1986 …2020
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Research Output 1986 2019

2005
30 Citations (Scopus)

Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP

Ghosh, P., Park, C., Peterson, M. S., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Apr 15 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 8, p. 2177-2180 4 p.

Research output: Contribution to journalArticle

Organophosphonates
Messenger RNA
Competitive Binding
Guanosine
Nucleosides
2006
32 Citations (Scopus)

Arylamine N-acetyltransferase Aggregation and Constitutive Ubiquitylation

Liu, F., Zhang, N., Zhou, X., Hanna, P. E., Wagner, C. R., Koepp, D. M. & Walters, K. J., Aug 18 2006, In : Journal of Molecular Biology. 361, 3, p. 482-492 11 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Ubiquitination
Cricetinae
Mutation
Tryptophan
5 Citations (Scopus)

Characterization of a radiolabeled small molecule targeting leukocyte function-associated antigen-1 expression in lymphoma and leukemia

Poria, R. B., Norenberg, J. P., Anderson, T. L., Erion, J., Wagner, C. R., Arterburn, J. B. & Larson, R. S., Nov 20 2006, In : Cancer Biotherapy and Radiopharmaceuticals. 21, 5, p. 418-426 9 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
Lymphoma
Leukemia
Lutetium
Fluorescein
106 Citations (Scopus)

Chemically controlled self-assembly of protein nanorings

Carlson, J. C. T., Jena, S. S., Flenniken, M., Chou, T. F., Siegel, R. A. & Wagner, C. R., Jun 14 2006, In : Journal of the American Chemical Society. 128, 23, p. 7630-7638 9 p.

Research output: Contribution to journalArticle

Nanorings
Self assembly
Proteins
Peptides
Tetrahydrofolate Dehydrogenase
1 Citation (Scopus)
Pharmaceutical Chemistry
7-methylguanosine triphosphate
38 Citations (Scopus)

NMR-based Model Reveals the Structural Determinants of Mammalian Arylamine N-Acetyltransferase Substrate Specificity

Zhang, N., Liu, L., Liu, F., Wagner, C. R., Hanna, P. E. & Walters, K. J., Oct 13 2006, In : Journal of Molecular Biology. 363, 1, p. 188-200 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetyltransferases
Structural Models
Substrate Specificity
2-toluidine
Organophosphonates
Amino Acids
Nucleosides
Iodine
phosphoramidic acid
2007
58 Citations (Scopus)

Arylamine N-acetyltransferase I

Minchin, R. F., Hanna, P. E., Dupret, J. M., Wagner, C. R., Rodrigues-Lima, F. & Butcher, N. J., Sep 11 2007, In : International Journal of Biochemistry and Cell Biology. 39, 11, p. 1999-2005 7 p.

Research output: Contribution to journalShort survey

Arylamine N-Acetyltransferase
hydrazine
Genes
Folic Acid
Chromosomes, Human, Pair 8
31 Citations (Scopus)

Arylamine N-acetyltransferases: Characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2

Liu, L., Von Vett, A., Zhang, N., Walters, K. J., Wagner, C. R. & Hanna, P. E., Sep 1 2007, In : Chemical research in toxicology. 20, 9, p. 1300-1308 9 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Molecular interactions
Substrate Specificity
Acetyltransferases
27 Citations (Scopus)

Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate

Chou, T. F., Tikh, I. B., Horta, B. A. C., Ghosh, B., De Alencastro, R. B. & Wagner, C. R., May 18 2007, In : Journal of Biological Chemistry. 282, 20, p. 15137-15147 11 p.

Research output: Contribution to journalArticle

Lysine-tRNA Ligase
Hydrolysis
Adenosine Monophosphate
Adenosine
Monomers
6 Citations (Scopus)

Evidence that Human Histidine Triad Nucleotide Binding Protein 3 (Hint3) is a Distinct Branch of the Histidine Triad (HIT) Superfamily

Chou, T. F., Cheng, J., Tikh, I. B. & Wagner, C. R., Nov 2 2007, In : Journal of Molecular Biology. 373, 4, p. 978-989 12 p.

Research output: Contribution to journalArticle

Histidine
Carrier Proteins
Nucleotides
Lysine-tRNA Ligase
Catalytic Domain
11 Citations (Scopus)

Impact of the C-terminal loop of histidine triad nucleotide binding protein 1 (Hint1) on substrate specificity

Chou, T. F., Sham, Y. Y. & Wagner, C. R., Nov 13 2007, In : Biochemistry. 46, 45, p. 13074-13079 6 p.

