20032020

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Article
2020

Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice

Bosnakovski, D., Shams, A. S., Yuan, C., da Silva, M. T., Ener, E. T., Baumann, C. W., Lindsay, A. J., Verma, M., Asakura, A., Lowe, D. A. & Kyba, M., May 1 2020, In : Journal of Clinical Investigation. 130, 5, p. 2465-2477 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

Bosnakovski, D., da Silva, M. T., Sunny, S. T., Ener, E. T., Toso, E. A., Yuan, C., Cui, Z., Walters, M. A., Jadhav, A. & Kyba, M., Sep 11 2019, In : Science advances. 5, 9, eaaw7781.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Contemporary Formulations for Drug Delivery of Anticancer Bioactive Compounds

Ackova, D. G., Smilkov, K. & Bosnakovski, D., Jan 1 2019, In : Recent Patents on Anti-Cancer Drug Discovery. 14, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

n-3 polyunsaturated fatty acids provoke a specific transcriptional profile in rabbit adipose-derived stem cells in vitro

Vackova, E., Bosnakovski, D., Bjørndal, B., Yonkova, P., Grigorova, N., Ivanova, Z., Penchev, G., Simeonova, G., Miteva, L., Milanova, A., Vlaykova, T., Stanilova, S. & Penchev Georgiev, I., Jan 1 2019, In : Journal of Animal Physiology and Animal Nutrition. 103, 3, p. 925-934 10 p.

Research output: Contribution to journalArticle

2018

Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA

Lee, J. K., Bosnakovski, D., Toso, E. A., Dinh, T., Banerjee, S., Bohl, T. E., Shi, K., Orellana, K., Kyba, M. & Aihara, H., Dec 11 2018, In : Cell reports. 25, 11, p. 2955-2962.e3

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression

Bosnakovski, D., Gearhart, M. D., Toso, E. A., Ener, E. T., Choi, S. H. & Kyba, M., Dec 1 2018, In : Scientific reports. 8, 1, 16957.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2017

Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model

Bosnakovski, D., Chan, S. S. K., Recht, O. O., Hartweck, L. M., Gustafson, C. J., Athman, L. L., Lowe, D. A. & Kyba, M., Dec 1 2017, In : Nature communications. 8, 1, 550.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy

Bosnakovski, D., Gearhart, M. D., Toso, E. A., Recht, O. O., Cucak, A., Jain, A. K., Barton, M. C. & Kyba, M., Oct 1 2017, In : DMM Disease Models and Mechanisms. 10, 10, p. 1211-1216 6 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain

Bosnakovski, D., Toso, E. A., Hartweck, L. M., Magli, A., Lee, H. A., Thompson, E. R., Dandapat, A., Perlingeiro, R. C. R. & Kyba, M., Jan 1 2017, In : Journal of cell science. 130, 21, p. 3685-3697 13 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2016

Adipogenic potential of stem cells derived from rabbit subcutaneous and visceral adipose tissue in vitro

Vachkova, E., Bosnakovski, D., Yonkova, P., Grigorova, N., Ivanova, Z., Todorov, P., Penchev, G., Milanova, A., Simeonova, G., Stanilova, S. & Georgiev, I. P., Sep 1 2016, In : In Vitro Cellular and Developmental Biology - Animal. 52, 8, p. 829-837 9 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes

Choi, S. H., Gearhart, M. D., Cui, Z., Bosnakovski, D., Kim, M., Schennum, N. & Kyba, M., Jun 20 2016, In : Nucleic acids research. 44, 11, p. 5161-5173 13 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

Perspectives in engineered mesenchymal stem/stromal cells based anti- cancer drug delivery systems

Ackova, D. G., Kanjevac, T., Rimondini, L. & Bosnakovski, D., Feb 1 2016, In : Recent Patents on Anti-Cancer Drug Discovery. 11, 1, p. 98-111 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen

Choi, S. H., Bosnakovski, D., Strasser, J. M., Toso, E. A., Walters, M. A. & Kyba, M., Aug 1 2016, In : Journal of Biomolecular Screening. 21, 7, p. 680-688 9 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2014

Dominant Lethal Pathologies in Male Mice Engineered to Contain an X-Linked DUX4 Transgene

Dandapat, A., Bosnakovski, D., Hartweck, L. M., Arpke, R. W., Baltgalvis, K. A., Vang, D., Baik, J., Darabi, R., Perlingeiro, R. C. R., Hamra, F. K., Gupta, K., Lowe, D. A. & Kyba, M., Jan 1 2014, In : Cell reports. 8, 5, p. 1484-1496 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity

Bosnakovski, D., Choi, S. H., Strasser, J. M., Toso, E. A., Walters, M. A. & Kyba, M., Feb 1 2014, In : Skeletal Muscle. 4, 1, 4.

