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Research Output

2020

Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform

Gonatopoulos-Pournatzis, T., Aregger, M., Brown, K. R., Farhangmehr, S., Braunschweig, U., Ward, H. N., Ha, K. C. H., Weiss, A., Billmann, M., Durbic, T., Myers, C. L., Blencowe, B. J. & Moffat, J., May 1 2020, In : Nature biotechnology. 38, 5, p. 638-648 11 p.

Research output: Contribution to journalArticle

Publisher Correction: Integrating yeast chemical genomics and mammalian cell pathway analysis (Acta Pharmacologica Sinica, (2019), 40, 9, (1245-1255), 10.1038/s41401-019-0231-y)

Zhou, F. L., Li, S. C., Zhu, Y., Guo, W. J., Shao, L. J., Nelson, J., Simpkins, S., Yang, D. H., Liu, Q., Yashiroda, Y., Xu, J. B., Fan, Y. Y., Yue, J. M., Yoshida, M., Xia, T., Myers, C. L., Boone, C. & Wang, M. W., Jan 1 2020, (Accepted/In press) In : Acta Pharmacologica Sinica.

Research output: Contribution to journalComment/debate

Open Access

Single-cell gene expression analyses reveal distinct self-renewing and proliferating subsets in the leukemia stem cell compartment in acute myeloid leukemia

Sachs, K., Sarver, A. L., Noble-Orcutt, K. E., LaRue, R. S., Antony, M. L., Chang, D., Lee, Y., Navis, C. M., Hillesheim, A. L., Nykaza, I. R., Ha, N. A., Hansen, C. J., Karadag, F. K., Bergerson, R. J., Verneris, M. R., Meredith, M. M., Schomaker, M. L., Linden, M. A., Myers, C. L., Largaespada, D. A. & 1 others, Sachs, Z., Feb 1 2020, In : Cancer Research. 80, 3, p. 458-470 13 p.

Research output: Contribution to journalArticle

Skp, cullin, F-box (SCF)-Met30 and SCF-Cdc4- mediated proteolysis of CENP-A prevents mislocalization of CENP-A for chromosomal stability in budding yeast

Au, W. C., Zhang, T., Mishra, P. K., Eisenstatt, J. R., Walker, R. L., Ocampo, J., Dawson, A., Warren, J., Costanzo, M., Baryshnikova, A., Flick, K., Clark, D. J., Meltzer, P. S., Baker, R. E., Myers, C., Boone, C., Kaiser, P. & Basrai, M. A., Jan 1 2020, In : PLoS genetics. 16, 2, e1008597.

Research output: Contribution to journalArticle

Open Access
2019

Discovering genetic interactions bridging pathways in genome-wide association studies

Fang, G., Wang, W., Paunic, V., Heydari, H., Costanzo, M., Liu, X., Liu, X., VanderSluis, B., Oately, B., Steinbach, M., Van Ness, B., Schadt, E. E., Pankratz, N. D., Boone, C., Kumar, V. & Myers, C. L., Dec 1 2019, In : Nature communications. 10, 1, 4274.

Research output: Contribution to journalArticle

Open Access

Domain insertion permissibility-guided engineering of allostery in ion channels

Coyote-Maestas, W., He, Y., Myers, C. L. & Schmidt, D., Dec 1 2019, In : Nature communications. 10, 1, 290.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Integrating yeast chemical genomics and mammalian cell pathway analysis

Zhou, F. L., Li, S. C., Zhu, Y., Guo, W. J., Shao, L. J., Nelson, J., Simpkins, S., Yang, D. H., Liu, Q., Yashiroda, Y., Xu, J. B., Fan, Y. Y., Yue, J. M., Yoshida, M., Xia, T., Myers, C. L., Boone, C. & Wang, M. W., Sep 1 2019, In : Acta Pharmacologica Sinica. 40, 9, p. 1245-1255 11 p.

