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Personal profile

Research interests

Aneuploidy is a major contributing factor to metastatic progression, and is found in ninety percent of solid cancerous tumors.  For a diploid cell to become an colony of aneuploid tumor cells, the cell must both (1) mis-segregate a chromosome and (2) avoid the p53-dependent cell cycle arrest that is normally triggered in response to inadvertently becoming aneuploid.  I am actively examining how somatic cells both regulate chromosome segregation and trigger p53 accumulation when chromosomes mis-segregate.  This work involves identifying and characterizing cancer-associated mutations that impair these two processes.  I have considerable expertise in the fields of cell biology, mitosis and cell cycle, quantitative fluorescence microscopy and membrane biophysics.

Research interests

  • Histone H3.3
  • Aneuploidy
  • ATRX
  • Cancer
  • p53
  • glioblastoma
  • mitosis

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Research Output

Manipulating cultured mammalian cells for mitosis research

Day, C. A., Langfald, A. & Hinchcliffe, E. H., 2020, Methods in Cell Biology. Tran, P. (ed.). Academic Press Inc., p. 43-61 19 p. (Methods in Cell Biology; vol. 158).

Research output: Chapter in Book/Report/Conference proceedingChapter

  • A novel computational framework for D(t) from Fluorescence Recovery after Photobleaching data reveals various anomalous diffusion types in live cell membranes

    Kang, M., Day, C. A. & Kenworthy, A. K., Nov 1 2019, In : Traffic. 20, 11, p. 867-880 14 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Microsurgery and microinjection techniques in mitosis research

    Day, C. A., Hornick, J., Langfald, A., Mader, C. & Hinchcliffe, E. H., 2018, Methods in Cell Biology. Maiato, H. & Schuh, M. (eds.). Academic Press Inc., p. 159-172 14 p. (Methods in Cell Biology; vol. 145).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation

    Hinchcliffe, E. H., Day, C. A., Karanjeet, K. B., Fadness, S., Langfald, A., Vaughan, K. T. & Dong, Z., Jun 1 2016, In : Nature Cell Biology. 18, 6, p. 668-675 8 p.

    Research output: Contribution to journalArticle

  • 37 Scopus citations

    Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles

    Schlebach, J. P., Barrett, P. J., Day, C. A., Kim, J. H., Kenworthy, A. K. & Sanders, C. R., Mar 1 2016, In : Biochemistry. 55, 7, p. 985-988 4 p.

    Research output: Contribution to journalArticle

    Open Access
  • 9 Scopus citations