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Research Output 1986 2019

2019

Genetic manipulation of sex ratio in mammals: the Reaper comes for Mickey

Smanski, M. J. & Zarkower, D. A., Jan 1 2019, In : EMBO Reports. 20, 8, e48577.

Research output: Contribution to journalComment/debate

Mammals
Sex Ratio
Agriculture
Animals
Genes
2018
1 Citation (Scopus)

DMRT5, DMRT3, and EMX2 cooperatively repress GSX2 at the pallium–subpallium boundary to maintain cortical identity in dorsal telencephalic progenitors

Desmaris, E., Keruzore, M., Saulnier, A., Ratié, L., Assimacopoulos, S., De Clercq, S., Nan, X., Roychoudhury, K., Qin, S., Kricha, S., Chevalier, C., Lingner, T., Henningfeld, K. A., Zarkower, D. A., Mallamaci, A., Theil, T., Campbell, K., Pieler, T., Li, M., Grove, E. A. & 1 others, Bellefroid, E. J., Oct 17 2018, In : Journal of Neuroscience. 38, 42, p. 9105-9121 17 p.

Research output: Contribution to journalArticle

Open Access
Telencephalon
Embryonic Structures
Phenotype
Homeobox Genes
Neocortex
8 Citations (Scopus)

DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation

De Clercq, S., Keruzore, M., Desmaris, E., Pollart, C., Assimacopoulos, S., Preillon, J., Ascenzo, S., Matson, C. K., Lee, M., Nan, X., Li, M., Nakagawa, Y., Hochepied, T., Zarkower, D., Grove, E. A. & Bellefroid, E. J., Feb 1 2018, In : Cerebral Cortex. 28, 2, p. 493-509 17 p.

Research output: Contribution to journalArticle

Open Access
Hippocampus
Cerebral Cortex
Neocortex
Zinc Fingers
Transcription Factors
5 Citations (Scopus)

Sexually Dimorphic unc-6/Netrin Expression Controls Sex-Specific Maintenance of Synaptic Connectivity

Weinberg, P., Berkseth, M., Zarkower, D. A. & Hobert, O., Feb 19 2018, In : Current Biology. 28, 4, p. 623-629.e3

Research output: Contribution to journalArticle

Open Access
Neurons
Maintenance
gender
Transcription
Animals
Open Access
Germ Cells
Embryonic Structures
Gastrulation
Yolk Sac
Genitalia
2017
11 Citations (Scopus)

DMRT proteins and coordination of mammalian spermatogenesis

Zhang, T. & Zarkower, D. A., Oct 1 2017, In : Stem Cell Research. 24, p. 195-202 8 p.

Research output: Contribution to journalArticle

Open Access
Spermatogenesis
Genes
Proteins
Histone Code
Prophase
21 Citations (Scopus)

In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

Rahmoun, M., Lavery, R., Laurent-Chaballier, S., Bellora, N., Philip, G. K., Rossitto, M., Symon, A., Pailhoux, E., Cammas, F., Chung, J., Bagheri-Fam, S., Murphy, M., Bardwell, V., Zarkower, D., Boizet-Bonhoure, B., Clair, P., Harley, V. R. & Poulat, F., Jul 1 2017, In : Nucleic acids research. 45, 12, p. 7191-7211 21 p.

Research output: Contribution to journalArticle

Sertoli Cells
Testis
Genes
Gonads
Chromatin
3 Citations (Scopus)

Regulation of mitosis-meiosis transition by the ubiquitin ligase β-trcp in male germ cells

Nakagawa, T., Zhang, T., Kushi, R., Nakano, S., Endo, T., Nakagawa, M., Yanagihara, N., Zarkower, D. A. & Nakayama, K., Nov 15 2017, In : Development (Cambridge). 144, 22, p. 4137-4147 11 p.

Research output: Contribution to journalArticle

germ cell
Meiosis
Ligases
Ubiquitin
induction
5 Citations (Scopus)

Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary

Minkina, A., Lindeman, R. E., Gearhart, M. D., Chassot, A. A., Chaboissier, M. C., Ghyselinck, N. B., Bardwell, V. J. & Zarkower, D. A., Apr 15 2017, In : Developmental Biology. 424, 2, p. 208-220 13 p.

