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Research Output 1990 2019

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Article
2019

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma

Diessner, B. J., Marko, T. A., Scott, R. M., Eckert, A. L., Stuebner, K. M., Hohenhaus, A. E., Selting, K. A., Largaespada, D. A., Modiano, J. & Spector, L. G., Jun 1 2019, In : Cancer medicine. 8, 6, p. 3216-3226 11 p.

Research output: Contribution to journalArticle

Open Access
Osteosarcoma
Dogs
Neoplasm Metastasis
Neoplasms
Canidae
1 Citation (Scopus)

Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis

Fan, Y., Bazai, S. K., Daian, F., Arechederra, M., Richelme, S., Temiz, N. A., Yim, A., Habermann, B. H., Dono, R., Largaespada, D. A. & Maina, F., Mar 1 2019, In : Journal of Hepatology. 70, 3, p. 470-482 13 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Mutagenesis
Carcinogenesis
Liver
Genes
2 Citations (Scopus)

Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas

Rathe, S., Popescu, F. E., Johnson, J. E., Watson, A. L., Marko, T. A., Moriarity, B. S., Ohlfest, J. R. & Largaespada, D. A., Dec 1 2019, In : Scientific reports. 9, 1, 358.

Research output: Contribution to journalArticle

Osteosarcoma
RNA Sequence Analysis
Gene Fusion
Immunotherapy
Canidae

Sleeping beauty insertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors

Beckmann, P. J., Larson, J. D., Larsson, A. T., Ostergaard, J. P., Wagner, S., Rahrmann, E. P., Shamsan, G. A., Otto, G. M., Williams, R. L., Wang, J., Lee, C., Tschida, B. R., Das, P., Dubuc, A. M., Moriarity, B. S., Picard, D., Wu, X., Rodriguez, F. J., Rosemarie, Q., Krebs, R. D. & 13 othersMolan, A. M., Demer, A. M., Frees, M. M., Rizzardi, A. E., Schmechel, S. C., Eberhart, C. G., Jenkins, R. B., Wechsler-Reya, R. J., Odde, D. J., Huang, A., Taylor, M. D., Sarver, A. L. & Largaespada, D. A., Mar 1 2019, In : Cancer Research. 79, 5, p. 905-917 13 p.

Research output: Contribution to journalArticle

Beauty
Central Nervous System Neoplasms
Medulloblastoma
Insertional Mutagenesis
Primitive Neuroectodermal Tumors
1 Citation (Scopus)

Sleeping beauty screen identifies RREB1 and other genetic drivers in human B-cell lymphoma

Rahrmann, E. P., Wolf, N. K., Otto, G. M., Heltemes Harris, L. M., Ramsey, L. B., Shu, J., LaRue, R. S., Linden, M. A., Rathe, S., Starr, T., Farrar, M. A., Moriarity, B. S. & Largaespada, D. A., Feb 1 2019, In : Molecular Cancer Research. 17, 2, p. 567-582 16 p.

Research output: Contribution to journalArticle

Beauty
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Carrier Proteins
Follicular Lymphoma
1 Citation (Scopus)

Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation

Li, X. X., Lu, X. Y., Zhang, S. J., Chiu, A. P., Lo, L. H., Largaespada, D. A., Chen, Q. B. & Keng, V. W., Mar 1 2019, In : Biomedicine and Pharmacotherapy. 111, p. 68-75 8 p.

Research output: Contribution to journalArticle

Lipogenesis
Inflammation
Liver
Palmitic Acid
Oleic Acid
2018
7 Citations (Scopus)

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice

Riordan, J. D., Feddersen, C. R., Tschida, B. R., Beckmann, P. J., Keng, V. W., Linden, M. A., Amin, K., Stipp, C. S., Largaespada, D. A. & Dupuy, A. J., Mar 1 2018, In : Hepatology. 67, 3, p. 924-939 16 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Mutation
Liver
Wounds and Injuries
Genes
9 Citations (Scopus)
Gene Expression Profiling
Osteosarcoma
Survival
Multigene Family
Neoplasms
7 Citations (Scopus)

Social stress shortens lifespan in mice

Razzoli, M., Nyuyki-Dufe, K., Gurney, A., Erickson, C., McCallum, J., Spielman, N., Marzullo, M., Patricelli, J., Kurata, M., Pope, E. A., Touma, C., Palme, R., Largaespada, D. A., Allison, D. B. & Bartolomucci, A., Aug 1 2018, In : Aging cell. 17, 4, e12778.

