20002023
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Research Output 2000 2019

2019
1 Citation (Scopus)

A Cinchona Alkaloid Antibiotic That Appears to Target ATP Synthase in Streptococcus pneumoniae

Wang, X., Zeng, Y., Sheng, L., Larson, P., Liu, X., Zou, X., Wang, S., Guo, K., Ma, C., Zhang, G., Cui, H., Ferguson, D. M., Li, Y., Zhang, J. & Aldrich, C. C., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2305-2332 28 p.

Research output: Contribution to journalArticle

Cinchona Alkaloids
Quinuclidines
Streptococcus pneumoniae
Adenosine Triphosphate
Anti-Bacterial Agents

Development of an imidazole salt catalytic system for the preparation of bis(indolyl) methanes and bis(naphthyl)methane

Wang, X. & Aldrich, C., Apr 1 2019, In : PloS one. 14, 4, e0216008.

Research output: Contribution to journalArticle

Open Access
naphthols
Naphthols
imidazoles
Methane
methane

Investigation of (S)-(-)-acidomycin: A selective antimycobacterial natural product that inhibits biotin synthase

Bockman, M. R., Engelhart, C. A., Cramer, J. D., Howe, M. D., Mishra, N. K., Zimmerman, M., Larson, P., Alvarez-Cabrera, N., Park, S. W., Boshoff, H. I. M., Bean, J. M., Young, V. G., Ferguson, D. M., Dartois, V., Jarrett, J. T., Schnappinger, D. & Aldrich, C., Apr 12 2019, In : ACS Infectious Diseases. 5, 4, p. 598-617 20 p.

Research output: Contribution to journalArticle

Biological Products
Microbial Sensitivity Tests
Biotin
Tuberculosis
Multidrug-Resistant Tuberculosis
tuberculosis
drugs
Crystal structure
Nuclear magnetic resonance
crystal structure

Mechanism of a Standalone β-Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme

Robinson, S. L., Christenson, J. K., Richman, J. E., Jenkins, D. J., Neres, J., Fonseca, D. R., Aldrich, C. & Wackett, L. P., Jul 1 2019, In : ChemBioChem. 20, 13, p. 1701-1711 11 p.

Research output: Contribution to journalArticle

Lactones
Ligases
Assays
Enzymes
Xanthomonas campestris
1 Citation (Scopus)

Noncompetitive inhibitors of TNFR1 probe conformational activation states

Lo, C. H., Schaaf, T. M., Grant, B. D., Lim, C. K. W., Bawaskar, P., Aldrich, C., Thomas, D. D. & Sachs, J. N., Jul 30 2019, In : Science signaling. 12, 592, eaav5637.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
Chemical activation
Dimerization
Molecules
Ligands
2 Citations (Scopus)

Spirocyclic and Bicyclic 8-Nitrobenzothiazinones for Tuberculosis with Improved Physicochemical and Pharmacokinetic Properties

Zhang, G., Howe, M. & Aldrich, C., Mar 14 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 348-351 4 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Tuberculosis
Solubility
Antitubercular Agents
Diamines
2018

2 nd SCI/RSC Symposium on Medicinal Chemistry for Global Health: A Unique Opportunity for the Field

Aldrich, C. & Calderón, F., Apr 13 2018, In : ACS Infectious Diseases. 4, 4, p. 424-428 5 p.

Research output: Contribution to journalReview article

Pharmaceutical Chemistry
Global Health
6 Citations (Scopus)

Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification

Bockman, M. R., Engelhart, C. A., Dawadi, S., Larson, P., Tiwari, D., Ferguson, D. M., Schnappinger, D. & Aldrich, C. C., Jul 13 2018, In : ACS Infectious Diseases. 4, 7, p. 1102-1113 12 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Nucleosides
Anti-Bacterial Agents
Ligases
Biotin
6 Citations (Scopus)

Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis

Dawadi, S., Boshoff, H. I. M., Park, S. W., Schnappinger, D. & Aldrich, C., Apr 12 2018, In : ACS Medicinal Chemistry Letters. 9, 4, p. 386-391 6 p.