Research output: Contribution to journalArticle

Tretinoin
Ovary
Granulosa Cells
Gonads
Fertility
2016
25 Citations (Scopus)

DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment

Zhang, T., Oatley, J., Bardwell, V. J. & Zarkower, D. A., Sep 1 2016, In : PLoS genetics. 12, 9, e1006293.

Research output: Contribution to journalArticle

germ cell
stem cells
Stem Cells
transcription factors
Maintenance
2015
38 Citations (Scopus)

An ancient protein-DNA interaction underlying metazoan sex determination

Murphy, M. W., Lee, J. K., Rojo, S., Gearhart, M. D., Kurahashi, K., Banerjee, S., Loeuille, G. A., Bashamboo, A., McElreavey, K., Zarkower, D., Aihara, H. & Bardwell, V. J., Jun 3 2015, In : Nature Structural and Molecular Biology. 22, 6, p. 442-451 10 p.

Research output: Contribution to journalArticle

DNA
Sexual Development
Proteins
Exonucleases
Chromatin Immunoprecipitation
3 Citations (Scopus)
Caenorhabditis elegans
Gonads
Messenger RNA
Sex Differentiation
RNA Isoforms
69 Citations (Scopus)

Restriction site-associated DNA sequencing (RAD-seq) reveals an extraordinary number of transitions among gecko sex-determining systems

Gamble, T., Coryell, J., Ezaz, T., Lynch, J., Scantlebury, D. P. & Zarkower, D. A., May 1 2015, In : Molecular biology and evolution. 32, 5, p. 1296-1309 14 p.

Research output: Contribution to journalArticle

Sex Chromosomes
Lizards
Gekkonidae
sex chromosomes
DNA Sequence Analysis
55 Citations (Scopus)

Sexual cell-fate reprogramming in the ovary by DMRT1

Lindeman, R. E., Gearhart, M. D., Minkina, A., Krentz, A. D., Bardwell, V. J. & Zarkower, D. A., Mar 16 2015, In : Current Biology. 25, 6, p. 764-771 8 p.

Research output: Contribution to journalArticle

Ovary
germ cells
Genes
gender
genes
2014
60 Citations (Scopus)

Anolis sex chromosomes are derived from a single ancestral pair

Gamble, T., Geneva, A. J., Glor, R. E. & Zarkower, D. A., Jan 1 2014, In : Evolution. 68, 4, p. 1027-1041 15 p.

Research output: Contribution to journalArticle

Anolis
Sex Chromosomes
sex chromosomes
chromosome
Phylogeny
1 Citation (Scopus)

Chinmo mutant fly testis stem cells switching sex farewell to maleness

Zarkower, D. A., Nov 24 2014, In : Developmental Cell. 31, 4, p. 385-387 3 p.

Research output: Contribution to journalShort survey

Stem cells
Diptera
Testis
Stem Cells
Adult Stem Cells
48 Citations (Scopus)

DMRT1 protects male gonadal cells from retinoid-dependent sexual transdifferentiation

Minkina, A., Matson, C. K., Lindeman, R. E., Ghyselinck, N. B., Bardwell, V. J. & Zarkower, D. A., Jun 9 2014, In : Developmental Cell. 29, 5, p. 511-520 10 p.

Research output: Contribution to journalArticle

Retinoids
Sertoli Cells
Genes
Tretinoin
Testis
47 Citations (Scopus)

Identification of sex-specific molecular markers using restriction site-associated DNA sequencing

Gamble, T. & Zarkower, D. A., Jan 1 2014, In : Molecular Ecology Resources. 14, 5, p. 902-913 12 p.

Research output: Contribution to journalArticle

DNA Sequence Analysis
Anolis carolinensis
Sex Chromosomes
sequence analysis
sex chromosomes
9 Citations (Scopus)

Non-homologous sex chromosomes in two geckos (Gekkonidae: Gekkota) with female heterogamety

Matsubara, K., Gamble, T., Matsuda, Y., Zarkower, D., Sarre, S. D., Georges, A., Graves, J. A. M. & Ezaz, T., Jan 1 2014, In : Cytogenetic and Genome Research. 143, 4, p. 251-258 8 p.