Research output: Contribution to journalArticle

Cell Aging
Cardiovascular Diseases
Sinus of Valsalva
Life Expectancy
Aggression
2017
2 Citations (Scopus)

Data Descriptor: Transcriptomic analysis of gene signatures associated with sickle pain

Paul, J. A., Aich, A., Abrahante, J. E., Wang, Y., LaRue, R. S., Rathe, S. K., Kalland, K., Mittal, A., Jha, R., Peng, F., Largaespada, D. A., Bagchi, A. & Gupta, K., May 16 2017, In : Scientific Data. 4, 170051.

Research output: Contribution to journalArticle

Pain
Descriptors
pain
Signature
Genes
4 Citations (Scopus)

Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumors

Carlson, M., Watson, A. L., Anderson, L., Largaespada, D. A. & Provenzano, P. P., Nov 1 2017, In : Journal of biomedical optics. 22, 11, 116010.

Research output: Contribution to journalArticle

Open Access
Chemotherapy
chemotherapy
Doxorubicin
Tumors
tumors

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Pomeroy, E. J., Lee, L. A., Lee, R. D. W., Schirm, D. K., Temiz, N. A., Ma, J., Gruber, T. A., Diaz-Flores, E., Moriarity, B. S., Downing, J. R., Shannon, K. M., Largaespada, D. A. & Eckfeldt, C. E., Jun 8 2017, In : Oncogene. 36, 23, p. 3263-3273 11 p.

Research output: Contribution to journalArticle

ras Genes
Oncogenes
Acute Myeloid Leukemia
Leukemia
Recurrence
7 Citations (Scopus)

Sleeping beauty insertional mutagenesis in mice identifies drivers of steatosis-associated hepatic tumors

Tschida, B. R., Temiz, N. A., Kuka, T. P., Lee, L. A., Riordan, J. D., Tierrablanca, C. A., Hullsiek, R., Wagner, S., Hudson, W. A., Linden, M. A., Amin, K., Beckmann, P. J., Heuer, R. A., Sarver, A. L., Yang, J. D., Roberts, L. R., Nadeau, J. H., Dupuy, A. J., Keng, V. W. & Largaespada, D. A., Dec 1 2017, In : Cancer Research. 77, 23, p. 6576-6588 13 p.

Research output: Contribution to journalArticle

Beauty
Insertional Mutagenesis
Hepatocellular Carcinoma
Liver
Neoplasms
2016
7 Citations (Scopus)

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors

Patel, A. V., Chaney, K. E., Choi, K., Largaespada, D. A., Kumar, A. R. & Ratner, N., Jan 1 2016, In : EBioMedicine. 9, p. 110-119 10 p.

Research output: Contribution to journalArticle

Neurilemmoma
Tumors
Genes
Cells
Neurofibromatosis 1
Beauty
Mutagenesis
Adenocarcinoma
Genes
Mutation
43 Citations (Scopus)

CFTR is a tumor suppressor gene in murine and human intestinal cancer

Than, B. L. N., Linnekamp, J. F., Starr, T., Largaespada, D. A., Rod, A., Zhang, Y., Bruner, V., Abrahante - Llorens, J. E., Schumann, A., Luczak, T., Niemczyk, A., O'Sullivan, G., Medema, J. P., Fijneman, R. J. A., Meijer, G. A., Van Den Broek, E., Hodges, C. A., Scott, P. M., Vermeulen, L. & Cormier, R. T., Aug 11 2016, In : Oncogene. 35, 32, p. 4191-4199 9 p.

Research output: Contribution to journalArticle

Intestinal Neoplasms
Tumor Suppressor Genes
Colon
Organoids
Genes
9 Citations (Scopus)

CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin

Kendall, J. J., Chaney, K. E., Patel, A. V., Rizvi, T. A., Largaespada, D. A. & Ratner, N., Aug 1 2016, In : Oncotarget. 7, 33, p. 53191-53203 13 p.

