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Research Output 1989 2019

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Article
2019
1 Citation (Scopus)

In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K

Gorr, S. U., Flory, C. M. & Schumacher, R. J., May 1 2019, In : PloS one. 14, 5, e0216669.

Research output: Contribution to journalArticle

Open Access
antimicrobial peptides
Galleria mellonella
Toxicity
peptides
toxicity
1 Citation (Scopus)

Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity

Oppegard, L. M., Delgado, J. L., Kulkarni, C. A., Towle, T. R., Hart, D. E., Williams, B. P., Lentz, S. R. C., Norris, B., Flory, C. M., Schumacher, R. J., Murry, D. J., Kerns, R. J. & Hiasa, H., Apr 15 2019, In : Investigational New Drugs. 37, 2, p. 378-383 6 p.

Research output: Contribution to journalArticle

Open Access
Type I DNA Topoisomerase
Fluoroquinolones
Heterografts
Human Activities
Poisoning
2017
4 Citations (Scopus)

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, p. 1259-1275.e6

Research output: Contribution to journalArticle

Open Access
Biguanides
Cytochrome P-450 CYP3A
Mitochondria
Heme
Cytochrome P-450 Enzyme System
2010
49 Citations (Scopus)

Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis

Jüngel, A., Ospelt, C., Lesch, M., Thiel, M., Sunyer, T., Schorr, O., Michel, B. A., Gay, R. E., Kolling, C., Flory, C., Gay, S. & Neidhart, M., May 1 2010, In : Annals of the Rheumatic Diseases. 69, 5, p. 898-902 5 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 13
Matrix Metalloproteinase Inhibitors
Cartilage
Rheumatoid Arthritis
Animals
2007
68 Citations (Scopus)

Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: Potential proinflammatory mechanisms

Thiel, M. J., Schaefer, C. J., Lesch, M. E., Mobley, J. L., Dudley, D. T., Tecle, H., Barrett, S. D., Schrier, D. J. & Flory, C. M., Oct 1 2007, In : Arthritis and rheumatism. 56, 10, p. 3347-3357 11 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
Interleukin-1
Rheumatoid Arthritis
Matrix Metalloproteinase 3
2006
34 Citations (Scopus)

PD-0200347, an α2δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: A PKCα dependent effect

Boileau, C., Martel-Pelletier, J., Brunet, J., Schrier, D., Flory, C. M., Boily, M. & Pelletier, J. P., May 1 2006, In : Annals of the Rheumatic Diseases. 65, 5, p. 573-580 8 p.

Research output: Contribution to journalArticle

Calcium Channels
Chondrocytes
Chemical activation
Ligands
Electric potential
2005
48 Citations (Scopus)

Oral treatment with PD-0200347, an α2δ ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes

Boileau, C., Martel-Pelletier, J., Brunet, J., Tardif, G., Schrier, D., Flory, C., El-Kattan, A., Boily, M. & Pelletier, J. P., Feb 1 2005, In : Arthritis and rheumatism. 52, 2, p. 488-500 13 p.

Research output: Contribution to journalArticle

Metalloproteases
Nitric Oxide Synthase Type II
Chondrocytes
Osteoarthritis
Cartilage
2003
82 Citations (Scopus)

In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes

Pelletier, J. P., Fernandes, J. C., Brunet, J., Moldovan, F., Schrier, D., Flory, C. M. & Martel-Pelletier, J., Jun 1 2003, In : Arthritis and Rheumatism. 48, 6, p. 1582-1593 12 p.

Research output: Contribution to journalArticle

MAP Kinase Kinase 2
MAP Kinase Kinase 1
Osteoarthritis
Rabbits
Chondrocytes
2000
18 Citations (Scopus)

Ribozymes as tools for therapeutic target validation in arthritis

Jarvis, T. C., Bouhana, K. S., Lesch, M. E., Brown, S. A., Parry, T. J., Schrier, D. J., Hunt, S. W., Pavco, P. A. & Flory, C. M., Jul 1 2000, In : Journal of Immunology. 165, 1, p. 493-498 6 p.

