Carston R Wagner &ndash; Research Output

Article

Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein

Ghosh, P., Cheng, J., Chou, T. F., Jia, Y., Avdulov, S. V., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Aug 1 2008, In : Protein Expression and Purification. 60, 2, p. 132-139 8 p.

Research output: Contribution to journal › Article

Peptide Initiation Factors

Tetrahydrofolate Dehydrogenase

Proteins

Trimethoprim

Anions

43 Citations (Scopus)

Fluorescent tumour imaging of type I IGF receptor in vivo: comparison of antibody-conjugated quantum dots and small-molecule fluorophore

Zhang, H., Zeng, X., Li, Q., Gaillard-Kelly, M., Wagner, C. R. & Yee, D., Jul 7 2009, In : British Journal of Cancer. 101, 1, p. 71-79 9 p.

Research output: Contribution to journal › Article

Quantum Dots

IGF Type 1 Receptor

Down-Regulation

Heterografts

Antibodies

151 Citations (Scopus)

Future research directions in idiopathic pulmonary fibrosis: Summary of a National Heart, Lung, and Blood Institute Working Group

Crystal, R. G., Bitterman, P. B., Mossman, B., Schwarz, M. I., Sheppard, D., Almasy, L., Chapman, H. A., Friedman, S. L., King, T. E., Leinwand, L. A., Liotta, L., Martin, G. R., Schwartz, D. A., Schultz, G. S., Wagner, C. R. & Musson, R. A., Jul 15 2002, In : American journal of respiratory and critical care medicine. 166, 2, p. 236-246 11 p.

Research output: Contribution to journal › Article

National Heart, Lung, and Blood Institute (U.S.)

Idiopathic Pulmonary Fibrosis

Molecular Diagnostic Techniques

Laser Capture Microdissection

Human Genome Project

13 Citations (Scopus)

Hamster Monomorphic Arylamine N-Acetyltransferase: Expression in Escherichia coli and Purification

Bergstrom, C. P., Wagner, C. R., Ann, D. K. & Hanna, P. E., Feb 1 1995, In : Protein Expression and Purification. 6, 1, p. 45-55 11 p.

Research output: Contribution to journal › Article

Arylamine N-Acetyltransferase

Acetyltransferases

Cricetinae

hydrazine

Escherichia coli

25 Citations (Scopus)

HINT1 protein: A new therapeutic target to enhance opioid antinociception and block mechanical allodynia

Garzón, J., Herrero-Labrador, R., Rodríguez-Muñoz, M., Shah, R., Vicente-Sánchez, A., Wagner, C. R. & Sánchez-Blázquez, P., Feb 2015, In : Neuropharmacology. 89, p. 412-423 12 p.

Research output: Contribution to journal › Article

Hyperalgesia

Staphylococcal Protein A

N-Methyl-D-Aspartate Receptors

Opioid Analgesics

mu Opioid Receptor

23 Citations (Scopus)

Human arylamine N-acetyltransferase 1: In vitro and intracellular inactivation by nitrosoarene metabolites of toxic and carcinogenic arylamines

Liu, L., Wagner, C. R. & Hanna, P. E., Oct 1 2008, In : Chemical research in toxicology. 21, 10, p. 2005-2016 12 p.

Research output: Contribution to journal › Article

Poisons

Metabolites

HeLa Cells

Acetylation

Detoxification

10 Citations (Scopus)

Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection

Cheng, J., Zhou, X., Chou, T. F., Ghosh, B., Liu, B. & Wagner, C. R., Dec 8 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 22, p. 6379-6381 3 p.

Research output: Contribution to journal › Article

Bacteriophage T7

Bacteriophages

Display devices

Ribonucleotides

Amino Acids

11 Citations (Scopus)

Impact of the C-terminal loop of histidine triad nucleotide binding protein 1 (Hint1) on substrate specificity

Chou, T. F., Sham, Y. Y. & Wagner, C. R., Nov 13 2007, In : Biochemistry. 46, 45, p. 13074-13079 6 p.

Research output: Contribution to journal › Article

Substrate Specificity

Histidine

Escherichia coli

Carrier Proteins

Nucleotides

3 Citations (Scopus)

Induction of the p53 tumor suppressor in cancer cells through inhibition of cap-dependent translation

Harris, B. R. E., Wang, D., Zhang, Y., Ferrari, M., Okon, A., Cleary, M. P., Wagner, C. R. & Yang, D., May 1 2018, In : Molecular and cellular biology. 38, 10, e00367.

