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Research Output 1986 2019

2009
54 Citations (Scopus)

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

Ghosh, B., Benyumov, A., Ghosh, P., Jia, Y., Avdulov, S. V., Dahlberg, P. S., Peterson, M., Smith, K., Polunovsky, V. A., Bitterman, P. B. & Wagner, C. R., May 15 2009, In : ACS Chemical Biology. 4, 5, p. 367-377 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Tissue
Messenger RNA
Prodrugs
Zebrafish
3 Citations (Scopus)

Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190

Zhou, X., Zhang, N., Liu, L., Walters, K. J., Hanna, P. E. & Wagner, C. R., Dec 1 2009, In : FEBS Journal. 276, 23, p. 6928-6941 14 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Mutagenesis
hydrazine
Site-Directed Mutagenesis
2008

A letter from the editors. RE: Impact factors

Amidon, G. L., Wagner, C. R. & Lee, K. D., Jul 1 2008, In : Molecular Pharmaceutics. 5, 4, 1 p.

Research output: Contribution to journalEditorial

30 Citations (Scopus)

Enzyme nanorings

Chou, T. F., So, C., White, B. R., Carlson, J. C. T., Sarikaya, M. & Wagner, C. R., Dec 23 2008, In : ACS Nano. 2, 12, p. 2519-2525 7 p.

Research output: Contribution to journalArticle

Nanorings
enzymes
Enzymes
fusion
proteins
7 Citations (Scopus)

Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein

Ghosh, P., Cheng, J., Chou, T. F., Jia, Y., Avdulov, S. V., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Aug 1 2008, In : Protein Expression and Purification. 60, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Tetrahydrofolate Dehydrogenase
Proteins
Trimethoprim
Anions
22 Citations (Scopus)
Poisons
Metabolites
HeLa Cells
Acetylation
Detoxification
9 Citations (Scopus)
Molecular modeling
Charge distribution
Binding energy
charge distribution
field theory (physics)
20 Citations (Scopus)

Self-assembly of antibodies by chemical induction

Li, Q., Hapka, D., Chen, H., Vallera, D. A. & Wagner, C. R., Dec 15 2008, In : Angewandte Chemie - International Edition. 47, 52, p. 10179-10182 4 p.

Research output: Contribution to journalArticle

Antibodies
Self assembly
Proteins
Tetrahydrofolate Dehydrogenase
Trimethoprim
2007
57 Citations (Scopus)

Arylamine N-acetyltransferase I

Minchin, R. F., Hanna, P. E., Dupret, J. M., Wagner, C. R., Rodrigues-Lima, F. & Butcher, N. J., Sep 11 2007, In : International Journal of Biochemistry and Cell Biology. 39, 11, p. 1999-2005 7 p.

Research output: Contribution to journalShort survey

Arylamine N-Acetyltransferase
hydrazine
Genes
Folic Acid
Chromosomes, Human, Pair 8
30 Citations (Scopus)

Arylamine N-acetyltransferases: Characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2

Liu, L., Von Vett, A., Zhang, N., Walters, K. J., Wagner, C. R. & Hanna, P. E., Sep 1 2007, In : Chemical Research in Toxicology. 20, 9, p. 1300-1308 9 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Molecular interactions
Substrate Specificity
Acetyltransferases
26 Citations (Scopus)

Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate

Chou, T. F., Tikh, I. B., Horta, B. A. C., Ghosh, B., De Alencastro, R. B. & Wagner, C. R., May 18 2007, In : Journal of Biological Chemistry. 282, 20, p. 15137-15147 11 p.

Research output: Contribution to journalArticle

Lysine-tRNA Ligase
Hydrolysis
Adenosine Monophosphate
Adenosine
Monomers
6 Citations (Scopus)

Evidence that Human Histidine Triad Nucleotide Binding Protein 3 (Hint3) is a Distinct Branch of the Histidine Triad (HIT) Superfamily

Chou, T. F., Cheng, J., Tikh, I. B. & Wagner, C. R., Nov 2 2007, In : Journal of Molecular Biology. 373, 4, p. 978-989 12 p.

