Research Output per year
Personal profile
Research interests
Aneuploidy is a major contributing factor to metastatic progression, and is found in ninety percent of solid cancerous tumors. For a diploid cell to become an colony of aneuploid tumor cells, the cell must both (1) mis-segregate a chromosome and (2) avoid the p53-dependent cell cycle arrest that is normally triggered in response to inadvertently becoming aneuploid. I am actively examining how somatic cells both regulate chromosome segregation and trigger p53 accumulation when chromosomes mis-segregate. This work involves identifying and characterizing cancer-associated mutations that impair these two processes. I have considerable expertise in the fields of cell biology, mitosis and cell cycle, quantitative fluorescence microscopy and membrane biophysics.
Research interests
- Histone H3.3
- Aneuploidy
- ATRX
- Cancer
- p53
- glioblastoma
- mitosis
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Research Output
A novel computational framework for D(t) from Fluorescence Recovery after Photobleaching data reveals various anomalous diffusion types in live cell membranes
Kang, M., Day, C. A. & Kenworthy, A. K., Nov 1 2019, In : Traffic. 20, 11, p. 867-880 14 p.Research output: Contribution to journal › Article
Microsurgery and microinjection techniques in mitosis research
Day, C. A., Hornick, J., Langfald, A., Mader, C. & Hinchcliffe, E. H., 2018, Methods in Cell Biology. Maiato, H. & Schuh, M. (eds.). Academic Press Inc., p. 159-172 14 p. (Methods in Cell Biology; vol. 145).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation
Hinchcliffe, E. H., Day, C. A., Karanjeet, K. B., Fadness, S., Langfald, A., Vaughan, K. T. & Dong, Z., Jun 1 2016, In : Nature Cell Biology. 18, 6, p. 668-675 8 p.Research output: Contribution to journal › Article
33
Scopus
citations
Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles
Schlebach, J. P., Barrett, P. J., Day, C. A., Kim, J. H., Kenworthy, A. K. & Sanders, C. R., Mar 1 2016, In : Biochemistry. 55, 7, p. 985-988 4 p.Research output: Contribution to journal › Article
8
Scopus
citations
Functions of cholera toxin B-subunit as a raft cross-linker
Day, C. A. & Kenworthy, A. K., Jan 1 2015, In : Essays in Biochemistry. 57, p. 135-145 11 p.Research output: Contribution to journal › Article
17
Scopus
citations