If you made any changes in Pure, your changes will be visible here soon.

Research Output 2000 2019

Filter
Article
2019

A Cinchona Alkaloid Antibiotic That Appears to Target ATP Synthase in Streptococcus pneumoniae

Wang, X., Zeng, Y., Sheng, L., Larson, P., Liu, X., Zou, X., Wang, S., Guo, K., Ma, C., Zhang, G., Cui, H., Ferguson, D. M., Li, Y., Zhang, J. & Aldrich, C., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2305-2332 28 p.

Research output: Contribution to journalArticle

Cinchona Alkaloids
Quinuclidines
Streptococcus pneumoniae
Adenosine Triphosphate
Anti-Bacterial Agents

Development of an imidazole salt catalytic system for the preparation of bis(indolyl) methanes and bis(naphthyl)methane

Wang, X. & Aldrich, C., Apr 1 2019, In : PloS one. 14, 4, e0216008.

Research output: Contribution to journalArticle

Open Access
naphthols
Naphthols
imidazoles
Methane
methane

Investigation of (S)-(-)-acidomycin: A selective antimycobacterial natural product that inhibits biotin synthase

Bockman, M. R., Engelhart, C. A., Cramer, J. D., Howe, M. D., Mishra, N. K., Zimmerman, M., Larson, P., Alvarez-Cabrera, N., Park, S. W., Boshoff, H. I. M., Bean, J. M., Young, V. G., Ferguson, D. M., Dartois, V., Jarrett, J. T., Schnappinger, D. & Aldrich, C., Apr 12 2019, In : ACS Infectious Diseases. 5, 4, p. 598-617 20 p.

Research output: Contribution to journalArticle

Biological Products
Microbial Sensitivity Tests
Biotin
Tuberculosis
Multidrug-Resistant Tuberculosis

Mechanism of a Standalone β-Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme

Robinson, S. L., Christenson, J. K., Richman, J. E., Jenkins, D. J., Neres, J., Fonseca, D. R., Aldrich, C. & Wackett, L. P., Jan 1 2019, In : ChemBioChem.

Research output: Contribution to journalArticle

Lactones
Ligases
Assays
Enzymes
Xanthomonas campestris

Spirocyclic and Bicyclic 8-Nitrobenzothiazinones for Tuberculosis with Improved Physicochemical and Pharmacokinetic Properties

Zhang, G., Howe, M. & Aldrich, C., Mar 14 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 348-351 4 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Tuberculosis
Solubility
Antitubercular Agents
Diamines
2018
5 Citations (Scopus)

Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification

Bockman, M. R., Engelhart, C. A., Dawadi, S., Larson, P., Tiwari, D., Ferguson, D. M., Schnappinger, D. & Aldrich, C. C., Jul 13 2018, In : ACS Infectious Diseases. 4, 7, p. 1102-1113 12 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Nucleosides
Anti-Bacterial Agents
Ligases
Biotin
5 Citations (Scopus)

Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis

Dawadi, S., Boshoff, H. I. M., Park, S. W., Schnappinger, D. & Aldrich, C., Apr 12 2018, In : ACS Medicinal Chemistry Letters. 9, 4, p. 386-391 6 p.

Research output: Contribution to journalArticle

Open Access
Siderophores
Salicylates
Biosynthesis
Nucleosides
Tuberculosis
4 Citations (Scopus)

Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis

Howe, M. D., Kordus, S. L., Cole, M. S., Bauman, A. A., Aldrich, C., Baughn, A. & Minato, Y., Nov 12 2018, In : Frontiers in cellular and infection microbiology. 8, 1 p.

Research output: Contribution to journalArticle

Open Access
Aminosalicylic Acid
Mycobacterium tuberculosis
Folic Acid
Methionine
4-Aminobenzoic Acid
3 Citations (Scopus)

Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole

Minato, Y., Dawadi, S., Kordus, S. L., Sivanandam, A., Aldrich, C. C. & Baughn, A. D., Mar 8 2018, In : Nature Communications. 9, 1

Research output: Contribution to journalArticle

4 Citations (Scopus)

Scalable Synthesis of Hydrido-Disiloxanes from Silanes: A One-Pot Preparation of 1,3-Diphenyldisiloxane from Phenylsilane

Buonomo, J. A., Eiden, C. G. & Aldrich, C. C., Jan 18 2018, In : Synthesis (Germany). 50, 2, p. 278-281 4 p.

Research output: Contribution to journalArticle

Open Access
Silanes
disiloxane
8 Citations (Scopus)

Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae

Bailey, D. C., Alexander, E., Rice, M. R., Drake, E. J., Mydy, L. S., Aldrich, C. & Gulick, A. M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 20, p. 7841-7852 12 p.

