No photo of Carston R Wagner
Contact Expert

View Scopus Profile

Carston R Wagner

1986 …2025

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Article

Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein

Ghosh, P., Cheng, J., Chou, T. F., Jia, Y., Avdulov, S., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Aug 1 2008, In : Protein Expression and Purification. 60, 2, p. 132-139 8 p.

Research output: Contribution to journal › Article

7 Scopus citations

Fluorescent tumour imaging of type I IGF receptor in vivo: comparison of antibody-conjugated quantum dots and small-molecule fluorophore

Zhang, H., Zeng, X., Li, Q., Gaillard-Kelly, M., Wagner, C. R. & Yee, D., Jul 7 2009, In : British Journal of Cancer. 101, 1, p. 71-79 9 p.

Research output: Contribution to journal › Article

44 Scopus citations

Future research directions in idiopathic pulmonary fibrosis: Summary of a National Heart, Lung, and Blood Institute Working Group

Crystal, R. G., Bitterman, P. B., Mossman, B., Schwarz, M. I., Sheppard, D., Almasy, L., Chapman, H. A., Friedman, S. L., King, T. E., Leinwand, L. A., Liotta, L., Martin, G. R., Schwartz, D. A., Schultz, G. S., Wagner, C. R. & Musson, R. A., Jul 15 2002, In : American journal of respiratory and critical care medicine. 166, 2, p. 236-246 11 p.

Research output: Contribution to journal › Article

152 Scopus citations

Hamster Monomorphic Arylamine N-Acetyltransferase: Expression in Escherichia coli and Purification

Bergstrom, C. P., Wagner, C. R., Ann, D. K. & Hanna, P. E., Feb 1 1995, In : Protein Expression and Purification. 6, 1, p. 45-55 11 p.

Research output: Contribution to journal › Article

13 Scopus citations

HINT1 protein: A new therapeutic target to enhance opioid antinociception and block mechanical allodynia

Garzón, J., Herrero-Labrador, R., Rodríguez-Muñoz, M., Shah, R., Vicente-Sánchez, A., Wagner, C. R. & Sánchez-Blázquez, P., Feb 2015, In : Neuropharmacology. 89, p. 412-423 12 p.

Research output: Contribution to journal › Article

26 Scopus citations

Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A

Strom, A., Tong, C. L. & Wagner, C. R., Jan 1 2020, (Accepted/In press) In : FEBS Letters.

Research output: Contribution to journal › Article

Human arylamine N-acetyltransferase 1: In vitro and intracellular inactivation by nitrosoarene metabolites of toxic and carcinogenic arylamines

Liu, L., Wagner, C. R. & Hanna, P. E., Oct 1 2008, In : Chemical research in toxicology. 21, 10, p. 2005-2016 12 p.

Research output: Contribution to journal › Article

23 Scopus citations

Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection

Cheng, J., Zhou, X., Chou, T. F., Ghosh, B., Liu, B. & Wagner, C. R., Dec 8 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 22, p. 6379-6381 3 p.

Research output: Contribution to journal › Article

10 Scopus citations

Impact of the C-terminal loop of histidine triad nucleotide binding protein 1 (Hint1) on substrate specificity

Chou, T. F., Sham, Y. Y. & Wagner, C. R., Nov 13 2007, In : Biochemistry. 46, 45, p. 13074-13079 6 p.

Research output: Contribution to journal › Article

11 Scopus citations

Induction of the p53 tumor suppressor in cancer cells through inhibition of cap-dependent translation

Harris, B. R. E., Wang, D., Zhang, Y., Ferrari, M., Okon, A., Cleary, M. P., Wagner, C. R. & Yang, D., May 1 2018, In : Molecular and cellular biology. 38, 10, e00367.

Research output: Contribution to journal › Article

Open Access
3 Scopus citations

Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain

Shah, R., Chou, T. F., Maize, K. M., Strom, A., Finzel, B. C. & Wagner, C. R., Sep 23 2017, In : Biochemical and Biophysical Research Communications. 491, 3, p. 760-766 7 p.

