Daniel L Mueller

MD, Professor, Director Rheumatic and Autoimmune Diseases

1989 …2024
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Personal profile

Personal profile

I am currently a Professor of Medicine and Director of Rheumatic and Autoimmune Diseases. I am also a Core Faculty member within the Center for Immunology, where I lead its Center for Autoimmune Diseases Research Program. Finally, I am an active clinician in the practice of Rheumatology, with a focus on inflammatory arthritis. I hold the John F. Finn Arthritis Foundation Land Grant Chair.

My research program examines the regulation of CD4 T cell and B cell antigen responsiveness and immune self-tolerance in individuals prone to the development of autoimmune arthritis. This includes the investigation of CD4 T cell anergy induction and Foxp3+ Treg cell generation in mouse models of arthritis (Martinez RJ et al.; Taylor JJ et al.; Kalekar L et al.), as well investigations of self-antigen driven B cell activation, Ig gene recombination, and differentiation in humans with rheumatoid arthritis (Lloyd KA et al.; Steen J. et al.; Titcombe PJ et al.).

Research interests

  • Immunological Tolerance
  • Rheumatology

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Projects 2007 2024

Research Output 1989 2020

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

ElTanbouly, M. A., Zhao, Y., Nowak, E., Li, J., Schaafsma, E., Le Mercier, I., Ceeraz, S., Lines, J. L., Peng, C., Carriere, C., Huang, X., Day, M., Koehn, B., Lee, S. W., Morales, M. S., Hogquist, K. A., Jameson, S. C., Mueller, D., Rothstein, J., Blazar, B. R. & 2 others, Cheng, C. & Noelle, R. J., Jan 17 2020, In : Science. 367, 6475, eaay0524.

Research output: Contribution to journalArticle

Peripheral Tolerance
T-Lymphocytes
Autoantigens
T-Lymphocyte Subsets
Autoimmunity

Adenosine 2a Receptor Signal Blockade of Murine Autoimmune Arthritis via Inhibition of Pathogenic Germinal Center–Follicular Helper T Cells

Schmiel, S. E., Kalekar, L. A., Zhang, N., Blankespoor, T. W., Robinson, L. J. & Mueller, D. L., May 2019, In : Arthritis and Rheumatology. 71, 5, p. 773-783 11 p.

Research output: Contribution to journalArticle

Purinergic P1 Receptors
Helper-Inducer T-Lymphocytes
Germinal Center
Glucose-6-Phosphate Isomerase
Arthritis
1 Citation (Scopus)
Germinal Center
Opioid Analgesics
Oxycodone
Vaccines
Haptens
9 Citations (Scopus)

Differential ACPA binding to nuclear antigens reveals a PAD-independent pathway and a distinct subset of acetylation cross-reactive autoantibodies in rheumatoid arthritis

Lloyd, K. A., Wigerblad, G., Sahlström, P., Garimella, M. G., Chemin, K., Steen, J., Titcombe, P. J., Marklein, B., Zhou, D., Stålesen, R., Ossipova, E., Lundqvist, C., Ekwall, O., Rönnelid, J., Mueller, D. L., Karlsson, M. C. I., Kaplan, M. J., Skriner, K., Klareskog, L., Wermeling, F. & 2 others, Malmström, V. & Grönwall, C., Jan 1 2019, In : Frontiers in immunology. 10, JAN

Research output: Contribution to journalArticle

Open Access
Nuclear Antigens
Acetylation
Protein Binding
Autoantibodies
Rheumatoid Arthritis
13 Citations (Scopus)

Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell–Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis

Steen, J., Forsström, B., Sahlström, P., Odowd, V., Israelsson, L., Krishnamurthy, A., Badreh, S., Mathsson Alm, L., Compson, J., Ramsköld, D., Ndlovu, W., Rapecki, S., Hansson, M., Titcombe, P. J., Bang, H., Mueller, D. L., Catrina, A. I., Grönwall, C., Skriner, K., Nilsson, P. & 3 others, Lightwood, D., Klareskog, L. & Malmström, V., Feb 1 2019, In : Arthritis and Rheumatology. 71, 2, p. 196-209 14 p.

Research output: Contribution to journalArticle

Amino Acid Motifs
Blood Proteins
Rheumatoid Arthritis
Monoclonal Antibodies
Autoantibodies