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Research Output 1986 2019

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2019

Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice

Shah, R. M., Peterson, C., Strom, A., Dillenburg, M., Finzel, B., Kitto, K. F., Fairbanks, C., Wilcox, G. & Wagner, C. R., Oct 16 2019, In : ACS Chemical Neuroscience. 10, 10, p. 4385-4393 9 p.

Research output: Contribution to journalArticle

Nociception
N-Methylaspartate
Opioid Analgesics
N-Methyl-D-Aspartate Receptors
Aptitude

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

Csizmar, C. M., Petersburg, J. R., Perry, T. J., Rozumalski, L., Hackel, B. J. & Wagner, C. R., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 251-261 11 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Cell membranes
Antigens
Ligands
Cell Membrane

Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Sanchez, J. J., Sanchez, J. E., Noor, S., Ruffaner-Hanson, C. D., Davies, S., Wagner, C. R., Jantzie, L. L., Mellios, N., Savage, D. D. & Milligan, E. D., Apr 8 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Lymphocyte Function-Associated Antigen-1
Integrins
Alcohols
Interleukin-1
Spinal Ganglia
2018

111 In-DANBIRT in Vivo Molecular Imaging of Inflammatory Cells in Atherosclerosis

Mota, R., Campen, M. J., Cuellar, M. E., Garver, W. S., Hesterman, J., Qutaish, M., Daniels, T., Nysus, M., Wagner, C. R. & Norenberg, J. P., Jan 1 2018, In : Contrast Media and Molecular Imaging. 2018, 6508724.

Research output: Contribution to journalArticle

Open Access
Molecular Imaging
High Fat Diet
Atherosclerotic Plaques
Atherosclerosis
Ozone
8 Citations (Scopus)

Engineering Reversible Cell-Cell Interactions with Lipid Anchored Prosthetic Receptors

Csizmar, C. M., Petersburg, J. R., Hendricks, A., Stern, L. A., Hackel, B. J. & Wagner, C. R., Apr 18 2018, In : Bioconjugate Chemistry. 29, 4, p. 1291-1301 11 p.

Research output: Contribution to journalArticle

Open Access
Nanorings
Cell Engineering
Cell membranes
Prosthetics
Cell Communication
3 Citations (Scopus)

Eradication of Established Tumors by Chemically Self-Assembled Nanoring Labeled T Cells

Petersburg, J., Shen, J., Csizmar, C. M., Murphy, K. A., Spanier, J. A., Gabrielse, K., Griffith, T. S., Fife, B. T. & Wagner, C. R., Jul 24 2018, In : ACS nano. 12, 7, p. 6563-6576 14 p.

Research output: Contribution to journalArticle

Nanorings
T-cells
Antigen Receptors
Antigens
Prosthetics
3 Citations (Scopus)

Induction of the p53 tumor suppressor in cancer cells through inhibition of cap-dependent translation

Harris, B. R. E., Wang, D., Zhang, Y., Ferrari, M., Okon, A., Cleary, M. P., Wagner, C. R. & Yang, D., May 1 2018, In : Molecular and cellular biology. 38, 10, e00367.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Protein Biosynthesis
Apoptosis
Double-Stranded DNA Breaks
5' Untranslated Regions
1 Citation (Scopus)

Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia

Shah, R. M., Maize, K. M., West, H. T., Strom, A. M., Finzel, B. C. & Wagner, C. R., Aug 17 2018, In : Journal of Molecular Biology. 430, 17, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

Isaacs Syndrome
Mutation
Enzymes
Adenosine Monophosphate
Histidine

Tunable Supramolecular Assemblies from Amphiphilic Nucleoside Phosphoramidate Nanofibers by Enzyme Activation

West, H. T., Csizmar, C. M. & Wagner, C. R., Jul 9 2018, In : Biomacromolecules. 19, 7, p. 2650-2656 7 p.