Research output: Contribution to journal › Article

4 Scopus citations

Inhibition of CMP-sialic acid transport into golgi vesicles by nucleoside monophosphates

Chiaramonte, M., Koviach, J. L., Moore, C., Iyer, V. V., Wagner, C. R., Halcomb, R. L., Miller, W., Melançon, P. & Kuchta, R. D., Nov 27 2001, In : Biochemistry. 40, 47, p. 14260-14267 8 p.

Research output: Contribution to journal › Article

15 Scopus citations

Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice

Shah, R. M., Peterson, C., Strom, A., Dillenburg, M., Finzel, B., Kitto, K. F., Fairbanks, C., Wilcox, G. & Wagner, C. R., Oct 16 2019, In : ACS Chemical Neuroscience. 10, 10, p. 4385-4393 9 p.

Research output: Contribution to journal › Article

1 Scopus citations

In vivo evaluation of site-specifically PEGylated chemically self-assembled protein nanostructures

Shah, R., Petersburg, J., Gangar, A. C., Fegan, A., Wagner, C. R. & Kumarapperuma, S. C., Jul 5 2016, In : Molecular Pharmaceutics. 13, 7, p. 2193-2203 11 p.

Research output: Contribution to journal › Article

8 Scopus citations

Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: A comparison of human and hamster enzymes

Wang, H., Wagner, C. R. & Hanna, P. E., Feb 1 2005, In : Chemical research in toxicology. 18, 2, p. 183-197 15 p.

Research output: Contribution to journal › Article

20 Scopus citations

Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines

Liu, L., Wagner, C. R. & Hanna, P. E., Dec 21 2009, In : Chemical research in toxicology. 22, 12, p. 1962-1974 13 p.

Research output: Contribution to journal › Article

24 Scopus citations

Kinetic mechanism of human histidine triad nucleotide binding protein 1

Zhou, X., Chou, T. F., Aubol, B. E., Park, C. J., Wolfenden, R., Adams, J. & Wagner, C. R., May 21 2013, In : Biochemistry. 52, 20, p. 3588-3600 13 p.

Research output: Contribution to journal › Article

15 Scopus citations

Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins

Chou, T. F. & Wagner, C. R., Feb 16 2007, In : Journal of Biological Chemistry. 282, 7, p. 4719-4727 9 p.

Research output: Contribution to journal › Article

44 Scopus citations

Mass Spectrometric Investigation of the Mechanism of Inactivation of Hamster Arylamine N-Acetyltransferase 1 by N-Hydroxy-2-Acetylaminofluorene

Guo, Z., Wagner, C. R. & Hanna, P. E., Mar 1 2004, In : Chemical research in toxicology. 17, 3, p. 275-286 12 p.

Research output: Contribution to journal › Article

24 Scopus citations

Molecular Basis for Nonadditive Mutational Effects in Escherichia coli Dihydrofolate Reductase

Wagner, C. R., Huang, Z., Singleton, S. F. & Benkovic, S. J., Dec 1995, In : Biochemistry. 34, 48, p. 15671-15680 10 p.

Research output: Contribution to journal › Article

41 Scopus citations

Molecular modeling of geometries, charge distributions, and binding energies of small, druglike molecules containing nitrogen heterocycles and exocyclic amino groups in the gas phase and in aqueous solution

White, B. R., Wagner, C. R., Trahlar, D. G. & Amin, E. A., Oct 14 2008, In : Journal of Chemical Theory and Computation. 4, 10, p. 1718-1732 15 p.

Research output: Contribution to journal › Article

10 Scopus citations

Monitoring the Intracellular Metabolism of Nucleoside Phosphoramidate Pronucleotides by 31P NMR

Kim, J., Drontle, D. P. & Wagner, C. R., Mar 26 2004, In : Nucleosides, Nucleotides and Nucleic Acids. 23, 1-2, p. 483-493 11 p.

Research output: Contribution to journal › Article

6 Scopus citations

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

Csizmar, C. M., Petersburg, J. R., Perry, T. J., Rozumalski, L., Hackel, B. J. & Wagner, C. R., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 251-261 11 p.

Research output: Contribution to journal › Article

3 Scopus citations

NMR-based Model Reveals the Structural Determinants of Mammalian Arylamine N-Acetyltransferase Substrate Specificity

Zhang, N., Liu, L., Liu, F., Wagner, C. R., Hanna, P. E. & Walters, K. J., Oct 13 2006, In : Journal of Molecular Biology. 363, 1, p. 188-200 13 p.