Research output: Contribution to journalArticle

Catenins
Neurilemmoma
Apoptosis
Cell Survival
Neurofibromatosis 1
123 Citations (Scopus)

Divergent clonal selection dominates medulloblastoma at recurrence

Morrissy, A. S., Garzia, L., Shih, D. J. H., Zuyderduyn, S., Huang, X., Skowron, P., Remke, M., Cavalli, F. M. G., Ramaswamy, V., Lindsay, P. E., Jelveh, S., Donovan, L. K., Wang, X., Luu, B., Zayne, K., Li, Y., Mayoh, C., Thiessen, N., Mercier, E., Mungall, K. L. & 118 othersMa, Y., Tse, K., Zeng, T., Shumansky, K., Roth, A. J. L., Shah, S., Farooq, H., Kijima, N., Holgado, B. L., Lee, J. J. Y., Matan-Lithwick, S., Liu, J., Mack, S. C., Manno, A., Michealraj, K. A., Nor, C., Peacock, J., Qin, L., Reimand, J., Rolider, A., Thompson, Y. Y., Wu, X., Pugh, T., Ally, A., Bilenky, M., Butterfield, Y. S. N., Carlsen, R., Cheng, Y., Chuah, E., Corbett, R. D., Dhalla, N., He, A., Lee, D., Li, H. I., Long, W., Mayo, M., Plettner, P., Qian, J. Q., Schein, J. E., Tam, A., Wong, T., Birol, I., Zhao, Y., Faria, C. C., Pimentel, J., Nunes, S., Shalaby, T., Grotzer, M., Pollack, I. F., Hamilton, R. L., Li, X. N., Bendel, A. E., Fults, D. W., Walter, A. W., Kumabe, T., Tominaga, T., Collins, V. P., Cho, Y. J., Hoffman, C., Lyden, D., Wisoff, J. H., Garvin, J. H., Stearns, D. S., Massimi, L., Schüller, U., Sterba, J., Zitterbart, K., Puget, S., Ayrault, O., Dunn, S. E., Tirapelli, D. P. C., Carlotti, C. G., Wheeler, H., Hallahan, A. R., Ingram, W., MacDonald, T. J., Olson, J. J., Van Meir, E. G., Lee, J. Y., Wang, K. C., Kim, S. K., Cho, B. K., Pietsch, T., Fleischhack, G., Tippelt, S., Ra, Y. S., Bailey, S., Lindsey, J. C., Clifford, S. C., Eberhart, C. G., Cooper, M. K., Packer, R. J., Massimino, M., Garre, M. L., Bartels, U., Tabori, U., Hawkins, C. E., Dirks, P., Bouffet, E., Rutka, J. T., Wechsler-Reya, R. J., Weiss, W. A., Collier, L. S., Dupuy, A. J., Korshunov, A., Jones, D. T. W., Kool, M., Northcott, P. A., Pfister, S. M., Largaespada, D. A., Mungall, A. J., Moore, R. A., Jabado, N., Bader, G. D., Jones, S. J. M., Malkin, D., Marra, M. A. & Taylor, M. D., Jan 21 2016, In : Nature. 529, 7586, p. 351-357 7 p.

Research output: Contribution to journalArticle

Medulloblastoma
Recurrence
Clone Cells
Therapeutics
Image-Guided Radiotherapy
8 Citations (Scopus)

Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma

Shu, J., Li, L., Sarver, A. E., Pope, E. A., Varshney, J., Thayanithy, V., Spector, L., Largaespada, D. A., Steer, C. J. & Subramanian, S., Apr 19 2016, In : Oncotarget. 7, 16, p. 21298-21314 17 p.

Research output: Contribution to journalArticle

Open Access
Osteosarcoma
Gene Expression
Histone Code
Beauty
Imprinting (Psychology)
17 Citations (Scopus)

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

Wu, J., Keng, V. W., Patmore, D. M., Kendall, J. J., Patel, A. V., Jousma, E., Jessen, W. J., Choi, K., Tschida, B. R., Silverstein, K. A. T., Fan, D., Schwartz, E. B., Fuchs, J. R., Zou, Y., Kim, M. O., Dombi, E., Levy, D. E., Huang, G., Cancelas, J. A., Stemmer-Rachamimov, A. O. & 3 othersSpinner, R. J., Largaespada, D. A. & Ratner, N., Mar 1 2016, In : Cell Reports. 14, 8, p. 1979-1990 12 p.

Research output: Contribution to journalArticle

Catenins
Neurofibroma
Mutagenesis
Insertional Mutagenesis
Schwann Cells
23 Citations (Scopus)

mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress

Yun, Y. S., Kim, K. H., Tschida, B., Sachs, Z., Noble-Orcutt, K. E., Moriarity, B. S., Ai, T., Ding, R., Williams, J., Chen, L., Largaespada, D. & Kim, D. H., Feb 18 2016, In : Molecular Cell. 61, 4, p. 625-639 15 p.

