Photo of David A Largaespada
Contact Expert

View Scopus Profile

David A Largaespada

Accepting PhD Students

1990 …2024
If you made any changes in Pure, your changes will be visible here soon.

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 19 Similar Profiles
Beauty Medicine & Life Sciences
Genes Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Insertional Mutagenesis Medicine & Life Sciences
Mutagenesis Medicine & Life Sciences
Neoplasm Genes Medicine & Life Sciences
Acute Myeloid Leukemia Medicine & Life Sciences
Myeloid Leukemia Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1999 2024

Recurrent tumor-specific transcripts as a source of neoantigens for NF1-associated malignant peripheral nerve sheath tumor immunoprevention

Largaespada, D. A.

NIH NATIONAL CANCER INSTITUTE (NCI)

9/25/19 → 8/31/21

Project: Research project

Neurilemmoma
Neoplasms

APOBEC MUTAGENESIS IN BREAST CANCER

Harris, R., Aihara, H., Harki, D. A., Largaespada, D. A. & Yee, D.

NIH NATIONAL CANCER INSTITUTE (NCI)

8/9/19 → 7/31/24

Project: Research project

Mutagenesis
Breast Neoplasms

Combating Cellular Senescence to Prevent Anthracycline Cardiotoxicity

Zordoky, B., Bartolomucci, A., Largaespada, D. A. & Sadak, K. T.

ST. BALDRICK'S FOUNDATION

7/1/19 → 6/30/20

Project: Research project

Cell Aging
Anthracyclines
Cardiotoxicity

Cancer Center Support Grant

Yee, D., AbuSalah, A. M., Basu, S., Beckman, K. B., Bielinsky, A. K., Cooley, S. A., De For, T. E., Falconer, S. N., Felices, M., Griffin, T. J., Hallstrom, T. C., Hatsukami, D. K., Hendrickson, E. A., Hirsch, B. A., Joseph, A. M., Kirstein, M. N., Konety, B. R., Koopmeiners, J., Kuntz, K. M., Lange, C. A., Largaespada, D. A., Le, C. T., LeBeau, A., Lindgren, B. R., Luo, X., Mc Carthy, J. B., McKenna, D. H., Miller, J. S., Moriarity, B. S., Nelson, H. H., O'Sullivan, G., Ondrey, F. G., Pennell, C. A., Petersen, A. J., Peterson, B. A., Peterson, L. A., Sarver, A. L., Shimizu, Y., Siegfried, J. M., Temiz, N. A., Turesky, R., Vogel, R., Wagner, J. E., Wang, J., Weigel, B. J., Weisdorf, D. J., Woo, J. & Yamamoto, M.

NIH NATIONAL CANCER INSTITUTE (NCI)

2/1/19 → 1/31/24

Project: Research project

Neoplasms

Development of Mutation Suppression Therapy in a Swine Model of NF1

Largaespada, D. A., Kirstein, M. N. & Moertel, C. L.

Recombinetics, Inc.

2/1/19 → 1/31/22

Project: Research project

Swine
Mutation
Therapeutics

Research Output 1990 2019

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma

Diessner, B. J., Marko, T. A., Scott, R. M., Eckert, A. L., Stuebner, K. M., Hohenhaus, A. E., Selting, K. A., Largaespada, D. A., Modiano, J. & Spector, L. G., Jun 2019, In : Cancer medicine. 8, 6, p. 3216-3226 11 p.

Research output: Contribution to journal › Article

Open Access
Osteosarcoma
Dogs
Neoplasm Metastasis
Neoplasms
Canidae
1 Citation (Scopus)

CRISPR/Cas9-Based Positive Screens for Cancer-Related Traits

Slipek, N. J., Varshney, J. & Largaespada, D. A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 137-144 8 p. (Methods in Molecular Biology; vol. 1907).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Clustered Regularly Interspaced Short Palindromic Repeats
Genome
Cell Line
Atlases
Genomics
3 Citations (Scopus)

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Huang, M., Tailor, J., Zhen, Q., Gillmor, A. H., Miller, M. L., Weishaupt, H., Chen, J., Zheng, T., Nash, E. K., McHenry, L. K., An, Z., Ye, F., Takashima, Y., Clarke, J., Ayetey, H., Cavalli, F. M. G., Luu, B., Moriarity, B. S., Ilkhanizadeh, S., Chavez, L. & 18 others, Yu, C., Kurian, K. M., Magnaldo, T., Sevenet, N., Koch, P., Pollard, S. M., Dirks, P., Snyder, M. P., Largaespada, D. A., Cho, Y. J., Phillips, J. J., Swartling, F. J., Morrissy, A. S., Kool, M., Pfister, S. M., Taylor, M. D., Smith, A. & Weiss, W. A., Sep 5 2019, In : Cell Stem Cell. 25, 3, p. 433-446.e7

Research output: Contribution to journal › Article

Open Access
Neuroepithelial Cells
Medulloblastoma
Genetic Predisposition to Disease
Carcinogenesis
Stem Cells
2 Citations (Scopus)

Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis

Fan, Y., Bazai, S. K., Daian, F., Arechederra, M., Richelme, S., Temiz, N. A., Yim, A., Habermann, B. H., Dono, R., Largaespada, D. A. & Maina, F., Mar 1 2019, In : Journal of Hepatology. 70, 3, p. 470-482 13 p.

Research output: Contribution to journal › Article

Receptor Protein-Tyrosine Kinases
Mutagenesis
Carcinogenesis
Liver
Genes
1 Citation (Scopus)

HBx-K130M/V131I promotes liver cancer in transgenic mice via AKT/FOXO1 signaling pathway and arachidonic acid metabolism

Chiu, A. P., Tschida, B. R., Sham, T. T., Lo, L. H., Moriarity, B. S., Li, X. X., Lo, R. C., Hinton, D. E., Rowlands, D. K., Chan, C. O., Mok, D. K. W., Largaespada, D. A., Warner, N. & Keng, V. W., Jul 1 2019, In : Molecular Cancer Research. 17, 7, p. 1582-1593 12 p.

Research output: Contribution to journal › Article

Open Access
Liver Neoplasms
Arachidonic Acid
Transgenic Mice
Hepatocellular Carcinoma
Chronic Hepatitis B