Research output: Contribution to journalArticle

Nanofibers
Nucleosides
Enzymes
Chemical activation
Hydrogel
2017
2 Citations (Scopus)

A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides

Maize, K. M., Shah, R., Strom, A., Kumarapperuma, S., Zhou, A., Wagner, C. R. & Finzel, B. C., Nov 6 2017, In : Molecular pharmaceutics. 14, 11, p. 3987-3997 11 p.

Research output: Contribution to journalArticle

Nucleosides
nucleoside phosphotransferase
Prodrugs
Nucleotides
Calorimetry
3 Citations (Scopus)

Anchimerically Activatable Antiviral ProTides

Okon, A., Matos De Souza, M. R., Shah, R., Amorim, R., Da Costa, L. J. & Wagner, C. R., Jan 1 2017, In : ACS Medicinal Chemistry Letters. 8, 9, p. 958-962 5 p.

Research output: Contribution to journalArticle

Open Access
Dengue Virus
Viruses
Antiviral Agents
Cytotoxicity
Virus Replication
7 Citations (Scopus)

Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma

Okon, A., Han, J., Dawadi, S., Demosthenous, C., Aldrich, C., Gupta, M. & Wagner, C. R., Oct 12 2017, In : Journal of Medicinal Chemistry. 60, 19, p. 8131-8144 14 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Nucleotides
Chemical Phenomena
Nucleosides
Sulfur
8 Citations (Scopus)
Protons
Trajectories
Catalysis
Proton transfer
Enzymes
4 Citations (Scopus)
Neuralgia
Histidine
Analgesia
Opioid Analgesics
Metal ions
2 Citations (Scopus)
pain
histidine
nucleotides
Neuralgia
Fluorescent Dyes
7 Citations (Scopus)

Titratable Avidity Reduction Enhances Affinity Discrimination in Mammalian Cellular Selections of Yeast-Displayed Ligands

Stern, L. A., Csizmar, C. M., Woldring, D. R., Wagner, C. R. & Hackel, B. J., May 8 2017, In : ACS Combinatorial Science. 19, 5, p. 315-323 9 p.

Research output: Contribution to journalArticle

Yeast
Ligands
Cells
Fibronectins
Binders
2016
7 Citations (Scopus)

Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1

Shah, R., Strom, A., Zhou, A., Maize, K. M., Finzel, B. C. & Wagner, C. R., Aug 11 2016, In : ACS Medicinal Chemistry Letters. 7, 8, p. 780-784 5 p.

Research output: Contribution to journalArticle

Molecular Probes
Tobacco Use Disorder
Calorimetry
Neuralgia
Thermodynamics
8 Citations (Scopus)

In vivo evaluation of site-specifically PEGylated chemically self-assembled protein nanostructures

Shah, R., Petersburg, J., Gangar, A. C., Fegan, A., Wagner, C. R. & Kumarapperuma, S. C., Jul 5 2016, In : Molecular Pharmaceutics. 13, 7, p. 2193-2203 11 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Nanostructures
Epidermal Growth Factor Receptor
leucyl-alanyl-arginyl-leucyl-leucyl-threonine
Proteins
2015
25 Citations (Scopus)

HINT1 protein: A new therapeutic target to enhance opioid antinociception and block mechanical allodynia

Garzón, J., Herrero-Labrador, R., Rodríguez-Muñoz, M., Shah, R., Vicente-Sánchez, A., Wagner, C. R. & Sánchez-Blázquez, P., Jan 1 2015, In : Neuropharmacology. 89, p. 412-423 12 p.

Research output: Contribution to journalArticle

Hyperalgesia
Staphylococcal Protein A
N-Methyl-D-Aspartate Receptors
Opioid Analgesics
mu Opioid Receptor
6 Citations (Scopus)

Prosthetic antigen receptors

Shen, J., Vallera, D. A. & Wagner, C. R., Aug 19 2015, In : Journal of the American Chemical Society. 137, 32, p. 10108-10111 4 p.