Research output: Contribution to journalArticle

Heat-Shock Proteins
Proteins
Mutation
mechanistic target of rapamycin complex 1
Protein Biosynthesis
129 Citations (Scopus)

Phase i trials using sleeping beauty to generate CD19-specific CAR T cells

Kebriaei, P., Singh, H., Huls, M. H., Figliola, M. J., Bassett, R., Olivares, S., Jena, B., Dawson, M. J., Kumaresan, P. R., Su, S., Maiti, S., Dai, J., Moriarity, B., Forget, M. A., Senyukov, V., Orozco, A., Liu, T., McCarty, J., Jackson, R. N., Moyes, J. S. & 19 othersRondon, G., Qazilbash, M., Ciurea, S., Alousi, A., Nieto, Y., Rezvani, K., Marin, D., Popat, U., Hosing, C., Shpall, E. J., Kantarjian, H., Keating, M., Wierda, W., Do, K. A., Largaespada, D. A., Lee, D. A., Hackett, P. B., Champlin, R. E. & Cooper, L. J. N., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3363-3376 14 p.

Research output: Contribution to journalArticle

Beauty
Hematopoietic Stem Cell Transplantation
T-Lymphocytes
Antigen Receptors
T-Cell Antigen Receptor
1 Citation (Scopus)

RALB provides critical survival signals downstream of Ras in acute myeloid leukemia

Eckfeldt, C. E., Pomeroy, E. J., Lee, R. D. W., Hazen, K. S., Lee, L. A., Moriarity, B. S. & Largaespada, D. A., Jan 1 2016, In : Oncotarget. 7, 40, p. 65147-65156 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Survival
Phosphatidylinositol 3-Kinase
Proto-Oncogenes
Myeloid Cells
15 Citations (Scopus)

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens

Temiz, N. A., Moriarity, B. S., Wolf, N. K., Riordan, J. D., Dupuy, A. J., Largaespada, D. A. & Sarver, A. L., Jan 1 2016, In : Genome Research. 26, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Beauty
Ligation
RNA
Polymerase Chain Reaction
7 Citations (Scopus)

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia

Heltemes Harris, L. M., Larson, J. D., Starr, T., Hubbard, G. K., Sarver, A. L., Largaespada, D. A. & Farrar, M. A., Jun 30 2016, In : Oncogene. 35, 26, p. 3454-3464 11 p.

Research output: Contribution to journalArticle

STAT5 Transcription Factor
Beauty
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transcriptional Activation
B-Lymphocytes
9 Citations (Scopus)

Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma

Marko, T. A., Shamsan, G. A., Edwards, E. N., Hazelton, P. E., Rathe, S., Cornax, I., Overn, P. R., Varshney, J., Diessner, B. J., Moriarity, B. S., O'Sullivan, G., Odde, D. J. & Largaespada, D. A., Dec 14 2016, In : Scientific Reports. 6, 39059.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Osteosarcoma
Neoplasm Metastasis
Cell Line
Clustered Regularly Interspaced Short Palindromic Repeats
6 Citations (Scopus)

Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency

Sachs, Z., Been, R. A., Decoursin, K. J., Nguyen, H. T., Mohd Hassan, N. A., Noble-Orcutt, K. E., Eckfeldt, C. E., Pomeroy, E. J., Diaz-Flores, E., Geurts, J. L., Diers, M. D., Hasz, D. E., Morgan, K. J., Macmillan, M. L., Shannon, K. M., Largaespada, D. A. & Wiesner, S. M., Sep 30 2016, In : Haematologica. 101, 10, p. 1190-1199 10 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Maintenance
Neoplasms
Neurofibromatosis 1 Genes
Granulocyte-Macrophage Colony-Stimulating Factor Receptors
15 Citations (Scopus)

Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML

Kurata, M., Rathe, S., Bailey, N. J., Aumann, N. K., Jones, J. M., Veldhuijzen, G. W., Moriarity, B. S. & Largaespada, D. A., Nov 3 2016, In : Scientific Reports. 6, 36199.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Cytarabine
Guide RNA
Drug Resistance
Acute Myeloid Leukemia
2015
43 Citations (Scopus)

