1990 …2024
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Research Output 1990 2019

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Review article
2018
11 Citations (Scopus)

CRISPR/Cas9 library screening for drug target discovery

Kurata, M., Yamamoto, K., Moriarity, B. S., Kitagawa, M. & Largaespada, D. A., Feb 1 2018, In : Journal of Human Genetics. 63, 2, p. 179-186 8 p.

Research output: Contribution to journalReview article

Clustered Regularly Interspaced Short Palindromic Repeats
Drug Discovery
Pharmaceutical Preparations
Essential Genes
Drug Resistance
2017
8 Citations (Scopus)

Transposons As Tools for Functional Genomics in Vertebrate Models

Kawakami, K., Largaespada, D. A. & Ivics, Z., Nov 1 2017, In : Trends in Genetics. 33, 11, p. 784-801 18 p.

Research output: Contribution to journalReview article

Genomics
Vertebrates
Mutagenesis
DNA Transposable Elements
Neoplasms
2016
15 Citations (Scopus)

Engineered swine models of cancer

Watson, A. L., Carlson, D. F., Largaespada, D. A., Hackett, P. B. & Fahrenkrug, S. C., May 9 2016, In : Frontiers in Genetics. 7, MAY, 78.

Research output: Contribution to journalReview article

Swine
Neoplasms
Clustered Regularly Interspaced Short Palindromic Repeats
Technology
Endonucleases
11 Citations (Scopus)

Understanding the osteosarcoma pathobiology: A comparative oncology approach

Varshney, J., Scott, M. C., Largaespada, D. A. & Subramanian, S., Mar 1 2016, In : Veterinary Sciences. 3, 1, 3.

Research output: Contribution to journalReview article

osteosarcoma
Osteosarcoma
dogs
Canidae
animal models
2015
22 Citations (Scopus)
Beauty
Insertional Mutagenesis
Neoplasm Genes
Genetic Association Studies
Neoplasms
4 Citations (Scopus)

Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma

Chiu, A. P., Tschida, B. R., Lo, L. H., Moriarity, B. S., Rowlands, D. K., Largaespada, D. A. & Keng, V. W., Nov 14 2015, In : World Journal of Gastroenterology. 21, 42, p. 12157-12170 14 p.

Research output: Contribution to journalReview article

Hepatitis B
Hepatocellular Carcinoma
Liver Neoplasms
Reverse Genetics
Virus Diseases
2014
15 Citations (Scopus)

Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies

Tschida, B. R., Largaespada, D. A. & Keng, V. W., Jan 1 2014, In : Seminars in Cell and Developmental Biology. 27, p. 86-95 10 p.

Research output: Contribution to journalReview article

Reverse Genetics
Beauty
Insertional Mutagenesis
Neoplasms
Mutation
2013
57 Citations (Scopus)

Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy

Hackett, P. B., Largaespada, D. A., Switzer, K. C. & Cooper, L. J. N., Jan 1 2013, In : Translational Research. 161, 4, p. 265-283 19 p.

Research output: Contribution to journalReview article

Beauty
Gene therapy
Mutagenesis
DNA Transposable Elements
T-cells
2012
5 Citations (Scopus)

In vivo models for defining molecular subtypes of the primitive neuroectodermal tumor genome: Current challenges and solutions

Larson, J. D. & Largaespada, D. A., Jul 1 2012, In : In Vivo. 26, 4, p. 487-500 14 p.

Research output: Contribution to journalReview article

Primitive Neuroectodermal Tumors
Molecular Models
Tumors
Genes
Genome
2010
148 Citations (Scopus)

A transposon and transposase system for human application

Hackett, P. B., Largaespada, D. A. & Cooper, L. J. N., Apr 1 2010, In : Molecular Therapy. 18, 4, p. 674-683 10 p.

Research output: Contribution to journalReview article

Transposases
Beauty
T-Cell Antigen Receptor Specificity
Viruses
Costs and Cost Analysis
2007
17 Citations (Scopus)

Transposable elements and the dynamic somatic genome

Collier, L. S. & Largaespada, D. A., Oct 31 2007, In : Genome Biology. 8, SUPPL. 1, S5.

Research output: Contribution to journalReview article

DNA Transposable Elements
somatic cells
transposons
genome
Genome
23 Citations (Scopus)

Transposons for cancer gene discovery: Sleeping beauty and beyond

Collier, L. S. & Largaespada, D. A., Oct 31 2007, In : Genome Biology. 8, SUPPL. 1, S15.

Research output: Contribution to journalReview article

Beauty
Neoplasm Genes
Genetic Association Studies
transposons
cancer
2006
5 Citations (Scopus)

Models of acute myeloid leukemia: Prospects for drug development and testing

Yin, B. & Largaespada, D. A., Aug 24 2006, In : Drug Discovery Today: Disease Models. 3, 2, p. 137-142 6 p.

