1989 …2019

Research output per year

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Article
2019

In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K

Gorr, S. U., Flory, C. M. & Schumacher, R. J., May 2019, In : PloS one. 14, 5, e0216669.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity

Oppegard, L. M., Delgado, J. L., Kulkarni, C. A., Towle, T. R., Hart, D. E., Williams, B. P., Lentz, S. R. C., Norris, B., Flory, C. M., Schumacher, R. J., Murry, D. J., Kerns, R. J. & Hiasa, H., Apr 15 2019, In : Investigational New Drugs. 37, 2, p. 378-383 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2017

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, p. 1259-1275.e6

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2010

Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis

Jüngel, A., Ospelt, C., Lesch, M., Thiel, M., Sunyer, T., Schorr, O., Michel, B. A., Gay, R. E., Kolling, C., Flory, C., Gay, S. & Neidhart, M., May 1 2010, In : Annals of the Rheumatic Diseases. 69, 5, p. 898-902 5 p.

Research output: Contribution to journalArticle

51 Scopus citations
2007

Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: Potential proinflammatory mechanisms

Thiel, M. J., Schaefer, C. J., Lesch, M. E., Mobley, J. L., Dudley, D. T., Tecle, H., Barrett, S. D., Schrier, D. J. & Flory, C. M., Oct 1 2007, In : Arthritis and rheumatism. 56, 10, p. 3347-3357 11 p.

Research output: Contribution to journalArticle

68 Scopus citations
2006

PD-0200347, an α2δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: A PKCα dependent effect

Boileau, C., Martel-Pelletier, J., Brunet, J., Schrier, D., Flory, C., Boily, M. & Pelletier, J. P., May 1 2006, In : Annals of the Rheumatic Diseases. 65, 5, p. 573-580 8 p.

Research output: Contribution to journalArticle

36 Scopus citations
2005

Oral treatment with PD-0200347, an α2δ ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes

Boileau, C., Martel-Pelletier, J., Brunet, J., Tardif, G., Schrier, D., Flory, C., El-Kattan, A., Boily, M. & Pelletier, J. P., Feb 1 2005, In : Arthritis and rheumatism. 52, 2, p. 488-500 13 p.

Research output: Contribution to journalArticle

48 Scopus citations
2003

In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes

Pelletier, J. P., Fernandes, J. C., Brunet, J., Moldovan, F., Schrier, D., Flory, C. & Martel-Pelletier, J., Jun 1 2003, In : Arthritis and Rheumatism. 48, 6, p. 1582-1593 12 p.

Research output: Contribution to journalArticle

82 Scopus citations
2000

Ribozymes as tools for therapeutic target validation in arthritis

Jarvis, T. C., Bouhana, K. S., Lesch, M. E., Brown, S. A., Parry, T. J., Schrier, D. J., Hunt, S. W., Pavco, P. A. & Flory, C. M., Jul 1 2000, In : Journal of Immunology. 165, 1, p. 493-498 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
1998

Characterization of rat lung ICAM-1

Beck-Schimmer, B., Schimmer, R. C., Schmal, H., Flory, C. M., Friedl, H. P., Pasch, T. & Ward, P. A., Aug 28 1998, In : Inflammation Research. 47, 7, p. 308-315 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Role of chemokines and cytokines in a reactivation model of arthritis in rats induced by injection with streptococcal cell walls

Schrier, D. J., Schimmer, R. C., Flory, C. M., Tung, D. K. L. & Ward, P. A., Mar 1998, In : Journal of Leukocyte Biology. 63, 3, p. 359-363 5 p.

Research output: Contribution to journalArticle

50 Scopus citations

Streptococcal cell wall-induced arthritis: Requirements for IL-4, IL- 10, IFN-γ, and monocyte chemoattractant protein-1

Schimmer, R. C., Schrier, D. J., Flory, C. M., Laemont, K. D., Tung, D., Metz, A. L., Friedl, H. P., Conroy, M. C., Warren, J. S., Beck, B. & Ward, P. A., Feb 1 1998, In : Journal of Immunology. 160, 3, p. 1466-1471 6 p.

Research output: Contribution to journalArticle

21 Scopus citations
1997

Expression of Lung Vascular and Airway ICAM-1 after Exposure to Bacterial Lipopolysaccharide

Beck-Schimmer, B., Schimmer, R. C., Warner, R. L., Schmal, H., Nordblom, G., Flory, C. M., Lesch, M. E., Friedl, H. P., Schrier, D. J. & Ward, P. A., Jan 1 1997, In : American journal of respiratory cell and molecular biology. 17, 3, p. 344-352 9 p.

Research output: Contribution to journalArticle

104 Scopus citations

Hypoxic-ischemic injury induces monocyte chemoattractant protein-1 expression in neonatal rat brain

Ivacko, J., Szaflarski, J., Malinak, C., Flory, C., Warren, J. S. & Silverstein, F. S., Jul 1997, In : Journal of Cerebral Blood Flow and Metabolism. 17, 7, p. 759-770 12 p.

Research output: Contribution to journalArticle

85 Scopus citations

Streptococcal Cell Wall-Induced Arthritis: Requirements for Neutrophils, P-Selectin, Intercellular Adhesion Molecule-1, and Macrophage-lnflammatory Protein-2

Schimmer, R. C., Schrier, D. J., Flory, C. M., Dykens, J., Tung, D. K. L., Jacobson, P. B., Friedl, H. P., Conroy, M. C., Schimmer, B. B. & Ward, P. A., Oct 15 1997, In : Journal of Immunology. 159, 8, p. 4103-4108 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-κB activation

Kilgore, K. S., Schmidt, E., Shanley, T. P., Flory, C. M., Maheswari, V., Tramontini, N. L., Cohen, H., Ward, P. A., Friedl, H. P. & Warren, J. S., Jun 16 1997, In : American Journal of Pathology. 150, 6, p. 2019-2031 13 p.

