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Research Output 2001 2019

2019
5 Citations (Scopus)

Critical role of C5a in sickle cell disease

Vercellotti, G. M., Dalmasso, A. P., Schaid, T. R., Nguyen, J., Chen, C., Ericson, M. E., Abdulla, F., Killeen, T., Lindorfer, M. A., Taylor, R. P. & Belcher, J. D., Mar 2019, In : American Journal of Hematology. 94, 3, p. 327-337 11 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Anaphylatoxin C5a Receptor
P-Selectin
Complement Activation
Immunoglobulin G

Morphine promotes neovascularizing retinopathy in sickle transgeneic mice

Gupta, K., Chen, C., Lutty, G. A. & Hebbel, R. P., Apr 9 2019, In : Blood Advances. 3, 7, p. 1073-1083 11 p.

Research output: Contribution to journalArticle

Open Access
Morphine
Transgenic Mice
Opioid Receptors
Vascular Endothelial Growth Factor Receptor-2
Sickle Cell Anemia
2018
14 Citations (Scopus)

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

Belcher, J. D., Chen, C., Nguyen, J., Abdulla, F., Zhang, P., Nguyen, H., Nguyen, P., Killeen, T., Miescher, S. M., Brinkman, N., Nath, K. A., Steer, C. J. & Vercellotti, G. M., Apr 2018, In : PloS one. 13, 4, e0196455.

Research output: Contribution to journalArticle

Open Access
heme oxygenase (biliverdin-producing)
Hemopexin
sickle cell anemia
Heme Oxygenase-1
Haptoglobins
2 Citations (Scopus)

Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vasoocclusion, inflammation and anemia

Belcher, J. D., Gomperts, E., Nguyen, J., Chen, C., Abdulla, F., Kiser, Z. M., Gallo, D., Levy, H., Otterbein, L. E. & Vercellotti, G. M., Oct 2018, In : PloS one. 13, 10, e0205194.

Research output: Contribution to journalArticle

Open Access
sickle cell anemia
carbon monoxide
Sickle Cell Anemia
Carbon Monoxide
anemia
2017
22 Citations (Scopus)

Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate

Belcher, J. D., Chen, C., Nguyen, J., Zhang, P., Abdulla, F., Nguyen, P., Killeen, T., Xu, P., O'Sullivan, G., Nath, K. A. & Vercellotti, G. M., May 10 2017, In : Antioxidants and Redox Signaling. 26, 14, p. 748-762 15 p.

Research output: Contribution to journalArticle

Open Access
Oxidative stress
Sickle Cell Anemia
Oxidative Stress
Inflammation
Heme
2016
20 Citations (Scopus)
Hemopexin
Sickle Cell Anemia
Blood Vessels
Inflammation
Liver
2015
13 Citations (Scopus)

The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-κB activation in transgenic sickle mice

Belcher, J. D., Chen, C., Nguyen, J., Abdulla, F., Nguyen, P., Nguyen, M., Okeley, N. M., Benjamin, D. R., Senter, P. D. & Vercellotti, G. M., Feb 23 2015, In : PloS one. 10, 2, e0117772.

Research output: Contribution to journalArticle

sickle cell anemia
Sickle Cell Anemia
endothelium
Transgenic Mice
Endothelium
2014
248 Citations (Scopus)

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Belcher, J. D., Chen, C., Nguyen, J., Milbauer, L., Abdulla, F., Alayash, A. I., Smith, A., Nath, K. A., Hebbel, R. P. & Vercellotti, G. M., Jan 16 2014, In : Blood. 123, 3, p. 377-390 14 p.

Research output: Contribution to journalArticle

Endothelial cells
Sickle Cell Anemia
Heme
Endothelial Cells
Chemical activation
22 Citations (Scopus)

H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

Vercellotti, G. M., Khan, F. B., Nguyen, J., Chen, C., Bruzzone, C. M., Bechtel, H., Brown, G., Nath, K. A., Steer, C. J., Hebbel, R. P. & Belcher, J. D., Jan 1 2014, In : Frontiers in Pharmacology. 5 APR, Article 79.