Research output: Contribution to journalArticle

Revealing Functional Crosstalk between Distinct Bioprocesses through Reciprocal Functional Tests of Genetically Interacting Genes

Chen, D., Xu, W., Wang, Y., Ye, Y., Wang, Y., Yu, M., Gao, J., Wei, J., Dong, Y., Zhang, H., Fu, X., Ma, K., Wang, H., Yang, Z., Zhou, J., Cheng, W., Wang, S., Chen, J., Grant, B. D., Myers, C. L. & 2 others, Shi, A. & Xia, T., Nov 26 2019, In : Cell reports. 29, 9, p. 2646-2658.e5

Research output: Contribution to journalArticle

Open Access

Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments

Simpkins, S. W., Deshpande, R., Nelson, J., Li, S. C., Piotrowski, J. S., Ward, H. N., Yashiroda, Y., Osada, H., Yoshida, M., Boone, C. & Myers, C. L., Feb 1 2019, In : Nature Protocols. 14, 2, p. 415-440 26 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

A genome-wide screen reveals a role for the HIR histone chaperone complex in preventing mislocalization of budding yeast CENP-A

Ciftci-Yilmaz, S., Au, W. C., Mishra, P. K., Eisenstatt, J. R., Chang, J., Dawson, A. R., Zhu, I., Rahman, M., Bilke, S., Costanzo, M., Baryshnikova, A., Myers, C. L., Meltzer, P. S., Landsman, D., Baker, R. E., Boone, C. & Basrai, M. A., Sep 2018, In : Genetics. 210, 1, p. 203-218 16 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Chemical genomic guided engineering of gamma-valerolactone tolerant yeast

Bottoms, S., Dickinson, Q., McGee, M., Hinchman, L., Higbee, A., Hebert, A., Serate, J., Xie, D., Zhang, Y., Coon, J. J., Myers, C. L., Landick, R. & Piotrowski, J. S., Jan 12 2018, In : Microbial Cell Factories. 17, 1, 5.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Different modes of negative regulation of plant immunity by calmodulin-related genes

Lu, Y., Truman, W., Liu, X., Bethke, G., Zhou, M., Myers, C. L., Katagiri, F. & Glazebrook, J., Apr 2018, In : Plant physiology. 176, 4, p. 3046-3061 16 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Integrating coexpression networks with GWAS to prioritize causal genes in maize

Schaefer, R. J., Michno, J. M., Jeffers, J., Hoekenga, O., Dilkes, B., Baxter, I. & Myersc, C. L., Dec 2018, In : Plant Cell. 30, 12, p. 2922-2942 21 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Integrating genetic and protein–protein interaction networks maps a functional wiring diagram of a cell

VanderSluis, B., Costanzo, M., Billmann, M., Ward, H. N., Myers, C. L., Andrews, B. J. & Boone, C., Oct 2018, In : Current Opinion in Microbiology. 45, p. 170-179 10 p.

Research output: Contribution to journalReview article

6 Scopus citations

In vitro pluripotent stem cell differentiation to hepatocyte ceases further maturation at an equivalent stage of e15 in mouse embryonic liver development

Raju, R., Chau, D., Notelaers, T., Myers, C. L., Verfaillie, C. M. & Hu, W. S., Jul 1 2018, In : Stem Cells and Development. 27, 13, p. 910-921 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

MOSAIC: A chemical-genetic interaction data repository and web resource for exploring chemical modes of action

Nelson, J., Simpkins, S. W., Safizadeh, H., Li, S. C., Piotrowski, J. S., Hirano, H., Yashiroda, Y., Osada, H., Yoshida, M., Boone, C. & Myers, C. L., Apr 1 2018, In : Bioinformatics. 34, 7, p. 1251-1252 2 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions

Simpkins, S. W., Nelson, J., Deshpande, R., Li, S. C., Piotrowski, J. S., Wilson, E. H., Gebre, A. A., Safizadeh, H., Okamoto, R., Yoshimura, M., Costanzo, M., Yashiroda, Y., Ohya, Y., Osada, H., Yoshida, M., Boone, C. & Myers, C. L., Oct 2018, In : PLoS Computational Biology. 14, 10, e1006532.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Systematic analysis of complex genetic interactions