Research output: Contribution to journal › Article

Open Access

Neoplasms

Protein Biosynthesis

Apoptosis

Double-Stranded DNA Breaks

5' Untranslated Regions

4 Citations (Scopus)

Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain

Shah, R., Chou, T. F., Maize, K. M., Strom, A., Finzel, B. C. & Wagner, C. R., Sep 23 2017, In : Biochemical and Biophysical Research Communications. 491, 3, p. 760-766 7 p.

Research output: Contribution to journal › Article

Neuralgia

Histidine

Analgesia

Opioid Analgesics

Metal ions

15 Citations (Scopus)

Inhibition of CMP-sialic acid transport into golgi vesicles by nucleoside monophosphates

Chiaramonte, M., Koviach, J. L., Moore, C., Iyer, V. V., Wagner, C. R., Halcomb, R. L., Miller, W., Melançon, P. & Kuchta, R. D., Nov 27 2001, In : Biochemistry. 40, 47, p. 14260-14267 8 p.

Research output: Contribution to journal › Article

Cytidine Monophosphate N-Acetylneuraminic Acid

Nucleosides

Sugars

Nucleotides

Glycosylation

Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice

Shah, R. M., Peterson, C., Strom, A., Dillenburg, M., Finzel, B., Kitto, K. F., Fairbanks, C., Wilcox, G. & Wagner, C. R., Oct 16 2019, In : ACS Chemical Neuroscience. 10, 10, p. 4385-4393 9 p.

Research output: Contribution to journal › Article

Nociception

N-Methylaspartate

Opioid Analgesics

N-Methyl-D-Aspartate Receptors

Aptitude

8 Citations (Scopus)

In vivo evaluation of site-specifically PEGylated chemically self-assembled protein nanostructures

Shah, R., Petersburg, J., Gangar, A. C., Fegan, A., Wagner, C. R. & Kumarapperuma, S. C., Jul 5 2016, In : Molecular Pharmaceutics. 13, 7, p. 2193-2203 11 p.

Research output: Contribution to journal › Article

Tetrahydrofolate Dehydrogenase

Nanostructures

Epidermal Growth Factor Receptor

leucyl-alanyl-arginyl-leucyl-leucyl-threonine

Proteins

20 Citations (Scopus)

Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: A comparison of human and hamster enzymes

Wang, H., Wagner, C. R. & Hanna, P. E., Feb 1 2005, In : Chemical research in toxicology. 18, 2, p. 183-197 15 p.

Research output: Contribution to journal › Article

N-hydroxy-4-acetylaminobiphenyl

Arylamine N-Acetyltransferase

Acetyltransferases

Cricetinae

Enzymes

24 Citations (Scopus)

Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines

Liu, L., Wagner, C. R. & Hanna, P. E., Dec 21 2009, In : Chemical research in toxicology. 22, 12, p. 1962-1974 13 p.

Research output: Contribution to journal › Article

Arylamine N-Acetyltransferase

Metabolites

Protein Isoforms

Acetylation

HeLa Cells

14 Citations (Scopus)

Kinetic mechanism of human histidine triad nucleotide binding protein 1

Zhou, X., Chou, T. F., Aubol, B. E., Park, C. J., Wolfenden, R., Adams, J. & Wagner, C. R., May 21 2013, In : Biochemistry. 52, 20, p. 3588-3600 13 p.

Research output: Contribution to journal › Article

Hydrolysis

Adenosine Monophosphate

Kinetics

Nucleophiles

Catalytic Domain

43 Citations (Scopus)

Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins

Chou, T. F. & Wagner, C. R., Feb 16 2007, In : Journal of Biological Chemistry. 282, 7, p. 4719-4727 9 p.

Research output: Contribution to journal › Article

Lysine-tRNA Ligase

Histidine

Adenosine Monophosphate

Carrier Proteins

Nucleotides

24 Citations (Scopus)

Mass Spectrometric Investigation of the Mechanism of Inactivation of Hamster Arylamine N-Acetyltransferase 1 by N-Hydroxy-2-Acetylaminofluorene

Guo, Z., Wagner, C. R. & Hanna, P. E., Mar 1 2004, In : Chemical research in toxicology. 17, 3, p. 275-286 12 p.

Research output: Contribution to journal › Article

2-Acetylaminofluorene

Cricetinae

Acetylation

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry

Arylamine N-Acetyltransferase

41 Citations (Scopus)

Molecular Basis for Nonadditive Mutational Effects in Escherichia coli Dihydrofolate Reductase

Wagner, C. R., Huang, Z., Singleton, S. F. & Benkovic, S. J., Jan 1 1995, In : Biochemistry. 34, 48, p. 15671-15680 10 p.

