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Research Output 1975 2019

2019

The retinal environment induces microglia-like properties in recruited myeloid cells

McPherson, S. W., Heuss, N. D., Lehmann, U., Roehrich, H., Abedin, M. & Gregerson, D. S., Jul 20 2019, In : Journal of Neuroinflammation. 16, 1, 151.

Research output: Contribution to journalArticle

Open Access
Microglia
Myeloid Cells
Retina
Diphtheria Toxin
Tamoxifen
2018
2 Citations (Scopus)

Optic nerve as a source of activated retinal microglia post-injury

Heuss, N. D., Pierson, M. J., Roehrich, H., Mc Pherson, S. W., Gram, A. L., Li, L. & Gregerson, D. S., Jul 23 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Microglia
Myeloid Cells
Optic Nerve Injuries
Optic Nerve
Wounds and Injuries
2017
4 Citations (Scopus)
Retinal Cone Photoreceptor Cells
Macrophages
Microglia
Retina
Photoreceptor Cells
2015
9 Citations (Scopus)

Immunoproteasome deficiency protects in the retina after optic nerve crush

Schuld, N. J., Hussong, S. A., Kapphahn, R. J., Lehmann, U., Roehrich, H., Rageh, A. A., Heuss, N. D., Bratten, W., Gregerson, D. S. & Ferrington, D. A., May 15 2015, In : PloS one. 10, 5, e0126768.

Research output: Contribution to journalArticle

Nerve Crush
Optic Nerve
optics
retina
Retina
2014
14 Citations (Scopus)
Galactosidases
Regulatory T-Lymphocytes
Autoimmunity
Dendritic Cells
Retina
10 Citations (Scopus)

Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice

Heuss, N. D., Pierson, M. J., Montaniel, K. R. C., McPherson, S. W., Lehmann, U., Hussong, S. A., Ferrington, D. A., Low, W. C. & Gregerson, D. S., Aug 13 2014, In : Journal of Neuroinflammation. 11, 1, 143.

Research output: Contribution to journalArticle

Dendritic Cells
Nerve Crush
Retinal Ganglion Cells
Microglia
Optic Nerve
2013
9 Citations (Scopus)

Corneal Wound Healing Is Compromised by Immunoproteasome Deficiency

Ferrington, D. A., Roehrich, H., Chang, A. A., Huang, C. W., Maldonado, M., Bratten, W., Rageh, A. A., Heuss, N. D., Gregerson, D. S., Nelson, E. F. & Yuan, C., Jan 30 2013, In : PloS one. 8, 1, e54347.

Research output: Contribution to journalArticle

Immune system
cornea
tissue repair
Cell culture
Wound Healing
16 Citations (Scopus)

Immunoproteasome Deficiency Modifies the Alternative Pathway of NFκB Signaling

Maldonado, M., Kapphahn, R. J., Terluk, M. R., Heuss, N. D., Yuan, C., Gregerson, D. S. & Ferrington, D. A., Feb 14 2013, In : PloS one. 8, 2, e56187.

Research output: Contribution to journalArticle

Transcription Factor RelA
Transcription Factors
Genes
Chemical activation
Retinal Pigments
14 Citations (Scopus)

Local "on-demand" generation and function of antigen-specific Foxp3+ regulatory T cells

Mc Pherson, S. W., Heuss, N. D. & Gregerson, D. S., May 15 2013, In : Journal of Immunology. 190, 10, p. 4971-4981 11 p.

Research output: Contribution to journalArticle

Galactosidases
Regulatory T-Lymphocytes
Antigens
Diphtheria Toxin
Retina
2012
145 Citations (Scopus)

Immunoproteasomes: Structure, function, and antigen presentation

Ferrington, D. A. & Gregerson, D. S., 2012, Progress in Molecular Biology and Translational Science. Elsevier B.V., p. 75-112 38 p. (Progress in Molecular Biology and Translational Science; vol. 109).

Research output: Chapter in Book/Report/Conference proceedingChapter

Antigen Presentation
Peptides
Immune System
Antigen-Presenting Cells
Proteasome Endopeptidase Complex
24 Citations (Scopus)

Local activation of dendritic cells alters the pathogenesis of autoimmune disease in the retina

Heuss, N. D., Lehmann, U., Norbury, C. C., McPherson, S. W. & Gregerson, D. S., Feb 1 2012, In : Journal of Immunology. 188, 3, p. 1191-1200 10 p.

