David A Largaespada

Accepting PhD Students

1990 …2024
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Projects 1999 2024

Genomics
Neoplasms
Neurilemmoma
Drug Discovery
Beauty
Neoplasm Genes
Genetic Association Studies
Pets
Glioma
Animal Models
Dogs

Research Output 1990 2019

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma

Diessner, B. J., Marko, T. A., Scott, R. M., Eckert, A. L., Stuebner, K. M., Hohenhaus, A. E., Selting, K. A., Largaespada, D. A., Modiano, J. & Spector, L. G., Jun 1 2019, In : Cancer medicine. 8, 6, p. 3216-3226 11 p.

Research output: Contribution to journalArticle

Open Access
Osteosarcoma
Dogs
Neoplasm Metastasis
Neoplasms
Canidae

CRISPR/Cas9-Based Positive Screens for Cancer-Related Traits

Slipek, N. J., Varshney, J. & Largaespada, D. A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 137-144 8 p. (Methods in Molecular Biology; vol. 1907).

Research output: Chapter in Book/Report/Conference proceedingChapter

Clustered Regularly Interspaced Short Palindromic Repeats
Genome
Cell Line
Atlases
Genomics
1 Citation (Scopus)

Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis

Fan, Y., Bazai, S. K., Daian, F., Arechederra, M., Richelme, S., Temiz, N. A., Yim, A., Habermann, B. H., Dono, R., Largaespada, D. A. & Maina, F., Mar 1 2019, In : Journal of Hepatology. 70, 3, p. 470-482 13 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Mutagenesis
Carcinogenesis
Liver
Genes

HBx-K130M/V131I promotes liver cancer in transgenic mice via AKT/FOXO1 signaling pathway and arachidonic acid metabolism

Chiu, A. P., Tschida, B. R., Sham, T. T., Lo, L. H., Moriarity, B. S., Li, X. X., Lo, R. C., Hinton, D. E., Rowlands, D. K., Chan, C. O., Mok, D. K. W., Largaespada, D. A., Warner, N. & Keng, V. W., Jul 1 2019, In : Molecular Cancer Research. 17, 7, p. 1582-1593 12 p.

Research output: Contribution to journalArticle

Open Access
Liver Neoplasms
Arachidonic Acid
Transgenic Mice
Hepatocellular Carcinoma
Chronic Hepatitis B
4 Citations (Scopus)

Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas

Rathe, S., Popescu, F. E., Johnson, J. E., Watson, A. L., Marko, T. A., Moriarity, B. S., Ohlfest, J. R. & Largaespada, D. A., Dec 1 2019, In : Scientific reports. 9, 1, 358.

Research output: Contribution to journalArticle

Osteosarcoma
RNA Sequence Analysis
Gene Fusion
Immunotherapy
Canidae