1997 …2024

Research output per year

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Research Output

2020
Open Access

Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity

Walton, K., Fernandez, M. R., Sagatys, E. M., Reff, J., Kim, J., Lee, M. C., Kiluk, J. V., Hui, J. Y. C., McKenna, D., Hupp, M., Forster, C., Linden, M. A., Lawrence, N. J., Lawrence, H. R., Pidala, J., Pavletic, S. Z., Blazar, B. R., Sebti, S. M., Cleveland, J. L., Anasetti, C. & 1 others, Betts, B. C., May 7 2020, In : JCI Insight. 5, 9

Research output: Contribution to journalArticle

Open Access

Transfusion of uncrossmatched group o erythrocyte-containing products does not interfere with most ABO typings

Biomedical Excellence for Safer Transfusion Collaborative, Jan 1 2020, (Accepted/In press) In : Anesthesiology. p. 525-534 10 p.

Research output: Contribution to journalArticle

Variations in novel cellular therapy products manufacturing

Biomedical Excellence for Safer Transfusion (BEST) Collaborative, Jan 1 2020, (Accepted/In press) In : Cytotherapy. 22, 6, p. 337-342 6 p.

Research output: Contribution to journalArticle

2019

Cell therapies for trauma and critical care medicine: critical issues in translation for cellular and novel therapies in trauma and critical care

Stroncek, D. F., Mathew, A. J. & McKenna, D. H., Feb 1 2019, In : Transfusion. 59, p. 854-857 4 p.

Research output: Contribution to journalArticle

Open Access

Cryopreservation of Hematopoietic Stem Cells: Emerging Assays, Cryoprotectant Agents, and Technology to Improve Outcomes

Hornberger, K. M., Yu, G., McKenna, D. H. & Hubel, A., Jun 1 2019, In : Transfusion Medicine and Hemotherapy. 46, 3, p. 188-196 9 p.

Research output: Contribution to journalReview article

4 Scopus citations

First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia

Cooley, S., He, F., Bachanova, V., Vercellotti, G. M., DeFor, T. E., Curtsinger, J. M., Robertson, P., Grzywacz, B., Conlon, K. C., Waldmann, T. A., McKenna, D. H., Blazar, B. R., Weisdorf, D. J. & Miller, J. S., Jan 1 2019, In : Blood Advances. 3, 13, p. 1970-1980 11 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Lung inflammatory environments differentially alter mesenchymal stromal cell behavior

Abreu, S. C., Enes, S. R., Dearborn, J., Goodwin, M., Coffey, A., Borg, Z. D., Dos Santos, C. C., Wargo, M. J., Cruz, F. F., Loi, R., DeSarno, M., Ashikaga, T., Antunes, M. A., Rocco, P. R. M., Liu, K. D., Lee, J. W., Matthay, M. A., McKenna, D. H. & Weiss, D. J., Jan 1 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 317, 6, p. L823-L831

Research output: Contribution to journalArticle

Open Access
Open Access
4 Scopus citations

Preservation of cell-based immunotherapies for clinical trials

LI, R. U. I., JOHNSON, RACHEL., YU, GUANGLIN., MCKENNA, DAVID. H. & HUBEL, ALLISON., Sep 2019, In : Cytotherapy. 21, 9, p. 943-957 15 p.

Research output: Contribution to journalReview article

3 Scopus citations

Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial

Matthay, M. A., Calfee, C. S., Zhuo, H., Thompson, B. T., Wilson, J. G., Levitt, J. E., Rogers, A. J., Gotts, J. E., Wiener-Kronish, J. P., Bajwa, E. K., Donahoe, M. P., McVerry, B. J., Ortiz, L. A., Exline, M., Christman, J. W., Abbott, J., Delucchi, K. L., Caballero, L., McMillan, M., McKenna, D. H. & 1 others, Liu, K. D., Feb 2019, In : The Lancet Respiratory Medicine. 7, 2, p. 154-162 9 p.