Kuzmin, E., VanderSluis, B., Wang, W., Tan, G., Deshpande, R., Chen, Y., Usaj, M., Balint, A., Usaj, M. M., Van Leeuwen, J., Koch, E. N., Pons, C., Dagilis, A. J., Pryszlak, M., Wang, J. Z. Y., Hanchard, J., Riggi, M., Xu, K., Heydari, H., Luis, B. J. S. & 12 others, Shuteriqi, E., Zhu, H., Van Dyk, N., Sharifpoor, S., Costanzo, M., Loewith, R., Caudy, A., Bolnick, D., Brown, G. W., Andrews, B. J., Boone, C. & Myers, C. L., Apr 20 2018, In : Science. 360, 6386, aao1729.

Research output: Contribution to journalArticle

Open Access
54 Scopus citations

Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity

Kayatekin, C., Amasino, A., Gaglia, G., Flannick, J., Bonner, J. M., Fanning, S., Narayan, P., Barrasa, M. I., Pincus, D., Landgraf, D., Nelson, J., Hesse, W. R., Costanzo, M., Myers, C. L., Boone, C., Florez, J. C. & Lindquist, S., Mar 22 2018, In : Cell. 173, 1, p. 62-73.e9

Research output: Contribution to journalArticle

Open Access
16 Scopus citations
2017

Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

Morales, E. H., Pinto, C. A., Luraschi, R., Muñoz-Villagrán, C. M., Cornejo, F. A., Simpkins, S. W., Nelson, J., Arenas, F. A., Piotrowski, J. S., Myers, C. L., Mori, H. & Vásquez, C. C., Jan 1 2017, In : Nature communications. 8, 15320.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

A new natural product analog of blasticidin S reveals cellular uptake facilitated by the NorA multidrug transporter

Davison, J. R., Lohith, K. M., Wang, X., Bobyk, K., Mandadapu, S. R., Lee, S. L., Cencic, R., Nelson, J., Simpkins, S., Frank, K. M., Pelletier, J., Myers, C. L., Piotrowski, J., Smith, H. E. & Bewley, C. A., Jun 2017, In : Antimicrobial agents and chemotherapy. 61, 6, e02635-16.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Chemical Genomics, Structure Elucidation, and in Vivo Studies of the Marine-Derived Anticlostridial Ecteinamycin

Wyche, T. P., Alvarenga, R. F. R., Piotrowski, J. S., Duster, M. N., Warrack, S. R., Cornilescu, G., De Wolfe, T. J., Hou, Y., Braun, D. R., Ellis, G. A., Simpkins, S. W., Nelson, J., Myers, C. L., Steele, J., Mori, H., Safdar, N., Markley, J. L., Rajski, S. R. & Bugni, T. S., Sep 15 2017, In : ACS Chemical Biology. 12, 9, p. 2287-2295 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Coculture of Marine Invertebrate-Associated Bacteria and Interdisciplinary Technologies Enable Biosynthesis and Discovery of a New Antibiotic, Keyicin

Adnani, N., Chevrette, M. G., Adibhatla, S. N., Zhang, F., Yu, Q., Braun, D. R., Nelson, J., Simpkins, S. W., McDonald, B. R., Myers, C. L., Piotrowski, J. S., Thompson, C. J., Currie, C. R., Li, L., Rajski, S. R. & Bugni, T. S., Dec 15 2017, In : ACS Chemical Biology. 12, 12, p. 3093-3102 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Development of expression-based biomarkers of dasatinib response in hematologic malignancies

Akre, M. K., Mitra, A., Wang, W., Myers, C. L. & Van Ness, B., Dec 1 2017, In : Blood cancer journal. 7, 12, 652.