Research output: Contribution to journalArticle

27 Scopus citations
2013
7 Scopus citations

Mesenchymal stem cells for anti-cancer drug delivery

Gjorgieva, D., Zaidman, N. & Bosnakovski, D., Nov 26 2013, In : Recent Patents on Anti-Cancer Drug Discovery. 8, 3, p. 310-318 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2012

Advancing with ceramic biocomposites for bone graft implants

Zaidman, N. & Bosnakovski, D., Jan 1 2012, In : Recent Patents on Regenerative Medicine. 2, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2011

Decreased proliferation Kinetics of mouse myoblasts overexpressing FRG1

Chen, S. C., Frett, E., Marx, J., Bosnakovski, D., Reed, X., Kyba, M. & Kennedy, B. K., 2011, In : PloS one. 6, 5, e19780.

Research output: Contribution to journalArticle

9 Scopus citations

Functional Myogenic Engraftment from Mouse iPS Cells

Darabi, R., Pan, W., Bosnakovski, D., Baik, J., Kyba, M. & Perlingeiro, R. C. R., Nov 1 2011, In : Stem Cell Reviews and Reports. 7, 4, p. 948-957 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

Inducible cassette exchange: A rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells

Iacovino, M., Bosnakovski, D., Fey, H., Rux, D., Bajwa, G., Mahen, E., Mitanoska, A., Xu, Z. & Kyba, M., Oct 2011, In : STEM CELLS. 29, 10, p. 1580-1588 9 p.

Research output: Contribution to journalArticle

92 Scopus citations
2009

Biphasic myopathic phenotype of mouse DUX, an ORF within conserved FSHD-related repeats

Bosnakovski, D., Daughters, R. S., Xu, Z., Slack, J. M. W. & Kyba, M., Sep 16 2009, In : PloS one. 4, 9, e7003.

Research output: Contribution to journalArticle

41 Scopus citations

Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery

Gang, E. J., Darabi, R., Bosnakovski, D., Xu, Z., Kamm, K. E., Kyba, M. & Perlingeiro, R. C. R., Sep 10 2009, In : Experimental Cell Research. 315, 15, p. 2624-2636 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2008

An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies

Bosnakovski, D., Xu, Z., Ji Gang, E., Galindo, C. L., Liu, M., Simsek, T., Garner, H. R., Agha-Mohammadi, S., Tassin, A., Coppée, F., Belayew, A., Perlingeiro, R. R. & Kyba, M., Oct 22 2008, In : EMBO Journal. 27, 20, p. 2766-2779 14 p.

Research output: Contribution to journalArticle

170 Scopus citations

DUX4c, an FSHD candidate gene, interferes with myogenic regulators and abolishes myoblast differentiation

Bosnakovski, D., Lamb, S., Simsek, T., Xu, Z., Belayew, A., Perlingeiro, R. & Kyba, M., Nov 1 2008, In : Experimental Neurology. 214, 1, p. 87-96 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Pax3 activation promotes the differentiation of mesenchymal stem cells toward the myogenic lineage

Gang, E. J., Bosnakovski, D., Simsek, T., To, K. & Perlingeiro, R. C. R., May 1 2008, In : Experimental Cell Research. 314, 8, p. 1721-1733 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Prospective isolation of skeletal muscle stem cells with a Pax7 reporter

Bosnakovski, D., Xu, Z., Li, W., Thet, S., Cleaver, O., Perlingeiro, R. C. R. & Kyba, M., Dec 1 2008, In : STEM CELLS. 26, 12, p. 3194-3204 11 p.

