1986 …2023
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Personal profile

Research interests

Dan’s laboratory has a long-standing interest in regenerative and stem cell biology with a focus on the heart and skeletal muscle. In their studies of the heart and skeletal muscle, the Garry laboratory utilizes an array of technologies including gene disruption strategies, transgenesis, single cell genome analysis, gene editing (TALEN and CRISPR technologies), inducible ES/EB model systems, hiPSC technologies, FACS and other cellular, biochemical and molecular biological techniques. In addition, their use of lower organisms such as zebrafish and newt, which are highly regenerative model systems have successfully uncovered critical regenerative factors. Human iPSCs are another important model for cardiovascular disease investigation for the lab. Using these technologies, the Garry lab was among the first to discover the molecular markers of stem cell populations that regulate critical networks during heart and skeletal muscle development and regeneration. For example, their studies have uncovered novel Ets and Forkhead transcription factors, microRNAs and signaling pathways that direct fate determination of stem cell populations. The manipulation of these pathways using chemical genetics and molecular technologies has provided a platform focused on rebuilding and repairing the injured heart and skeletal muscle.
Dan Garry (garry@umn.edu) is the Director of the Lillehei Heart Institute and the Paul and Sheila Wellstone Muscular Dystrophy Center at the University of Minnesota. Having obtained his M.D./Ph.D. degrees at the University of Minnesota, he completed postdoctoral research training at Cold Spring Harbor Laboratory and the University of Texas Southwestern Medical Center in Dallas. He served as the Director for the Center for Cardiac Regeneration and Stem Cell Biology at UT Southwestern, and he was the holder of the Gail Griffiths Hill Endowed Chair in Cardiology. In 2007, Dan was recruited to lead the cardiovascular enterprise at the University of Minnesota and was the recipient of the St. Jude Endowed Chair in Cardiovascular Sciences. He is a physician scientist and practices clinically in the field of advanced heart failure, mechanical circulatory support, and cardiac transplantation.
Dan has served as a mentor to more than 40 graduate students, postdoctoral fellows, and clinical fellows, and has successfully directed their sponsored research projects and career development. His laboratory has been continuously funded by the NIH for more than fifteen years and he has directed large programmatic grants focused on stem cell biology and regenerative medicine (AHA DeHaan Myogenesis Network, NHLBI Progenitor Cell Biology Consortium, etc.). He has more than 100 scientific publications and representative publications.

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Stem Cells Medicine & Life Sciences
Regeneration Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences
Heart Failure Medicine & Life Sciences
Myoglobin Medicine & Life Sciences
Cardiac Myocytes Medicine & Life Sciences
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Muscles Medicine & Life Sciences

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Projects 2007 2023

Research Output 1986 2019

2 Citations (Scopus)

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure

Berry, J. L., Zhu, W., Tang, Y. L., Krishnamurthy, P., Ge, Y., Cooke, J. P., Chen, Y., Garry, D. J., Yang, H. T., Rajasekaran, N. S., Koch, W. J., Li, S., Domae, K., Qin, G., Cheng, K., Kamp, T. J., Ye, L., Hu, S., Ogle, B. M., Rogers, J. M. & 13 others, Abel, E. D., Davis, M. E., Prabhu, S. D., Liao, R., Pu, W. T., Wang, Y., Ping, P., Bursac, N., Vunjak-Novakovic, G., Wu, J. C., Bolli, R., Menasché, P. & Zhang, J., Jan 4 2019, In : Circulation research. 124, 1, p. 161-169 9 p.

Research output: Contribution to journalReview article

Open Access
Biological Science Disciplines
Bioengineering
Stem Cells
Heart Failure
Human Engineering

Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis

Singh, B. N., Gong, W., Das, S., Theisen, J. W. M., Sierra-Pagan, J. E., Yannopoulos, D., Skie, E., Shah, P., Garry, M. G. & Garry, D. J., Dec 1 2019, In : Scientific reports. 9, 1, 9736.

Research output: Contribution to journalArticle

Open Access
Embryonic Development
cdc Genes
Doxycycline
Cell Proliferation
Proto-Oncogene Proteins c-ets

Interspecies Chimeras and the Generation of Humanized Organs

Garry, D. J. & Garry, M. G., Jan 4 2019, In : Circulation research. 124, 1, p. 23-25 3 p.

Research output: Contribution to journalComment/debate

Blastocyst
Swine
Heart Failure
Gene Editing

Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification

Magli, A., Baik, J., Pota, P., Cordero, C. O., Kwak, I. Y., Garry, D. J., Love, P. E., Dynlacht, B. D. & Perlingeiro, R., Dec 1 2019, In : Nature communications. 10, 1, 2316.

Research output: Contribution to journalArticle

Open Access
LIM Domain Proteins
chromosomes
Chromosomes
specifications
Carrier Proteins
3 Citations (Scopus)

Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm

Magli, A., Baik, J., Mills, L. J., Kwak, I., Dillon, B. S., Mondragon Gonzalez, R., Stafford, D. A., Swanson, S. A., Stewart, R., Thomson, J. A., Garry, D. J., Dynlacht, B. D., Perlingeiro, R. C. R. & Becker, P. B. (ed.), Feb 26 2019, In : PLoS Biology. 17, 2, e3000153.

Research output: Contribution to journalArticle

Open Access
Chromatin Assembly and Disassembly
Mesoderm
Chromatin
chromatin
Homeobox Genes