Research output: Contribution to journalLetter

Open Access

Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens

Hart, T., Tong, A. H. Y., Chan, K., Van Leeuwen, J., Seetharaman, A., Aregger, M., Chandrashekhar, M., Hustedt, N., Seth, S., Noonan, A., Habsid, A., Sizova, O., Nedyalkova, L., Climie, R., Tworzyanski, L., Lawson, K., Sartori, M. A., Alibeh, S., Tieu, D., Masud, S. & 12 others, Mero, P., Weiss, A., Brown, K. R., Usaj, M., Billmann, M., Rahman, M., Constanzo, M., Myers, C. L., Andrews, B. J., Boone, C., Durocher, D. & Moffat, J., Jan 1 2017, In : G3: Genes, Genomes, Genetics. 7, 8, p. 2719-2727 9 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping

Rizzolo, K., Huen, J., Kumar, A., Phanse, S., Vlasblom, J., Kakihara, Y., Zeineddine, H. A., Minic, Z., Snider, J., Wang, W., Pons, C., Seraphim, T. V., Boczek, E. E., Alberti, S., Costanzo, M., Myers, C. L., Stagljar, I., Boone, C., Babu, M. & Houry, W. A., Sep 12 2017, In : Cell reports. 20, 11, p. 2735-2748 14 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Functional annotation of chemical libraries across diverse biological processes

Piotrowski, J. S., Li, S. C., Deshpande, R., Simpkins, S. W., Nelson, J., Yashiroda, Y., Barber, J. M., Safizadeh, H., Wilson, E., Okada, H., Gebre, A. A., Kubo, K., Torres, N. P., Leblanc, M. A., Andrusiak, K., Okamoto, R., Yoshimura, M., Derango-Adem, E., Van Leeuwen, J., Shirahige, K. & 10 others, Baryshnikova, A., Brown, G. W., Hirano, H., Costanzo, M., Andrews, B., Ohya, Y., Osada, H., Yoshida, M., Myers, C. L. & Boone, C., Sep 1 2017, In : Nature Chemical Biology. 13, 9, p. 982-993 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Pathway-based discovery of genetic interactions in breast cancer

Wang, W., Xu, Z. Z., Costanzo, M., Boone, C., Lange, C. A. & Myers, C. L., Sep 2017, In : PLoS genetics. 13, 9, e1006973.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

TheCellMap.org: A web-accessible database for visualizing and mining the global yeast genetic interaction network

Usaj, M., Tan, Y., Wang, W., VanderSluis, B., Zou, A., Myers, C. L., Costanzo, M., Andrews, B. & Boone, C., May 1 2017, In : G3: Genes, Genomes, Genetics. 7, 5, p. 1539-1549 11 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

The highly buffered Arabidopsis immune signaling network conceals the functions of its components

Hillmer, R. A., Tsuda, K., Rallapalli, G., Asai, S., Truman, W., Papke, M. D., Sakakibara, H., Jones, J. D. G., Myers, C. L. & Katagiri, F., May 2017, In : PLoS genetics. 13, 5, e1006639.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

Unraveling gene function in agricultural species using gene co-expression networks

Schaefer, R. J., Michno, J. M. & Myers, C. L., Jan 1 2017, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1860, 1, p. 53-63 11 p.

Research output: Contribution to journalReview article

Open Access
21 Scopus citations

Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology

Mechanic, L. E., Lindström, S., Daily, K. M., Sieberts, S. K., Amos, C. I., Chen, H. S., Cox, N. J., Dathe, M., Feuer, E. J., Guertin, M. J., Hoffman, J., Liu, Y., Moore, J. H., Myers, C. L., Ritchie, M. D., Schildkraut, J., Schumacher, F., Witte, J. S., Wang, W., Williams, S. M. & 3 others, Gillanders, E. M., U4C Challenge Participants & U4C Challenge Data Contributors, Sep 2017, In : PLoS genetics. 13, 9, e1006945.