Research output: Contribution to journalArticle

56 Scopus citations
2018

Clinical-scale production of cGMP compliant CD3/CD19 cell-depleted NK cells in the evolution of NK cell immunotherapy at a single institution

Williams, S. M., Sumstad, D., Kadidlo, D., Curtsinger, J., Luo, X., Miller, J. S. & Mckenna, D. H., Jun 2018, In : Transfusion. 58, 6, p. 1458-1467 10 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Current practices for viability testing of cryopreserved cord blood products: an international survey by the cellular therapy team of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative

for the Biomedical Excellence for Safer Transfusion (BEST) Collaborative, Sep 2018, In : Transfusion. 58, 9, p. 2184-2191 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Optimal Storage Conditions for Apheresis Research (OSCAR): a Biomedical Excellence for Safer Transfusion (BEST) Collaborative study

on behalf of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative, Feb 1 2018, In : Transfusion. 58, 2, p. 461-469 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017
Open Access
9 Scopus citations

Clinical methods of cryopreservation for donor lymphocyte infusions vary in their ability to preserve functional T-cell subpopulations

Biomedical Excellence for Safer Transfusion (BEST) Collaborative Group, Jun 2017, In : Transfusion. 57, 6, p. 1555-1565 11 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

How do i participate in T-cell immunotherapy?

Suhoski Davis, M. M., McKenna, D. H. & Norris, P. J., May 2017, In : Transfusion. 57, 5, p. 1115-1121 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access

Impact of starting material (fresh versus cryopreserved marrow) on mesenchymal stem cell culture

Kaplan, A., Sackett, K., Sumstad, D., Kadidlo, D. & McKenna, D. H., Sep 2017, In : Transfusion. 57, 9, p. 2216-2219 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Improved Post-Thaw Function and Epigenetic Changes in Mesenchymal Stromal Cells Cryopreserved Using Multicomponent Osmolyte Solutions

Pollock, K., Samsonraj, R. M., Dudakovic, A., Thaler, R., Stumbras, A., McKenna, D. H., Dosa, P. I., Van Wijnen, A. J. & Hubel, A., Jun 1 2017, In : Stem Cells and Development. 26, 11, p. 828-842 15 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Manufacturing differences affect human bone marrow stromal cell characteristics and function: Comparison of production methods and products from multiple centers

Liu, S., De Castro, L. F., Jin, P., Civini, S., Ren, J., Reems, J. A., Cancelas, J., Nayak, R., Shaw, G., O'Brien, T., McKenna, D. H., Armant, M., Silberstein, L., Gee, A. P., Hei, D. J., Hematti, P., Kuznetsov, S. A., Robey, P. G. & Stroncek, D. F., Jan 1 2017, In : Scientific reports. 7, 46731.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Optimization of cGMP purification and expansion of umbilical cord blood–derived T-regulatory cells in support of first-in-human clinical trials

McKenna, D. H., Sumstad, D., Kadidlo, D. M., Batdorf, B., Lord, C. J., Merkel, S. C., Koellner, C. M., Curtsinger, J. M., June, C. H., Riley, J. L., Levine, B. L., Miller, J. S., Brunstein, C. G., Wagner, J. E., Blazar, B. R. & Hippen, K. L., Feb 1 2017, In : Cytotherapy. 19, 2, p. 250-262 13 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Traveling treatment: medical tourism in the emerging era of potentially transmissible therapeutics

Hreh, M., Cohn, C. S., McKenna, D. & Gniadek, T. J., Oct 2017, In : Transfusion. 57, 10, p. 2549-2550 2 p.

Research output: Contribution to journalArticle

2016

Challenges in the cGMP manufacturing of MSCs for multicenter academia trials

McKenna, D., Apr 1 2016, In : Transfusion. 56, 4, p. 18S-19S

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Combinations of Osmolytes, Including Monosaccharides, Disaccharides, and Sugar Alcohols Act in Concert During Cryopreservation to Improve Mesenchymal Stromal Cell Survival

Pollock, K., Yu, G., Moller-Trane, R., Koran, M., Dosa, P. I., McKenna, D. H. & Hubel, A., Nov 2016, In : Tissue Engineering - Part C: Methods. 22, 11, p. 999-1008 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cord blood banking and quality issues

Murphy, A., McKenna, D. H. & Mc Cullough, J., Mar 1 2016, In : Transfusion. 56, 3, p. 645-652 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
Open Access
5 Scopus citations

Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft

Wagner, J. E., Brunstein, C. G., Boitano, A. E., Defor, T. E., McKenna, D., Sumstad, D., Blazar, B. R., Tolar, J., Le, C., Jones, J., Cooke, M. P. & Bleul, C. C., Jan 7 2016, In : Cell Stem Cell. 18, 1, p. 144-155 12 p.