Research output: Contribution to journalArticle

Dendritic Cells
Autoimmune Diseases
Retina
T-Lymphocytes
Adoptive Transfer
6 Citations (Scopus)
Regulatory T-Lymphocytes
T-Lymphocytes
Antigens
Retina
Green Fluorescent Proteins
2011
4 Citations (Scopus)

Generation of regulatory t cells to antigen expressed in the retina

Mc Pherson, S. W., Heuss, N. D., Lehmann, U. & Gregerson, D. S., Aug 1 2011, In : Current Immunology Reviews. 7, 3, p. 344-349 6 p.

Research output: Contribution to journalArticle

Thymus Gland
Retina
T-Lymphocytes
Antigens
Regulatory T-Lymphocytes
2010
39 Citations (Scopus)

Dendritic cells are early responders to retinal injury

Lehmann, U., Heuss, N. D., Mc Pherson, S. W., Roehrich, H. & Gregerson, D. S., Oct 1 2010, In : Neurobiology of Disease. 40, 1, p. 177-184 8 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Dendritic Cells
Wounds and Injuries
Retina
Microglia
2009
15 Citations (Scopus)
Lymphopenia
Autoimmune Diseases
Retina
T-Lymphocytes
Galactosidases
17 Citations (Scopus)

Peripheral induction of tolerance by retinal antigen expression

Gregerson, D. S., Heuss, N. D., Lehmann, U. & McPherson, S. W., Jul 15 2009, In : Journal of Immunology. 183, 2, p. 814-822 9 p.

Research output: Contribution to journalArticle

Galactosidases
Peripheral Tolerance
Antigens
Transgenic Mice
T-Lymphocytes
23 Citations (Scopus)

Viral sequestration of antigen subverts cross presentation to CD8 + T cells

Tewalt, E. F., Grant, J. M., Granger, E. L., Palmer, D. C., Heuss, N. D., Gregerson, D. S., Restifo, N. P. & Norbury, C. C., May 1 2009, In : PLoS pathogens. 5, 5, e1000457.

Research output: Contribution to journalArticle

Cross-Priming
Viral Antigens
T-Lymphocytes
Antigens
Viruses
2008
8 Citations (Scopus)

Evidence for extrathymic generation of regulatory T cells specific for a retinal antigen

Gregerson, D. S., Heuss, N. D., Lehmann, U. & Mc Pherson, S. W., Apr 1 2008, In : Ophthalmic Research. 40, 3-4, p. 154-159 6 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Retina
Photoreceptor Cells
Antigens
Transgenic Mice
50 Citations (Scopus)

Immunoproteasome responds to injury in the retina and brain

Ferrington, D. A., Hussong, S. A., Roehrich, H., Kapphahn, B., Kavanaugh, S. M., Heuss, N. D. & Gregerson, D. S., Jul 1 2008, In : Journal of Neurochemistry. 106, 1, p. 158-169 12 p.

Research output: Contribution to journalArticle

Retina
Brain
T-cells
Cytotoxic T-Lymphocytes
Wounds and Injuries

Use of a β-galactosidase reporter coupled to cell-specific promoters to examine differentiation of neural progenitor cells in vivo and in vitro

Gregerson, D. S., Jan 1 2008, Stem Cells and Regenerative Medicine. World Scientific Publishing Co., p. 265-289 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

beta-Galactosidase
Stem Cells
In Vitro Techniques
2007
25 Citations (Scopus)
Epithelial Cells
T-Lymphocytes
Major Histocompatibility Complex
Antigens
Coculture Techniques
2006
22 Citations (Scopus)

Bystander killing of neurons by cytotoxic T cells specific for a glial antigen

Mc Pherson, S. W., Heuss, N. D., Roehrich, H. & Gregerson, D. S., Apr 1 2006, In : Glia. 53, 5, p. 457-466 10 p.

Research output: Contribution to journalArticle

Photoreceptor Cells
Neuroglia
Astrocytes
T-Lymphocytes
Neurons
30 Citations (Scopus)

Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells

Ferrington, D. A., Tran, T. N., Lew, K. L., Van Remmen, H. & Gregerson, D. S., Sep 1 2006, In : Experimental Eye Research. 83, 3, p. 638-650 13 p.