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations
2016

A gene-centered C. elegans protein–DNA interaction network provides a framework for functional predictions

Fuxman Bass, J. I., Pons, C., Kozlowski, L., Reece-Hoyes, J. S., Shrestha, S., Holdorf, A. D., Mori, A., Myers, C. L. & Walhout, A. J. M., Oct 1 2016, In : Molecular Systems Biology. 12, 10, 884.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

A global genetic interaction network maps a wiring diagram of cellular function

Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., Pelechano, V., Styles, E. B., Billmann, M., Van Leeuwen, J., Van Dyk, N., Lin, Z. Y., Kuzmin, E., Nelson, J., Piotrowski, J. S., Srikumar, T. & 34 others, Bahr, S., Chen, Y., Deshpande, R., Kurat, C. F., Li, S. C., Li, Z., Usaj, M. M., Okada, H., Pascoe, N., Luis, B. J. S., Sharifpoor, S., Shuteriqi, E., Simpkins, S. W., Snider, J., Suresh, H. G., Tan, Y., Zhu, H., Malod-Dognin, N., Janjic, V., Przulj, N., Troyanskaya, O. G., Stagljar, I., Xia, T., Ohya, Y., Gingras, A. C., Raught, B., Boutros, M., Steinmetz, L. M., Moore, C. L., Rosebrock, A. P., Caudy, A. A., Myers, C. L., Andrews, B. & Boone, C., Sep 23 2016, In : Science. 353, 6306, 1420.

Research output: Contribution to journalArticle

Open Access
325 Scopus citations

Co-expression network analysis of duplicate genes in maize (Zea mays L.) reveals no subgenome bias

Li, L., Briskine, R., Schaefer, R., Schnable, P. S., Myers, C. L., Flagel, L. E., Springer, N. M. & Muehlbauer, G. J., Nov 4 2016, In : BMC Genomics. 17, 1, 875.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Exploring genetic suppression interactions on a global scale

Van Leeuwen, J., Pons, C., Mellor, J. C., Yamaguchi, T. N., Friesen, H., Koschwanez, J., Ušaj, M. M., Pechlaner, M., Takar, M., Ušaj, M., Vander Sluis, B., Andrusiak, K., Bansal, P., Baryshnikova, A., Boone, C. E., Cao, J., Cote, A., Gebbia, M., Horecka, G., Horecka, I. & 22 others, Kuzmin, E., Legro, N., Liang, W., Van Lieshout, N., McNee, M., San Luis, B. J., Shaeri, F., Shuteriqi, E., Sun, S., Yang, L., Youn, J. Y., Yuen, M., Costanzo, M., Gingras, A. C., Aloy, P., Oostenbrink, C., Murray, A., Graham, T. R., Myers, C. L., Andrews, B. J., Roth, F. P. & Boone, C., Nov 4 2016, In : Science. 354, 6312, aag0839.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci

Styles, E. B., Founk, K. J., Zamparo, L. A., Sing, T. L., Altintas, D., Ribeyre, C., Ribaud, V., Rougemont, J., Mayhew, D., Costanzo, M., Usaj, M., Verster, A. J., Koch, E. N., Novarina, D., Graf, M., Luke, B., Muzi-Falconi, M., Myers, C. L., Mitra, R. D., Shore, D. & 4 others, Brown, G. W., Zhang, Z., Boone, C. & Andrews, B. J., Sep 28 2016, In : Cell Systems. 3, 3, p. 264-277.e10

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Fine-mapping of 18q21.1 locus identifies single nucleotide polymorphisms associated with nonsyndromic cleft lip with or without cleft palate

Mitra, A. K., Stessman, H. A. F., Schaefer, R. J., Wang, W., Myers, C. L., Van Ness, B. G. & Beiraghi, S., May 23 2016, In : Frontiers in Genetics. 7, MAY, 88.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mechanism of imidazolium ionic liquids toxicity in Saccharomyces cerevisiae and rational engineering of a tolerant, xylose-fermenting strain

