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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 1 Finished
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Thermodynamic and Allosteric Basis of Paradoxical Activation in V600E Mutant BRAF Cancers
Rasmussen, D. M. (PI)
NIH NATIONAL CANCER INSTITUTE (NCI)
1/4/21 → 1/3/24
Project: Research project
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Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors
Rasmussen, D. M., Semonis, M. M., Greene, J. T., Muretta, J. M., Thompson, A. R., Toledo Ramos, S., Thomas, D. D., Pomerantz, W. C. K., Freedman, T. S. & Levinson, N. M., May 14 2024, In: eLife. 13, 13:RP95481.Research output: Contribution to journal › Article › peer-review
Open Access -
Exploring the conformational landscapes of protein kinases: perspectives from FRET and DEER
Baker, Z. D., Rasmussen, D. M. & Levinson, N. M., Jun 2024, In: Biochemical Society transactions. 52, 3, p. 1071-1083 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding
Faber, E. B., Sun, L., Tang, J., Roberts, E., Ganeshkumar, S., Wang, N., Rasmussen, D., Majumdar, A., Hirsch, L. E., John, K., Yang, A., Khalid, H., Hawkinson, J. E., Levinson, N. M., Chennathukuzhi, V., Harki, D. A., Schönbrunn, E. & Georg, G. I., Dec 2023, In: Nature communications. 14, 1, 3213.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Allostery governs Cdk2 activation and differential recognition of CDK inhibitors
Majumdar, A., Burban, D. J., Muretta, J. M., Thompson, A. R., Engel, T. A., Rasmussen, D. M., Subrahmanian, M. V., Veglia, G., Thomas, D. D. & Levinson, N. M., Apr 2021, In: Nature Chemical Biology. 17, 4, p. 456-464 9 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states
Lake, E. W., Muretta, J. M., Thompson, A. R., Rasmussen, D. M., Majumdar, A., Faber, E. B., Ruff, E. F., Thomas, D. D. & Levinson, N. M., Dec 18 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 51, p. E11894-E11903Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations