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Research Output 1994 2019

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Article
2019

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Saha, A., Taylor, P. A., Lees, C. J., Panoskaltsis-Mortari, A., Osborn, M. J., Feser, C. J., Thangavelu, G., Melchinger, W., Refaeli, Y., Hill, G. R., Munn, D. H., Murphy, W. J., Serody, J. S., Maillard, I., Kreymborg, K., van den Brink, M., Dong, C., Huang, S., Zang, X., Allison, J. P. & 2 others, Zeiser, R. & Blazar, B. R., Jan 1 2019, In : JCI Insight. 4, 19, e127716.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
T-Lymphocytes
Mortality
Metabolic Networks and Pathways
Oxygen Consumption
1 Citation (Scopus)

Revertant mosaic fibroblasts in recessive dystrophic epidermolysis bullosa

Twaroski, K., Eide, C., Riddle, M. J., Xia, L., Lees, C. J., Chen, W., Mathews, W., Keene, D. R., McGrath, J. A. & Tolar, J., Dec 1 2019, In : British Journal of Dermatology. 181, 6, p. 1247-1253 7 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa Dystrophica
Fibroblasts
Keratinocytes
Mosaicism
Skin

Semidominant GPNMB Mutations in Amyloidosis Cutis Dyschromica

Onoufriadis, A., Hsu, C. K., Eide, C. R., Nanda, A., Orchard, G. E., Tomita, K., Sheriff, A., Scott, W., Tierney, C., Lee, J. Y. W., Gomaa, N. S., Desomchoke, R., Lwin, S. M., Tu, W. T., Chen, L. Y., Huang, H. Y., Chao, S. C., Yu-Yun Lee, J., Bare, Y., Hayday, T. & 12 others, Guy, A. L., Liu, L., Lees, C., Hirdler, T., Lovell, P., Xia, L., Dayrit, J. F., Calonje, E., Simpson, M. A., Tolar, J., Parsons, M. & McGrath, J. A., Dec 2019, In : Journal of Investigative Dermatology. 139, 12, p. 2550-2554.e9

Research output: Contribution to journalArticle

Amyloidosis
Mutation
2018
5 Citations (Scopus)

Crispr/cas9-based cellular engineering for targeted gene overexpression

Osborn, M. J., Lees, C. J., McElroy, A. N., Merkel, S. C., Eide, C. R., Mathews, W., Feser, C. J., Tschann, M., McElmury, R. T., Webber, B. R., Kim, C. J., Blazar, B. R. & Tolar, J., Apr 2018, In : International journal of molecular sciences. 19, 4, 946.

Research output: Contribution to journalArticle

Open Access
Cell Engineering
genes
Genes
engineering
T-cells
2017
6 Citations (Scopus)

Rapid generation of Col7a1 mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells

Webber, B. R., O'Connor, K. T., Mc Elmurry, R. T., Durgin, E. N., Eide, C. R., Lees, C. J., Riddle, M. J., Mathews, W. E., Frank, N. Y., Kluth, M. A., Ganss, C., Moriarity, B. S., Frank, M. H., Osborn, M. J. & Tolar, J., Oct 1 2017, In : Laboratory Investigation. 97, 10, p. 1218-1224 7 p.

Research output: Contribution to journalArticle

Open Access
Epidermolysis Bullosa Dystrophica
Immunosuppressive Agents
Mesenchymal Stromal Cells
Skin
Clustered Regularly Interspaced Short Palindromic Repeats
2016
2015
5 Citations (Scopus)
Germ Cell and Embryonal Neoplasms
MicroRNAs
Methylation
Histology
Stem Cells
2014
47 Citations (Scopus)
Epidermolysis Bullosa Dystrophica
Gene therapy
Induced Pluripotent Stem Cells
Stem cells
Genes
2011
63 Citations (Scopus)
Iduronidase
Mucopolysaccharidosis I
Induced Pluripotent Stem Cells
Stem cells
Grafts
109 Citations (Scopus)
Epidermolysis Bullosa Dystrophica
Induced Pluripotent Stem Cells
Stem cells
Skin
Erosion
67 Citations (Scopus)
Iduronidase
Mucopolysaccharidoses
Genetic Therapy
Mucopolysaccharidosis I
DNA
2008
93 Citations (Scopus)

Sleeping beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies

Huang, X., Guo, H., Kang, J., Choi, S., Zhou, T. C., Tammana, S., Lees, C. J., Li, Z. Z., Milone, M., Levine, B. L., Tolar, J., June, C. H., McIvor, R. S., Wagner, J. E., Blazar, B. R. & Zhou, X., Jan 1 2008, In : Molecular Therapy. 16, 3, p. 580-589 10 p.

Research output: Contribution to journalArticle

Beauty
Human Engineering
Cell- and Tissue-Based Therapy
T-Lymphocytes
Neoplasms
56 Citations (Scopus)

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

Taylor, P. A., Ehrhardt, M. J., Lees, C. J., Panoskaltsis-Mortari, A., Krieg, A. M., Sharpe, A. H., Murphy, W. J., Serody, J. S., Hemmi, H., Akira, S., Levy, R. B. & Blazar, B. R., Oct 15 2008, In : Blood. 112, 8, p. 3508-3516 9 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Cytosine
Guanine
Bone
Bone Marrow
2007
57 Citations (Scopus)

Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)

Taylor, P. A., Ehrhardt, M. J., Lees, C. J., Tolar, J., Weigel, B. J., Panoskaltsis-Mortari, A., Serody, J. S., Brinkmann, V. & Blazar, B. R., Nov 1 2007, In : Blood. 110, 9, p. 3480-3488 9 p.

