Accepting PhD Students

20002018
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Personal profile

Research interests

The goal of the research in our lab is to investigate the genetics and signaling pathways that drive acute myeloid leukemia (AML) to provide a foundation for the development of novel targeted treatment approaches. Our research is focused on identifying the critical mediators of RAS signaling that drive AML growth and survival using molecular genetic approaches in the most clinically relevant genetically engineered mouse models, human AML cell lines, and primary AML patient samples in vitro and in patient-derived AML xenografts. We are evaluating the role of clinically-relevant biochemical signaling pathway inhibitors alone and in combination with novel chemotherapeutic and immunotherapy approaches to maximize the translational potential of our studies. We are utilizing cutting-edge multi-parameter flow cytometry and next generation sequencing to characterize AML treatment response and identify potential mechanisms of treatment resistance. In total, these translational studies will provide novel insights for the development of rationally designed targeted therapies for human AML.

Keywords

  • targeted cancer therapy
  • immunotherapy
  • acute myeloid leukemia
  • Ras signaling
  • preclincal models

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Acute Myeloid Leukemia Medicine & Life Sciences
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Projects 2013 2014

Research Output 2000 2018

A real-world study of clofarabine and cytarabine combination therapy for patients with acute myeloid leukemia

He, F., Sapkota, S., Parker, S., De For, T. E., Warlick, E. D., Ustun, C., Eckfeldt, C. E., Rashidi, A., Kurtzweil, A., Weisdorf, D. J. & Bejanyan, N., Feb 9 2018, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-8 8 p.

Research output: Contribution to journalArticle

Cytarabine
Acute Myeloid Leukemia
Therapeutics
clofarabine
Cytogenetics
2 Citations

Allogeneic Hematopoietic Cell Transplantation for Older Patients: Prognosis Determined by Disease Risk Index

He, F., Cao, Q., Lazaryan, A., Brunstein, C., Holtan, S., Warlick, E., Ustun, C., McClune, B., Arora, M., Rashidi, A., Eckfeldt, C., Weisdorf, D. J. & Bejanyan, N., Sep 1 2017, In : Biology of Blood and Marrow Transplantation. 23, 9, p. 1485-1490 6 p.

Research output: Contribution to journalArticle

Cell Transplantation
Recurrence
Hematologic Neoplasms
Confidence Intervals
Treatment Failure

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Pomeroy, E. J., Lee, L. A., Lee, R. D. W., Schirm, D. K., Temiz, N. A., Ma, J., Gruber, T. A., Diaz-Flores, E., Moriarity, B. S., Downing, J. R., Shannon, K. M., Largaespada, D. A. & Eckfeldt, C. E., Jun 8 2017, In : Oncogene. 36, 23, p. 3263-3273 11 p.

Research output: Contribution to journalArticle

ras Genes
Oncogenes
Acute Myeloid Leukemia
Leukemia
Recurrence

Successful treatment of two cases of classical Hodgkin lymphoma-associated hemophagocytic lymphohistiocyosis with R-CEPP

Boland, P. J., Hegerova, L., Williams, S. J., McKenna, R. W., Bachanova, V. & Eckfeldt, C. E., Feb 1 2017, In : Leukemia and Lymphoma. 58, 2, p. 478-481 4 p.

Research output: Contribution to journalLetter

Hodgkin Disease
1 Citations

RALB provides critical survival signals downstream of Ras in acute myeloid leukemia

Eckfeldt, C. E., Pomeroy, E. J., Lee, R. D. W., Hazen, K. S., Lee, L. A., Moriarity, B. S. & Largaespada, D. A., Jan 1 2016, In : Oncotarget. 7, 40, p. 65147-65156 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Survival
Phosphatidylinositol 3-Kinase
Proto-Oncogenes
Myeloid Cells