Research output: Contribution to journalArticle

172 Scopus citations
1996

Expression of monocyte chemoattractant protein-1 in the corpus luteum of the rat

Townson, D. H., Warren, J. S., Flory, C. M., Naftalin, D. M. & Landis Keyes, P., Feb 1 1996, In : Biology of reproduction. 54, 2, p. 513-520 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint

Flory, C. M., Pavco, P. A., Jarvis, T. C., Lesch, M. E., Wincott, F. E., Beigelman, L., Hunt, S. W. & Schrier, D. J., Jan 23 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 2, p. 754-758 5 p.

Research output: Contribution to journalArticle

66 Scopus citations

Role of intercellular adhesion molecule-1 in glucan-induced pulmonary granulomatosis in the rat

Barton, P. A., Imlay, M. M., Flory, C. M. & Warren, J. S., Aug 1996, In : Journal of Laboratory and Clinical Medicine. 128, 2, p. 181-193 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
15 Scopus citations

The membrane attack complex of complement induces interleukin-8 and monocyte chemoattractant protein-1 secretion from human umbilical vein endothelial cells

Kilgore, K. S., Flory, C. M., Miller, B. F., Evans, V. M. & Warren, J. S., Sep 1 1996, In : American Journal of Pathology. 149, 3, p. 953-961 9 p.

Research output: Contribution to journalArticle

126 Scopus citations
1995

Regulation of monocyte chemoattractant protein-1 gene expression and secretion in rat pulmonary alveolar macrophages by lipopolysaccharide, tumor necrosis factor-alpha, and interleukin-1 beta.

Brieland, J. K., Flory, C. M., Jones, M. L., Miller, G. R., Remick, D. G., Warren, J. S. & Fantone, J. C., Jan 1995, In : American journal of respiratory cell and molecular biology. 12, 1, p. 104-109 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Regulatory roles of tumor necrosis factor-α and interleukin-1β in monocyte chemoattractant protein-1-mediated pulmonary granuloma formation in the rat

Flory, C. M., Jones, M. L., Miller, B. F. & Warren, J. S., Jan 1 1995, In : American Journal of Pathology. 146, 2, p. 450-462 13 p.

Research output: Contribution to journalArticle

61 Scopus citations
1993

Analysis of monocyte chemoattractant protein 1-mediated lung injury using rat lung organ cultures

Warren, J. S., Jones, M. L. & Flory, C. M., Dec 1 1993, In : American Journal of Pathology. 143, 3, p. 894-906 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Expression of monocyte chemoattractant protein-1 (MCP-1) by rat alveolar macrophages during chronic lung injury.

Brieland, J. K., Jones, M. L., Flory, C. M., Miller, G. R., Warren, J. S., Phan, S. H. & Fantone, J. C., Sep 1993, In : American Journal of Respiratory Cell and Molecular Biology. 9, 3, p. 300-305 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Pulmonary granuloma formation in the rat is partially dependent on monocyte chemoattractant protein 1

Flory, C. M., Jones, M. L. & Warren, J. S., Jan 1 1993, In : Laboratory Investigation. 69, 4, p. 396-404 9 p.

Research output: Contribution to journalArticle

83 Scopus citations
1992

Effects of in vivo T lymphocyte subset depletion on mycobacterial infections in mice

Flory, C. M., Hubbard, R. D. & Collins, F. M., Jan 1 1992, In : Journal of Leukocyte Biology. 51, 3, p. 225-229 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Immunization of mice with mycobacterial culture filtrate proteins

HUBBARD, R. D., FLORY, C. M. & COLLINS, F. M., Jan 1992, In : Clinical & Experimental Immunology. 87, 1, p. 94-98 5 p.

Research output: Contribution to journalArticle

95 Scopus citations

Immunization of mice with the antigen A60 oi Mycobacterium bovis BCG

HUBBARD, R. D., FLORY, C. M., COLLINS, F. M. & COCITO, C., Apr 1992, In : Clinical & Experimental Immunology. 88, 1, p. 129-131 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

Potential role of monocyte chemoattractant protein 1/JE in monocyte/macrophage-dependent IgA immune complex alveolitis in the rat

Jones, M. L., Mulligan, M. S., Flory, C. M., Ward, P. A. & Warren, J. S., Sep 23 1992, In : Journal of Immunology. 149, 6, p. 2147-2154 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

T-cell immune responses in Mycobacterium avium-infected mice

Hubbard, R. D., Flory, C. M. & Collins, F. M., Jan 1 1992, In : Infection and immunity. 60, 1, p. 150-153 4 p.

Research output: Contribution to journalArticle

26 Scopus citations
1991

Memory T cell-mediated resistance to Mycobacterium tuberculosis infection in innately susceptible and resistant mice

Hubbard, R. D., Flory, C. M. & Collins, F. M., Jan 1 1991, In : Infection and immunity. 59, 6, p. 2012-2016 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
44 Scopus citations
1990
31 Scopus citations
1989
24 Scopus citations

Leukocytes of rainbow trout (Oncorhynchus mykiss) phonephros: Cell types producing superoxide anion

Płytycz, B., Flory, C. M., Galvan, I. & Bayne, C. J., Jan 1 1989, In : Developmental and Comparative Immunology. 13, 3, p. 217-224 8 p.

Research output: Contribution to journalArticle

58 Scopus citations