Projects per year
Personal profile
Research interests
Aneuploidy is a major contributing factor to metastatic progression, and is found in ninety percent of solid cancerous tumors. For a diploid cell to become an colony of aneuploid tumor cells, the cell must both (1) mis-segregate a chromosome and (2) avoid the p53-dependent cell cycle arrest that is normally triggered in response to inadvertently becoming aneuploid. I am actively examining how somatic cells both regulate chromosome segregation and trigger p53 accumulation when chromosomes mis-segregate. This work involves identifying and characterizing cancer-associated mutations that impair these two processes. I have considerable expertise in the fields of cell biology, mitosis and cell cycle, quantitative fluorescence microscopy and membrane biophysics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Interest Keywords
- Histone H3.3
- Aneuploidy
- ATRX
- Cancer
- p53
- glioblastoma
- mitosis
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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The Utility of Fluorescence Recovery after Photobleaching (FRAP) to Study the Plasma Membrane
Day, C. A. & Kang, M., May 2023, In: Membranes. 13, 5, 492.Research output: Contribution to journal › Review article › peer-review
Open Access -
H3K27me3 in Diffuse Midline Glioma and Epithelial Ovarian Cancer: Opposing Epigenetic Changes Leading to the Same Poor Outcomes
Day, C. A., Hinchcliffe, E. H. & Robinson, J. P., Nov 2022, In: Cells. 11, 21, 3376.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma
Zhang, L., Nesvick, C. L., Day, C. A., Choi, J., Lu, V. M., Peterson, T., Power, E. A., Anderson, J. B., Hamdan, F. H., Decker, P. A., Simons, R., Welby, J. P., Siada, R., Ge, J., Kaptzan, T., Johnsen, S. A., Hinchcliffe, E. H. & Daniels, D. J., Oct 1 2022, In: Neuro-Oncology. 24, 10, p. 1700-1711 12 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Using Microinjection of Mammalian Cultured Cells to Study Cell Division
Day, C., Langfald, A. & Hinchcliffe, E. H., 2022, Methods in Molecular Biology. Humana Press Inc., Vol. 2415. p. 105-122 18 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability
Almacellas, E., Pelletier, J., Day, C., Ambrosio, S., Tauler, A. & Mauvezin, C., Jun 23 2020, In: Autophagy. 17, 3, p. 796-813 18 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations
Press/Media
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Institute Scientists Receive Award for Pediatric Brain Tumor Research
Edward H Hinchcliffe, Charles A Day & James Robinson
10/21/20
1 item of Media coverage
Press/Media: Expert Comment or Interview