Research output: Contribution to journalArticle

Substrate Specificity
Histidine
Escherichia coli
Carrier Proteins
Nucleotides
43 Citations (Scopus)

Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins

Chou, T. F. & Wagner, C. R., Feb 16 2007, In : Journal of Biological Chemistry. 282, 7, p. 4719-4727 9 p.

Research output: Contribution to journalArticle

Lysine-tRNA Ligase
Histidine
Adenosine Monophosphate
Carrier Proteins
Nucleotides
57 Citations (Scopus)

Phosphoramidate pronucleotides: A comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins

Chou, T. F., Baraniak, J., Kaczmarek, R., Zhou, X., Cheng, J., Ghosh, B. & Wagner, C. R., Mar 1 2007, In : Molecular pharmaceutics. 4, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

Substrate Specificity
Histidine
Carrier Proteins
Nucleotides
Escherichia coli
2008

A letter from the editors. RE: Impact factors

Amidon, G. L., Wagner, C. R. & Lee, K. D., Jul 1 2008, In : Molecular Pharmaceutics. 5, 4, 1 p.

Research output: Contribution to journalEditorial

31 Citations (Scopus)

Enzyme nanorings

Chou, T. F., So, C., White, B. R., Carlson, J. C. T., Sarikaya, M. & Wagner, C. R., Dec 23 2008, In : ACS Nano. 2, 12, p. 2519-2525 7 p.

Research output: Contribution to journalArticle

Nanorings
enzymes
Enzymes
fusion
proteins
7 Citations (Scopus)

Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein

Ghosh, P., Cheng, J., Chou, T. F., Jia, Y., Avdulov, S. V., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Aug 1 2008, In : Protein Expression and Purification. 60, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Tetrahydrofolate Dehydrogenase
Proteins
Trimethoprim
Anions
23 Citations (Scopus)
Poisons
Metabolites
HeLa Cells
Acetylation
Detoxification
10 Citations (Scopus)
Molecular modeling
Charge distribution
Binding energy
charge distribution
field theory (physics)
20 Citations (Scopus)

Self-assembly of antibodies by chemical induction

Li, Q., Hapka, D., Chen, H., Vallera, D. A. & Wagner, C. R., Dec 15 2008, In : Angewandte Chemie - International Edition. 47, 52, p. 10179-10182 4 p.

Research output: Contribution to journalArticle

Antibodies
Self assembly
Proteins
Tetrahydrofolate Dehydrogenase
Trimethoprim
43 Citations (Scopus)

Fluorescent tumour imaging of type I IGF receptor in vivo: comparison of antibody-conjugated quantum dots and small-molecule fluorophore

Zhang, H., Zeng, X., Li, Q., Gaillard-Kelly, M., Wagner, C. R. & Yee, D., Jul 7 2009, In : British Journal of Cancer. 101, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

Quantum Dots
IGF Type 1 Receptor
Down-Regulation
Heterografts
Antibodies
10 Citations (Scopus)

Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection

Cheng, J., Zhou, X., Chou, T. F., Ghosh, B., Liu, B. & Wagner, C. R., Dec 8 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 22, p. 6379-6381 3 p.

Research output: Contribution to journalArticle

Bacteriophage T7
Bacteriophages
Display devices
Ribonucleotides
Amino Acids
24 Citations (Scopus)

Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines

Liu, L., Wagner, C. R. & Hanna, P. E., Dec 21 2009, In : Chemical research in toxicology. 22, 12, p. 1962-1974 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Metabolites
Protein Isoforms
Acetylation
HeLa Cells
56 Citations (Scopus)

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

Ghosh, B., Benyumov, A., Ghosh, P., Jia, Y., Avdulov, S. V., Dahlberg, P. S., Peterson, M., Smith, K., Polunovsky, V. A., Bitterman, P. B. & Wagner, C. R., May 15 2009, In : ACS Chemical Biology. 4, 5, p. 367-377 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Tissue
Messenger RNA
Prodrugs
Zebrafish
3 Citations (Scopus)

Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190

Zhou, X., Zhang, N., Liu, L., Walters, K. J., Hanna, P. E. & Wagner, C. R., Dec 1 2009, In : FEBS Journal. 276, 23, p. 6928-6941 14 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Mutagenesis
hydrazine
Site-Directed Mutagenesis
2010
144 Citations (Scopus)

Chemically controlled protein assembly: Techniques and applications

Fegan, A., White, B., Carlson, J. C. T. & Wagner, C. R., Jun 9 2010, In : Chemical Reviews. 110, 6, p. 3315-3336 22 p.

