Projects per year
Personal profile
Research interests
Aneuploidy is a major contributing factor to metastatic progression, and is found in ninety percent of solid cancerous tumors. For a diploid cell to become an colony of aneuploid tumor cells, the cell must both (1) mis-segregate a chromosome and (2) avoid the p53-dependent cell cycle arrest that is normally triggered in response to inadvertently becoming aneuploid. I am actively examining how somatic cells both regulate chromosome segregation and trigger p53 accumulation when chromosomes mis-segregate. This work involves identifying and characterizing cancer-associated mutations that impair these two processes. I have considerable expertise in the fields of cell biology, mitosis and cell cycle, quantitative fluorescence microscopy and membrane biophysics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Interest Keywords
- Histone H3.3
- Aneuploidy
- ATRX
- Cancer
- p53
- glioblastoma
- mitosis
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Working towards targeted therapy in H3K27M tumors: Aurora Kinase Inhibitors and the role of epigenome programing
Hinchcliffe, E. H. (PI) & Day, C. A. (CoI)
MAYO CLINIC ROCHESTER, NATIONAL INSTITUTES OF HEALTH (NIH)
9/1/20 → 5/31/25
Project: Research project
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Editorial: Activation of the cGAS-STING pathway by extra-nuclear DNA and its pharmacognostic modulation in human disease
McCourt, P. M., Day, C. A. & Paul, S., 2025, In: Frontiers in Pharmacology. 16, 1519429.Research output: Contribution to journal › Editorial › peer-review
Open Access -
H3F3A K27M mutations drive a repressive transcriptome by modulating chromatin accessibility independent of H3K27me3 in Diffuse Midline Glioma
Bhattarai, S., Hakkim, F. L., Day, C. A., Grigore, F., Langfald, A., Entin, I., Hinchcliffe, E. H. & Robinson, J. P., Dec 2025, In: Epigenetics and Chromatin. 18, 1, 23.Research output: Contribution to journal › Article › peer-review
Open Access -
The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis
Day, C. A., Grigore, F., Hakkim, F. L., Paul, S., Langfald, A., Weberg, M., Fadness, S., Schwab, P., Sepaniac, L., Stumpff, J., Vaughan, K. T., Daniels, D. J., Robinson, J. P. & Hinchcliffe, E. H., Jan 20 2025, In: Current Biology. 35, 2, p. 354-362.e7Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The Utility of Fluorescence Recovery after Photobleaching (FRAP) to Study the Plasma Membrane
Day, C. A. & Kang, M., May 2023, In: Membranes. 13, 5, 492.Research output: Contribution to journal › Review article › peer-review
Open Access6 Scopus citations -
H3K27me3 in Diffuse Midline Glioma and Epithelial Ovarian Cancer: Opposing Epigenetic Changes Leading to the Same Poor Outcomes
Day, C. A., Hinchcliffe, E. H. & Robinson, J. P., Nov 2022, In: Cells. 11, 21, 3376.Research output: Contribution to journal › Review article › peer-review
Open Access14 Scopus citations
Press/Media
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Institute Scientists Receive Award for Pediatric Brain Tumor Research
Hinchcliffe, E. H., Day, C. A. & Robinson, J.
10/21/20
1 item of Media coverage
Press/Media: Expert Comment or Interview