A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma

Mirabello, L., Koster, R., Moriarity, B. S., Spector, L. G., Meltzer, P. S., Gary, J., Machiela, M. J., Pankratz, N., Panagiotou, O. A., Largaespada, D., Wang, Z., Gastier-Foster, J. M., Gorlick, R., Khanna, C., de Toledo, S. R. C., Petrilli, A. S., Patiño-Garcia, A., Sierrasesúmaga, L., Lecanda, F., Andrulis, I. L. & 32 othersWunder, J. S., Gokgoz, N., Serra, M., Hattinger, C., Picci, P., Scotlandi, K., Flanagan, A. M., Tirabosco, R., Amary, M. F., Halai, D., Ballinger, M. L., Thomas, D. M., Davis, S., Barkauskas, D. A., Marina, N., Helman, L., Otto, G. M., Becklin, K. L., Wolf, N. K., Weg, M. T., Tucker, M., Wacholder, S., Fraumeni, J. F., Caporaso, N. E., Boland, J. F., Hicks, B. D., Vogt, A., Burdett, L., Yeager, M., Hoover, R. N., Chanock, S. J. & Savage, S. A., Sep 1 2015, In : Cancer discovery. 5, 9, p. 920-931 12 p.

Research output: Contribution to journalArticle

Osteosarcoma
Genome
Neoplasm Metastasis
Cause of Death
Genome-Wide Association Study
95 Citations (Scopus)

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

Moriarity, B. S., Otto, G. M., Rahrmann, E. P., Rathe, S. K., Wolf, N. K., Weg, M. T., Manlove, L. A., Larue, R. S., Temiz, N. A., Molyneux, S. D., Choi, K., Holly, K. J., Sarver, A. L., Scott, M. C., Forster, C. L., Modiano, J. F., Khanna, C., Hewitt, S. M., Khokha, R., Yang, Y. & 3 othersGorlick, R., Dyer, M. A. & Largaespada, D. A., May 27 2015, In : Nature Genetics. 47, 6, p. 615-624 10 p.

Research output: Contribution to journalArticle

Beauty
Osteosarcoma
Neoplasm Metastasis
Genes
Oncogenes
18 Citations (Scopus)

Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma

Becker, C. M., Oberoi, R. K., McFarren, S. J., Muldoon, D. M., Pafundi, D. H., Pokorny, J. L., Brinkmann, D. H., Ohlfest, J. R., Sarkaria, J. N., Largaespada, D. A. & Elmquist, W. F., Sep 1 2015, In : Neuro-Oncology. 17, 9, p. 1210-1219 10 p.

Research output: Contribution to journalArticle

Penetrance
Glioblastoma
Phosphatidylinositol 3-Kinases
P-Glycoprotein
Blood-Brain Barrier
11 Citations (Scopus)

Parthenolide prodrug LC-1 slows growth of intracranial glioma

Hexum, J. K., Becker, C. M., Kempema, A. M., Ohlfest, J. R., Largaespada, D. A. & Harki, D. A., May 26 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 12, p. 2493-2495 3 p., 22641.

Research output: Contribution to journalArticle

Prodrugs
Glioma
Tumors
Brain
Bearings (structural)
96 Citations (Scopus)

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

Zuckermann, M., Hovestadt, V., Knobbe-Thomsen, C. B., Zapatka, M., Northcott, P. A., Schramm, K., Belic, J., Jones, D. T. W., Tschida, B., Moriarity, B., Largaespada, D., Roussel, M. F., Korshunov, A., Reifenberger, G., Pfister, S. M., Lichter, P., Kawauchi, D. & Gronych, J., Jun 11 2015, In : Nature communications. 6, 7391.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
suppressors
tumor suppressor genes
Brain Neoplasms
genes
10 Citations (Scopus)

Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues

Kempema, A. M., Widen, J. C., Hexum, J. K., Andrews, T. E., Wang, D., Rathe, S. K., Meece, F. A., Noble, K. E., Sachs, Z., Largaespada, D. A. & Harki, D. A., Jul 23 2015, In : Bioorganic and Medicinal Chemistry. 23, 15, p. 4737-4745 9 p.