Research output: Contribution to journalArticle

Sex Chromosomes
Lizards
Chromosomes
Chromosomes, Human, 6-12 and X
Chromosomes, Human, 21-22 and Y
44 Citations (Scopus)

Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads

Lambeth, L. S., Raymond, C. S., Roeszler, K. N., Kuroiwa, A., Nakata, T., Zarkower, D. A. & Smith, C. A., May 15 2014, In : Developmental Biology. 389, 2, p. 160-172 13 p.

Research output: Contribution to journalArticle

Gonads
Chickens
Sex Differentiation
Feminization
Sex Chromosomes
28 Citations (Scopus)
Spermatogenesis
Meiosis
Germ Cells
Spermatogonia
Spermatocytes
2013
21 Citations (Scopus)

A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite

Chong, T., Collins, J. J., Brubacher, J. L., Zarkower, D. A. & Newmark, P. A., Jun 12 2013, In : Nature communications. 4, 1814.

Research output: Contribution to journalArticle

Transcription Factors
Genes
Accessories
Conservation
Animals
36 Citations (Scopus)

DMRT Genes in Vertebrate Gametogenesis

Zarkower, D. A., Jan 1 2013, Current Topics in Developmental Biology. Academic Press Inc., p. 327-356 30 p. (Current Topics in Developmental Biology; vol. 102).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gametogenesis
Vertebrates
Sex Differentiation
Genes
Nucleotide Motifs
24 Citations (Scopus)

Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line

Krentz, A. D., Murphy, M. W., Zhang, T., Sarver, A. L., Jain, S., Griswold, M. D., Bardwell, V. J. & Zarkower, D. A., May 1 2013, In : Developmental Biology. 377, 1, p. 67-78 12 p.

Research output: Contribution to journalArticle

Germ Cells
Testis
Teratoma
Neoplasms
Glial Cell Line-Derived Neurotrophic Factor
23 Citations (Scopus)

The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals

Saulnier, A., Keruzore, M., De Clercq, S., Bar, I., Moers, V., Magnani, D., Walcher, T., Filippis, C., Kricha, S., Parlier, D., Viviani, L., Matson, C. K., Nakagawa, Y., Theil, T., Götz, M., Mallamaci, A., Marine, J. C., Zarkower, D. & Bellefroid, E. J., Nov 1 2013, In : Cerebral Cortex. 23, 11, p. 2552-2567 16 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Mammals
Telencephalon
Transcription Factors
Down-Regulation
18 Citations (Scopus)

TRA-1 ChIP-seq reèeals regulators of sexual differentiation and multileèel feedback in nematode sex determination

Berkseth, M., Ikegami, K., Arur, S., Lieb, J. D. & Zarkower, D. A., Oct 1 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 40, p. 16033-16038 6 p.

Research output: Contribution to journalArticle

Sex Differentiation
Binding Sites
Caenorhabditis
High-Throughput Nucleotide Sequencing
Caenorhabditis elegans
2012
7 Citations (Scopus)

Karyotypes of two species of malagasy ground gecko (paroedura: Gekkonidae)

Main, H., Scantlebury, D. P., Zarkower, D. A. & Gamble, T., Jan 1 2012, In : African Journal of Herpetology. 61, 1, p. 81-90 10 p.

Research output: Contribution to journalArticle

Gekkonidae
karyotype
karyotyping
lizards
lizard
172 Citations (Scopus)

Sex and the singular DM domain: Insights into sexual regulation, evolution and plasticity

Matson, C. K. & Zarkower, D. A., Mar 1 2012, In : Nature Reviews Genetics. 13, 3, p. 163-174 12 p.

