1986 …2020
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Research Output 1986 2019

2000
243 Citations (Scopus)

Pronucleotides: Toward the in vivo delivery of antiviral and anticancer nucleotides

Wagner, C. R., Iyer, V. V. & McIntee, E. J., Nov 9 2000, In : Medicinal Research Reviews. 20, 6, p. 417-451 35 p.

Research output: Contribution to journalArticle

Antiviral Agents
Nucleotides
Prodrugs
Nucleosides
Pharmacology
63 Citations (Scopus)

Synthesis, in vitro anti-breast cancer activity, and intracellular decomposition of amino acid methyl ester and alkyl amide phosphoramidate monoesters of 3'-azido-3'-deoxythymidine (AZT)

Iyer, V. V., Griesgraber, G. W., Radmer, M. R., McIntee, E. J. & Wagner, C. R., Jun 1 2000, In : Journal of Medicinal Chemistry. 43, 11, p. 2266-2274 9 p.

Research output: Contribution to journalArticle

Zidovudine
MCF-7 Cells
Amides
Esters
Thermodynamic properties
8 Citations (Scopus)

Synthesis and antiviral activity of amino acid carbamate derivatives of AZT

Chang, S. L., Griesgraber, G., Abraham, T. W., Garg, T., Song, H., Zimmerman, C. L. & Wagner, C. R., Jan 1 2000, In : Nucleosides, Nucleotides and Nucleic Acids. 19, 1-2, p. 87-100 14 p.

Research output: Contribution to journalArticle

Carbamates
Amides
Antiviral Agents
Esters
Derivatives
1999
28 Citations (Scopus)

Antiviral nucleoside drug delivery via amino acid phosphoramidates

Wagner, C. R., Chang, S. L., Griesgraber, G. W., Song, H., McIntee, E. J. & Zimmerman, C. L., Jan 1 1999, In : Nucleosides and Nucleotides. 18, 4-5, p. 913-919 7 p.

Research output: Contribution to journalArticle

Tissue Distribution
Cell Extracts
Drug delivery
Nucleosides
Metabolism
1998

Amino acid phosphoramidates of antiviral 3-deazaadenosine analogs exhibit high potency and low cytotoxicity

McIntee, E. J., Wagner, C. R., Giordano, V., Jeang, K. T. & Chiang, P. K., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

Cytotoxicity
Human immunodeficiency virus 1
Antiviral Agents
cytotoxicity
Amino Acids
17 Citations (Scopus)
Arylamine N-Acetyltransferase
2-Acetylaminofluorene
Cricetinae
Acetyltransferases
DNA Adducts
1997

Antiviral nucleotide drug delivery via amino acid phosphoramidates

Wagner, C. R., McIntee, E. J., Chang, S. L. & Zimmerman, C., Dec 1 1997, In : FASEB Journal. 11, 9, p. A836

Research output: Contribution to journalArticle

nucleosides
Drug delivery
Nucleosides
Antiviral Agents
Nucleotides
39 Citations (Scopus)

Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein

Sticha, K. R. K., Sieg, C. A., Bergstrom, C. P., Hanna, P. E. & Wagner, C. R., Jan 1 1997, In : Protein Expression and Purification. 10, 1, p. 141-153 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Tetrahydrofolate Dehydrogenase
Cricetinae
Acetyltransferases
Thrombin
38 Citations (Scopus)

Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors

Wagner, C. R., Ballato, G., Akanni, A. O., McIntee, E. J., Larson, R. S., Chang, S. L. & Abul-Hajj, Y. J., Jun 15 1997, In : Cancer Research. 57, 12, p. 2341-2345 5 p.

Research output: Contribution to journalArticle

Zidovudine
Breast Neoplasms
Growth
Inhibitory Concentration 50
T-Cell Leukemia
15 Citations (Scopus)

Synthesis, biological activity and decomposition studies of amino acid phosphomonoester amidates of acyclovir

Abraham, T. W., McIntee, E. J., Iyer, V. V., Schinazi, R. F. & Wagner, C. R., Jan 1 1997, In : Nucleosides and Nucleotides. 16, 10-11, p. 2079-2092 14 p.

Research output: Contribution to journalReview article

Acyclovir
Bioactivity
Decomposition
Amino Acids
valacyclovir
1996
13 Citations (Scopus)

Arylamine N-acetyltransferases: Expression in Escherichia coli, purification, and substrate specificities of recombinant hamster monomorphic and polymorphic isozymes

Wagner, C. R., Bergstrom, C. P., Koning, K. R. & Hanna, P. E., Feb 27 1996, In : Drug Metabolism and Disposition. 24, 2, p. 245-253 9 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Enteropeptidase
Substrate Specificity
Cricetinae
Isoenzymes
6 Citations (Scopus)

Methotrexate resistance of mouse dihydrofolate reductase: Effect of substitution of phenylalanine-31 by serine or tryptophan

Evenson, D. A., Adams, J., McIvor, R. S. & Wagner, C. R., Apr 26 1996, In : Journal of Medicinal Chemistry. 39, 9, p. 1763-1766 4 p.