Research output: Contribution to journalArticle

Retinal Pigments
Caspases
Epithelial Cells
Oxidants
Apoptosis
13 Citations (Scopus)
Vertebrate Photoreceptor Cells
Reporter Genes
Brain
Stem Cells
Genes
42 Citations (Scopus)

Identification of EGFRvIII-derived CTL epitopes estricted by HLA A0201 for dendritic cell based immunotherapy of gliomas

Wu, A. H., Xiao, J., Anker, L., Hall, W. A., Gregerson, D. S., Cavenee, W. K., Chen, W. & Low, W. C., Jan 1 2006, In : Journal of neuro-oncology. 76, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

T-Lymphocyte Epitopes
Cytotoxic T-Lymphocytes
Glioma
Immunotherapy
Dendritic Cells
13 Citations (Scopus)
Cytotoxic T-Lymphocytes
Epithelial Cells
Antigens
Antigen Presentation
Major Histocompatibility Complex
2005
3 Citations (Scopus)
Arrestin
Retinal Rod Photoreceptor Cells
Epitopes
Interleukin-4
Interleukin-10
2004
8 Citations (Scopus)

APC derived from donor splenocytes support retinal autoimmune disease in allogeneic recipients

Gregerson, D. S. & Kawashima, H., Aug 1 2004, In : Journal of Leukocyte Biology. 76, 2, p. 383-387 5 p.

Research output: Contribution to journalArticle

Retinal Diseases
Autoimmune Diseases
Adoptive Transfer
Major Histocompatibility Complex
Bone Marrow Transplantation
29 Citations (Scopus)

The antigen-presenting activity of fresh, adult parenchymal microglia and perivascular cells from retina

Gregerson, D. S., Sam, T. N. & McPherson, S. W., Jun 1 2004, In : Journal of Immunology. 172, 11, p. 6587-6597 11 p.

Research output: Contribution to journalArticle

Microglia
Retina
Antigens
T-Lymphocytes
Brain
2003
40 Citations (Scopus)
Retina
Major Histocompatibility Complex
Antigen-Presenting Cells
Cell Count
Microglia
10 Citations (Scopus)

Effects of Total Body Irradiation and Cyclosporin A on the Lethality of Toxic Shock Syndrome Toxin-1 in a Rabbit Model of Toxic Shock Syndrome

Dinges, M. M., Gregerson, D. S., Tripp, T. J., McCormick, J. K. & Schlievert, P. M., Oct 15 2003, In : Journal of Infectious Diseases. 188, 8, p. 1142-1145 4 p.

Research output: Contribution to journalArticle

Whole-Body Irradiation
Septic Shock
Cyclosporine
Superantigens
Rabbits
29 Citations (Scopus)

Resting CD8 T cells recognize β-galactosidase expressed in the immune-privileged retina and mediate autoimmune disease when activated

Mc Pherson, S. W., Yang, J., Chan, C. C., Dou, C. & Gregerson, D. S., Nov 1 2003, In : Immunology. 110, 3, p. 386-396 11 p.

Research output: Contribution to journalArticle

Galactosidases
Autoimmune Diseases
Retina
T-Lymphocytes
Major Histocompatibility Complex
2002
13 Citations (Scopus)

Peripheral expression of ocular antigens in regulation and therapy of ocular autoimmunity

Gregerson, D. S., Aug 1 2002, In : International Reviews of Immunology. 21, 2-3, p. 101-121 21 p.

Research output: Contribution to journalReview article

Autoimmunity
Antigens
Retina
Therapeutics
Immune System
33 Citations (Scopus)

Spontaneous induction of immunoregulation by an endogenous retinal antigen

Gregerson, D. S. & Dou, C., Sep 1 2002, In : Investigative Ophthalmology and Visual Science. 43, 9, p. 2984-2991 8 p.

Research output: Contribution to journalArticle

Delayed Hypersensitivity
Intraocular Injections
Transgenic Mice
Antigens
Immunization
2001
13 Citations (Scopus)

Failure of memory (CD44 high) CD4 T cells to recognize their target antigen in retina

Gregerson, D. S. & Xiao, J., Nov 10 2001, In : Journal of Neuroimmunology. 120, 1-2, p. 34-41 8 p.

Research output: Contribution to journalArticle

Retina
T-Lymphocytes
Antigens
Galactosidases
T-Cell Antigen Receptor Specificity
2000
9 Citations (Scopus)

Local regulation of immune responses: Corneal endothelial cells alter T cell activation and cytokine production

Mi, P., Gregerson, D. S. & Kawashima, H., Mar 2000, In : Cytokine. 12, 3, p. 253-264 12 p.

Research output: Contribution to journalArticle

T-cells
Endothelial cells
Endothelial Cells
Chemical activation
Cytokines
1999
36 Citations (Scopus)

Effects of continuous localized infusion of granulocyte-macrophage colony-stimulating factor and inoculations of irradiated glioma cells on tumor regression

Wallenfriedman, M. A., Conrad, J. A., DelaBarre, L., Graupman, P. C., Lee, G., Garwood, M., Gregerson, D. S., Jean, W. C., Hall, W. A. & Low, W. C., Jun 1999, In : Journal of neurosurgery. 90, 6, p. 1064-1071 8 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Glioma
Gliosarcoma
Neoplasms
Neoplasm Antigens
36 Citations (Scopus)

Ex vivo transduction of corneal epithelial progenitor cells using a retroviral vector

Bradshaw, J. J., Obritsch, W. F., Cho, B. J., Gregerson, D. S. & Holland, E. J., Jan 20 1999, In : Investigative Ophthalmology and Visual Science. 40, 1, p. 230-235 6 p.