Research output: Contribution to journalArticle

Open Access
Siderophores
Salicylates
Biosynthesis
Nucleosides
Tuberculosis
4 Citations (Scopus)

Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis

Howe, M. D., Kordus, S. L., Cole, M. S., Bauman, A. A., Aldrich, C., Baughn, A. & Minato, Y., Nov 12 2018, In : Frontiers in cellular and infection microbiology. 8, 1 p.

Research output: Contribution to journalArticle

Open Access
Aminosalicylic Acid
Mycobacterium tuberculosis
Folic Acid
Methionine
4-Aminobenzoic Acid
4 Citations (Scopus)

Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole

Minato, Y., Dawadi, S., Kordus, S. L., Sivanandam, A., Aldrich, C. C. & Baughn, A. D., Mar 8 2018, In : Nature Communications. 9, 1

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

PKS–NRPS Enzymology and Structural Biology: Considerations in Protein Production

Skiba, M. A., Maloney, F. P., Dan, Q., Fraley, A. E., Aldrich, C., Smith, J. L. & Brown, W. C., Jan 1 2018, Methods in Enzymology. Moore, B. S. (ed.). Academic Press Inc., p. 45-88 44 p. (Methods in Enzymology; vol. 604).

Research output: Chapter in Book/Report/Conference proceedingChapter

Peptide Synthases
Polyketide Synthases
Lead compounds
Dissection
Cloning
6 Citations (Scopus)

Scalable Synthesis of Hydrido-Disiloxanes from Silanes: A One-Pot Preparation of 1,3-Diphenyldisiloxane from Phenylsilane

Buonomo, J. A., Eiden, C. G. & Aldrich, C. C., Jan 18 2018, In : Synthesis (Germany). 50, 2, p. 278-281 4 p.

Research output: Contribution to journalArticle

Open Access
Silanes
disiloxane

Special Issue on Drug Discovery for Global Health

Aldrich, C. C. & Calderon, F., Apr 13 2018, In : ACS Infectious Diseases. 4, 4, p. 429-430 2 p.

Research output: Contribution to journalEditorial

Drug Discovery
Global Health
9 Citations (Scopus)

Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae

Bailey, D. C., Alexander, E. M., Rice, M. R., Drake, E. J., Mydy, L. S., Aldrich, C. & Gulick, A. M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 20, p. 7841-7852 12 p.

Research output: Contribution to journalArticle

Open Access
Siderophores
Biosynthesis
Klebsiella pneumoniae
Stereoselectivity
Kinetics

Structural Basis of Polyketide Synthase O-Methylation

Skiba, M. A., Bivins, M. M., Schultz, J., Bernard, S. M., Fiers, W. D., Dan, Q., Kulkarni, S., Wipf, P., Gerwick, W. H., Sherman, D. H., Aldrich, C. & Smith, J. L., Dec 21 2018, In : ACS Chemical Biology. 13, 12, p. 3221-3228 8 p.

Research output: Contribution to journalArticle

Polyketide Synthases
Methylation
Methyltransferases
Hydroxyl Radical
Biosynthetic Pathways
6 Citations (Scopus)

Targeting protein biotinylation enhances tuberculosis chemotherapy

Tiwari, D., Park, S. W., Essawy, M. M., Dawadi, S., Mason, A., Nandakumar, M., Zimmerman, M., Mina, M., Ho, H. P., Engelhart, C. A., Ioerger, T., Sacchettini, J. C., Rhee, K., Ehrt, S., Aldrich, C. C., Dartois, V. & Schnappinger, D., Apr 25 2018, In : Science Translational Medicine. 10, 438, eaal1803.

Research output: Contribution to journalArticle

Biotinylation
Protein Transport
Tuberculosis
Drug Therapy
Ligases
6 Citations (Scopus)

Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes

Gulick, A. M. & Aldrich, C., Nov 1 2018, In : Natural Product Reports. 35, 11, p. 1156-1184 29 p.