Research output: Contribution to journalArticle

Dimerization
Proteins
DNA Gyrase
Ligands
Bacterial DNA
47 Citations (Scopus)

Chemically self-assembled antibody nanorings (CSANs): Design and characterization of an anti-CD3 IgM biomimetic

Li, Q., So, C. R., Fegan, A., Cody, V., Sarikaya, M., Vallera, D. A. & Wagner, C. R., Dec 8 2010, In : Journal of the American Chemical Society. 132, 48, p. 17247-17257 11 p.

Research output: Contribution to journalArticle

Nanorings
Biomimetics
Antibodies
Immunoglobulin M
Monoclonal antibodies
30 Citations (Scopus)

Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP

Jia, Y., Chiu, T. L., Amin, E. A., Polunovsky, V., Bitterman, P. B. & Wagner, C. R., Apr 1 2010, In : European Journal of Medicinal Chemistry. 45, 4, p. 1304-1313 10 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Guanosine Monophosphate
Quantitative Structure-Activity Relationship
Libraries
RNA Cap-Binding Proteins

DHFR Fusion proteins for the cellular delivery of methotrexate labeled oligonucleotides

Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Dec 1 2010, 7th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2010. p. 27-28 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Oligonucleotides
Fusion reactions
Proteins
12 Citations (Scopus)

Probing the Impact of the echinT C-Terminal Domain on Structure and Catalysis

Bardaweel, S., Pace, J., Chou, T. F., Cody, V. & Wagner, C. R., Dec 10 2010, In : Journal of Molecular Biology. 404, 4, p. 627-638 12 p.

Research output: Contribution to journalArticle

Catalysis
Escherichia coli
Bacteria
Gram-Positive Bacteria
Adenosine Monophosphate
2011

Chemically induced self-assembly of enzyme nanorings.

White, B. R., Li, Q. & Wagner, C. R., Sep 15 2011, In : Methods in molecular biology (Clifton, N.J.). 743, p. 17-26 10 p.

Research output: Contribution to journalArticle

Dimerization
Enzymes
Technology
Tetrahydrofolate Dehydrogenase
Proteins
8 Citations (Scopus)

E. coli Histidine triad nucleotide binding protein 1 (echint) is a catalytic regulator of d-alanine dehydrogenase (dada) activity in vivo

Bardaweel, S., Ghosh, B., Chou, T. F., Sadowsky, M. J. & Wagner, C. R., Jul 11 2011, In : PloS one. 6, 7, e20897.

Research output: Contribution to journalArticle

alanine dehydrogenase
Alanine Dehydrogenase
histidine
Histidine
Escherichia coli
13 Citations (Scopus)

Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191

Birkus, G., Kutty, N., Frey, C. R., Shribata, R., Chou, T., Wagner, C. R., McDermott, M. & Cihlar, T., May 1 2011, In : Antimicrobial agents and chemotherapy. 55, 5, p. 2166-2173 8 p.

Research output: Contribution to journalArticle

Cathepsin A
Lysosomes
Phenylalanine
Esters
Hydrolysis
2012
78 Citations (Scopus)

Blood-nanoparticle interactions and in Vivo biodistribution: Impact of surface peg and ligand properties

Shah, N. B., Vercellotti, G. M., White, J. G., Fegan, A., Wagner, C. R. & Bischof, J. C., Aug 6 2012, In : Molecular pharmaceutics. 9, 8, p. 2146-2155 10 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Ligands
Surface Properties
Blood Proteins
63 Citations (Scopus)

Cap-Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target

Jia, Y., Polunovsky, V., Bitterman, P. B. & Wagner, C. R., Jul 1 2012, In : Medicinal Research Reviews. 32, 4, p. 786-814 29 p.

Research output: Contribution to journalReview article

Peptide Initiation Factors
Pharmaceutical Preparations
Neoplasms
X-Rays
Pharmacology
16 Citations (Scopus)

Chemically self-assembled antibody nanostructures as potential drug carriers

Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Nov 5 2012, In : Molecular Pharmaceutics. 9, 11, p. 3218-3227 10 p.

Research output: Contribution to journalArticle

Drug Carriers
Nanostructures
Methotrexate
Antibodies
Trimethoprim
10 Citations (Scopus)

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers

Gangar, A., Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Feb 15 2012, In : Journal of the American Chemical Society. 134, 6, p. 2895-2897 3 p.

