
Opioid Analgesics
Gases
Quantitative Structure-Activity Relationship
Molecular Dynamics Simulation
76 Citations (Scopus)

Molecular docking reveals a novel binding site model for fentanyl at the μ-opioid receptor

Subramanian, G., Paterlini, M. G., Portoghese, P. S. & Ferguson, D. M., Feb 10 2000, In : Journal of Medicinal Chemistry. 43, 3, p. 381-391 11 p.

Research output: Contribution to journalArticle

Opioid Receptors
Fentanyl
Binding Sites
Ligands
Opiate Alkaloids
83 Citations (Scopus)

Potent and selective indolomorphinan antagonists of the kappa-opioid receptor

Stevens, W. C., Jones, R. M., Subramanian, G., Metzger, T. G., Ferguson, D. M. & Portoghese, P. S., Jul 13 2000, In : Journal of Medicinal Chemistry. 43, 14, p. 2759-2769 11 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Guanidines
naltrindole
Guanidine
Amines
77 Citations (Scopus)

Stereochemical requirements for receptor recognition of the μ-opioid peptide endomorphin-1

Paterlini, M. G., Avitabile, F., Ostrowski, B. G., Ferguson, D. M. & Portoghese, P. S., Jan 1 2000, In : Biophysical journal. 78, 2, p. 590-599 10 p.

Research output: Contribution to journalArticle

Opioid Peptides
Peptides
Enkephalins
Ileum
Proline
19 Citations (Scopus)

Synthesis and evaluation of 4-(N,N-diarylamino)piperidines with high selectivity to the δ-opioid receptor: A combined 3D-QSAR and ligand docking study

Podlogar, B. L., Poda, G. I., Demeter, D. A., Zhang, S. P., Carson, J. R., Neilson, L. A., Reitz, A. B. & Ferguson, D. M., Jul 8 2000, In : Drug Design and Discovery. 17, 1, p. 34-50 17 p.

Research output: Contribution to journalArticle

Piperidines
Quantitative Structure-Activity Relationship
Opioid Receptors
Ligands
Binding Sites
1999
22 Citations (Scopus)

Effects of C2'-Substitution on arabinonucleic acid structure and conformation

Venkateswarlu, D. & Ferguson, D. M., Jun 16 1999, In : Journal of the American Chemical Society. 121, 23, p. 5609-5610 2 p.

Research output: Contribution to journalArticle

Conformations
Substitution reactions
Acids
10 Citations (Scopus)

Simulated annealing - Optimal histogram methods

Ferguson, D. M. & Garrett, D. G., Dec 1 1999, In : Advances in Chemical Physics. 105, p. 311-336 26 p.

Research output: Contribution to journalArticle

simulated annealing
Simulated annealing
histograms
36 Citations (Scopus)

Structural properties of DNA:RNA duplexes containing 2'-O-methyl and 2'-S-methyl substitutions: A molecular dynamics investigation

Venkateswarlu, D., Lind, K. E., Mohan, V., Manoharan, M. & Ferguson, D. M., May 15 1999, In : Nucleic acids research. 27, 10, p. 2189-2195 7 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
RNA
DNA
Ribonuclease H
Nucleic Acid Conformation
1998
52 Citations (Scopus)

Conformational analysis and automated receptor docking of selective arylacetamide-based κ-opioid agonists

Subramanian, G., Germana Paterlini, M., Larson, D. L., Portoghese, P. S. & Ferguson, D. M., Nov 19 1998, In : Journal of Medicinal Chemistry. 41, 24, p. 4777-4789 13 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Ligands
Molecular Dynamics Simulation
Opiate Alkaloids
Space Flight
79 Citations (Scopus)

Conformational analysis of the endogenous μ-opioid agonist endomorphin-1 using NMR spectroscopy and molecular modeling

Podlogar, B. L., Paterlini, M. G., Ferguson, D. M., Leo, G. C., Demeter, D. A., Brown, F. K. & Reitz, A. B., Nov 13 1998, In : FEBS Letters. 439, 1-2, p. 13-20 8 p.

Research output: Contribution to journalArticle

Molecular modeling
Opioid Analgesics
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Ligands
119 Citations (Scopus)

Constant temperature simulations using the Langevin equation with velocity Verlet integration

Paterlini, M. G. & Ferguson, D. M., Sep 15 1998, In : Chemical Physics. 236, 1-3, p. 243-252 10 p.

Research output: Contribution to journalArticle

friction
Friction
proteins
Neon
formulations
4 Citations (Scopus)

Parameterization and Simulation of the Physical Properties of Phosphorothioate Nucleic Acids

Lind, K. E., Sherlin, L. D., Mohan, V., Griffey, R. H. & Ferguson, D. M., Dec 1 1998, In : ACS Symposium Series. 682, p. 41-54 14 p.

Research output: Contribution to journalArticle

Nucleic acids
Parameterization
Nucleic Acids
DNA
Physical properties
27 Citations (Scopus)

Structural characteristics of 2'-O-(2-methoxyethyl)-modified nucleic acids from molecular dynamics simulations

Lind, K. E., Mohan, V., Manoharan, M. & Ferguson, D. M., Aug 15 1998, In : Nucleic acids research. 26, 16, p. 3694-3699 6 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Nucleic Acids
Databases
1997
21 Citations (Scopus)

A computational analysis of interaction energies in methane and neopentane dimer systems

Metzger, T. G., Ferguson, D. M. & Glauser, W. A., Jan 15 1997, In : Journal of Computational Chemistry. 18, 1, p. 70-79 10 p.

Research output: Contribution to journalArticle

Computational Analysis
Methane
Dimer
Dimers
Energy
24 Citations (Scopus)

Knowledge-based modeling of a bacterial dichloromethane dehalogenase

Marsh, A. & Ferguson, D. M., Jul 14 1997, In : Proteins: Structure, Function and Genetics. 28, 2, p. 217-226 10 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Methylene Chloride
Catalysis
Methylophilus
Glutathione