Research output: Contribution to journalReview article

Open Access
Biological Products
Peptide Synthases
Polyketide Synthases
Catalytic Domain
Carrier Proteins
9 Citations (Scopus)

Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular

Negatu, D. A., Liu, J. J. J., Zimmerman, M., Kaya, F., Dartois, V., Aldrich, C., Gengenbacher, M. & Dicka, T., Mar 1 2018, In : Antimicrobial agents and chemotherapy. 62, 3, e01571-17.

Research output: Contribution to journalArticle

Open Access
Pyrazinamide
Mycobacterium tuberculosis
Libraries
Mycobacterium Infections
Bacterial Load
2017

ACS Infectious Diseases Special Issue Focused on Drug Discovery for Global Health

Aldrich, C. & Calderón, F., May 12 2017, In : ACS Infectious Diseases. 3, 5, 1 p.

Research output: Contribution to journalEditorial

Drug Discovery
Communicable Diseases
Global Health
7 Citations (Scopus)

Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma

Okon, A., Han, J., Dawadi, S., Demosthenous, C., Aldrich, C., Gupta, M. & Wagner, C. R., Oct 12 2017, In : Journal of Medicinal Chemistry. 60, 19, p. 8131-8144 14 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Nucleotides
Chemical Phenomena
Nucleosides
Sulfur
11 Citations (Scopus)

Chemoselective Reduction of Phosphine Oxides by 1,3-Diphenyl-Disiloxane

Buonomo, J. A., Eiden, C. G. & Aldrich, C. C., Oct 17 2017, In : Chemistry - A European Journal. 23, 58, p. 14434-14438 5 p.

Research output: Contribution to journalArticle

Open Access
phosphine
Oxides
Silanes
Chemical activation
Phosphines

Introducing a New Associate Editor for ACS Infectious Diseases

Aldrich, C., Feb 10 2017, In : ACS Infectious Diseases. 3, 2, 1 p.

Research output: Contribution to journalEditorial

Communicable Diseases
2 Citations (Scopus)
Open Access
Kinetic parameters
Scaffolds
Medicine
Rate constants
Enzymes
6 Citations (Scopus)

Structure-Based Optimization of Pyridoxal 5′-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis

Liu, F., Dawadi, S., Maize, K. M., Dai, R., Park, S. W., Schnappinger, D., Finzel, B. C. & Aldrich, C., Jul 13 2017, In : Journal of Medicinal Chemistry. 60, 13, p. 5507-5520 14 p.

Research output: Contribution to journalArticle

Open Access
Pyridoxal Phosphate
Enzyme Inhibitors
Biotin
Transaminases
Mycobacterium tuberculosis
4 Citations (Scopus)

Synthesis and analysis of bacterial folate metabolism intermediates and antifolates

Dawadi, S., Kordus, S. L., Baughn, A. & Aldrich, C., Jan 1 2017, In : Organic Letters. 19, 19, p. 5220-5223 4 p.

Research output: Contribution to journalArticle

Aminosalicylic Acid
Pterins
Folic Acid Antagonists
Multidrug-Resistant Tuberculosis
Imines
3 Citations (Scopus)
Open Access
Pyridoxal Phosphate
Cyclization
Enzymes
Enzyme inhibition
Dimerization
2 Citations (Scopus)

Synthesis of Transition-State Inhibitors of Chorismate Utilizing Enzymes from Bromobenzene cis-1,2-Dihydrodiol

Zhang, X. K., Liu, F., Fiers, W. D., Sun, W. M., Guo, J., Liu, Z. & Aldrich, C. C., Apr 7 2017, In : Journal of Organic Chemistry. 82, 7, p. 3432-3440 9 p.

Research output: Contribution to journalArticle

Open Access
Enzymes
Siderophores
Salicylic Acid
Salicylates
Pyruvic Acid
3 Citations (Scopus)

The Ecstasy and Agony of Assay Interference Compounds

Aldrich, C., Bertozzi, C., Georg, G. I., Kiessling, L., Lindsley, C., Liotta, D., Merz, K. M., Schepartz, A. & Wang, S., Mar 14 2017, In : Biochemistry. 56, 10, p. 1363-1366 4 p.

