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David A Largaespada

Accepting PhD Students

1990 …2024
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Projects 1999 2024

APOBEC MUTAGENESIS IN BREAST CANCER

Harris, R., Aihara, H., Harki, D. A., Largaespada, D. A. & Yee, D.

NIH NATIONAL CANCER INSTITUTE (NCI)

8/9/19 → 7/31/24

Project: Research project

Mutagenesis
Breast Neoplasms

Combating Cellular Senescence to Prevent Anthracycline Cardiotoxicity

Zordoky, B., Bartolomucci, A., Largaespada, D. A. & Sadak, K. T.

ST. BALDRICK'S FOUNDATION

7/1/19 → 6/30/20

Project: Research project

Cell Aging
Anthracyclines
Cardiotoxicity

Cancer Center Support Grant

Yee, D., AbuSalah, A. M., Basu, S., Beckman, K. B., Bielinsky, A. K., Cooley, S. A., De For, T. E., Falconer, S. N., Felices, M., Griffin, T. J., Hallstrom, T. C., Hatsukami, D. K., Hendrickson, E. A., Hirsch, B. A., Joseph, A. M., Kirstein, M. N., Konety, B. R., Koopmeiners, J., Kuntz, K. M., Lange, C. A., Largaespada, D. A., Le, C. T., LeBeau, A., Lindgren, B. R., Luo, X., Mc Carthy, J. B., McKenna, D. H., Miller, J. S., Moriarity, B. S., Nelson, H. H., O'Sullivan, G., Ondrey, F. G., Pennell, C. A., Petersen, A. J., Peterson, B. A., Peterson, L. A., Sarver, A. L., Shimizu, Y., Siegfried, J. M., Temiz, N. A., Turesky, R., Vogel, R., Wagner, J. E., Wang, J., Weigel, B. J., Weisdorf, D. J., Woo, J. & Yamamoto, M.

NIH NATIONAL CANCER INSTITUTE (NCI)

2/1/19 → 1/31/24

Project: Research project

Neoplasms

Functional Genomics of Cancer Progression

Largaespada, D. A.

AMERICAN CANCER SOCIETY, INC.

1/1/18 → 12/31/22

Project: Research project

Genomics
Neoplasms

High through-put combinatorial drug and target discovery

Largaespada, D. A.

Boston Children's Hospital

12/1/17 → 11/30/19

Project: Research project

Neurilemmoma
Drug Discovery

Research Output 1990 2019

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma

Diessner, B. J., Marko, T. A., Scott, R. M., Eckert, A. L., Stuebner, K. M., Hohenhaus, A. E., Selting, K. A., Largaespada, D. A., Modiano, J. & Spector, L. G., Jun 1 2019, In : Cancer medicine. 8, 6, p. 3216-3226 11 p.

Research output: Contribution to journal › Article

Open Access
Osteosarcoma
Dogs
Neoplasm Metastasis
Neoplasms
Canidae

CRISPR/Cas9-Based Positive Screens for Cancer-Related Traits

Slipek, N. J., Varshney, J. & Largaespada, D. A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 137-144 8 p. (Methods in Molecular Biology; vol. 1907).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Clustered Regularly Interspaced Short Palindromic Repeats
Genome
Cell Line
Atlases
Genomics
1 Citation (Scopus)

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Huang, M., Tailor, J., Zhen, Q., Gillmor, A. H., Miller, M. L., Weishaupt, H., Chen, J., Zheng, T., Nash, E. K., McHenry, L. K., An, Z., Ye, F., Takashima, Y., Clarke, J., Ayetey, H., Cavalli, F. M. G., Luu, B., Moriarity, B. S., Ilkhanizadeh, S., Chavez, L. & 18 others, Yu, C., Kurian, K. M., Magnaldo, T., Sevenet, N., Koch, P., Pollard, S. M., Dirks, P., Snyder, M. P., Largaespada, D. A., Cho, Y. J., Phillips, J. J., Swartling, F. J., Morrissy, A. S., Kool, M., Pfister, S. M., Taylor, M. D., Smith, A. & Weiss, W. A., Sep 5 2019, In : Cell Stem Cell. 25, 3, p. 433-446.e7

Research output: Contribution to journal › Article

Open Access
Neuroepithelial Cells
Medulloblastoma
Genetic Predisposition to Disease
Carcinogenesis
Stem Cells
2 Citations (Scopus)

Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis

Fan, Y., Bazai, S. K., Daian, F., Arechederra, M., Richelme, S., Temiz, N. A., Yim, A., Habermann, B. H., Dono, R., Largaespada, D. A. & Maina, F., Mar 1 2019, In : Journal of Hepatology. 70, 3, p. 470-482 13 p.

Research output: Contribution to journal › Article

Receptor Protein-Tyrosine Kinases
Mutagenesis
Carcinogenesis
Liver
Genes

HBx-K130M/V131I promotes liver cancer in transgenic mice via AKT/FOXO1 signaling pathway and arachidonic acid metabolism

Chiu, A. P., Tschida, B. R., Sham, T. T., Lo, L. H., Moriarity, B. S., Li, X. X., Lo, R. C., Hinton, D. E., Rowlands, D. K., Chan, C. O., Mok, D. K. W., Largaespada, D. A., Warner, N. & Keng, V. W., Jul 1 2019, In : Molecular Cancer Research. 17, 7, p. 1582-1593 12 p.

Research output: Contribution to journal › Article

Open Access
Liver Neoplasms
Arachidonic Acid
Transgenic Mice
Hepatocellular Carcinoma
Chronic Hepatitis B