Research output: Contribution to journalArticle

Open Access
131 Scopus citations

Umbilical cord blood-derived T regulatory cells to prevent GVHD: Kinetics, toxicity profile, and clinical effect

Brunstein, C. G., Miller, J. S., McKenna, D. H., Hippen, K. L., DeFor, T. E., Sumstad, D., Curtsinger, J., Verneris, M. R., MacMillan, M. L., Levine, B. L., Riley, J. L., June, C. H., Le, C., Weisdorf, D. J., McGlave, P. B., Blazar, B. R. & Wagner, J. E., Feb 25 2016, In : Blood. 127, 8, p. 1044-1051 8 p.

Research output: Contribution to journalArticle

Open Access
157 Scopus citations
2015

A reproducible immunopotency assay to measure mesenchymal stromal cell-mediated T-cell suppression

Bloom, D. D., Centanni, J. M., Bhatia, N., Emler, C. A., Drier, D., Leverson, G. E., McKenna, D. H., Gee, A. P., Lindblad, R., Hei, D. J. & Hematti, P., Jan 1 2015, In : Cytotherapy. 17, 2, p. 140-151 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Cell therapy product administration and safety: Data capture and analysis from the Production Assistance for Cellular Therapies (PACT) program

Lindblad, R. W., Ibenana, L., Wagner, J. E., McKenna, D. H., Hei, D. J., Hematti, P., Couture, L. A., Silberstein, L. E., Armant, M., Rooney, C. M., Gee, A. P., Welniak, L. A., Heath Mondoro, T., Wood, D. A. & Styers, D., Mar 1 2015, In : Transfusion. 55, 3, p. 674-679 6 p.

Research output: Contribution to journalReview article

3 Scopus citations

Clinical mesenchymal stromal cell products undergo functional changes in response to freezing

Pollock, K., Sumstad, D., Kadidlo, D., McKenna, D. H. & Hubel, A., Jan 1 2015, In : Cytotherapy. 17, 1, p. 38-45 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Freshly thawed and continuously cultured human bone marrow-derived mesenchymal stromal cells comparably ameliorate allergic airways inflammation in immunocompetent mice

Cruz, F. F., Borg, Z. D., Goodwin, M., Sokocevic, D., Wagner, D., McKenna, D. H., Rocco, P. R. M. & Weiss, D. J., Jan 1 2015, In : Stem Cells Translational Medicine. 4, 6, p. 615-624 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
13 Scopus citations

Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply

Wilson, J., McKenna, D., Liu, K. D. & Matthay, M. A., Apr 1 2015, In : The Lancet Respiratory Medicine. 3, 4, p. e12-e13

Research output: Contribution to journalLetter

1 Scopus citations

Mesenchymal stem (stromal) cells for treatment of ARDS: A phase 1 clinical trial

Wilson, J. G., Liu, K. D., Zhuo, H., Caballero, L., McMillan, M., Fang, X., Cosgrove, K., Vojnik, R., Calfee, C. S., Lee, J. W., Rogers, A. J., Levitt, J., Wiener-Kronish, J., Bajwa, E. K., Leavitt, A., McKenna, D., Thompson, B. T. & Matthay, M. A., Jan 1 2015, In : The Lancet Respiratory Medicine. 3, 1, p. 24-32 9 p.

Research output: Contribution to journalArticle

229 Scopus citations

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

Phinney, D. G., Di Giuseppe, M., Njah, J., Sala, E., Shiva, S., St Croix, C. M., Stolz, D. B., Watkins, S. C., Di, Y. P., Leikauf, G. D., Kolls, J., Riches, D. W. H., Deiuliis, G., Kaminski, N., Boregowda, S. V., McKenna, D. H. & Ortiz, L. A., Oct 7 2015, In : Nature communications. 6, 8472.

