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David A Largaespada

Accepting PhD Students

1990 …2022
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Projects 1999 2022

Functional Genomics of Cancer Progression

Largaespada, D. A.

AMERICAN CANCER SOCIETY, INC.

1/1/18 → 12/31/22

Project: Research project

Genomics
Neoplasms

High through-put combinatorial drug and target discovery

Largaespada, D. A.

CHILDREN'S HOSPITAL BOSTON

12/1/17 → 11/30/19

Project: Research project

Neurilemmoma
Drug Discovery

Sleeping Beauty for Cancer Gene Discovery

Largaespada, D. A.

Genentech, Inc.

10/25/17 → 10/24/20

Project: Research project

Beauty
Neoplasm Genes
Genetic Association Studies

Novel combined immunotherapeutic strategies for glioma:

Pluhar, L., Hunt, M., Largaespada, D. A., O'Sullivan, G. & Olin, M. R.

NIH NATIONAL CANCER INSTITUTE (NCI)

9/30/17 → 8/31/20

Project: Research project

Pets
Glioma
Animal Models
Dogs

Enhancing Pediatric Sarcoma Immunotherapy by Drug Induce

Largaespada, D. A.

ALEXS LEMONADE STAND FDN

9/1/16 → 8/31/18

Project: Research project

Sarcoma
Immunotherapy
Pediatrics
Pharmaceutical Preparations
Neoplasms

Research Output 1990 2018

1 Citations

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice

Riordan, J. D., Feddersen, C. R., Tschida, B. R., Beckmann, P. J., Keng, V. W., Linden, M. A., Amin, K., Stipp, C. S., Largaespada, D. A. & Dupuy, A. J. Mar 1 2018 In : Hepatology. 67, 3, p. 924-939 16 p.

Research output: Contribution to journal › Article

Hepatocellular Carcinoma
Mutation
Liver
Wounds and Injuries
Genes
1 Citations

Comparative transcriptome analysis quantifies immune cell transcript levels, metastatic progression, and survival in osteosarcoma

Scott, M. C., Temiz, N. A., Sarver, A. E., LaRue, R. S., Rathe, S. K., Varshney, J., Wolf, N. K., Moriarity, B. S., O'Brien, T. D., Spector, L. G., Largaespada, D. A., Modiano, J. F., Subramanian, S. & Sarver, A. L. Jan 15 2018 In : Cancer Research. 78, 2, p. 326-337 12 p.

Research output: Contribution to journal › Article

Gene Expression Profiling
Osteosarcoma
Survival
Multigene Family
Neoplasms
1 Citations

CRISPR/Cas9 library screening for drug target discovery

Kurata, M., Yamamoto, K., Moriarity, B. S., Kitagawa, M. & Largaespada, D. A. Feb 1 2018 In : Journal of Human Genetics. 63, 2, p. 179-186 8 p.

Research output: Contribution to journal › Review article

Clustered Regularly Interspaced Short Palindromic Repeats
Drug Discovery
Pharmaceutical Preparations
Essential Genes
Drug Resistance

Social stress shortens lifespan in mice

Razzoli, M., Nyuyki-Dufe, K., Gurney, A., Erickson, C., McCallum, J., Spielman, N., Marzullo, M., Patricelli, J., Kurata, M., Pope, E. A., Touma, C., Palme, R., Largaespada, D. A., Allison, D. B. & Bartolomucci, A. Aug 1 2018 In : Aging cell. 17, 4, e12778

Research output: Contribution to journal › Article

Cell Aging
Cardiovascular Diseases
Sinus of Valsalva
Life Expectancy
Aggression

Data Descriptor: Transcriptomic analysis of gene signatures associated with sickle pain

Paul, J. A., Aich, A., Abrahante, J. E., Wang, Y., LaRue, R. S., Rathe, S. K., Kalland, K., Mittal, A., Jha, R., Peng, F., Largaespada, D. A., Bagchi, A. & Gupta, K. May 16 2017 In : Scientific Data. 4, 170051

Research output: Contribution to journal › Article

Pain
Descriptors
pain
Signature
Genes