Research output: Contribution to journal › Article

38 Scopus citations

Nonadditivity of Mutational Effects at the Folate Binding Site of Escherichia coli Dihydrofolate Reductase

Huang, Z., Wagner, C. R. & Benkovic, S. J., Sep 1 1994, In : Biochemistry. 33, 38, p. 11576-11585 10 p.

Research output: Contribution to journal › Article

44 Scopus citations

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

Ghosh, B., Benyumov, A., Ghosh, P., Jia, Y., Avdulov, S. V., Dahlberg, P. S., Peterson, M., Smith, K., Polunovsky, V. A., Bitterman, P. B. & Wagner, C. R., May 15 2009, In : ACS Chemical Biology. 4, 5, p. 367-377 11 p.

Research output: Contribution to journal › Article

57 Scopus citations

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1

Wang, H., Vath, G. M., Kawamura, A., Bates, C. A., Sim, E., Hanna, P. E. & Wagner, C. R., Feb 1 2005, In : Protein Journal. 24, 2, p. 65-77 13 p.

Research output: Contribution to journal › Article

20 Scopus citations

Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein

Sticha, K. R. K., Sieg, C. A., Bergstrom, C. P., Hanna, P. E. & Wagner, C. R., Jun 1997, In : Protein Expression and Purification. 10, 1, p. 141-153 13 p.

Research output: Contribution to journal › Article

40 Scopus citations

Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats

Song, H., Griesgraber, G. W., Wagner, C. R. & Zimmerman, C. L., May 2 2002, In : Antimicrobial agents and chemotherapy. 46, 5, p. 1357-1363 7 p.

Research output: Contribution to journal › Article

20 Scopus citations

Phospholipid autoxidation

Porter, N. A. & Wagner, C. R., 1986, In : Advances in Free Radical Biology and Medicine. 2, 2, p. 283-323 41 p.

Research output: Contribution to journal › Article

32 Scopus citations

Phosphoramidate pronucleotides: A comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins

Chou, T. F., Baraniak, J., Kaczmarek, R., Zhou, X., Cheng, J., Ghosh, B. & Wagner, C. R., Mar 1 2007, In : Molecular Pharmaceutics. 4, 2, p. 208-217 10 p.

Research output: Contribution to journal › Article

58 Scopus citations

Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors

Wagner, C. R., Ballato, G., Akanni, A. O., McIntee, E. J., Larson, R. S., Chang, S. L. & Abul-Hajj, Y. J., Jun 15 1997, In : Cancer Research. 57, 12, p. 2341-2345 5 p.

Research output: Contribution to journal › Article

38 Scopus citations

Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190

Zhou, X., Zhang, N., Liu, L., Walters, K. J., Hanna, P. E. & Wagner, C. R., Dec 1 2009, In : FEBS Journal. 276, 23, p. 6928-6941 14 p.

Research output: Contribution to journal › Article

3 Scopus citations

Probing the Impact of the echinT C-Terminal Domain on Structure and Catalysis

Bardaweel, S., Pace, J., Chou, T. F., Cody, V. & Wagner, C. R., Dec 10 2010, In : Journal of Molecular Biology. 404, 4, p. 627-638 12 p.

Research output: Contribution to journal › Article

12 Scopus citations

Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies

Wang, H., Vath, G. M., Gleason, K. J., Hanna, P. E. & Wagner, C. R., Jun 29 2004, In : Biochemistry. 43, 25, p. 8234-8246 13 p.

Research output: Contribution to journal › Article

57 Scopus citations

Probing the Molecular Basis of Resistance to Pyrimethamine by Site-Directed Mutagenesis

Wagner, C. R. & Benkovic, S. J., Jul 1 1992, In : Journal of medicinal chemistry. 35, 15, p. 2912-2915 4 p.

Research output: Contribution to journal › Article

2 Scopus citations

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers

Gangar, A., Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Feb 15 2012, In : Journal of the American Chemical Society. 134, 6, p. 2895-2897 3 p.

Research output: Contribution to journal › Article

10 Scopus citations

Pronucleotides: Toward the in vivo delivery of antiviral and anticancer nucleotides

Wagner, C. R., Iyer, V. V. & McIntee, E. J., Nov 9 2000, In : Medicinal Research Reviews. 20, 6, p. 417-451 35 p.