Research output: Contribution to journalArticle

242 Scopus citations

Postthaw characterization of umbilical cord blood: Markers of storage lesion

Hubel, A., Spindler, R., Curtsinger, J. M., Lindgren, B., Wiederoder, S. & McKenna, D. H., May 1 2015, In : Transfusion. 55, 5, p. 1033-1039 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Systemic administration of human bone marrow-derived mesenchymal stromal cell extracellular vesicles ameliorates Aspergillus hyphal extract-induced allergic airway inflammation in immunocompetent mice

Cruz, F. F., Borg, Z. D., Goodwin, M., Sokocevic, D., Wagner, D. E., Coffey, A., Antunes, M., Robinson, K. L., Mitsialis, S. A., Kourembanas, S., Thane, K., Hoffman, A. M., McKenna, D. H., Rocco, P. R. M. & Weiss, D. J., Nov 2015, In : Stem Cells Translational Medicine. 4, 11, p. 1302-1316 15 p.

Research output: Contribution to journalArticle

73 Scopus citations
2014

An Update from the United States National Heart, Lung, and Blood Institute-funded Production Assistance for Cellular Therapies (PACT) Program: A Decade of Cell Therapy

Wood, D., Wesselschmidt, R., Hematti, P., Gee, A. P., Rooney, C., Silberstein, L., Armant, M., Couture, L., Wagner, J. E., Mckenna, D. H., Hei, D., Mondoro, T. H., Welniak, L. & Lindblad, R., Apr 2014, In : Clinical and translational science. 7, 2, p. 93-99 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
190 Scopus citations

Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation

McAuley, D. F., Curley, G. F., Hamid, U. I., Laffey, J. G., Abbott, J., McKenna, D. H., Fang, X., Matthay, M. A. & Lee, J. W., May 1 2014, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 306, 9, p. L809-L815

Research output: Contribution to journalArticle

71 Scopus citations
2 Scopus citations

Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome

Liu, K. D., Wilson, J. G., Zhuo, H., Caballero, L., McMillan, M. L., Fang, X., Cosgrove, K., Calfee, C. S., Lee, J. W., Kangelaris, K. N., Gotts, J. E., Rogers, A. J., Levitt, J. E., Wiener-Kronish, J. P., Delucchi, K. L., Leavitt, A. D., McKenna, D. H., Thompson, B. T. & Matthay, M. A., Dec 1 2014, In : Annals of Intensive Care. 4, 1, p. 1-9 9 p., 22.

Research output: Contribution to journalArticle

32 Scopus citations
32 Scopus citations

Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia

Asmussen, S., Ito, H., Traber, D. L., Lee, J. W., Cox, R. A., Hawkins, H. K., McAuley, D. F., McKenna, D. H., Traber, L. D., Zhuo, H., Wilson, J., Herndon, D. N., Prough, D. S., Liu, K. D., Matthay, M. A. & Enkhbaatar, P., Sep 2014, In : Thorax. 69, 9, p. 819-825 7 p.

Research output: Contribution to journalArticle

63 Scopus citations

Mesenchymal stem or stromal cells: A review of clinical applications and manufacturing practices

Sharma, R. R., Pollock, K., Hubel, A. & McKenna, D., May 2014, In : Transfusion. 54, 5, p. 1418-1437 20 p.

Research output: Contribution to journalReview article

220 Scopus citations

Unrelated donor allogeneic hematopoietic stem cell transplantation for patients with hemoglobinopathies using a reduced-intensity conditioning regimen and third-party mesenchymal stromal cells

Kharbanda, S., Smith, A. R., Hutchinson, S. K., McKenna, D. H., Ball, J. B., Lamb, L. S., Agarwal, R., Weinberg, K. I. & Wagner, J. E., Apr 2014, In : Biology of Blood and Marrow Transplantation. 20, 4, p. 581-586 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
24 Scopus citations