Research output: Contribution to journalArticle

Catalytic RNA
Arthritis
Matrix Metalloproteinase 3
Cartilage
Messenger RNA
1998
11 Citations (Scopus)

Characterization of rat lung ICAM-1

Beck-Schimmer, B., Schimmer, R. C., Schmal, H., Flory, C. M., Friedl, H. P., Pasch, T. & Ward, P. A., Aug 28 1998, In : Inflammation Research. 47, 7, p. 308-315 8 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Lung
Alveolar Macrophages
Endothelial Cells
Pulmonary Artery
49 Citations (Scopus)

Role of chemokines and cytokines in a reactivation model of arthritis in rats induced by injection with streptococcal cell walls

Schrier, D. J., Schimmer, R. C., Flory, C. M., Tung, D. K. L. & Ward, P. A., Jan 1 1998, In : Journal of Leukocyte Biology. 63, 3, p. 359-363 5 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Chemokines
Cell Wall
Arthritis
Cytokines
21 Citations (Scopus)

Streptococcal cell wall-induced arthritis: Requirements for IL-4, IL- 10, IFN-γ, and monocyte chemoattractant protein-1

Schimmer, R. C., Schrier, D. J., Flory, C. M., Laemont, K. D., Tung, D., Metz, A. L., Friedl, H. P., Conroy, M. C., Warren, J. S., Beck, B. & Ward, P. A., Feb 1 1998, In : Journal of Immunology. 160, 3, p. 1466-1471 6 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Interleukin-4
Interleukin-10
Cell Wall
Arthritis
1997
104 Citations (Scopus)

Expression of Lung Vascular and Airway ICAM-1 after Exposure to Bacterial Lipopolysaccharide

Beck-Schimmer, B., Schimmer, R. C., Warner, R. L., Schmal, H., Nordblom, G., Flory, C. M., Lesch, M. E., Friedl, H. P., Schrier, D. J. & Ward, P. A., Jan 1 1997, In : American Journal of Respiratory Cell and Molecular Biology. 17, 3, p. 344-352 9 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Blood Vessels
Lipopolysaccharides
Lung
Up-Regulation
85 Citations (Scopus)

Hypoxic-ischemic injury induces monocyte chemoattractant protein-1 expression in neonatal rat brain

Ivacko, J., Szaflarski, J., Malinak, C., Flory, C. M., Warren, J. S. & Silverstein, F. S., Jan 1 1997, In : Journal of Cerebral Blood Flow and Metabolism. 17, 7, p. 759-770 12 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Wounds and Injuries
Brain
Messenger RNA
Prosencephalon
42 Citations (Scopus)

Streptococcal Cell Wall-Induced Arthritis: Requirements for Neutrophils, P-Selectin, Intercellular Adhesion Molecule-1, and Macrophage-lnflammatory Protein-2

Schimmer, R. C., Schrier, D. J., Flory, C. M., Dykens, J., Tung, D. K. L., Jacobson, P. B., Friedl, H. P., Conroy, M. C., Schimmer, B. B. & Ward, P. A., Oct 15 1997, In : Journal of Immunology. 159, 8, p. 4103-4108 6 p.

Research output: Contribution to journalArticle

P-Selectin
Intercellular Adhesion Molecule-1
Cell Wall
Arthritis
Edema
169 Citations (Scopus)

Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-κB activation

Kilgore, K. S., Schmidt, E., Shanley, T. P., Flory, C. M., Maheswari, V., Tramontini, N. L., Cohen, H., Ward, P. A., Friedl, H. P. & Warren, J. S., Jun 16 1997, In : American Journal of Pathology. 150, 6, p. 2019-2031 13 p.