Research output: Contribution to journalArticle

Stem cells
Cells
Stem Cells
Myeloid Cells
Acute Myeloid Leukemia
23 Citations (Scopus)

Transposon mutagenesis screen identifies potential lung cancer drivers and CUL3 as a tumor suppressor

Dorr, C., Janik, C., Weg, M., Been, R. A., Bader, J., Kang, R., Ng, B., Foran, L., Landman, S. R., O'Sullivan, G., Steinbach, M. S., Sarver, A. L., Silverstein, K. A., Largaespada, D. A. & Starr, T., Aug 1 2015, In : Molecular Cancer Research. 13, 8, p. 1238-1247 10 p.

Research output: Contribution to journalArticle

Mutagenesis
Lung Neoplasms
Beauty
Non-Small Cell Lung Carcinoma
Neoplasms
2014
3 Citations (Scopus)

Antigen-specific culture of memory-like CD8 T cells for adoptive immunotherapy

Litterman, A. J., Zellmer, D. M., LaRue, R. S., Jameson, S. C. & Largaespada, D. A., Sep 1 2014, In : Cancer Immunology Research. 2, 9, p. 839-845 7 p.

Research output: Contribution to journalArticle

Adoptive Immunotherapy
T-Lymphocytes
Phenotype
Antigens
Interleukin-2
39 Citations (Scopus)

Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity

Watson, A. L., Anderson, L. K., Greeley, A. D., Keng, V. W., Rahrmann, E. P., Halfond, A. L., Powell, N. M., Collins, M. H., Rizvi, T., Moertel, C. L., Ratner, N. & Largaespada, D. A., Jan 1 2014, In : Oncotarget. 5, 6, p. 1502-1514 13 p.

Research output: Contribution to journalArticle

Schwann Cells
Neurilemmoma
Phosphatidylinositol 3-Kinases
Neurofibromatosis 1
Plexiform Neurofibroma
10 Citations (Scopus)

Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice

Been, R. A., Linden, M. A., Hager, C. J., DeCoursin, K. J., Abrahante - Llorens, J. E., Landman, S. R., Steinbach, M. S., Sarver, A. L., Largaespada, D. A. & Starr, T., May 14 2014, In : PloS one. 9, 5, e97280.

Research output: Contribution to journalArticle

Histiocytic Sarcoma
Beauty
sarcoma
transposons
Mutagenesis
7 Citations (Scopus)

HomeRun vector assembly system: A flexible and standardized cloning system for assembly of multi-modular DNA constructs

Li, M., Shukla, D., Rhodes, B. H., Lall, A., Shu, J., Moriarity, B. S. & Largaespada, D. A., Jun 24 2014, In : PloS one. 9, 6, e100948.

Research output: Contribution to journalArticle

Cloning
Organism Cloning
molecular cloning
DNA
Synthetic Biology
14 Citations (Scopus)

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Sachs, Z., LaRue, R. S., Nguyen, H. T., Sachs, K., Noble, K. E., Hassan, N. A. M., Diaz-Flores, E., Rathe, S. K., Sarver, A. L., Bendall, S. C., Ha, N. A., Diers, M. D., Nolan, G. P., Shannon, K. M. & Largaespada, D. A., Nov 20 2014, In : Blood. 124, 22, p. 3274-3283 10 p.

Research output: Contribution to journalArticle

Oncogenes
Acute Myeloid Leukemia
Gene expression
Leukemia
Stem cells
290 Citations (Scopus)

PVT1 dependence in cancer with MYC copy-number increase

Tseng, Y. Y., Moriarity, B. S., Gong, W., Akiyama, R., Tiwari, A., Kawakami, H., Ronning, P., Reuland, B., Guenther, K., Beadnell, T. C., Essig, J., Otto, G. M., O'Sullivan, M. G., Largaespada, D. A., Schwertfeger, K. L., Marahrens, Y., Kawakami, Y. & Bagchi, A., Jan 1 2014, In : Nature. 512, 1, p. 82-86 5 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Neoplasms
Genes
Proteins
myc Genes
11 Citations (Scopus)

Simple and efficient methods for enrichment and isolation of endonuclease modified cells

Moriarity, B. S., Rahrmann, E. P., Beckmann, D. A., Conboy, C. B., Watson, A. L., Carlson, D. F., Olson, E. R., Hyland, K. A., Fahrenkrug, S. C., Scott McIvor, R. & Largaespada, D. A., May 5 2014, In : PloS one. 9, 5, e96114.