Research output: Contribution to journalArticle

Nanorings
Antigen Receptors
T-cells
Antigens
Prosthetics
17 Citations (Scopus)

Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E

Smith, K. A., Zhou, B., Avdulov, S. V., Benyumov, A., Peterson, M., Liu, Y., Okon, A., Hergert, P., Braziunas, J., Wagner, C. R., Borok, Z. & Bitterman, P. B., Dec 18 2015, In : Scientific reports. 5, 18233.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Transforming Growth Factors
Transforming Growth Factor beta
Fibrosis
Epithelial Cells
2014
14 Citations (Scopus)

Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α

Cao, J., He, L., Lin, G., Hu, C., Dong, R., Zhang, J., Zhu, H., Hu, Y., Wagner, C. R., He, Q. & Yang, B., May 1 2014, In : Biochemical Pharmacology. 89, 1, p. 20-30 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Peptide Initiation Factors
Ouabain
Cardiac Glycosides
Heart Neoplasms
13 Citations (Scopus)

Reversible Re-programing of Cell-Cell Interactions

Gabrielse, K., Gangar, A., Kumar, N., Lee, J. C., Fegan, A., Shen, J. J., Li, Q., Vallera, D. & Wagner, C. R., May 12 2014, In : Angewandte Chemie - International Edition. 53, 20, p. 5112-5116 5 p.

Research output: Contribution to journalArticle

Nanorings
Lipids
Antigens
Ligands
Antigen Receptors
10 Citations (Scopus)

Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells

Chen, E. Z., Jacobson, B. A., Patel, M. R., Okon, A. M., Li, S., Xiong, K., Vaidya, A. J., Bitterman, P. B., Wagner, C. R. & Kratzke, R. A., Jan 1 2014, In : Investigational New Drugs. 32, 4, p. 598-603 6 p.

Research output: Contribution to journalArticle

Mesothelioma
Protein Biosynthesis
Pemetrexed
Prodrugs
Messenger RNA
2013
79 Citations (Scopus)

A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation

Rashidian, M., Mahmoodi, M. M., Shah, R., Dozier, J. K., Wagner, C. R. & Distefano, M. D., Mar 20 2013, In : Bioconjugate Chemistry. 24, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

Hydrazones
Oximes
Ligation
Aniline
Catalysts
30 Citations (Scopus)

Distinct Translational Control in CD4+ T Cell Subsets

Bjur, E., Larsson, O., Yurchenko, E., Zheng, L., Gandin, V., Topisirovic, I., Li, S., Wagner, C. R., Sonenberg, N. & Piccirillo, C. A., May 1 2013, In : PLoS genetics. 9, 5, e1003494.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
translation (genetics)
T-lymphocytes
Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
14 Citations (Scopus)

Kinetic mechanism of human histidine triad nucleotide binding protein 1

Zhou, X., Chou, T. F., Aubol, B. E., Park, C. J., Wolfenden, R., Adams, J. & Wagner, C. R., May 21 2013, In : Biochemistry. 52, 20, p. 3588-3600 13 p.

Research output: Contribution to journalArticle

Hydrolysis
Adenosine Monophosphate
Kinetics
Nucleophiles
Catalytic Domain
27 Citations (Scopus)

Simultaneous dual protein labeling using a triorthogonal reagent

Rashidian, M., Kumarapperuma, S. C., Gabrielse, K., Fegan, A., Wagner, C. R. & Distefano, M. D., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16388-16396 9 p.

Research output: Contribution to journalArticle

Labeling
Proteins
Tetrahydrofolate Dehydrogenase
Fluorophores
Polyethylene glycols
14 Citations (Scopus)

Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily

Maize, K. M., Wagner, C. R. & Finzel, B. C., Jul 1 2013, In : FEBS Journal. 280, 14, p. 3389-3398 10 p.