Research output: Contribution to journalReview article

Acute Myeloid Leukemia
Pharmaceutical Preparations
Drug Discovery
Transgenic Mice
Leukemia
13 Citations (Scopus)

Transforming science: Cancer gene identification

Collier, L. S. & Largaespada, D. A., Feb 1 2006, In : Current Opinion in Genetics and Development. 16, 1, p. 23-29 7 p.

Research output: Contribution to journalReview article

Neoplasm Genes
Oncogenes
Mutagenesis
Genes
Beauty
2005
22 Citations (Scopus)

Cancer gene discovery using the sleeping beauty transposon

Starr, T. & Largaespada, D. A., Jan 1 2005, In : Cell Cycle. 4, 12, p. 1744-1748 5 p.

Research output: Contribution to journalReview article

Beauty
Neoplasm Genes
Genetic Association Studies
Mutation
Genetic Translocation
31 Citations (Scopus)

Hopping around the tumor genome: Transposons for cancer gene discovery

Collier, L. S. & Largaespada, D. A., Nov 1 2005, In : Cancer Research. 65, 21, p. 9607-9610 4 p.

Research output: Contribution to journalReview article

Neoplasm Genes
Genetic Association Studies
Beauty
Genome
Hematopoietic System
44 Citations (Scopus)

Insertional mutagenesis in mice: New perspectives and tools

Carlson, C. M. & Largaespada, D. A., Jul 1 2005, In : Nature Reviews Genetics. 6, 7, p. 568-580 13 p.

Research output: Contribution to journalReview article

insertional mutagenesis
Insertional Mutagenesis
mice
Genome
Phenotype
33 Citations (Scopus)

Nonviral vectors for cancer gene therapy: Prospects for integrating vectors and combination therapies

Ohlfest, J. R., Freese, A. B. & Largaespada, D. A., Dec 1 2005, In : Current gene therapy. 5, 6, p. 629-641 13 p.

Research output: Contribution to journalReview article

Neoplasm Genes
Genetic Therapy
Neoplasms
Therapeutics
Genes
111 Citations (Scopus)

Sleeping Beauty Transposon-Mediated Gene Therapy for Prolonged Expression

Hackett, P. B., Ekker, S. C., Largaespada, D. A. & Mc Ivor, R. S., Dec 1 2005, In : Advances in Genetics. 54, p. 189-232 44 p.

Research output: Contribution to journalReview article

Beauty
Genetic Therapy
Base Pairing
Plasmids
Chromosomes
2003
8 Citations (Scopus)

A bad rap: Rap1 signaling and oncogenesis

Largaespada, D. A., Jul 1 2003, In : Cancer Cell. 4, 1, p. 3-4 2 p.

Research output: Contribution to journalReview article

Carcinogenesis
Myelopoiesis
GTPase-Activating Proteins
Genes
Neoplasms
13 Citations (Scopus)
Genetically Modified Animals
DNA Transposable Elements
Vertebrates
Gene Transfer Techniques
Technology
1 Citation (Scopus)

Genetically modified mice in cancer research.

Largaespada, D. A., Dec 1 2003, In : Methods in molecular biology (Clifton, N.J.). 209, p. 311-332 22 p.

Research output: Contribution to journalReview article

Animal Disease Models
Genetic Engineering
Genetic Predisposition to Disease
Transgenes
Transgenic Mice
21 Citations (Scopus)

MTID: A database of Sleeping Beauty transposon insertions in mice

Roberg-Perez, K., Carlson, C. M. & Largaespada, D. A., Jan 1 2003, In : Nucleic acids research. 31, 1, p. 78-81 4 p.

Research output: Contribution to journalReview article

Beauty
Databases
Nucleotides
Mutagens
Genes
2000
25 Citations (Scopus)

Genetic heterogeneity in acute myeloid leukemia: Maximizing information flow from MuLV mutagenesis studies

Largaespada, D. A., Jan 1 2000, In : Leukemia. 14, 7, p. 1174-1184 11 p.

Research output: Contribution to journalReview article

Murine Leukemia Viruses
Genetic Heterogeneity
Acute Myeloid Leukemia
Mutagenesis
Myeloid Leukemia
1997
140 Citations (Scopus)

Mouse models of human disease. Part II: Recent progress and future directions

Bedell, M. A., Largaespada, D. A., Jenkins, N. A. & Copeland, N. G., Jan 1 1997, In : Genes and Development. 11, 1, p. 11-43 33 p.

Research output: Contribution to journalReview article

Animal Disease Models
Computer Communication Networks
Inborn Genetic Diseases
Chromosome Mapping
Information Systems