Research output: Contribution to journalArticle

Complement Membrane Attack Complex
Complement Factor B
Chemokine CCL2
Interleukin-8
Human Umbilical Vein Endothelial Cells
1996
65 Citations (Scopus)

Expression of monocyte chemoattractant protein-1 in the corpus luteum of the rat

Townson, D. H., Warren, J. S., Flory, C. M., Naftalin, D. M. & Landis Keyes, P., Feb 1 1996, In : Biology of Reproduction. 54, 2, p. 513-520 8 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Corpus Luteum
Monocytes
Macrophages
Pregnancy
66 Citations (Scopus)

Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint

Flory, C. M., Pavco, P. A., Jarvis, T. C., Lesch, M. E., Wincott, F. E., Beigelman, L., Hunt, S. W. & Schrier, D. J., Jan 23 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 2, p. 754-758 5 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 3
Catalytic RNA
Synovial Membrane
Knee Joint
Rabbits
4 Citations (Scopus)

Role of intercellular adhesion molecule-1 in glucan-induced pulmonary granulomatosis in the rat

Barton, P. A., Imlay, M. M., Flory, C. M. & Warren, J. S., Jan 1 1996, In : Journal of Laboratory and Clinical Medicine. 128, 2, p. 181-193 13 p.

Research output: Contribution to journalArticle

Glucans
Intercellular Adhesion Molecule-1
Rats
Granuloma
Lung
15 Citations (Scopus)
Intra-Articular Injections
Matrix Metalloproteinase 3
Synovial Fluid
Interleukin-1
Phospholipases A2
124 Citations (Scopus)

The membrane attack complex of complement induces interleukin-8 and monocyte chemoattractant protein-1 secretion from human umbilical vein endothelial cells

Kilgore, K. S., Flory, C. M., Miller, B. F., Evans, V. M. & Warren, J. S., Sep 1 1996, In : American Journal of Pathology. 149, 3, p. 953-961 9 p.

Research output: Contribution to journalArticle

Complement Membrane Attack Complex
Chemokine CCL2
Human Umbilical Vein Endothelial Cells
Interleukin-8
Monocytes
1995
58 Citations (Scopus)

Regulation of monocyte chemoattractant protein-1 gene expression and secretion in rat pulmonary alveolar macrophages by lipopolysaccharide, tumor necrosis factor-alpha, and interleukin-1 beta.

Brieland, J. K., Flory, C. M., Jones, M. L., Miller, G. R., Remick, D. G., Warren, J. S. & Fantone, J. C., Jan 1 1995, In : American Journal of Respiratory Cell and Molecular Biology. 12, 1, p. 104-109 6 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Alveolar Macrophages
Interleukin-1beta
Gene expression
Lipopolysaccharides
61 Citations (Scopus)

Regulatory roles of tumor necrosis factor-α and interleukin-1β in monocyte chemoattractant protein-1-mediated pulmonary granuloma formation in the rat

Flory, C. M., Jones, M. L., Miller, B. F. & Warren, J. S., Jan 1 1995, In : American Journal of Pathology. 146, 2, p. 450-462 13 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Granuloma
Interleukin-1
Tumor Necrosis Factor-alpha
Lung
1993
13 Citations (Scopus)

Analysis of monocyte chemoattractant protein 1-mediated lung injury using rat lung organ cultures

Warren, J. S., Jones, M. L. & Flory, C. M., Dec 1 1993, In : American Journal of Pathology. 143, 3, p. 894-906 13 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Organ Culture Techniques
Lung Injury
Monocytes
Lung
43 Citations (Scopus)

Expression of monocyte chemoattractant protein-1 (MCP-1) by rat alveolar macrophages during chronic lung injury.

Brieland, J. K., Jones, M. L., Flory, C. M., Miller, G. R., Warren, J. S., Phan, S. H. & Fantone, J. C., Jan 1 1993, In : American Journal of Respiratory Cell and Molecular Biology. 9, 3, p. 300-305 6 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Lung Injury
Rats
Pulmonary Fibrosis
Monocytes
83 Citations (Scopus)

Pulmonary granuloma formation in the rat is partially dependent on monocyte chemoattractant protein 1

Flory, C. M., Jones, M. L. & Warren, J. S., Jan 1 1993, In : Laboratory Investigation. 69, 4, p. 396-404 9 p.