Research output: Contribution to journalArticle

Hydrolases
Adenosine Monophosphate
Histidine
Carrier Proteins
Nucleotides
6 Citations (Scopus)

Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures

Gangar, A., Fegan, A., Kumarapperuma, S. C., Huynh, P., Benyumov, A. & Wagner, C. R., Sep 3 2013, In : Molecular Pharmaceutics. 10, 9, p. 3514-3518 5 p.

Research output: Contribution to journalArticle

Nanostructures
Antisense Oligonucleotides
Nucleic Acids
Methotrexate
Eukaryotic Initiation Factor-4E
39 Citations (Scopus)
gemcitabine
Guanosine Monophosphate
Lung Neoplasms
Breast Neoplasms
Prodrugs
2012
78 Citations (Scopus)

Blood-nanoparticle interactions and in Vivo biodistribution: Impact of surface peg and ligand properties

Shah, N. B., Vercellotti, G. M., White, J. G., Fegan, A., Wagner, C. R. & Bischof, J. C., Aug 6 2012, In : Molecular pharmaceutics. 9, 8, p. 2146-2155 10 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Ligands
Surface Properties
Blood Proteins
16 Citations (Scopus)

Chemically self-assembled antibody nanostructures as potential drug carriers

Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Nov 5 2012, In : Molecular Pharmaceutics. 9, 11, p. 3218-3227 10 p.

Research output: Contribution to journalArticle

Drug Carriers
Nanostructures
Methotrexate
Antibodies
Trimethoprim
10 Citations (Scopus)

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers

Gangar, A., Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Feb 15 2012, In : Journal of the American Chemical Society. 134, 6, p. 2895-2897 3 p.

Research output: Contribution to journalArticle

Oligonucleotides
Antibodies
Self assembly
Carrier Proteins
Proteins

Protein interface remodeling in a chemically induced protein dimer

White, B. R., Carlson, J. C. T., Kerns, J. L. & Wagner, C. R., Jul 1 2012, In : Journal of Molecular Recognition. 25, 7, p. 393-403 11 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Proteins
Nanostructures
Population Characteristics
Methotrexate
2 Citations (Scopus)

Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins

Bardaweel, S. K., Ghosh, B. & Wagner, C. R., Jan 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 1, p. 558-560 3 p.

Research output: Contribution to journalArticle

Carbamates
Histidine
Escherichia coli
Carrier Proteins
Nucleotides
2011

Chemically induced self-assembly of enzyme nanorings.

White, B. R., Li, Q. & Wagner, C. R., Sep 15 2011, In : Methods in molecular biology (Clifton, N.J.). 743, p. 17-26 10 p.

Research output: Contribution to journalArticle

Dimerization
Enzymes
Technology
Tetrahydrofolate Dehydrogenase
Proteins
8 Citations (Scopus)

E. coli Histidine triad nucleotide binding protein 1 (echint) is a catalytic regulator of d-alanine dehydrogenase (dada) activity in vivo

Bardaweel, S., Ghosh, B., Chou, T. F., Sadowsky, M. J. & Wagner, C. R., Jul 11 2011, In : PloS one. 6, 7, e20897.

Research output: Contribution to journalArticle

alanine dehydrogenase
Alanine Dehydrogenase
histidine
Histidine
Escherichia coli
13 Citations (Scopus)

Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191

Birkus, G., Kutty, N., Frey, C. R., Shribata, R., Chou, T., Wagner, C. R., McDermott, M. & Cihlar, T., May 1 2011, In : Antimicrobial agents and chemotherapy. 55, 5, p. 2166-2173 8 p.

Research output: Contribution to journalArticle

Cathepsin A
Lysosomes
Phenylalanine
Esters
Hydrolysis
2010
144 Citations (Scopus)

Chemically controlled protein assembly: Techniques and applications

Fegan, A., White, B., Carlson, J. C. T. & Wagner, C. R., Jun 9 2010, In : Chemical Reviews. 110, 6, p. 3315-3336 22 p.