Research output: Contribution to journalArticle

T-cells
Graft vs Host Disease
Regulatory T-Lymphocytes
Grafts
Transplantation (surgical)
2006
25 Citations (Scopus)

Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo antitumor protective responses

Weigel, B. J., Panoskaltsis-Mortari, A., Diers, M., Garcia, M., Lees, C., Krieg, A. M., Chen, W. & Blazar, B. R., Oct 1 2006, In : Experimental Hematology. 34, 10, p. 1403-1412 10 p.

Research output: Contribution to journalArticle

Dendritic Cells
Antigens
Vaccines
Neoplasms
Capital Punishment
2004
105 Citations (Scopus)

B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions

Taylor, P. A., Lees, C. J., Fournier, S., Allison, J. P., Sharpe, A. H. & Blazar, B. R., Jan 1 2004, In : Journal of Immunology. 172, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

Ligation
Down-Regulation
T-Lymphocytes
Graft vs Host Disease
Tissue Donors
112 Citations (Scopus)

In vivo imaging of graft-versus-host-disease in mice

Panoskaltsis-Mortari, A., Price, A., Hermanson, J. R., Taras, E., Lees, C., Serody, J. S. & Blazar, B. R., May 1 2004, In : Blood. 103, 9, p. 3590-3598 9 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
Fluorescence
Imaging techniques
Cell Movement
2003
82 Citations (Scopus)

Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

Blazar, B. R., Sharpe, A. H., Chen, A. I., Panoskaltsis-Mortari, A., Lees, C., Akiba, H., Yagita, H., Killeen, N. & Taylor, P. A., May 1 2003, In : Blood. 101, 9, p. 3741-3748 8 p.

Research output: Contribution to journalArticle

OX40 Ligand
Transplants
Graft Rejection
Graft vs Host Disease
Grafts
2002
49 Citations (Scopus)
Bone Marrow Cells
Liver
Bone
Cells
Transplants
59 Citations (Scopus)

Combined effects of calcineurin inhibitors or sirolimus with anti-CD40L mAb on alloengraftment under nonmyeloablative conditions

Taylor, P. A., Lees, C. J., Wilson, J. M., Ehrhardt, M. J., Campbell, M. T., Noelle, R. J. & Blazar, B. R., Nov 1 2002, In : Blood. 100, 9, p. 3400-3407 8 p.

Research output: Contribution to journalArticle

CD40 Ligand
Sirolimus
Monoclonal Antibodies
Cyclosporine
Tacrolimus
800 Citations (Scopus)

The infusion of ex vivo activated and expanded CD4 +CD25 + immune regulatory cells inhibits graft-versus-host disease lethality

Taylor, P. A., Lees, C. J. & Blazar, B. R., May 15 2002, In : Blood. 99, 10, p. 3493-3499 7 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
T-cells
Transplantation (surgical)
Isoantigens
2001
90 Citations (Scopus)

Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions

Taylor, P. A., Lees, C. J., Waldmann, H., Noelle, R. J. & Blazar, B. R., Jul 15 2001, In : Blood. 98, 2, p. 467-474 8 p.

Research output: Contribution to journalArticle

CD40 Ligand
Monoclonal Antibodies
T-cells
Chimerism
T-Lymphocytes
2000
61 Citations (Scopus)

Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions

Blazar, B. R., Lees, C. J., Martin, P. J., Noelle, R. J., Kwon, B., Murphy, W. & Taylor, P. A., Nov 1 2000, In : Journal of Immunology. 165, 9, p. 4901-4909 9 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Leukocytes
Lymphocytes
T-Lymphocytes
Bone Marrow Transplantation
1998
80 Citations (Scopus)

Engraftment of severe combined immune deficient mice receiving allogeneic bone marrow via in utero or postnatal transfer

Blazar, B. R., Taylor, P. A., Mc Elmurry, R. T., Tian, L., Panoskaltsis-Mortari, A., Lam, S., Lees, C. J., Waldschmidt, T. & Vallera, D. A., Nov 15 1998, In : Blood. 92, 10, p. 3949-3959 11 p.

Research output: Contribution to journalArticle

T-cells
Bone
Transplantation
Bone Marrow
Severe Combined Immunodeficiency
1996
8 Citations (Scopus)
Chinchilla
Lipoxygenase
Middle Ear
Glycoproteins
Epithelial Cells
7 Citations (Scopus)
Chinchilla
Middle Ear
Glycoproteins
Platelet Activating Factor
Epithelium
1995
18 Citations (Scopus)

Effect of platelet-activating factor on secretion of mucous glycoprotein from chinchilla middle ear epithelial cells in vitro

Lin, J., Kim, Y., Lees, C. J. & Juhn, S. K., Jan 1 1995, In : Oto-Rhino-Laryngology. 252, 2, p. 92-96 5 p.

Research output: Contribution to journalArticle

Chinchilla
Platelet Activating Factor
Middle Ear
Glycoproteins
Epithelial Cells
1994
35 Citations (Scopus)

Determining otitis media severity from middle ear fluid analysis.

Juhn, S. K., Garvis, W. J., Lees, C. J., Le, C. T. & Kim, C. S., May 1994, In : The Annals of otology, rhinology & laryngology. Supplement. 163, 5 II, p. 43-45 3 p.

Research output: Contribution to journalArticle

Otitis Media
Middle Ear
Otitis Media with Effusion
Suppurative Otitis Media
Collagenases