Research output: Contribution to journalArticle

Oligonucleotides
Antibodies
Self assembly
Carrier Proteins
Proteins

Protein interface remodeling in a chemically induced protein dimer

White, B. R., Carlson, J. C. T., Kerns, J. L. & Wagner, C. R., Jul 1 2012, In : Journal of Molecular Recognition. 25, 7, p. 393-403 11 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Proteins
Nanostructures
Population Characteristics
Methotrexate
2 Citations (Scopus)

Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins

Bardaweel, S. K., Ghosh, B. & Wagner, C. R., Jan 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 1, p. 558-560 3 p.

Research output: Contribution to journalArticle

Carbamates
Histidine
Escherichia coli
Carrier Proteins
Nucleotides
2013
79 Citations (Scopus)

A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation

Rashidian, M., Mahmoodi, M. M., Shah, R., Dozier, J. K., Wagner, C. R. & Distefano, M. D., Mar 20 2013, In : Bioconjugate Chemistry. 24, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

Hydrazones
Oximes
Ligation
Aniline
Catalysts
30 Citations (Scopus)

Distinct Translational Control in CD4+ T Cell Subsets

Bjur, E., Larsson, O., Yurchenko, E., Zheng, L., Gandin, V., Topisirovic, I., Li, S., Wagner, C. R., Sonenberg, N. & Piccirillo, C. A., May 1 2013, In : PLoS genetics. 9, 5, e1003494.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
translation (genetics)
T-lymphocytes
Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
14 Citations (Scopus)

Kinetic mechanism of human histidine triad nucleotide binding protein 1

Zhou, X., Chou, T. F., Aubol, B. E., Park, C. J., Wolfenden, R., Adams, J. & Wagner, C. R., May 21 2013, In : Biochemistry. 52, 20, p. 3588-3600 13 p.

Research output: Contribution to journalArticle

Hydrolysis
Adenosine Monophosphate
Kinetics
Nucleophiles
Catalytic Domain
27 Citations (Scopus)

Simultaneous dual protein labeling using a triorthogonal reagent

Rashidian, M., Kumarapperuma, S. C., Gabrielse, K., Fegan, A., Wagner, C. R. & Distefano, M. D., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16388-16396 9 p.

Research output: Contribution to journalArticle

Labeling
Proteins
Tetrahydrofolate Dehydrogenase
Fluorophores
Polyethylene glycols
14 Citations (Scopus)

Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily

Maize, K. M., Wagner, C. R. & Finzel, B. C., Jul 1 2013, In : FEBS Journal. 280, 14, p. 3389-3398 10 p.

Research output: Contribution to journalArticle

Hydrolases
Adenosine Monophosphate
Histidine
Carrier Proteins
Nucleotides
6 Citations (Scopus)

Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures

Gangar, A., Fegan, A., Kumarapperuma, S. C., Huynh, P., Benyumov, A. & Wagner, C. R., Sep 3 2013, In : Molecular Pharmaceutics. 10, 9, p. 3514-3518 5 p.

Research output: Contribution to journalArticle

Nanostructures
Antisense Oligonucleotides
Nucleic Acids
Methotrexate
Eukaryotic Initiation Factor-4E
39 Citations (Scopus)
gemcitabine
Guanosine Monophosphate
Lung Neoplasms
Breast Neoplasms
Prodrugs
2014
14 Citations (Scopus)

Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α

Cao, J., He, L., Lin, G., Hu, C., Dong, R., Zhang, J., Zhu, H., Hu, Y., Wagner, C. R., He, Q. & Yang, B., May 1 2014, In : Biochemical Pharmacology. 89, 1, p. 20-30 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Peptide Initiation Factors
Ouabain
Cardiac Glycosides
Heart Neoplasms
13 Citations (Scopus)

Reversible Re-programing of Cell-Cell Interactions

Gabrielse, K., Gangar, A., Kumar, N., Lee, J. C., Fegan, A., Shen, J. J., Li, Q., Vallera, D. & Wagner, C. R., May 12 2014, In : Angewandte Chemie - International Edition. 53, 20, p. 5112-5116 5 p.

Research output: Contribution to journalArticle

Nanorings
Lipids
Antigens
Ligands
Antigen Receptors
10 Citations (Scopus)

Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells

Chen, E. Z., Jacobson, B. A., Patel, M. R., Okon, A. M., Li, S., Xiong, K., Vaidya, A. J., Bitterman, P. B., Wagner, C. R. & Kratzke, R. A., Jan 1 2014, In : Investigational New Drugs. 32, 4, p. 598-603 6 p.

Research output: Contribution to journalArticle

Mesothelioma
Protein Biosynthesis
Pemetrexed
Prodrugs
Messenger RNA