Research output: Contribution to journalArticle

Dimerization
Proteins
DNA Gyrase
Ligands
Bacterial DNA
47 Citations (Scopus)

Chemically self-assembled antibody nanorings (CSANs): Design and characterization of an anti-CD3 IgM biomimetic

Li, Q., So, C. R., Fegan, A., Cody, V., Sarikaya, M., Vallera, D. A. & Wagner, C. R., Dec 8 2010, In : Journal of the American Chemical Society. 132, 48, p. 17247-17257 11 p.

Research output: Contribution to journalArticle

Nanorings
Biomimetics
Antibodies
Immunoglobulin M
Monoclonal antibodies
30 Citations (Scopus)

Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP

Jia, Y., Chiu, T. L., Amin, E. A., Polunovsky, V., Bitterman, P. B. & Wagner, C. R., Apr 1 2010, In : European Journal of Medicinal Chemistry. 45, 4, p. 1304-1313 10 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Guanosine Monophosphate
Quantitative Structure-Activity Relationship
Libraries
RNA Cap-Binding Proteins
12 Citations (Scopus)

Probing the Impact of the echinT C-Terminal Domain on Structure and Catalysis

Bardaweel, S., Pace, J., Chou, T. F., Cody, V. & Wagner, C. R., Dec 10 2010, In : Journal of Molecular Biology. 404, 4, p. 627-638 12 p.

Research output: Contribution to journalArticle

Catalysis
Escherichia coli
Bacteria
Gram-Positive Bacteria
Adenosine Monophosphate
2009
43 Citations (Scopus)

Fluorescent tumour imaging of type I IGF receptor in vivo: comparison of antibody-conjugated quantum dots and small-molecule fluorophore

Zhang, H., Zeng, X., Li, Q., Gaillard-Kelly, M., Wagner, C. R. & Yee, D., Jul 7 2009, In : British Journal of Cancer. 101, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

Quantum Dots
IGF Type 1 Receptor
Down-Regulation
Heterografts
Antibodies
10 Citations (Scopus)

Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection

Cheng, J., Zhou, X., Chou, T. F., Ghosh, B., Liu, B. & Wagner, C. R., Dec 8 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 22, p. 6379-6381 3 p.

Research output: Contribution to journalArticle

Bacteriophage T7
Bacteriophages
Display devices
Ribonucleotides
Amino Acids
24 Citations (Scopus)

Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines

Liu, L., Wagner, C. R. & Hanna, P. E., Dec 21 2009, In : Chemical research in toxicology. 22, 12, p. 1962-1974 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Metabolites
Protein Isoforms
Acetylation
HeLa Cells
56 Citations (Scopus)

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

Ghosh, B., Benyumov, A., Ghosh, P., Jia, Y., Avdulov, S. V., Dahlberg, P. S., Peterson, M., Smith, K., Polunovsky, V. A., Bitterman, P. B. & Wagner, C. R., May 15 2009, In : ACS Chemical Biology. 4, 5, p. 367-377 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Tissue
Messenger RNA
Prodrugs
Zebrafish
3 Citations (Scopus)

Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190

Zhou, X., Zhang, N., Liu, L., Walters, K. J., Hanna, P. E. & Wagner, C. R., Dec 1 2009, In : FEBS Journal. 276, 23, p. 6928-6941 14 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Mutagenesis
hydrazine
Site-Directed Mutagenesis
2008
31 Citations (Scopus)

Enzyme nanorings

Chou, T. F., So, C., White, B. R., Carlson, J. C. T., Sarikaya, M. & Wagner, C. R., Dec 23 2008, In : ACS Nano. 2, 12, p. 2519-2525 7 p.

Research output: Contribution to journalArticle

Nanorings
enzymes
Enzymes
fusion
proteins
7 Citations (Scopus)

Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein

Ghosh, P., Cheng, J., Chou, T. F., Jia, Y., Avdulov, S. V., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Aug 1 2008, In : Protein Expression and Purification. 60, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Tetrahydrofolate Dehydrogenase
Proteins
Trimethoprim
Anions