Research output: Contribution to journalReview article

Insect Genes
Cell Transdifferentiation
Genes
Sexual Development
Gonads
47 Citations (Scopus)

Sex determination

Gamble, T. & Zarkower, D. A., Apr 24 2012, In : Current Biology. 22, 8

Research output: Contribution to journalArticle

Animals
gender
Proteins
sexual reproduction
gender differences
2011
285 Citations (Scopus)

DMRT1 prevents female reprogramming in the postnatal mammalian testis

Matson, C. K., Murphy, M. W., Sarver, A. L., Griswold, M. D., Bardwell, V. J. & Zarkower, D. A., Aug 4 2011, In : Nature. 476, 7358, p. 101-105 5 p.

Research output: Contribution to journalArticle

Sertoli Cells
Granulosa Cells
Testis
Gonads
Mammals
68 Citations (Scopus)

DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary

Krentz, A. D., Murphy, M. W., Sarver, A. L., Griswold, M. D., Bardwell, V. J. & Zarkower, D. A., Jan 1 2011, In : Developmental Biology. 356, 1, p. 63-70 8 p.

Research output: Contribution to journalArticle

Oogenesis
Transcriptional Activation
Ovary
Germ Cells
Testis
2 Citations (Scopus)

Erratum: DMRT1 prevents female reprogramming in the postnatal mammalian testis (Nature (2011) 476 (101-104))

Matson, C. K., Murphy, M. W., Sarver, A. L., Griswold, M. D., Bardwell, V. J. & Zarkower, D. A., Sep 8 2011, In : Nature. 477, 7363, 1 p.

Research output: Contribution to journalComment/debate

35 Citations (Scopus)

MPK-1 ERK controls membrane organization in C. elegans oogenesis via a sex-determination module

Arur, S., Ohmachi, M., Berkseth, M., Nayak, S., Hansen, D., Zarkower, D. A. & Schedl, T., May 17 2011, In : Developmental Cell. 20, 5, p. 677-688 12 p.

Research output: Contribution to journalArticle

Oogenesis
Membranes
Finite element method
Spermatozoa
Phosphorylation
2010
9 Citations (Scopus)

EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad

Kalis, A. K., Murphy, M. W. & Zarkower, D. A., Jan 1 2010, In : Developmental Biology. 344, 2, p. 827-835 9 p.

Research output: Contribution to journalArticle

Gonads
Wnt Signaling Pathway
Reporter Genes
Genes
Catenins
15 Citations (Scopus)

Functional genomic identification of genes required for male gonadal differentiation in Caenorhabditis elegans

Kalis, A. K., Kroetz, M., Larson, K. M. & Zarkower, D. A., Jun 1 2010, In : Genetics. 185, 2, p. 523-535 13 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Catenins
Wnt Signaling Pathway
Cytokinesis
Genes
56 Citations (Scopus)
Testis
Genome
DNA
Genes
Sertoli Cells
161 Citations (Scopus)

The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells

Matson, C. K., Murphy, M. W., Griswold, M. D., Yoshida, S., Bardwell, V. J. & Zarkower, D. A., Oct 19 2010, In : Developmental Cell. 19, 4, p. 612-624 13 p.

Research output: Contribution to journalArticle

Meiosis
Mitosis
Germ Cells
Spermatogonia
Cells
2009
128 Citations (Scopus)

The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency

Krentz, A. D., Murphy, M. W., Kim, S., Cook, M. S., Capel, B., Zhu, R., Matin, A., Sarver, A. L., Parker, K. L., Griswold, M. D., Looijenga, L. H. J., Bardwell, V. J. & Zarkower, D. A., Dec 19 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 52, p. 22323-22328 6 p.

Research output: Contribution to journalArticle

Germ Cells
Teratoma
Cell Proliferation
Glial Cell Line-Derived Neurotrophic Factor
Gene Dosage
2008
21 Citations (Scopus)

Chapter 1 Somatic Sexual Differentiation in Caenorhabditis elegans

Wolff, J. R. & Zarkower, D. A., Dec 30 2008, Sex Determination and Sexual Development. Doren, M. (ed.). p. 1-39 39 p. (Current Topics in Developmental Biology; vol. 83).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sex Differentiation
Caenorhabditis elegans
X Chromosome
Sexual Development
Cell Lineage
2007
35 Citations (Scopus)

A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis

Kim, S., Namekawa, S. H., Niswander, L. M., Ward, J. O., Lee, J. T., Bardwell, V. J. & Zarkower, D. A., Apr 1 2007, In : PLoS genetics. 3, 4, p. 559-571 13 p.

