1985 …2023

Research output per year

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Research Output

2019

A Cinchona Alkaloid Antibiotic That Appears to Target ATP Synthase in Streptococcus pneumoniae

Wang, X., Zeng, Y., Sheng, L., Larson, P., Liu, X., Zou, X., Wang, S., Guo, K., Ma, C., Zhang, G., Cui, H., Ferguson, D. M., Li, Y., Zhang, J. & Aldrich, C. C., Mar 14 2019, In : Journal of medicinal chemistry. 62, 5, p. 2305-2332 28 p.

Research output: Contribution to journalArticle

2 Scopus citations

Investigation of (S)-(-)-acidomycin: A selective antimycobacterial natural product that inhibits biotin synthase

Bockman, M. R., Engelhart, C. A., Cramer, J. D., Howe, M. D., Mishra, N. K., Zimmerman, M., Larson, P., Alvarez-Cabrera, N., Park, S. W., Boshoff, H. I. M., Bean, J. M., Young, V. G., Ferguson, D. M., Dartois, V., Jarrett, J. T., Schnappinger, D. & Aldrich, C., Apr 12 2019, In : ACS Infectious Diseases. 5, 4, p. 598-617 20 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Acidic pH-responsive polymer nanoparticles as a TLR7/8 agonist delivery platform for cancer immunotherapy

Kim, H., Sehgal, D., Kucaba, T. A., Ferguson, D. M., Griffith, T. S. & Panyam, J., Nov 28 2018, In : Nanoscale. 10, 44, p. 20851-20862 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
7 Scopus citations

Polymeric nanoparticles encapsulating novel TLR7/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy

Kim, H., Niu, L., Larson, P., Kucaba, T. A., Murphy, K. A., James, B. R., Ferguson, D. M., Griffith, T. S. & Panyam, J., May 2018, In : Biomaterials. 164, p. 38-53 16 p.

Research output: Contribution to journalArticle

29 Scopus citations
2017
13 Scopus citations
2015
1 Scopus citations
2014

Structure-activity relationship analysis of imidazoquinolines with toll-like receptors 7 and 8 selectivity and enhanced cytokine induction

Schiaffo, C. E., Shi, C., Xiong, Z., Olin, M. R., Ohlfest, J. R., Aldrich, C. & Ferguson, D. M., Jan 23 2014, In : Journal of medicinal chemistry. 57, 2, p. 339-347 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Synthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity

Benoit, A. R., Schiaffo, C., Salomon, C. E., Goodell, J. R., Hiasa, H. & Ferguson, D. M., Jul 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 14, p. 3014-3017 4 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

Efficacy of substituted 9-aminoacridine derivatives in small cell lung cancer

Ryan, E., Jacobson, B. A., Benoit, A., Ferguson, D. M. & Robert, A. K., Apr 1 2013, In : Investigational New Drugs. 31, 2, p. 285-292 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structure and Stability of Human Telomeric G-Quadruplex with Preclinical 9-Amino Acridines

Ferreira, R., Artali, R., Benoit, A., Gargallo, R., Eritja, R., Ferguson, D. M., Sham, Y. Y. & Mazzini, S., Mar 15 2013, In : PloS one. 8, 3, e57701.

Research output: Contribution to journalArticle

20 Scopus citations
2012

9-Amino acridine pharmacokinetics, brain distribution, and in vitro/in vivo efficacy against malignant glioma

Teitelbaum, A. M., Gallardo, J. L., Bedi, J., Giri, R., Benoit, A. R., Olin, M. R., Morizio, K. M., Ohlfest, J. R., Remmel, R. P. & Ferguson, D. M., Jun 1 2012, In : Cancer chemotherapy and pharmacology. 69, 6, p. 1519-1527 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Discovery of imidazoquinolines with toll-like receptor 7/8 independent cytokine induction

Shi, C., Xiong, Z., Chittepu, P., Aldrich, C., Ohlfest, J. R. & Ferguson, D. M., May 14 2012, In : ACS Medicinal Chemistry Letters. 3, 6, p. 501-504 4 p.

Research output: Contribution to journalArticle

18 Scopus citations
11 Scopus citations
2010

Synthesis and cancer cell cytotoxicity of substituted xanthenes

Giri, R., Goodell, J. R., Xing, C., Benoit, A., Kaur, H., Hiasa, H. & Ferguson, D. M., Feb 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 4, p. 1456-1463 8 p.

Research output: Contribution to journalArticle

61 Scopus citations
2009

Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II

Oppegard, L. M., Ougolkov, A. V., Luchini, D. N., Schoon, R. A., Goodell, J. R., Kaur, H., Billadeau, D. D., Ferguson, D. M. & Hiasa, H., Jan 14 2009, In : European Journal of Pharmacology. 602, 2-3, p. 223-229 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents

Gálvez-Peralta, M., Hackbarth, J. S., Flatten, K. S., Kaufmann, S. H., Hiasa, H., Xing, C. & Ferguson, D. M., Aug 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 15, p. 4459-4462 4 p.

Research output: Contribution to journalArticle

15 Scopus citations
2008
89 Scopus citations
28 Scopus citations

Toward a structure-based model of salvinorin A recognition of the κ-opioid receptor

Kane, B. E., McCurdy, C. R. & Ferguson, D. M., Mar 27 2008, In : Journal of medicinal chemistry. 51, 6, p. 1824-1830 7 p.