Research output: Contribution to journalReview article

Tetrahydrofolate Dehydrogenase
Phenylalanine
Methotrexate
Tryptophan
Serine
82 Citations (Scopus)

Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-β- arabinofuranosylcytosine: Evidence of phosphoramidase activity

Abraham, T. W., Kalman, T. I., McIntee, E. J. & Wagner, C. R., Nov 26 1996, In : Journal of Medicinal Chemistry. 39, 23, p. 4569-4575 7 p.

Research output: Contribution to journalArticle

Aromatic Amino Acids
Cytarabine
Floxuridine
Thymidylate Synthase
T-Cell Leukemia
1995
52 Citations (Scopus)

Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication

Wagner, C. R., McIntee, E. J., Schinazi, R. F. & Abraham, T. W., Aug 17 1995, In : Bioorganic and Medicinal Chemistry Letters. 5, 16, p. 1819-1824 6 p.

Research output: Contribution to journalArticle

Aromatic Amino Acids
Zidovudine
HIV-1
Blood Cells
Blood
13 Citations (Scopus)

Hamster Monomorphic Arylamine N-Acetyltransferase: Expression in Escherichia coli and Purification

Bergstrom, C. P., Wagner, C. R., Ann, D. K. & Hanna, P. E., Feb 1 1995, In : Protein Expression and Purification. 6, 1, p. 45-55 11 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetyltransferases
Cricetinae
hydrazine
Escherichia coli
41 Citations (Scopus)

Molecular Basis for Nonadditive Mutational Effects in Escherichia coli Dihydrofolate Reductase

Wagner, C. R., Huang, Z., Singleton, S. F. & Benkovic, S. J., Jan 1 1995, In : Biochemistry. 34, 48, p. 15671-15680 10 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Escherichia coli
Hydrides
Free energy
Conformations
1994
44 Citations (Scopus)

A phosphoramidite-based synthesis of phosphoramidate amino acid diesters of antiviral nucleosides

Abraham, T. W. & Wagner, C. R., Sep 1 1994, In : Nucleosides and Nucleotides. 13, 9, p. 1891-1903 13 p.

Research output: Contribution to journalArticle

Nucleosides
Antiviral Agents
Stavudine
Amino Acids
Zidovudine
44 Citations (Scopus)

Nonadditivity of Mutational Effects at the Folate Binding Site of Escherichia coli Dihydrofolate Reductase

Huang, Z., Wagner, C. R. & Benkovic, S. J., Sep 1 1994, In : Biochemistry. 33, 38, p. 11576-11585 10 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Folic Acid
Escherichia coli
Binding Sites
Mutant Proteins
1992
25 Citations (Scopus)

Complementary Perturbation of the Kinetic Mechanism and Catalytic Effectiveness of Dihydrofolate Reductase by Side-Chain Interchange

Wagner, C. R., Thillet, J. & Benkovic, S. J., Feb 1 1992, In : Biochemistry. 31, 34, p. 7834-7840 7 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Interchanges
Escherichia coli
Rate constants
NADP
2 Citations (Scopus)

Probing the Molecular Basis of Resistance to Pyrimethamine by Site-Directed Mutagenesis

Wagner, C. R. & Benkovic, S. J., Jul 1 1992, In : Journal of Medicinal Chemistry. 35, 15, p. 2912-2915 4 p.

Research output: Contribution to journalArticle

1990
35 Citations (Scopus)

Site directed mutagenesis: a tool for enzyme mechanism dissection

Wagner, C. R. & Benkovic, S. J., Jan 1 1990, In : Trends in Biotechnology. 8, C, p. 263-270 8 p.

Research output: Contribution to journalArticle

Dissection
Mutagenesis
Site-Directed Mutagenesis
Catalytic Domain
Enzymes
1988
5 Citations (Scopus)

A Phospholipase C Protocol for Phospholipid Peroxidation Analysis

Wagner, C. R. & Porter, N. A., Sep 1 1988, In : Chemical Research in Toxicology. 1, 5, p. 274-280 7 p.

Research output: Contribution to journalArticle

High pressure liquid chromatography
Diglycerides
Type C Phospholipases
Phospholipids
Hydroxides
1986
32 Citations (Scopus)

Phospholipid autoxidation

Porter, N. A. & Wagner, C. R., Jan 1 1986, In : Advances in Free Radical Biology and Medicine. 2, 2, p. 283-323 41 p.

Research output: Contribution to journalArticle

Phospholipids
Complex Mixtures
Organic solvents
High pressure liquid chromatography
Biological membranes