Personal profile

Research interests

The goal of the research in our lab is to investigate the genetics and signaling pathways that drive acute myeloid leukemia (AML) to provide a foundation for the development of novel targeted treatment approaches. Our research is focused on identifying the critical mediators of RAS signaling that drive AML growth and survival using molecular genetic approaches in the most clinically relevant genetically engineered mouse models, human AML cell lines, and primary AML patient samples in vitro and in patient-derived AML xenografts. We are evaluating the role of clinically-relevant biochemical signaling pathway inhibitors alone and in combination with novel chemotherapeutic and immunotherapy approaches to maximize the translational potential of our studies. We are utilizing cutting-edge multi-parameter flow cytometry and next generation sequencing to characterize AML treatment response and identify potential mechanisms of treatment resistance. In total, these translational studies will provide novel insights for the development of rationally designed targeted therapies for human AML.


  • targeted cancer therapy
  • immunotherapy
  • acute myeloid leukemia
  • Ras signaling
  • preclincal models

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Acute Myeloid Leukemia Medicine & Life Sciences
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hematopoietic stem cells Agriculture & Biology
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Projects 2013 2014

Research Output 2000 2017

2 Citations
Cell Transplantation
Confidence Intervals
Hematologic Neoplasms

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Pomeroy, E. J., Lee, L. A., Lee, R. D. W., Schirm, D. K., Temiz, N. A., Ma, J., Gruber, T. A., Diaz-Flores, E., Moriarity, B. S., Downing, J. R., Shannon, K. M., Largaespada, D. A. & Eckfeldt, C. E. Jun 8 2017 In : Oncogene. 36, 23, p. 3263-3273 11 p.

Research output: Research - peer-reviewArticle

ras Genes
Acute Myeloid Leukemia

Successful treatment of two cases of classical Hodgkin lymphoma-associated hemophagocytic lymphohistiocyosis with R-CEPP

Boland, P. J., Hegerova, L. T., Williams, S. J., McKenna, R. W., Bachanova, V. & Eckfeldt, C. E. Feb 1 2017 In : Leukemia and Lymphoma. 58, 2, p. 478-481 4 p.

Research output: Research - peer-reviewLetter

Hodgkin Disease
1 Citations

RALB provides critical survival signals downstream of Ras in acute myeloid leukemia

Eckfeldt, C. E., Pomeroy, E. J., Lee, R. D. W., Hazen, K. S., Lee, L. A., Moriarity, B. S. & Largaespada, D. A. Jan 1 2016 In : Oncotarget. 7, 40, p. 65147-65156 10 p.

Research output: Research - peer-reviewArticle

Acute Myeloid Leukemia
Phosphatidylinositol 3-Kinase
Myeloid Cells
2 Citations

Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency

Sachs, Z., Been, R. A., Decoursin, K. J., Nguyen, H. T., Mohd Hassan, N. A., Noble-Orcutt, K. E., Eckfeldt, C. E., Pomeroy, E. J., Diaz-Flores, E., Geurts, J. L., Diers, M. D., Hasz, D. E., Morgan, K. J., Macmillan, M. L., Shannon, K. M., Largaespada, D. A. & Wiesner, S. M. Sep 30 2016 In : Haematologica. 101, 10, p. 1190-1199 10 p.

Research output: Research - peer-reviewArticle

Juvenile Myelomonocytic Leukemia
Neurofibromatosis 1 Genes
Granulocyte-Macrophage Colony-Stimulating Factor Receptors