Research output: Contribution to journal › Article

Tetrahydrofolate Dehydrogenase

Escherichia coli

Hydrides

Free energy

Conformations

10 Citations (Scopus)

Molecular modeling of geometries, charge distributions, and binding energies of small, druglike molecules containing nitrogen heterocycles and exocyclic amino groups in the gas phase and in aqueous solution

White, B. R., Wagner, C. R., Trahlar, D. G. & Amin, E. A., Oct 14 2008, In : Journal of Chemical Theory and Computation. 4, 10, p. 1718-1732 15 p.

Research output: Contribution to journal › Article

Molecular modeling

Charge distribution

Binding energy

charge distribution

field theory (physics)

6 Citations (Scopus)

Monitoring the Intracellular Metabolism of Nucleoside Phosphoramidate Pronucleotides by ³¹P NMR

Kim, J., Drontle, D. P. & Wagner, C. R., Mar 26 2004, In : Nucleosides, Nucleotides and Nucleic Acids. 23, 1-2, p. 483-493 11 p.

Research output: Contribution to journal › Article

Nucleosides

Metabolism

Nuclear magnetic resonance

Monitoring

Cells

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

Csizmar, C. M., Petersburg, J. R., Perry, T. J., Rozumalski, L., Hackel, B. J. & Wagner, C. R., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 251-261 11 p.

Research output: Contribution to journal › Article

Cell Adhesion Molecules

Cell membranes

Antigens

Ligands

Cell Membrane

38 Citations (Scopus)

NMR-based Model Reveals the Structural Determinants of Mammalian Arylamine N-Acetyltransferase Substrate Specificity

Zhang, N., Liu, L., Liu, F., Wagner, C. R., Hanna, P. E. & Walters, K. J., Oct 13 2006, In : Journal of Molecular Biology. 363, 1, p. 188-200 13 p.

Research output: Contribution to journal › Article

Arylamine N-Acetyltransferase

Acetyltransferases

Structural Models

Substrate Specificity

2-toluidine

44 Citations (Scopus)

Nonadditivity of Mutational Effects at the Folate Binding Site of Escherichia coli Dihydrofolate Reductase

Huang, Z., Wagner, C. R. & Benkovic, S. J., Sep 1 1994, In : Biochemistry. 33, 38, p. 11576-11585 10 p.

Research output: Contribution to journal › Article

Tetrahydrofolate Dehydrogenase

Folic Acid

Escherichia coli

Binding Sites

Mutant Proteins

56 Citations (Scopus)

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

Ghosh, B., Benyumov, A., Ghosh, P., Jia, Y., Avdulov, S. V., Dahlberg, P. S., Peterson, M., Smith, K., Polunovsky, V. A., Bitterman, P. B. & Wagner, C. R., May 15 2009, In : ACS Chemical Biology. 4, 5, p. 367-377 11 p.

Research output: Contribution to journal › Article

Epithelial-Mesenchymal Transition

Tissue

Messenger RNA

Prodrugs

Zebrafish

20 Citations (Scopus)

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1

Wang, H., Vath, G. M., Kawamura, A., Bates, C. A., Sim, E., Hanna, P. E. & Wagner, C. R., Feb 1 2005, In : Protein Journal. 24, 2, p. 65-77 13 p.

Research output: Contribution to journal › Article

Purification

Cricetinae

Fusion reactions

Acids

Substrates

39 Citations (Scopus)

Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein

Sticha, K. R. K., Sieg, C. A., Bergstrom, C. P., Hanna, P. E. & Wagner, C. R., Jan 1 1997, In : Protein Expression and Purification. 10, 1, p. 141-153 13 p.

Research output: Contribution to journal › Article

Arylamine N-Acetyltransferase

Tetrahydrofolate Dehydrogenase

Cricetinae

Acetyltransferases

Thrombin

19 Citations (Scopus)

Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats

Song, H., Griesgraber, G. W., Wagner, C. R. & Zimmerman, C. L., May 2 2002, In : Antimicrobial agents and chemotherapy. 46, 5, p. 1357-1363 7 p.

Research output: Contribution to journal › Article

Zidovudine

Pharmacokinetics

Amino Acids

phosphoramidic acid

Urine

32 Citations (Scopus)

Phospholipid autoxidation

Porter, N. A. & Wagner, C. R., Jan 1 1986, In : Advances in Free Radical Biology and Medicine. 2, 2, p. 283-323 41 p.