Research output: Contribution to journalArticle

Glucans
Chemokine CCL2
Granuloma
Vasculitis
Lung
1992
47 Citations (Scopus)

Effects of in vivo T lymphocyte subset depletion on mycobacterial infections in mice

Flory, C. M., Hubbard, R. D. & Collins, F. M., Jan 1 1992, In : Journal of Leukocyte Biology. 51, 3, p. 225-229 5 p.

Research output: Contribution to journalArticle

Lymphocyte Depletion
T-Lymphocyte Subsets
Infection
Inbred C57BL Mouse
Mycobacterium tuberculosis
95 Citations (Scopus)

Immunization of mice with mycobacterial culture filtrate proteins

HUBBARD, R. D., Flory, C. M. & COLLINS, F. M., Jan 1 1992, In : Clinical & Experimental Immunology. 87, 1, p. 94-98 5 p.

Research output: Contribution to journalArticle

Immunization
Mycobacterium tuberculosis
Proteins
Collodion
Polyacrylamide Gel Electrophoresis
13 Citations (Scopus)

Immunization of mice with the antigen A60 oi Mycobacterium bovis BCG

HUBBARD, R. D., Flory, C. M., COLLINS, F. M. & COCITO, C., Jan 1 1992, In : Clinical & Experimental Immunology. 88, 1, p. 129-131 3 p.

Research output: Contribution to journalArticle

Mycobacterium bovis
Immunization
Mycobacterium tuberculosis
Antigens
Cytoplasm
77 Citations (Scopus)

Potential role of monocyte chemoattractant protein 1/JE in monocyte/macrophage-dependent IgA immune complex alveolitis in the rat

Jones, M. L., Mulligan, M. S., Flory, C. M., Ward, P. A. & Warren, J. S., Sep 23 1992, In : Journal of Immunology. 149, 6, p. 2147-2154 8 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Antigen-Antibody Complex
Immunoglobulin A
Monocytes
Macrophages
26 Citations (Scopus)

T-cell immune responses in Mycobacterium avium-infected mice

Hubbard, R. D., Flory, C. M. & Collins, F. M., Jan 1 1992, In : Infection and immunity. 60, 1, p. 150-153 4 p.

Research output: Contribution to journalArticle

Mycobacterium avium
Tuberculin
Mycobacterium bovis
T-Lymphocytes
Mycobacterium Infections
1991
26 Citations (Scopus)

Memory T cell-mediated resistance to Mycobacterium tuberculosis infection in innately susceptible and resistant mice

Hubbard, R. D., Flory, C. M. & Collins, F. M., Jan 1 1991, In : Infection and immunity. 59, 6, p. 2012-2016 5 p.

Research output: Contribution to journalArticle

Mycobacterium Infections
Mycobacterium tuberculosis
T-Lymphocytes
Mycobacterium bovis
Cyclophosphamide
43 Citations (Scopus)
Cholinergic Agonists
Adrenergic beta-Agonists
Oncorhynchus mykiss
Adrenergic Agents
Cholinergic Agents
1990
31 Citations (Scopus)
Oncorhynchus mykiss
Phylogeny
Adrenergic Agents
Cholinergic Agents
Antibody Formation
1989
Oncorhynchus mykiss
Adrenergic Agents
Cholinergic Agents
Lymphocytes
In Vitro Techniques
24 Citations (Scopus)
Oncorhynchus kisutch
Spleen
Lymphoid Tissue
Blood Vessels
Chemical Sympathectomy
56 Citations (Scopus)

Leukocytes of rainbow trout (Oncorhynchus mykiss) phonephros: Cell types producing superoxide anion

Płytycz, B., Flory, C. M., Galvan, I. & Bayne, C. J., Jan 1 1989, In : Developmental and Comparative Immunology. 13, 3, p. 217-224 8 p.

Research output: Contribution to journalArticle

Oncorhynchus mykiss
Superoxides
Leukocytes
Glass
Suspensions