Research output: Contribution to journalArticle

Endonucleases
Genes
Transcription
nucleases
cells
40 Citations (Scopus)

The role of KCNQ1 in mouse and human gastrointestinal cancers

Than, B. L. N., Goos, J. A. C. M., Sarver, A. L., O'Sullivan, G., Rod, A., Starr, T., Fijneman, R. J. A., Meijer, G. A., Zhao, L., Zhang, Y., Largaespada, D. A., Scott, P. M. & Cormier, R. T., Jul 17 2014, In : Oncogene. 33, 29, p. 3861-3868 8 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
Organoids
Colon
Genes
Small Intestine
18 Citations (Scopus)

Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis

Rahrmann, E. P., Moriarity, B. S., Otto, G. M., Watson, A. L., Choi, K., Collins, M. H., Wallace, M., Webber, B. R., Forster, C. L., Rizzardi, A. E., Schmechel, S. C., Ratner, N. & Largaespada, D. A., Jan 1 2014, In : American Journal of Pathology. 184, 7, p. 2082-2098 17 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Neurilemmoma
Peripheral Nerves
Epidermal Growth Factor Receptor
Schwann Cells
19 Citations (Scopus)

Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia

Rathe, S., Moriarity, B. S., Stoltenberg, C. B., Kurata, M., Aumann, N. K., Rahrmann, E. P., Bailey, N. J., Melrose, E. G., Beckmann, D. A., Liska, C. R. & Largaespada, D. A., Aug 13 2014, In : Scientific reports. 4, 6048.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Cytarabine
Drug Resistance
Acute Myeloid Leukemia
RNA
2013
10 Citations (Scopus)

Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination

Litterman, A. J., Dudek, A. Z. & Largaespada, D. A., Dec 18 2013, In : OncoImmunology. 2, 10, e26294.

Research output: Contribution to journalArticle

Alkylating Agents
Regulatory T-Lymphocytes
Antineoplastic Agents
Vaccination
Vaccines
47 Citations (Scopus)

Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance

Watson, A. L., Rahrmann, E. P., Moriarity, B. S., Choi, K., Conboy, C. B., Greeley, A. D., Halfond, A. L., Anderson, L. K., Wahl, B. R., Keng, V. W., Rizzardi, A. E., Forster, C. L., Collins, M. H., Sarver, A. L., Wallace, M. R., Schmechel, S. C., Ratner, N. & Largaespada, D. A., Jan 1 2013, In : Cancer Discovery. 3, 6, p. 675-689 15 p.

Research output: Contribution to journalArticle

Catenins
Schwann Cells
Neurilemmoma
Neurofibroma
Maintenance

Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.

Watson, A. L., Rahrmann, E. P., Moriarity, B. S., Choi, K., Conboy, C. B., Greeley, A. D., Halfond, A. L., Anderson, L. K., Wahl, B. R., Keng, V. W., Rizzardi, A. E., Forster, C. L., Collins, M. H., Sarver, A. L., Wallace, M. R., Schmechel, S. C., Ratner, N. & Largaespada, D. A., Jun 2013, In : Cancer Discovery. 3, 6, p. 674-689 16 p.

Research output: Contribution to journalArticle

Catenins
Schwann Cells
Neurilemmoma
Maintenance
Neurofibroma
4 Citations (Scopus)

Expression of FGFR3 and FGFR4 and clinical risk factors associated with progression-free survival in synovial sarcoma

Charbonneau, B., Vogel, R. I., Manivel, J. C., Rizzardi, A., Schmechel, S. C., Ognjanovic, S., Subramanian, S., Largaespada, D. A. & Weigel, B. J., Sep 1 2013, In : Human pathology. 44, 9, p. 1918-1926 9 p.

Research output: Contribution to journalArticle

Synovial Sarcoma
Disease-Free Survival
Neoplasms
Tumor Biomarkers
Sarcoma
88 Citations (Scopus)

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis

Rahrmann, E. P., Watson, A. L., Keng, V. W., Choi, K., Moriarity, B. S., Beckmann, D. A., Wolf, N. K., Sarver, A. L., Collins, M. H., Moertel, C. L., Wallace, M. R., Gel, B., Serra, E., Ratner, N. & Largaespada, D. A., Jul 1 2013, In : Nature Genetics. 45, 7, p. 756-766 11 p.

Research output: Contribution to journalArticle

Neurilemmoma
Carcinogenesis
Proto-Oncogenes
Genes
Beauty