Research output: Contribution to journalArticle

Open Access
Siderophores
Biosynthesis
Klebsiella pneumoniae
Stereoselectivity
Kinetics

Structural Basis of Polyketide Synthase O-Methylation

Skiba, M. A., Bivins, M. M., Schultz, J. R., Bernard, S. M., Fiers, W. D., Dan, Q., Kulkarni, S., Wipf, P., Gerwick, W. H., Sherman, D. H., Aldrich, C. & Smith, J. L., Dec 21 2018, In : ACS Chemical Biology. 13, 12, p. 3221-3228 8 p.

Research output: Contribution to journalArticle

Polyketide Synthases
Methylation
Methyltransferases
Hydroxyl Radical
Biosynthetic Pathways
5 Citations (Scopus)

Targeting protein biotinylation enhances tuberculosis chemotherapy

Tiwari, D., Park, S. W., Essawy, M. M., Dawadi, S., Mason, A., Nandakumar, M., Zimmerman, M., Mina, M., Ho, H. P., Engelhart, C. A., Ioerger, T., Sacchettini, J. C., Rhee, K., Ehrt, S., Aldrich, C. C., Dartois, V. & Schnappinger, D., Apr 25 2018, In : Science Translational Medicine. 10, 438, eaal1803.

Research output: Contribution to journalArticle

Biotinylation
Protein Transport
Tuberculosis
Drug Therapy
Ligases
7 Citations (Scopus)

Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular

Negatu, D. A., Liu, J. J. J., Zimmerman, M., Kaya, F., Dartois, V., Aldrich, C., Gengenbacher, M. & Dicka, T., Mar 1 2018, In : Antimicrobial agents and chemotherapy. 62, 3, e01571-17.

Research output: Contribution to journalArticle

Pyrazinamide
Mycobacterium tuberculosis
Libraries
Mycobacterium Infections
Bacterial Load
2017
6 Citations (Scopus)

Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma

Okon, A., Han, J., Dawadi, S., Demosthenous, C., Aldrich, C., Gupta, M. & Wagner, C. R., Oct 12 2017, In : Journal of Medicinal Chemistry. 60, 19, p. 8131-8144 14 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Nucleotides
Chemical Phenomena
Nucleosides
Sulfur
10 Citations (Scopus)

Chemoselective Reduction of Phosphine Oxides by 1,3-Diphenyl-Disiloxane

Buonomo, J. A., Eiden, C. G. & Aldrich, C. C., Oct 17 2017, In : Chemistry - A European Journal. 23, 58, p. 14434-14438 5 p.

Research output: Contribution to journalArticle

Open Access
phosphine
Oxides
Silanes
Chemical activation
Phosphines
1 Citation (Scopus)
Open Access
Kinetic parameters
Scaffolds
Medicine
Rate constants
Enzymes
5 Citations (Scopus)

Structure-Based Optimization of Pyridoxal 5′-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis

Liu, F., Dawadi, S., Maize, K. M., Dai, R., Park, S. W., Schnappinger, D., Finzel, B. C. & Aldrich, C., Jul 13 2017, In : Journal of Medicinal Chemistry. 60, 13, p. 5507-5520 14 p.

Research output: Contribution to journalArticle

Pyridoxal Phosphate
Enzyme Inhibitors
Biotin
Transaminases
Mycobacterium tuberculosis
4 Citations (Scopus)

Synthesis and analysis of bacterial folate metabolism intermediates and antifolates

Dawadi, S., Kordus, S. L., Baughn, A. & Aldrich, C., Jan 1 2017, In : Organic Letters. 19, 19, p. 5220-5223 4 p.

Research output: Contribution to journalArticle

Aminosalicylic Acid
Pterins
Folic Acid Antagonists
Multidrug-Resistant Tuberculosis
Imines
3 Citations (Scopus)
Open Access
Pyridoxal Phosphate
Cyclization
Enzymes
Enzyme inhibition
Dimerization
2 Citations (Scopus)

Synthesis of Transition-State Inhibitors of Chorismate Utilizing Enzymes from Bromobenzene cis-1,2-Dihydrodiol

Zhang, X. K., Liu, F., Fiers, W. D., Sun, W. M., Guo, J., Liu, Z. & Aldrich, C., Apr 7 2017, In : Journal of Organic Chemistry. 82, 7, p. 3432-3440 9 p.