Research output: Contribution to journalArticle

106 Scopus citations

White fat progenitor cells reside in the adipose vasculature

Tang, W., Zeve, D., Suh, J. M., Bosnakovski, D., Kyba, M., Hammer, R. E., Tallquist, M. D. & Graff, J. M., Oct 24 2008, In : Science. 322, 5901, p. 583-586 4 p.

Research output: Contribution to journalArticle

719 Scopus citations
2007

SSEA-4 identifies mesenchymal stem cells from bone marrow

Gang, E. J., Bosnakovski, D., Figueiredo, C. A., Visser, J. W. & Perlingeiro, R. C. R., Feb 15 2007, In : Blood. 109, 4, p. 1743-1751 9 p.

Research output: Contribution to journalArticle

419 Scopus citations
2006

Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells (MSCs) in different hydrogels: Influence of collagen type II extracellular matrix on MSC chondrogenesis

Bosnakovski, D., Mizuno, M., Kim, G., Takagi, S., Okumura, M. & Fujinaga, T., Apr 20 2006, In : Biotechnology and bioengineering. 93, 6, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

357 Scopus citations

Gene expression profile of bovine bone marrow mesenchymal stem cell during spontaneous chondrogenic differentiation in pellet culture system

Bosnakovski, D., Mizuno, M., Kim, G., Takagi, S., Okumura, M. & Fujinaga, T., Feb 1 2006, In : Japanese Journal of Veterinary Research. 53, 3-4, p. 127-139 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2005

Isolation and multilineage differentiation of bovine bone marrow mesenchymal stem cells

Bosnakovski, D., Mizuno, M., Kim, G., Takagi, S., Okumura, M. & Fujinaga, T., Feb 1 2005, In : Cell and Tissue Research. 319, 2, p. 243-253 11 p.

Research output: Contribution to journalArticle

166 Scopus citations

Matrix metalloproteinase inhibitor RECK expression in canine tumors

Takagi, S., Kato, Y., Asano, K., Ohsaki, T., Bosnakovski, D., Hoshino, Y., Okumura, M., Kadosawa, T. & Fujinaga, T., Aug 1 2005, In : Journal of Veterinary Medical Science. 67, 8, p. 761-767 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Molecular cloning of canine membrane-anchored inhibitor of matrix metalloproteinase, RECK

Takagi, S., Kitamura, T., Hosaka, Y., Ohsaki, T., Bosnakovski, D., Kadosawa, T., Okumura, M. & Fujinaga, T., Apr 1 2005, In : Journal of Veterinary Medical Science. 67, 4, p. 385-391 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2004

Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells in pellet cultural system

Bosnakovski, D., Mizuno, M., Kim, G., Ishiguro, T., Okumura, M., Iwanaga, T., Kadosawa, T. & Fujinaga, T., May 1 2004, In : Experimental Hematology. 32, 5, p. 502-509 8 p.

Research output: Contribution to journalArticle

144 Scopus citations

Regeneration of cartilage tissue by autologous chondrocytes transplantation for cartilage defects in a experimental bovine model

Kim, G., Okumura, M., Bosnakovski, D., Ishiguro, T., Kadosawa, T. & Fujinaga, T., Mar 1 2004, In : Journal of Veterinary Medical Science. 66, 3, p. 263-267 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2003

Biological properties of allogenic articular chondrocytes on the surface of bovine cartilage explants in vitro

Kim, G., Okumura, M., Bosnakovski, D., Ishiguro, T., Kadosawa, T. & Fujinaga, T., Oct 1 2003, In : Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine. 50, 8, p. 418-423 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Effects of ascorbic acid on proliferation and biological properties of bovine chondrocytes in alginate beads

Kim, G., Okumura, M., Bosnakovski, D., Ishiguro, T., Park, C. H., Kadosawa, T. & Fujinaga, T., Aug 1 2003, In : Japanese Journal of Veterinary Research. 51, 2, p. 83-94 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Relationship of Disease Progression and Plasma Histamine Concentrations in 11 Dogs with Mast Cell Tumors

Ishiguro, T., Kadosawa, T., Takagi, S., Kim, G., Ohsaki, T., Bosnakovski, D., Okumura, M. & Fujinaga, T., Mar 1 2003, In : Journal of veterinary internal medicine. 17, 2, p. 194-198 5 p.

Research output: Contribution to journalArticle

31 Scopus citations