Dickinson, Q., Bottoms, S., Hinchman, L., McIlwain, S., Li, S., Myers, C. L., Boone, C., Coon, J. J., Hebert, A., Sato, T. K., Landick, R. & Piotrowski, J. S., Jan 20 2016, In : Microbial Cell Factories. 15, 1, 17.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Quantitative human cell encyclopedia

Andrews, B. J., Marian Walhout, A. J., Iyengar, R., Apweiler, R., Ardlie, K., Azeloglu, E. U., Birtwistle, M. R., Coon, J. J., Dolinski, K., Fan, T., FitzGerald, G. A., Gavin, A. C., Gingras, A. C., Gough, N. R., Hoffmann, A., Lee, M. J., Loew, L. M., CraigMak, H., Murphy, R. C., Myers, C. & 10 others, Snyder, M. P., Sorger, P. K., Stolovitzky, G., Subramaniam, S., Taipale, M., Travé, G., Troyanskaya, O. G., Uhlen, M., Vidal, M. & HumanCells ProjectWorkingGroup, Aug 30 2016, In : Science signaling. 9, 443, mr1.

Research output: Contribution to journalArticle

Open Access
2015

Chemical genomic profiling via barcode sequencing to predict compound mode of action

Piotrowski, J. S., Simpkins, S. W., Li, S. C., Deshpande, R., McIlwain, S. J., Ong, I. M., Myers, C. L., Boone, C. & Andersen, R. J., Jan 1 2015, In : Methods in Molecular Biology. 1263, p. 299-318 20 p.

Research output: Contribution to journalArticle

17 Scopus citations

Computational paradigms for analyzing genetic interaction networks

Pons, C., Costanzo, M., Boone, C. & Myers, C. L., Jan 1 2015, Systems Genetics: Linking Genotypes and Phenotypes. Cambridge University Press, p. 12-35 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Controlling microbial contamination during hydrolysis of AFEX-pretreated corn stover and switchgrass: Effects on hydrolysate composition, microbial response and fermentation

Serate, J., Xie, D., Pohlmann, E., Donald, C., Shabani, M., Hinchman, L., Higbee, A., McGee, M., La Reau, A., Klinger, G. E., Li, S., Myers, C. L., Boone, C., Bates, D. M., Cavalier, D., Eilert, D., Oates, L. G., Sanford, G., Sato, T. K., Dale, B. & 4 others, Landick, R., Piotrowski, J., Ong, R. G. & Zhang, Y., Nov 14 2015, In : Biotechnology for Biofuels. 8, 1, 356.

Research output: Contribution to journalArticle

18 Scopus citations

Correction: Discovering functional modules across diverse maize transcriptomes using COB, the Co-expression Browser

Schaefer, R. J., Briskine, R., Springer, N. M. & Myers, C. L., Mar 13 2015, In : PloS one. 10, 3, e0120222.

Research output: Contribution to journalComment/debate

Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing

Becker, J. R., Pons, C., Nguyen, H. D., Costanzo, M., Boone, C., Myers, C. L. & Bielinsky, A. K., Nov 2015, In : PLoS genetics. 11, 11, e1005659.

Research output: Contribution to journalArticle

17 Scopus citations

Plant-derived antifungal agent poacic acid targets β-1,3-glucan

Piotrowski, J. S., Okada, H., Lu, F., Li, S. C., Hinchman, L., Ranjan, A., Smith, D. L., Higbee, A. J., Ulbrich, A., Coon, J. J., Deshpande, R., Bukhman, Y. V., McIlwain, S., Ong, I. M., Myers, C. L., Boonec, C., Landicka, R., Ralpha, J., Kabbaged, M. & Ohyab, Y., Mar 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 12, p. E1490-E1497

Research output: Contribution to journalArticle

42 Scopus citations

Transcription Factor Activity Mapping of a Tissue-Specific in Vivo Gene Regulatory Network

MacNeil, L. T., Pons, C., Arda, H. E., Giese, G. E., Myers, C. L. & Walhout, A. J. M., Aug 26 2015, In : Cell Systems. 1, 2, p. 152-162 11 p.