Research output: Contribution to journalArticle

Open Access
Enzymes
Siderophores
Salicylic Acid
Salicylates
Pyruvic Acid
2016
10 Citations (Scopus)

2-Aryl-8-aza-3-deazaadenosine analogues of 5′-O-[N-(salicyl)sulfamoyl]adenosine: Nucleoside antibiotics that block siderophore biosynthesis in Mycobacterium tuberculosis

Krajczyk, A., Zeidler, J., Januszczyk, P., Dawadi, S., Boshoff, H. I., Barry, C. E., Ostrowski, T. & Aldrich, C., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 14, p. 3133-3143 11 p.

Research output: Contribution to journalArticle

Siderophores
Biosynthesis
Mycobacterium tuberculosis
Nucleosides
Anti-Bacterial Agents
9 Citations (Scopus)

Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction

Štular, T., Lešnik, S., Rožman, K., Schink, J., Zdouc, M., Ghysels, A., Liu, F., Aldrich, C., Haupt, V. J., Salentin, S., Daminelli, S., Schroeder, M., Langer, T., Gobec, S., Janežič, D. & Konc, J., Dec 22 2016, In : Journal of Medicinal Chemistry. 59, 24, p. 11069-11078 10 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Binding Sites
Ligands
Proteins
Drug Discovery
18 Citations (Scopus)

Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase

Skiba, M. A., Sikkema, A. P., Fiers, W. D., Gerwick, W. H., Sherman, D. H., Aldrich, C. C. & Smith, J. L., Dec 16 2016, In : ACS Chemical Biology. 11, 12, p. 3319-3327 9 p.

Research output: Contribution to journalArticle

Polyketide Synthases
Methyltransferases
Catalytic Domain
Acyl Carrier Protein
Polyketides
10 Citations (Scopus)

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis

Kuhn, M. L., Alexander, E., Minasov, G., Page, H. J., Warwrzak, Z., Shuvalova, L., Flores, K. J., Wilson, D., Shi, C., Aldrich, C. & Anderson, W. F., Aug 12 2016, In : ACS Infectious Diseases. 2, 8, p. 579-591 13 p.

Research output: Contribution to journalArticle

Mycolic Acids
Adenosine Monophosphate
Ligases
Mycobacterium tuberculosis
Tuberculosis
32 Citations (Scopus)

Structures of a nonribosomal peptide synthetase module bound to MbtH-like proteins support a highly dynamic domain architecture

Miller, B. R., Drake, E. J., Shi, C., Aldrich, C. & Gulick, A. M., Oct 21 2016, In : Journal of Biological Chemistry. 291, 43, p. 22559-22571 13 p.

Research output: Contribution to journalArticle

Peptide Synthases
Proteins
Condensation
Peptides
Escherichia coli Proteins
82 Citations (Scopus)

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

Drake, E. J., Miller, B. R., Shi, C., Tarrasch, J. T., Sundlov, J. A., Allen, L., Skiniotis, G., Aldrich, C. C. & Gulick, A. M., Jan 13 2016, In : Nature. 529, 7585, p. 235-238 4 p.

Research output: Contribution to journalArticle

Peptide Synthases
Bioengineering
Biological Products
Catalysis
Catalytic Domain
10 Citations (Scopus)

Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis

Dawadi, S., Kawamura, S., Rubenstein, A., Remmel, R. P. & Aldrich, C., Mar 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 6, p. 1314-1321 8 p.

Research output: Contribution to journalArticle

Siderophores
Biosynthesis
Prodrugs
Mycobacterium tuberculosis
Nucleosides
8 Citations (Scopus)
4-Aminobenzoic Acid
Folic Acid Antagonists
Dihydropteroate Synthase
Aminosalicylic Acid
Sulfonamides
8 Citations (Scopus)

Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates

Thiede, J. M., Kordus, S. L., Turman, B. J., Buonomo, J. A., Aldrich, C. C., Minato, Y. & Baughn, A. D., 2016, In : Scientific Reports. 6, 38083.

Research output: Contribution to journalArticle

4-Aminobenzoic Acid
Folic Acid Antagonists
Dihydropteroate Synthase
Aminosalicylic Acid
Sulfonamides
14 Citations (Scopus)

Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis

Fiers, W. D., Dodge, G. J., Sherman, D. H., Smith, J. L. & Aldrich, C. C., Dec 14 2016, In : Journal of the American Chemical Society. 138, 49, p. 16024-16036 13 p.

Research output: Contribution to journalArticle

Hydro-Lyases
Polyketides
Biosynthesis
Dehydration
Alkenes
2015
16 Citations (Scopus)

Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA

Dai, R., Geders, T. W., Liu, F., Park, S. W., Schnappinger, D., Aldrich, C. C. & Finzel, B. C., Jul 9 2015, In : Journal of Medicinal Chemistry. 58, 13, p. 5208-5217 10 p.