Research output: Contribution to journal › Article

Phospholipids

Complex Mixtures

Organic solvents

High pressure liquid chromatography

Biological membranes

57 Citations (Scopus)

Phosphoramidate pronucleotides: A comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins

Chou, T. F., Baraniak, J., Kaczmarek, R., Zhou, X., Cheng, J., Ghosh, B. & Wagner, C. R., Mar 1 2007, In : Molecular pharmaceutics. 4, 2, p. 208-217 10 p.

Research output: Contribution to journal › Article

Substrate Specificity

Histidine

Carrier Proteins

Nucleotides

Escherichia coli

38 Citations (Scopus)

Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors

Wagner, C. R., Ballato, G., Akanni, A. O., McIntee, E. J., Larson, R. S., Chang, S. L. & Abul-Hajj, Y. J., Jun 15 1997, In : Cancer Research. 57, 12, p. 2341-2345 5 p.

Research output: Contribution to journal › Article

Zidovudine

Breast Neoplasms

Growth

Inhibitory Concentration 50

T-Cell Leukemia

3 Citations (Scopus)

Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190

Zhou, X., Zhang, N., Liu, L., Walters, K. J., Hanna, P. E. & Wagner, C. R., Dec 1 2009, In : FEBS Journal. 276, 23, p. 6928-6941 14 p.

Research output: Contribution to journal › Article

Arylamine N-Acetyltransferase

Acetylation

Mutagenesis

hydrazine

Site-Directed Mutagenesis

12 Citations (Scopus)

Probing the Impact of the echinT C-Terminal Domain on Structure and Catalysis

Bardaweel, S., Pace, J., Chou, T. F., Cody, V. & Wagner, C. R., Dec 10 2010, In : Journal of Molecular Biology. 404, 4, p. 627-638 12 p.

Research output: Contribution to journal › Article

Catalysis

Escherichia coli

Bacteria

Gram-Positive Bacteria

Adenosine Monophosphate

57 Citations (Scopus)

Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies

Wang, H., Vath, G. M., Gleason, K. J., Hanna, P. E. & Wagner, C. R., Jun 29 2004, In : Biochemistry. 43, 25, p. 8234-8246 13 p.

Research output: Contribution to journal › Article

Arylamine N-Acetyltransferase

Acetylation

Mutagenesis

Site-Directed Mutagenesis

Iodoacetamide

2 Citations (Scopus)

Probing the Molecular Basis of Resistance to Pyrimethamine by Site-Directed Mutagenesis

Wagner, C. R. & Benkovic, S. J., Jul 1 1992, In : Journal of Medicinal Chemistry. 35, 15, p. 2912-2915 4 p.

Research output: Contribution to journal › Article

10 Citations (Scopus)

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers

Gangar, A., Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Feb 15 2012, In : Journal of the American Chemical Society. 134, 6, p. 2895-2897 3 p.

Research output: Contribution to journal › Article

Oligonucleotides

Antibodies

Self assembly

Carrier Proteins

Proteins

243 Citations (Scopus)

Pronucleotides: Toward the in vivo delivery of antiviral and anticancer nucleotides

Wagner, C. R., Iyer, V. V. & McIntee, E. J., Nov 9 2000, In : Medicinal Research Reviews. 20, 6, p. 417-451 35 p.

Research output: Contribution to journal › Article

Antiviral Agents

Nucleotides

Prodrugs

Nucleosides

Pharmacology

6 Citations (Scopus)

Prosthetic antigen receptors

Shen, J., Vallera, D. A. & Wagner, C. R., Aug 19 2015, In : Journal of the American Chemical Society. 137, 32, p. 10108-10111 4 p.

Research output: Contribution to journal › Article

Nanorings

Antigen Receptors

T-cells

Antigens

Prosthetics

Protein interface remodeling in a chemically induced protein dimer

White, B. R., Carlson, J. C. T., Kerns, J. L. & Wagner, C. R., Jul 1 2012, In : Journal of Molecular Recognition. 25, 7, p. 393-403 11 p.

Research output: Contribution to journal › Article

Tetrahydrofolate Dehydrogenase

Proteins

Nanostructures

Population Characteristics

Methotrexate

13 Citations (Scopus)

Reversible Re-programing of Cell-Cell Interactions

Gabrielse, K., Gangar, A., Kumar, N., Lee, J. C., Fegan, A., Shen, J. J., Li, Q., Vallera, D. & Wagner, C. R., May 12 2014, In : Angewandte Chemie - International Edition. 53, 20, p. 5112-5116 5 p.