Research output: Contribution to journalArticle

sex chromatin
Sex Chromatin
prophase
Meiosis
Pachytene Stage
91 Citations (Scopus)

Cell type-autonomous and non-autonomous requirements for Dmrt1 in postnatal testis differentiation

Kim, S., Bardwell, V. J. & Zarkower, D. A., Jul 15 2007, In : Developmental Biology. 307, 2, p. 314-327 14 p.

Research output: Contribution to journalArticle

Germ Cells
Sertoli Cells
Testis
Sex Differentiation
Nucleotide Motifs
51 Citations (Scopus)
DNA sequences
Vertebrates
DNA
Proteins
Sex Differentiation
2006
41 Citations (Scopus)

Mice mutant in the DM domain gene Dmrt4 are viable and fertile but have polyovular follicles

Balciuniene, J., Bardwell, V. J. & Zarkower, D. A., Dec 1 2006, In : Molecular and cellular biology. 26, 23, p. 8984-8991 8 p.

Research output: Contribution to journalArticle

Sex Differentiation
Genes
Phenotype
Nucleotide Motifs
Zinc Fingers
35 Citations (Scopus)

mRNA expression analysis and the molecular basis of neonatal testis defects in Dmrt1 mutant mice

Fahrioglu, U., Murphy, M. W., Zarkower, D. A. & Bardwell, V. J., Dec 1 2006, In : Sexual Development. 1, 1, p. 42-58 17 p.

Research output: Contribution to journalArticle

Testis
Germ Cells
Messenger RNA
Phenotype
Sex Differentiation
49 Citations (Scopus)

Somatic sex determination.

Zarkower, D. A., Dec 1 2006, In : WormBook : the online review of C. elegans biology. p. 1-12 12 p.

Research output: Contribution to journalReview article

Sex Differentiation
Proteins
Hedgehogs
Arthropods
Zinc Fingers
54 Citations (Scopus)

Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning

Seo, K. W., Wang, Y., Kokubo, H., Kettlewell, J. R., Zarkower, D. A. & Johnson, R. L., Feb 1 2006, In : Developmental Biology. 290, 1, p. 200-210 11 p.

Research output: Contribution to journalArticle

Somites
Transcription Factors
Myogenin
Critical Pathways
Homologous Recombination
2005
24 Citations (Scopus)

DSH-2 regulates asymmetric cell division in the early C. elegans somatic gonad

Chang, W., Lloyd, C. E. & Zarkower, D. A., Jun 1 2005, In : Mechanisms of Development. 122, 6, p. 781-789 9 p.

Research output: Contribution to journalArticle

Asymmetric Cell Division
Gonads
Frizzled Receptors
Wnt Signaling Pathway
Proteins
34 Citations (Scopus)

Genome-wide analysis of sex-enriched gene expression during C. elegans larval development

Thoemke, K., Yi, W., Ross, J. M., Kim, S., Reinke, V. & Zarkower, D. A., Aug 15 2005, In : Developmental Biology. 284, 2, p. 500-508 9 p.

Research output: Contribution to journalArticle

Genome
Gene Expression
Sexual Development
Genes
Sex Characteristics
29 Citations (Scopus)

The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins

Ross, J. M., Kalis, A. K., Murphy, M. W. & Zarkower, D. A., Jun 1 2005, In : Developmental Cell. 8, 6, p. 881-892 12 p.

Research output: Contribution to journalArticle

Basic Helix-Loop-Helix Transcription Factors
Neurogenesis
Nervous System
Neurology
Sense Organs
2004
21 Citations (Scopus)

A forkhead protein controls sexual identity of the C. elegans male somatic gonad

Chang, W., Tilmann, C., Thoemke, K., Markussen, F. H., Mathies, L. D., Kimble, J. & Zarkower, D. A., Mar 1 2004, In : Development. 131, 6, p. 1425-1436 12 p.

Research output: Contribution to journalReview article

Forkhead Transcription Factors
Gonads
hermaphrodite
animal
loss of function