Research output: Contribution to journalArticle

Fluorometry
Calorimetry
Biotin
Transaminases
Thermodynamics
14 Citations (Scopus)

Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase

Li, Y., Dodge, G. J., Fiers, W. D., Fecik, R. A., Smith, J. L. & Aldrich, C., Jun 10 2015, In : Journal of the American Chemical Society. 137, 22, p. 7003-7006 4 p.

Research output: Contribution to journalArticle

Polyketide Synthases
Hydro-Lyases
Substrate Specificity
Substrates
Metabolic Engineering
22 Citations (Scopus)

Human urinary composition controls antibacterial activity of siderocalin

Shields-Cutler, R. R., Crowley, J. R., Hung, C. S., Stapleton, A. E., Aldrich, C. C., Marschall, J. & Henderson, J. P., Jun 26 2015, In : Journal of Biological Chemistry. 290, 26, p. 15949-15960 12 p.

Research output: Contribution to journalArticle

Enterobactin
Escherichia coli
Lipocalins
Metabolites
Iron
11 Citations (Scopus)

Investigation and Conformational Analysis of Fluorinated Nucleoside Antibiotics Targeting Siderophore Biosynthesis

Dawadi, S., Viswanathan, K., Boshoff, H. I., Barry, C. E. & Aldrich, C., May 15 2015, In : Journal of Organic Chemistry. 80, 10, p. 4835-4850 16 p.

Research output: Contribution to journalArticle

Siderophores
Biosynthesis
Nucleosides
Conformations
Pharmacokinetics
47 Citations (Scopus)

Mitsunobu Reactions Catalytic in Phosphine and a Fully Catalytic System

Buonomo, J. A. & Aldrich, C., Oct 1 2015, In : Angewandte Chemie - International Edition. 54, 44, p. 13041-13044 4 p.

Research output: Contribution to journalArticle

phosphine
hydrazine
Byproducts
Hydrazine
Catalysts
12 Citations (Scopus)

Mycobacterium tuberculosis IMPDH in complexes with substrates, products and antitubercular compounds

Makowska-Grzyska, M., Kim, Y., Gorla, S. K., Wei, Y., Mandapati, K., Zhang, M., Maltseva, N., Modi, G., Boshoff, H. I., Gu, M., Aldrich, C., Cuny, G. D., Hedstrom, L. & Joachimiak, A., Oct 6 2015, In : PLoS One. 10, 10, e0138976.

Research output: Contribution to journalArticle

inosine monophosphate
Mycobacterium tuberculosis complex
Mycobacterium tuberculosis
tuberculosis
NAD
13 Citations (Scopus)

Polyketide Quinones Are Alternate Intermediate Electron Carriers during Mycobacterial Respiration in Oxygen-Deficient Niches

Anand, A., Verma, P., Singh, A. K., Kaushik, S., Pandey, R., Shi, C., Kaur, H., Chawla, M., Elechalawar, C. K., Kumar, D., Yang, Y., Bhavesh, N. S., Banerjee, R., Dash, D., Singh, A., Natarajan, V. T., Ojha, A. K., Aldrich, C. C. & Gokhale, R. S., Nov 19 2015, In : Molecular Cell. 60, 4, p. 637-650 14 p.

Research output: Contribution to journalArticle

Polyketides
Quinones
Respiration
Electrons
Oxygen
8 Citations (Scopus)

Stereocontrolled Synthesis of a Potential Transition-State Inhibitor of the Salicylate Synthase MbtI from Mycobacterium tuberculosis

Liu, Z., Liu, F. & Aldrich, C., Jul 2 2015, In : Journal of Organic Chemistry. 80, 13, p. 6545-6552 8 p.

Research output: Contribution to journalArticle

Salicylates
Iron
Siderophores
Salicylic Acid
Biosynthesis
15 Citations (Scopus)

Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis

Nelson, K., Viswanathan, K., Dawadi, S., Duckworth, B. P., Boshoff, H. I., Barry, C. E. & Aldrich, C., Jul 23 2015, In : Journal of Medicinal Chemistry. 58, 14, p. 5459-5475 17 p.

Research output: Contribution to journalArticle

Siderophores
Prodrugs
Mycobacterium tuberculosis
Area Under Curve
Pharmacokinetics
25 Citations (Scopus)

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in mycobacterium tuberculosis

Park, S. W., Casalena, D. E., Wilson, D. J., Dai, R., Nag, P. P., Liu, F., Boyce, J. P., Bittker, J. A., Schreiber, S. L., Finzel, B. C., Schnappinger, D. & Aldrich, C. C., Jan 22 2015, In : Chemistry and Biology. 22, 1, p. 76-86 11 p.