Research output: Contribution to journalArticle

Apoferritins
Ceruloplasmin
Sickle Cell Anemia
Transgenic Mice
Heme Oxygenase-1
2013
10 Citations (Scopus)
Platelet-Derived Growth Factor Receptors
Mesangial Cells
Morphine
Transgenic Mice
Kidney
48 Citations (Scopus)

MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice

Belcher, J. D., Young, M., Chen, C., Nguyen, J., Burhop, K., Tran, P. & Vercellotti, G. M., Jan 1 2013, In : Blood. 122, 15, p. 2757-2764 8 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Carbon Monoxide
Modulators
Transgenic Mice
Hemoglobins
2011
57 Citations (Scopus)

Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer

Fujioka, N., Nguyen, J., Chen, C., Li, Y., Pasrija, T., Niehans, G., Johnson, K. N., Gupta, V., Kratzke, R. A. & Gupta, K., Dec 1 2011, In : Anesthesia and Analgesia. 113, 6, p. 1353-1364 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Non-Small Cell Lung Carcinoma
Morphine
Opioid Receptors
67 Citations (Scopus)
Heme Oxygenase-1
Hemin
MicroRNAs
Proteins
Enzyme activity
2010
60 Citations (Scopus)
Beauty
Heme Oxygenase-1
Sickle Cell Anemia
Blood Vessels
Genes
2009
30 Citations (Scopus)

Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease

Beckman, J. D., Belcher, J. D., Vineyard, J. V., Chen, C., Nguyen, J., Nwaneri, M. O., O'Sullivan, G., Gulbahce, E., Hebbel, R. P. & Vercellotti, G. M., Oct 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 4, p. H1243-H1253

Research output: Contribution to journalArticle

Leukocytosis
Sickle Cell Anemia
Carbon Monoxide
Anti-Inflammatory Agents
Blood Vessels
2008
3 Citations (Scopus)
Gene therapy
Heme Oxygenase-1
Polymerase chain reaction
Polymorphism
Transgenes
2006
59 Citations (Scopus)
mu Opioid Receptor
Morphine
Vascular Endothelial Growth Factor A
Endothelial Cells
Platelet-Derived Growth Factor Receptors
38 Citations (Scopus)
Sympathomimetics
Escherichia coli O157
Cecum
Adrenergic Agents
Norepinephrine
2004
66 Citations (Scopus)

Adrenergic modulation of Escherichia coli O157:H7 adherence to the colonic mucosa

Green, B. T., Lyte, M., Chen, C., Xie, Y., Casey, M. A., Kulkarni-Narla, A., Vulchanova, L. & Brown, D. R., Dec 1 2004, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 287, 6 50-6, p. G1238-G1246

Research output: Contribution to journalArticle

Escherichia coli O157
Enterohemorrhagic Escherichia coli
Adrenergic Agents
Norepinephrine
Mucous Membrane
2003
79 Citations (Scopus)

Catecholamines modulate Escherichia coli O157:H7 adherence to murine cecal mucosa.

Chen, C., Brown, D. R., Xie, Y., Green, B. T. & Lyte, M., Aug 2003, In : Shock (Augusta, Ga.). 20, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

Escherichia coli O157
Catecholamines
Mucous Membrane
Dopamine
Norepinephrine
2001
50 Citations (Scopus)

Induction of hepatocyte proliferation and liver hyperplasia by the targeted expression of cyclin E and skp2

Nelsen, C. J., Hansen, L. K., Rickheim, D. G., Chen, C., Stanley, M. W., Krek, W. & Albrecht, J. H., Apr 5 2001, In : Oncogene. 20, 15, p. 1825-1831 7 p.

Research output: Contribution to journalArticle

Cyclin E
Hyperplasia
Hepatocytes
Transfection
Liver