Research output: Contribution to journal › Article

244 Scopus citations

Prosthetic antigen receptors

Shen, J., Vallera, D. A. & Wagner, C. R., Aug 19 2015, In : Journal of the American Chemical Society. 137, 32, p. 10108-10111 4 p.

Research output: Contribution to journal › Article

6 Scopus citations

Protein interface remodeling in a chemically induced protein dimer

White, B. R., Carlson, J. C. T., Kerns, J. L. & Wagner, C. R., Jul 1 2012, In : Journal of Molecular Recognition. 25, 7, p. 393-403 11 p.

Research output: Contribution to journal › Article

Repression of oncogenic cap-mediated translation by 4Ei-10 diminishes proliferation, enhances chemosensitivity and alters expression of malignancy-related proteins in mesothelioma

Ahmad, Z., Jacobson, B. A., McDonald, M. W., Vattendahl Vidal, N., Vattendahl Vidal, G., Chen, S., Dillenburg, M., Okon, A. M., Patel, M. R., Wagner, C. R. & Kratzke, R. A., Feb 1 2020, In : Cancer chemotherapy and pharmacology. 85, 2, p. 425-432 8 p.

Research output: Contribution to journal › Article

Reversible Re-programing of Cell-Cell Interactions

Gabrielse, K., Gangar, A., Kumar, N., Lee, J. C., Fegan, A., Shen, J. J., Li, Q., Vallera, D. & Wagner, C. R., May 12 2014, In : Angewandte Chemie - International Edition. 53, 20, p. 5112-5116 5 p.

Research output: Contribution to journal › Article

15 Scopus citations

Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191

Birkus, G., Kutty, N., Frey, C. R., Shribata, R., Chou, T., Wagner, C., McDermott, M. & Cihlar, T., May 1 2011, In : Antimicrobial agents and chemotherapy. 55, 5, p. 2166-2173 8 p.

Research output: Contribution to journal › Article

13 Scopus citations

Self-assembly of antibodies by chemical induction

Li, Q., Hapka, D., Chen, H., Vallera, D. A. & Wagner, C. R., Dec 15 2008, In : Angewandte Chemie - International Edition. 47, 52, p. 10179-10182 4 p.

Research output: Contribution to journal › Article

20 Scopus citations

Simultaneous dual protein labeling using a triorthogonal reagent

Rashidian, M., Kumarapperuma, S. C., Gabrielse, K., Fegan, A., Wagner, C. R. & Distefano, M. D., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16388-16396 9 p.

Research output: Contribution to journal › Article

30 Scopus citations

Site directed mutagenesis: a tool for enzyme mechanism dissection

Wagner, C. R. & Benkovic, S. J., 1990, In : Trends in biotechnology. 8, C, p. 263-270 8 p.

Research output: Contribution to journal › Article

35 Scopus citations

Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells

Chen, E. Z., Jacobson, B. A., Patel, M. R., Okon, A. M., Li, S., Xiong, K., Vaidya, A. J., Bitterman, P. B., Wagner, C. R. & Kratzke, R. A., Aug 2014, In : Investigational New Drugs. 32, 4, p. 598-603 6 p.

Research output: Contribution to journal › Article

11 Scopus citations

Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily

Maize, K. M., Wagner, C. R. & Finzel, B. C., Jul 1 2013, In : FEBS Journal. 280, 14, p. 3389-3398 10 p.

Research output: Contribution to journal › Article

17 Scopus citations

Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia

Shah, R. M., Maize, K. M., West, H. T., Strom, A. M., Finzel, B. C. & Wagner, C. R., Aug 17 2018, In : Journal of Molecular Biology. 430, 17, p. 2709-2721 13 p.

Research output: Contribution to journal › Article

Open Access
1 Scopus citations

Switch-on fluorescent/FRET probes to study human histidine triad nucleotide binding protein 1 (hHint1), a novel target for opioid tolerance and neuropathic pain

Shah, R., Zhou, A. & Wagner, C. R., Jan 1 2017, In : Organic and Biomolecular Chemistry. 15, 48, p. 10230-10237 8 p.

Research output: Contribution to journal › Article

4 Scopus citations