Research output: Contribution to journalArticle

Biosynthesis
Biotin
Mycobacterium tuberculosis
Drug Design
Transaminases
16 Citations (Scopus)

Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors

Bockman, M. R., Kalinda, A. S., Petrelli, R., De La Mora-Rey, T., Tiwari, D., Liu, F., Dawadi, S., Nandakumar, M., Rhee, K. Y., Schnappinger, D., Finzel, B. C. & Aldrich, C. C., Sep 24 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7349-7369 21 p.

Research output: Contribution to journalArticle

Ligases
Biotin
Mycobacterium tuberculosis
Nucleosides
Proteins
9 Citations (Scopus)

Tylosin polyketide synthase module 3: stereospecificity, stereoselectivity and steady-state kinetic analysis of β-processing domains via diffusible, synthetic substrates

Fiers, W. D., Dodge, G. J., Li, Y., Smith, J. L., Fecik, R. A. & Aldrich, C., Aug 1 2015, In : Chemical Science. 6, 8, p. 5027-5033 7 p.

Research output: Contribution to journalArticle

Tylosin
Polyketide Synthases
Hydro-Lyases
Stereoselectivity
Stereochemistry
7 Citations (Scopus)

Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase

Srivastava, S., Chaudhary, S., Thukral, L., Shi, C., Gupta, R. D., Gupta, R., Priyadarshan, K., Vats, A., Haque, A. S., Sankaranarayanan, R., Natarajan, V. T., Sharma, R., Aldrich, C. C. & Gokhale, R. S., Dec 17 2015, In : Chemistry and Biology. 22, 12, p. 1577-1587 11 p.

Research output: Contribution to journalArticle

Isomerases
Coenzyme A
Mycobacterium
Mycobacterium tuberculosis
Lipids
2014
25 Citations (Scopus)

Inhibition of mycobacterium tuberculosis transaminase BioA by aryl hydrazines and hydrazides

Dai, R., Wilson, D., Geders, T. W., Aldrich, C. & Finzel, B. C., Mar 3 2014, In : ChemBioChem. 15, 4, p. 575-586 12 p.

Research output: Contribution to journalArticle

hydrazine
Hydrazines
Transaminases
Mycobacterium tuberculosis
Tuberculosis
11 Citations (Scopus)

Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains

Li, Y., Fiers, W. D., Bernard, S. M., Smith, J. L., Aldrich, C. & Fecik, R. A., Dec 19 2014, In : ACS Chemical Biology. 9, 12, p. 2914-2922 9 p.

Research output: Contribution to journalArticle

Polyketides
Stereochemistry
Biological Products
Sulfides
Substrates
12 Citations (Scopus)

Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase

Xu, Z., Yin, W., Martinelli, L. K., Evans, J., Chen, J., Yu, Y., Wilson, D., Mizrahi, V., Qiao, C. & Aldrich, C., Mar 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 5, p. 1726-1735 10 p.

Research output: Contribution to journalArticle

pantothenate synthetase
Reaction intermediates
Mammals
Biosynthesis
Coenzyme A
26 Citations (Scopus)

Structure-activity relationship analysis of imidazoquinolines with toll-like receptors 7 and 8 selectivity and enhanced cytokine induction

Schiaffo, C. E., Shi, C., Xiong, Z., Olin, M. R., Ohlfest, J. R., Aldrich, C. & Ferguson, D. M., Jan 23 2014, In : Journal of Medicinal Chemistry. 57, 2, p. 339-347 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 8
Toll-Like Receptor 7
Structure-Activity Relationship
Cytokines
Interleukin-12
2013
61 Citations (Scopus)

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

Kim, J. H., O'Brien, K. M., Sharma, R., Boshoff, H. I. M., Rehren, G., Chakraborty, S., Wallach, J. B., Monteleone, M., Wilson, D., Aldrich, C., Barry, C. E., Rhee, K. Y., Ehrt, S. & Schnappinger, D., Nov 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. 19095-19100 6 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Ligases
Anti-Bacterial Agents
Pharmaceutical Preparations
NAD
19 Citations (Scopus)

Bisubstrate inhibitors of biotin protein ligase in mycobacterium tuberculosis resistant to cyclonucleoside formation

Shi, C., Tiwari, D., Wilson, D. J., Seiler, C. L., Schnappinger, D. & Aldrich, C. C., Dec 12 2013, In : ACS Medicinal Chemistry Letters. 4, 12, p. 1213-1217 5 p.

Research output: Contribution to journalArticle

Enzyme inhibition
Biosynthesis
Chemical stability
Ligases
Biotin