Research output: Contribution to journal › Article

Nanorings

Lipids

Antigens

Ligands

Antigen Receptors

13 Citations (Scopus)

Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191

Birkus, G., Kutty, N., Frey, C. R., Shribata, R., Chou, T., Wagner, C. R., McDermott, M. & Cihlar, T., May 1 2011, In : Antimicrobial agents and chemotherapy. 55, 5, p. 2166-2173 8 p.

Research output: Contribution to journal › Article

Cathepsin A

Lysosomes

Phenylalanine

Esters

Hydrolysis

20 Citations (Scopus)

Self-assembly of antibodies by chemical induction

Li, Q., Hapka, D., Chen, H., Vallera, D. A. & Wagner, C. R., Dec 15 2008, In : Angewandte Chemie - International Edition. 47, 52, p. 10179-10182 4 p.

Research output: Contribution to journal › Article

Antibodies

Self assembly

Proteins

Tetrahydrofolate Dehydrogenase

Trimethoprim

27 Citations (Scopus)

Simultaneous dual protein labeling using a triorthogonal reagent

Rashidian, M., Kumarapperuma, S. C., Gabrielse, K., Fegan, A., Wagner, C. R. & Distefano, M. D., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16388-16396 9 p.

Research output: Contribution to journal › Article

Labeling

Proteins

Tetrahydrofolate Dehydrogenase

Fluorophores

Polyethylene glycols

35 Citations (Scopus)

Site directed mutagenesis: a tool for enzyme mechanism dissection

Wagner, C. R. & Benkovic, S. J., Jan 1 1990, In : Trends in Biotechnology. 8, C, p. 263-270 8 p.

Research output: Contribution to journal › Article

Dissection

Mutagenesis

Site-Directed Mutagenesis

Catalytic Domain

Enzymes

10 Citations (Scopus)

Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells

Chen, E. Z., Jacobson, B. A., Patel, M. R., Okon, A. M., Li, S., Xiong, K., Vaidya, A. J., Bitterman, P. B., Wagner, C. R. & Kratzke, R. A., Jan 1 2014, In : Investigational New Drugs. 32, 4, p. 598-603 6 p.

Research output: Contribution to journal › Article

Mesothelioma

Protein Biosynthesis

Pemetrexed

Prodrugs

Messenger RNA

14 Citations (Scopus)

Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily

Maize, K. M., Wagner, C. R. & Finzel, B. C., Jul 1 2013, In : FEBS Journal. 280, 14, p. 3389-3398 10 p.

Research output: Contribution to journal › Article

Hydrolases

Adenosine Monophosphate

Histidine

Carrier Proteins

Nucleotides

1 Citation (Scopus)

Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia

Shah, R. M., Maize, K. M., West, H. T., Strom, A. M., Finzel, B. C. & Wagner, C. R., Aug 17 2018, In : Journal of Molecular Biology. 430, 17, p. 2709-2721 13 p.

Research output: Contribution to journal › Article

Isaacs Syndrome

Mutation

Enzymes

Adenosine Monophosphate

Histidine

2 Citations (Scopus)

Switch-on fluorescent/FRET probes to study human histidine triad nucleotide binding protein 1 (hHint1), a novel target for opioid tolerance and neuropathic pain

Shah, R., Zhou, A. & Wagner, C. R., Jan 1 2017, In : Organic and Biomolecular Chemistry. 15, 48, p. 10230-10237 8 p.

Research output: Contribution to journal › Article

pain

histidine

nucleotides

Neuralgia

Fluorescent Dyes

63 Citations (Scopus)

Synthesis, in vitro anti-breast cancer activity, and intracellular decomposition of amino acid methyl ester and alkyl amide phosphoramidate monoesters of 3'-azido-3'-deoxythymidine (AZT)

Iyer, V. V., Griesgraber, G. W., Radmer, M. R., McIntee, E. J. & Wagner, C. R., Jun 1 2000, In : Journal of Medicinal Chemistry. 43, 11, p. 2266-2274 9 p.

Research output: Contribution to journal › Article

Zidovudine

MCF-7 Cells

Amides

Esters

Thermodynamic properties

8 Citations (Scopus)

Synthesis and antiviral activity of amino acid carbamate derivatives of AZT

Chang, S. L., Griesgraber, G., Abraham, T. W., Garg, T., Song, H., Zimmerman, C. L. & Wagner, C. R., Jan 1 2000, In : Nucleosides, Nucleotides and Nucleic Acids. 19, 1-2, p. 87-100 14 p.

Research output: Contribution to journal › Article

Carbamates

Amides

Antiviral Agents

Esters

Derivatives