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Personal profile

Research interests

Aneuploidy is a major contributing factor to metastatic progression, and is found in ninety percent of solid cancerous tumors.  For a diploid cell to become an colony of aneuploid tumor cells, the cell must both (1) mis-segregate a chromosome and (2) avoid the p53-dependent cell cycle arrest that is normally triggered in response to inadvertently becoming aneuploid.  I am actively examining how somatic cells both regulate chromosome segregation and trigger p53 accumulation when chromosomes mis-segregate.  This work involves identifying and characterizing cancer-associated mutations that impair these two processes.  I have considerable expertise in the fields of cell biology, mitosis and cell cycle, quantitative fluorescence microscopy and membrane biophysics.

Research interests

  • Histone H3.3
  • Aneuploidy
  • ATRX
  • Cancer
  • p53
  • glioblastoma
  • mitosis

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Research Output 2004 2018

Microsurgery and microinjection techniques in mitosis research

Day, C. A., Hornick, J., Langfald, A., Mader, C. & Hinchcliffe, E. H., Jan 1 2018, Methods in Cell Biology. Maiato, H. & Schuh, M. (eds.). Academic Press Inc., p. 159-172 14 p. (Methods in Cell Biology; vol. 145).

Research output: Chapter in Book/Report/Conference proceedingChapter

Microsurgery
Microinjections
Mitosis
Micromanipulation
Cell Division
32 Citations (Scopus)

Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation

Hinchcliffe, E. H., Day, C. A., Karanjeet, K. B., Fadness, S., Langfald, A., Vaughan, K. T. & Dong, Z., Jun 1 2016, In : Nature Cell Biology. 18, 6, p. 668-675 8 p.

Research output: Contribution to journalArticle

Anaphase
Cell Cycle Checkpoints
Histones
Chromosomes
Phosphorylation
8 Citations (Scopus)

Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles

Schlebach, J. P., Barrett, P. J., Day, C. A., Kim, J. H., Kenworthy, A. K. & Sanders, C. R., Mar 1 2016, In : Biochemistry. 55, 7, p. 985-988 4 p.

Research output: Contribution to journalArticle

Membrane Proteins
Lipids
Structural properties
Liquids
Biochemical Phenomena
14 Citations (Scopus)

Functions of cholera toxin B-subunit as a raft cross-linker

Day, C. A. & Kenworthy, A. K., Jan 1 2015, In : Essays in Biochemistry. 57, p. 135-145 11 p.

Research output: Contribution to journalArticle

Cholera Toxin
Lipids
Membranes
Membrane structures
Proteins
20 Citations (Scopus)

Microtubule Motors Power Plasma Membrane Tubulation in Clathrin-Independent Endocytosis

Day, C. A., Baetz, N. W., Copeland, C. A., Kraft, L. J., Han, B., Tiwari, A., Drake, K. R., De Luca, H., Chinnapen, D. J. F., Davidson, M. W., Holmes, R. K., Jobling, M. G., Schroer, T. A., Lencer, W. I. & Kenworthy, A. K., Jun 1 2015, In : Traffic. 16, 6, p. 572-590 19 p.

Research output: Contribution to journalArticle

Clathrin
Cholera Toxin
Cell membranes
Endocytosis
Microtubules