Research output: Contribution to journalArticle

30 Scopus citations
2014

A community computational challenge to predict the activity of pairs of compounds

Bansal, M., Yang, J., Karan, C., Menden, M. P., Costello, J. C., Tang, H., Xiao, G., Li, Y., Allen, J., Zhong, R., Chen, B., Kim, M., Wang, T., Heiser, L. M., Realubit, R., Mattioli, M., Alvarez, M. J., Shen, Y., Gallahan, D., Singer, D. & 80 others, Saez-Rodriguez, J., Xie, Y., Stolovitzky, G., Califano, A., Abbuehl, J. P., Altman, R. B., Balcome, S., Bell, A., Bender, A., Berger, B., Bernard, J., Bieberich, A. A., Borboudakis, G., Chan, C., Chen, T. H., Choi, J., Coelho, L. P., Creighton, C. J., Dampier, W., Davisson, V. J., Deshpande, R., Diao, L., Di Camillo, B., Dundar, M., Ertel, A., Goswami, C. P., Gottlieb, A., Gould, M. N., Goya, J., Grau, M., Gray, J. W., Hejase, H. A., Hoffmann, M. F., Homicsko, K., Homilius, M., Hwang, W., Ijzerman, A. P., Kallioniemi, O., Karacali, B., Kaski, S., Kim, J., Krishnan, A., Lee, J., Lee, Y. S., Lenselink, E. B., Lenz, P., Li, L., Li, J., Liang, H., Mpindi, J. P., Myers, C. L., Newton, M. A., Overington, J. P., Parkkinen, J., Prill, R. J., Peng, J., Pestell, R., Qiu, P., Rajwa, B., Sadanandam, A., Sambo, F., Sridhar, A., Sun, W., Toffolo, G. M., Tozeren, A., Troyanskaya, O. G., Tsamardinos, I., Van Vlijmen, H. W. T., Wang, W., Wegner, J. K., Wennerberg, K., Van Westen, G. J. P., Xia, T., Yang, Y., Yao, V., Yuan, Y., Zeng, H., Zhang, S., Zhao, J. & Zhou, J., Dec 1 2014, In : Nature biotechnology. 32, 12, p. 1213-1222 10 p.

Research output: Contribution to journalArticle

116 Scopus citations

A community effort to assess and improve drug sensitivity prediction algorithms

Costello, J. C., Heiser, L. M., Georgii, E., Gönen, M., Menden, M. P., Wang, N. J., Bansal, M., Ammad-Ud-Din, M., Hintsanen, P., Khan, S. A., Mpindi, J. P., Kallioniemi, O., Honkela, A., Aittokallio, T., Wennerberg, K., Collins, J. J., Gallahan, D., Singer, D., Saez-Rodriguez, J., Kaski, S. & 31 others, Gray, J. W., Stolovitzky, G., Abbuehl, J. P., Allen, J., Altman, R. B., Balcome, S., Battle, A., Bender, A., Berger, B., Bernard, J., Bhattacharjee, M., Bhuvaneshwar, K., Bieberich, A. A., Boehm, F., Califano, A., Chan, C., Chen, B., Chen, T. H., Choi, J., Coelho, L. P., Cokelaer, T., Collins, J. C., Creighton, C. J., Cui, J., Dampier, W., Davisson, V. J., De Baets, B., Deshpande, R., DiCamillo, B., Myers, C. L. & NCI DREAM Community, Dec 1 2014, In : Nature biotechnology. 32, 12, p. 1202-1212 11 p.

Research output: Contribution to journalArticle

276 Scopus citations

Broad metabolic sensitivity profiling of a prototrophic yeast deletion collection

VanderSluis, B., Hess, D. C., Pesyna, C., Krumholz, E. W., Syed, T., Szappanos, B., Nislow, C., Papp, B., Troyanskaya, O. G., Myers, C. L. & Caudy, A. A., Jan 1 2014, In : Genome biology. 15, 4, R64.

Research output: Contribution to journalArticle

29 Scopus citations