Research output: Contribution to journalReview article

Biochemistry
Colloids
Spectrum analysis
Assays
7 Citations (Scopus)

The Ecstasy and Agony of Assay Interference Compounds

Aldrich, C., Bertozzi, C., Georg, G. I., Kiessling, L., Lindsley, C., Liotta, D., Merz, K. M., Schepartz, A. & Wang, S., Mar 27 2017, In : Journal of Chemical Information and Modeling. 57, 3, p. 387-390 4 p.

Research output: Contribution to journalReview article

Assays
interference
artifact
Screening
Molecules
12 Citations (Scopus)

The Ecstasy and Agony of Assay Interference Compounds

Aldrich, C., Bertozzi, C., Georg, G. I., Kiessling, L., Lindsley, C., Liotta, D., Merz, K. M., Schepartz, A. & Wang, S., Apr 13 2017, In : ACS Medicinal Chemistry Letters. 8, 4, p. 379-382 4 p.

Research output: Contribution to journalEditorial

Open Access
41 Citations (Scopus)

The Ecstasy and Agony of Assay Interference Compounds

Aldrich, C., Bertozzi, C., Georg, G. I., Kiessling, L., Lindsley, C., Liotta, D., Merz, K. M., Schepartz, A. & Wang, S., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2165-2168 4 p.

Research output: Contribution to journalEditorial

11 Citations (Scopus)

The Ecstasy and Agony of Assay Interference Compounds

Aldrich, C., Bertozzi, C., Georg, G. I., Kiessling, L., Lindsley, C., Liotta, D., Merz, K. M., Schepartz, A. & Wang, S., Mar 17 2017, In : ACS Chemical Biology. 12, 3, p. 575-578 4 p.

Research output: Contribution to journalReview article

Colloids
Assays
Computer simulation
Drug Discovery
31 Citations (Scopus)

The Ecstasy and Agony of Assay Interference Compounds

Aldrich, C., Bertozzi, C., Georg, G. I., Kiessling, L., Lindsley, C., Liotta, D., Merz, K. M., Schepartz, A. & Wang, S., Mar 22 2017, In : ACS Central Science. 3, 3, p. 143-147 5 p.

Research output: Contribution to journalReview article

Open Access
Assays
1 Citation (Scopus)

The Ecstasy and Agony of Assay Interference Compounds

Aldrich, C., Bertozzi, C., Georg, G. I., Kiessling, L., Lindsley, C., Liotta, D., Merz, K. M., Schepartz, A. & Wang, S., Mar 15 2017, In : ACS Chemical Neuroscience. 8, 3, p. 420-423 4 p.

Research output: Contribution to journalReview article

Colloids
Biological Products
Assays
Computer simulation
Drug Discovery
4 Citations (Scopus)

The Ecstasy and Agony of Assay Interference Compounds

Aldrich, C., Bertozzi, C., Georg, G. I., Kiessling, L., Lindsley, C., Liotta, D., Merz, K. M., Schepartz, A. & Wang, S., Apr 14 2017, In : ACS Infectious Diseases. 3, 4, p. 259-262 4 p.

Research output: Contribution to journalReview article

2016
10 Citations (Scopus)

2-Aryl-8-aza-3-deazaadenosine analogues of 5′-O-[N-(salicyl)sulfamoyl]adenosine: Nucleoside antibiotics that block siderophore biosynthesis in Mycobacterium tuberculosis

Krajczyk, A., Zeidler, J., Januszczyk, P., Dawadi, S., Boshoff, H. I., Barry, C. E., Ostrowski, T. & Aldrich, C., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 14, p. 3133-3143 11 p.

Research output: Contribution to journalArticle

Siderophores
Biosynthesis
Mycobacterium tuberculosis
Nucleosides
Anti-Bacterial Agents

Antibiotic Discovery for Mycobacteria

Aldrich, C., Jan 8 2016, In : ACS Infectious Diseases. 1, 12, p. 576-577 2 p.

Research output: Contribution to journalEditorial

Mycobacterium
Anti-Bacterial Agents

A Role for Chemists in Microbiome Research

Aldrich, C., Jul 8 2016, In : ACS Infectious Diseases. 2, 7, 1 p.

