Daniel L Mueller

MD, Professor, Director Rheumatic and Autoimmune Diseases

1989 …2020

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Personal profile

Personal profile

I am currently a Professor of Medicine and Director of Rheumatic and Autoimmune Diseases. I am also a Core Faculty member within the Center for Immunology, where I lead its Center for Autoimmune Diseases Research Program. Finally, I am an active clinician in the practice of Rheumatology, with a focus on inflammatory arthritis. I hold the John F. Finn Arthritis Foundation Land Grant Chair.

My research program examines the regulation of CD4 T cell and B cell antigen responsiveness and immune self-tolerance in individuals prone to the development of autoimmune arthritis. This includes the investigation of CD4 T cell anergy induction and Foxp3+ Treg cell generation in mouse models of arthritis (Martinez RJ et al.; Taylor JJ et al.; Kalekar L et al.), as well investigations of self-antigen driven B cell activation, Ig gene recombination, and differentiation in humans with rheumatoid arthritis (Lloyd KA et al.; Steen J. et al.; Titcombe PJ et al.).

Research interests

  • Immunological Tolerance
  • Rheumatology

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Projects

Research Output

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

ElTanbouly, M. A., Zhao, Y., Nowak, E., Li, J., Schaafsma, E., Le Mercier, I., Ceeraz, S., Lines, J. L., Peng, C., Carriere, C., Huang, X., Day, M., Koehn, B., Lee, S. W., Morales, M. S., Hogquist, K. A., Jameson, S. C., Mueller, D., Rothstein, J., Blazar, B. R. & 2 others, Cheng, C. & Noelle, R. J., Jan 17 2020, In : Science. 367, 6475, eaay0524.

Research output: Contribution to journalArticle

  • 6 Scopus citations

    Adenosine 2a Receptor Signal Blockade of Murine Autoimmune Arthritis via Inhibition of Pathogenic Germinal Center–Follicular Helper T Cells

    Schmiel, S. E., Kalekar, L. A., Zhang, N., Blankespoor, T. W., Robinson, L. J. & Mueller, D. L., May 2019, In : Arthritis and Rheumatology. 71, 5, p. 773-783 11 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Differential ACPA binding to nuclear antigens reveals a PAD-independent pathway and a distinct subset of acetylation cross-reactive autoantibodies in rheumatoid arthritis

    Lloyd, K. A., Wigerblad, G., Sahlström, P., Garimella, M. G., Chemin, K., Steen, J., Titcombe, P. J., Marklein, B., Zhou, D., Stålesen, R., Ossipova, E., Lundqvist, C., Ekwall, O., Rönnelid, J., Mueller, D. L., Karlsson, M. C. I., Kaplan, M. J., Skriner, K., Klareskog, L., Wermeling, F. & 2 others, Malmström, V. & Grönwall, C., 2019, In : Frontiers in immunology. 10, JAN, 3033.

    Research output: Contribution to journalArticle

    Open Access
  • 12 Scopus citations

    Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell–Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis

    Steen, J., Forsström, B., Sahlström, P., Odowd, V., Israelsson, L., Krishnamurthy, A., Badreh, S., Mathsson Alm, L., Compson, J., Ramsköld, D., Ndlovu, W., Rapecki, S., Hansson, M., Titcombe, P. J., Bang, H., Mueller, D. L., Catrina, A. I., Grönwall, C., Skriner, K., Nilsson, P. & 3 others, Lightwood, D., Klareskog, L. & Malmström, V., Feb 1 2019, In : Arthritis and Rheumatology. 71, 2, p. 196-209 14 p.

    Research output: Contribution to journalArticle

    Open Access
  • 22 Scopus citations