Research output: Contribution to journalArticle

36 Scopus citations
2006
39 Scopus citations

A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist

Kane, B. E., Nieto, M. J., McCurdy, C. R. & Ferguson, D. M., May 1 2006, In : FEBS Journal. 273, 9, p. 1966-1974 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Identification of compounds with anti-West Nile virus activity

Goodell, J. R., Puig-Basagoiti, F., Forshey, B. M., Shi, P. Y. & Ferguson, D. M., Mar 23 2006, In : Journal of medicinal chemistry. 49, 6, p. 2127-2137 11 p.

Research output: Contribution to journalArticle

117 Scopus citations

Molecular recognition of opioid receptor ligands

Kane, B. E., Svensson, B. & Ferguson, D. M., Mar 10 2006, In : AAPS Journal. 8, 1, p. E126-E137 15.

Research output: Contribution to journalArticle

67 Scopus citations

Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity

Goodell, J. R., Madhok, A. A., Hiasa, H. & Ferguson, D. M., Aug 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 16, p. 5467-5480 14 p.

Research output: Contribution to journalArticle

116 Scopus citations

Triaryl pyrazoline compound inhibits flavivirus RNA replication

Puig-Basagoiti, F., Tilgner, M., Forshey, B. M., Philpott, S. M., Espina, N. G., Wentworth, D. E., Goebel, S. J., Masters, P. S., Falgout, B., Ren, P., Ferguson, D. M. & Shi, P. Y., Apr 1 2006, In : Antimicrobial agents and chemotherapy. 50, 4, p. 1320-1329 10 p.

Research output: Contribution to journalArticle

100 Scopus citations
2005
82 Scopus citations

Opioid receptors

Ferguson, D. M., May 17 2005, In : Current topics in medicinal chemistry. 5, 3, p. 301-302 2 p.

Research output: Contribution to journalEditorial

2003
20 Scopus citations
2002

4 Molecular Modeling of Opioid Receptor-Ligand Complexes

McFadyen, I., Metzger, T., Subramanian, G., Poda, G., Jorvig, E. & Ferguson, D. M., Jan 1 2002, In : Progress in Medicinal Chemistry. 40, C, p. 107-135 29 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cation-π interactions: An energy decomposition analysis and its implication in δ-opioid receptor-ligand binding

Mo, Y., Subramanian, G., Gao, J. & Ferguson, D. M., May 1 2002, In : Journal of the American Chemical Society. 124, 17, p. 4832-4837 6 p.

Research output: Contribution to journalArticle

124 Scopus citations
2001
10 Scopus citations

Exploring the unique pharmacology of a novel opioid receptor, ZFOR1, using molecular modeling and the 'message-address' concept

McFadyen, I. J., Metzger, T. G., Paterlini, M. G. & Ferguson, D. M., Dec 1 2001, In : Protein Engineering. 14, 12, p. 953-960 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Transformation of a κ-opioid receptor antagonist to a κ-agonist by transfer of a guanidinium group from the 5′- to 6′-position of naltrindole

Kumar Sharma, S., Jones, R. M., Metzger, T. G., Ferguson, D. M. & Portoghese, P. S., Jun 21 2001, In : Journal of medicinal chemistry. 44, 13, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

46 Scopus citations
2000

Conformational landscape of selective μ-opioid agonists in gas phase and in aqueous solution: The fentanyl series

Subramanian, G. & Ferguson, D. M., Jul 8 2000, In : Drug Design and Discovery. 17, 1, p. 55-67 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Molecular docking reveals a novel binding site model for fentanyl at the μ-opioid receptor

Subramanian, G., Paterlini, M. G., Portoghese, P. S. & Ferguson, D. M., Feb 10 2000, In : Journal of Medicinal Chemistry. 43, 3, p. 381-391 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

Potent and selective indolomorphinan antagonists of the kappa-opioid receptor

Stevens, W. C., Jones, R. M., Subramanian, G., Metzger, T. G., Ferguson, D. M. & Portoghese, P. S., Jul 13 2000, In : Journal of medicinal chemistry. 43, 14, p. 2759-2769 11 p.

Research output: Contribution to journalArticle

83 Scopus citations

QSAR and CoMFA: A perspective on the practical application to drug discovery

Podlogar, B. L. & Ferguson, D. M., Jul 8 2000, In : Drug Design and Discovery. 17, 1, p. 4-12 9 p.

Research output: Contribution to journalReview article

66 Scopus citations

Stereochemical requirements for receptor recognition of the μ-opioid peptide endomorphin-1

Paterlini, M. G., Avitabile, F., Ostrowski, B. G., Ferguson, D. M. & Portoghese, P. S., Jan 1 2000, In : Biophysical journal. 78, 2, p. 590-599 10 p.

Research output: Contribution to journalArticle

77 Scopus citations
1999

Effects of C2'-Substitution on arabinonucleic acid structure and conformation

Venkateswarlu, D. & Ferguson, D. M., Jun 16 1999, In : Journal of the American Chemical Society. 121, 23, p. 5609-5610 2 p.

Research output: Contribution to journalArticle

23 Scopus citations

Structural properties of DNA:RNA duplexes containing 2'-O-methyl and 2'-S-methyl substitutions: A molecular dynamics investigation

Venkateswarlu, D., Lind, K. E., Mohan, V., Manoharan, M. & Ferguson, D. M., May 15 1999, In : Nucleic acids research. 27, 10, p. 2189-2195 7 p.

Research output: Contribution to journalArticle

36 Scopus citations
1998

Conformational analysis and automated receptor docking of selective arylacetamide-based κ-opioid agonists

Subramanian, G., Germana Paterlini, M., Larson, D. L., Portoghese, P. S. & Ferguson, D. M., Nov 19 1998, In : Journal of Medicinal Chemistry. 41, 24, p. 4777-4789 13 p.

Research output: Contribution to journalArticle

52 Scopus citations