Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Center for Functional Genomics of Immunotherapy (CFGI)
Largaespada, D. A. (PI), Moriarity, B. S. (CoI) & Stromnes, I. M. (CoI)
3/1/24 → 3/31/26
Project: Research project
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Linking ex vivo to in vivo patient-specific models of malignant peripheral nerve sheath tumors
Wood, D. K. (PI) & Largaespada, D. A. (CoI)
1/1/24 → 12/31/26
Project: Research project
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Leveraging a precision medicine platform to understand drug sensitivities in NF1 and PRC2 deficient malignant peripheral nerve sheath tumors
Largaespada, D. A. (PI)
8/1/23 → 7/31/26
Project: Research project
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Deconvoluting the Ewing sarcoma genetic program using ancestry-informed human iPSC modeling
Webber, B. R. (PI), Dutton, J. R. (CoI), Largaespada, D. A. (CoI) & Spector, L. G. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
4/7/23 → 3/31/28
Project: Research project
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Mechanistic insight into genome stability pathways
Largaespada, D. A. (PI)
UNIVERSITY OF VIRGINIA, NIH NIGMS NATL INST OF GENERAL
11/15/22 → 5/31/26
Project: Research project
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Transposon mutagenesis-guided crispr/cas9 screening strongly implicates dysregulation of hippo/yap signaling in malignant peripheral nerve sheath tumor development
Vélez-Reyes, G. L., Koes, N., Ryu, J. H., Kaufmann, G., Berner, M., Weg, M. T., Wolf, N. K., Rathe, S. K., Ratner, N., Moriarity, B. S. & Largaespada, D. A., Apr 1 2021, In: Cancers. 13, 7, 1584.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies
Skeate, J. G., Pomeroy, E. J., Slipek, N. J., Jones, B. J., Wick, B. J., Chang, J. W., Lahr, W. S., Stelljes, E. M., Patrinostro, X., Barnes, B., Zarecki, T., Krueger, J. B., Bridge, J. E., Robbins, G. M., McCormick, M. D., Leerar, J. R., Wenzel, K. T., Hornberger, K. M., Walker, K. & Smedley, D. & 4 others, , Jun 5 2024, In: Molecular Therapy. 32, 6, p. 1817-1834 18 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
NF1-dependent disruption of the blood-nerve-barrier is improved by blockade of P2RY14
Patritti-Cram, J., Rahrmann, E. P., Rizvi, T. A., Scheffer, K. C., Phoenix, T. N., Largaespada, D. A. & Ratner, N., Jul 19 2024, In: iScience. 27, 7, 110294.Research output: Contribution to journal › Article › peer-review
Open Access -
Radiation Therapy and Myeloid-Derived Suppressor Cells: Breaking Down Their Cancerous Partnership
Bergerud, K. M. B., Berkseth, M., Pardoll, D. M., Ganguly, S., Kleinberg, L. R., Lawrence, J., Odde, D. J., Largaespada, D. A., Terezakis, S. A. & Sloan, L., May 1 2024, In: International Journal of Radiation Oncology Biology Physics. 119, 1, p. 42-55 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access5 Scopus citations -
Retraction Note: Pluripotency of mesenchymal stem cells derived from adult marrow (Nature, (2002), 418, 6893, (41-49), 10.1038/nature00870)
Jiang, Y., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., Du, J., Aldrich, S., Lisberg, A., Low, W. C., Largaespada, D. A. & Verfaillie, C. M., Jun 27 2024, In: Nature. 630, 8018, p. 1020 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access1 Scopus citations
Press/Media
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HI’s new chief of staff looking to help build the Institute to even loftier heights
Fedie, E., Bode, A. M., Seabloom, D. E., Voytas, D. F. & Largaespada, D. A.
7/15/20
1 item of Media coverage
Press/Media: Expert Comment or Interview