Research output: Contribution to journalEditorial

Microbiota
Research

Defining the Chemistry of Infectious Diseases

Aldrich, C., Jan 8 2016, In : ACS Infectious Diseases. 2, 1, 1 p.

Research output: Contribution to journalEditorial

Communicable Diseases
9 Citations (Scopus)

Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction

Štular, T., Lešnik, S., Rožman, K., Schink, J., Zdouc, M., Ghysels, A., Liu, F., Aldrich, C., Haupt, V. J., Salentin, S., Daminelli, S., Schroeder, M., Langer, T., Gobec, S., Janežič, D. & Konc, J., Dec 22 2016, In : Journal of Medicinal Chemistry. 59, 24, p. 11069-11078 10 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Binding Sites
Ligands
Proteins
Drug Discovery
20 Citations (Scopus)

Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase

Skiba, M. A., Sikkema, A. P., Fiers, W. D., Gerwick, W. H., Sherman, D. H., Aldrich, C. C. & Smith, J. L., Dec 16 2016, In : ACS Chemical Biology. 11, 12, p. 3319-3327 9 p.

Research output: Contribution to journalArticle

Polyketide Synthases
Methyltransferases
Catalytic Domain
Acyl Carrier Protein
Polyketides

Going Viral

Kindrachuk, K. N. & Aldrich, C., Jan 8 2016, In : ACS Infectious Diseases. 1, 9, 1 p.

Research output: Contribution to journalEditorial

5 Citations (Scopus)

Measurement of nonribosomal peptide synthetase adenylation domain activity using a continuous hydroxylamine release assay

Duckworth, B. P., Wilson, D. J. & Aldrich, C. C., Feb 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 53-61 9 p. (Methods in Molecular Biology; vol. 1401).

Research output: Chapter in Book/Report/Conference proceedingChapter

Peptide Synthases
Hydroxylamine
Carrier Proteins
Chromogenic Compounds
Enzyme Assays
10 Citations (Scopus)

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis

Kuhn, M. L., Alexander, E., Minasov, G., Page, H. J., Warwrzak, Z., Shuvalova, L., Flores, K. J., Wilson, D., Shi, C., Aldrich, C. & Anderson, W. F., Aug 12 2016, In : ACS Infectious Diseases. 2, 8, p. 579-591 13 p.

Research output: Contribution to journalArticle

Mycolic Acids
Adenosine Monophosphate
Ligases
Mycobacterium tuberculosis
Tuberculosis
37 Citations (Scopus)

Structures of a nonribosomal peptide synthetase module bound to MbtH-like proteins support a highly dynamic domain architecture

Miller, B. R., Drake, E. J., Shi, C., Aldrich, C. & Gulick, A. M., Oct 21 2016, In : Journal of Biological Chemistry. 291, 43, p. 22559-22571 13 p.

Research output: Contribution to journalArticle

Peptide Synthases
Proteins
Condensation
Peptides
Escherichia coli Proteins
87 Citations (Scopus)

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

Drake, E. J., Miller, B. R., Shi, C., Tarrasch, J. T., Sundlov, J. A., Allen, L., Skiniotis, G., Aldrich, C. C. & Gulick, A. M., Jan 13 2016, In : Nature. 529, 7585, p. 235-238 4 p.

Research output: Contribution to journalArticle

Peptide Synthases
Bioengineering
Biological Products
Catalysis
Catalytic Domain
10 Citations (Scopus)

Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis

Dawadi, S., Kawamura, S., Rubenstein, A., Remmel, R. P. & Aldrich, C., Mar 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 6, p. 1314-1321 8 p.

Research output: Contribution to journalArticle

Siderophores
Biosynthesis
Prodrugs
Mycobacterium tuberculosis
Nucleosides
9 Citations (Scopus)

Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates

Thiede, J. M., Kordus, S. L., Turman, B. J., Buonomo, J. A., Aldrich, C. C., Minato, Y. & Baughn, A. D., 2016, In : Scientific Reports. 6, 38083.

Research output: Contribution to journalArticle

4-Aminobenzoic Acid
Folic Acid Antagonists
Dihydropteroate Synthase
Aminosalicylic Acid
Sulfonamides