Research output: Contribution to journalArticle

Stem Cells
Epithelial Cells
Cornea
Autografts
Rabbits
45 Citations (Scopus)

Retinal expression of a neo-self antigen, β-galactosidase, is not tolerogenic and creates a target for autoimmune uveoretinitis

Gregerson, D. S., Torseth, J. W., Mc Pherson, S. W., Roberts, J. P., Shinohara, T. & Zack, D. J., Jul 15 1999, In : Journal of Immunology. 163, 2, p. 1073-1080 8 p.

Research output: Contribution to journalArticle

Galactosidases
Autoantigens
Photoreceptor Cells
Transgenic Mice
Immunization
21 Citations (Scopus)

Systemic expression of rat soluble retinal antigen induces resistance to experimental autoimmune uveoretinitis

Mc Pherson, S. W., Roberts, J. P. & Gregerson, D. S., Oct 20 1999, In : Journal of Immunology. 163, 8, p. 4269-4276 8 p.

Research output: Contribution to journalArticle

Antigens
Chimerism
Autoantigens
Retina
Maintenance
1998
54 Citations (Scopus)

A new model of proliferative vitreoretinopathy

Frenzel, E. M., Neely, K. A., Walsh, A. W., Cameron, J. D. & Gregerson, D. S., Oct 1 1998, In : Investigative Ophthalmology and Visual Science. 39, 11, p. 2157-2164 8 p.

Research output: Contribution to journalArticle

Proliferative Vitreoretinopathy
Retinal Perforations
Intraocular Injections
Rabbits
dispase
25 Citations (Scopus)

Immune privilege in the retina

Gregerson, D. S., Dec 1 1998, In : Ocular Immunology and Inflammation. 6, 4, p. 257-267 11 p.

Research output: Contribution to journalReview article

Retina
24 Citations (Scopus)
Immunization
Autoantigens
Antigens
Peptides
Autoimmune Diseases
1997
98 Citations (Scopus)

A new, simple, nonradioactive, nontoxic in vitro assay to monitor corneal endothelial cell viability

Larson, E. M., Doughman, D. J., Gregerson, D. S. & Obritsch, W. F., Sep 1 1997, In : Investigative Ophthalmology and Visual Science. 38, 10, p. 1929-1933 5 p.

Research output: Contribution to journalArticle

Cell Survival
Endothelial Cells
Thymidine
Cell Count
Sodium Azide
24 Citations (Scopus)
Fas Ligand Protein
Delayed Hypersensitivity
Anterior Chamber
Isoantigens
Antigens
3 Citations (Scopus)

Antigen presentation in uveitis

Prasad, S. A. & Gregerson, D. S., Jan 1 1997, In : Eye. 11, 2, p. 176-182 7 p.

Research output: Contribution to journalArticle

Uveitis
Antigen Presentation
T-Lymphocytes
T-Cell Antigen Receptor
Clonal Anergy
Endothelial Cells
Interleukin-2
Hybridomas
lonomycin
Interleukin-5
4 Citations (Scopus)

Differential APC requirements of self- and nonself-reactive T cells and T cell hybridomas specific for retinal S-antigen

Prasad, S. A., Fling, S. P. & Gregerson, D. S., Feb 1997, In : Journal of Autoimmunity. 10, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Arrestin
Hybridomas
Interleukin-2
T-Lymphocytes
B-Lymphocytes
1 Citation (Scopus)

Effects of FAS/FAS-LIG and interaction on the induction of acaid

Kawashima, H., Yamagami, S. & Gregerson, D. S., Dec 1 1997, In : Investigative Ophthalmology and Visual Science. 38, 4, p. S183

Research output: Contribution to journalArticle

Antibodies
Intradermal Injections
Blocking Antibodies
Fas Ligand Protein
Anterior Chamber
121 Citations (Scopus)

Role of Fas-Fas ligand interactions in the immunorejection of allogeneic mouse corneal transplants

Yamagami, S., Kawashima, H., Tsuru, T., Yamagami, H., Kayagaki, N., Yagita, H., Okumura, K. & Gregerson, D. S., Oct 27 1997, In : Transplantation. 64, 8, p. 1107-1111 5 p.

Research output: Contribution to journalArticle

Fas Ligand Protein
Transplants
Corneal Transplantation
Corneal Endothelium
anti-Fas monoclonal antibody