Research output: Contribution to journalArticle

Histidine
Carrier Proteins
Nucleotides
Lysine-tRNA Ligase
Catalytic Domain
11 Citations (Scopus)

Impact of the C-terminal loop of histidine triad nucleotide binding protein 1 (Hint1) on substrate specificity

Chou, T. F., Sham, Y. Y. & Wagner, C. R., Nov 13 2007, In : Biochemistry. 46, 45, p. 13074-13079 6 p.

Research output: Contribution to journalArticle

Substrate Specificity
Histidine
Escherichia coli
Carrier Proteins
Nucleotides
40 Citations (Scopus)

Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins

Chou, T. F. & Wagner, C. R., Feb 16 2007, In : Journal of Biological Chemistry. 282, 7, p. 4719-4727 9 p.

Research output: Contribution to journalArticle

Lysine-tRNA Ligase
Histidine
Adenosine Monophosphate
Carrier Proteins
Nucleotides
56 Citations (Scopus)

Phosphoramidate pronucleotides: A comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins

Chou, T. F., Baraniak, J., Kaczmarek, R., Zhou, X., Cheng, J., Ghosh, B. & Wagner, C. R., Mar 1 2007, In : Molecular Pharmaceutics. 4, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

Substrate Specificity
Histidine
Carrier Proteins
Nucleotides
Escherichia coli
2006
30 Citations (Scopus)

Arylamine N-acetyltransferase Aggregation and Constitutive Ubiquitylation

Liu, F., Zhang, N., Zhou, X., Hanna, P. E., Wagner, C. R., Koepp, D. M. & Walters, K. J., Aug 18 2006, In : Journal of Molecular Biology. 361, 3, p. 482-492 11 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Ubiquitination
Cricetinae
Mutation
Tryptophan
4 Citations (Scopus)

Characterization of a radiolabeled small molecule targeting leukocyte function-associated antigen-1 expression in lymphoma and leukemia

Poria, R. B., Norenberg, J. P., Anderson, T. L., Erion, J., Wagner, C. R., Arterburn, J. B. & Larson, R. S., Nov 20 2006, In : Cancer Biotherapy and Radiopharmaceuticals. 21, 5, p. 418-426 9 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
Lymphoma
Leukemia
Lutetium
Fluorescein
104 Citations (Scopus)

Chemically controlled self-assembly of protein nanorings

Carlson, J. C. T., Jena, S. S., Flenniken, M., Chou, T. F., Siegel, R. A. & Wagner, C. R., Jun 14 2006, In : Journal of the American Chemical Society. 128, 23, p. 7630-7638 9 p.

Research output: Contribution to journalArticle

Nanorings
Self assembly
Proteins
Peptides
Tetrahydrofolate Dehydrogenase
1 Citation (Scopus)
Pharmaceutical Chemistry
7-methylguanosine triphosphate
38 Citations (Scopus)

NMR-based Model Reveals the Structural Determinants of Mammalian Arylamine N-Acetyltransferase Substrate Specificity

Zhang, N., Liu, L., Liu, F., Wagner, C. R., Hanna, P. E. & Walters, K. J., Oct 13 2006, In : Journal of Molecular Biology. 363, 1, p. 188-200 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetyltransferases
Structural Models
Substrate Specificity
2-toluidine
Organophosphonates
Amino Acids
Nucleosides
Iodine
phosphoramidic acid
2005
41 Citations (Scopus)

31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions

Chou, T. F., Bieganowski, P., Shilinski, K., Cheng, J., Brenner, C. & Wagner, C. R., Apr 15 2005, In : Journal of Biological Chemistry. 280, 15, p. 15356-15361 6 p.

Research output: Contribution to journalArticle

Purine Nucleosides
Adenosine Monophosphate
Salts
Escherichia coli
Nuclear magnetic resonance
14 Citations (Scopus)
Electrospray Ionization Mass Spectrometry
High Pressure Liquid Chromatography
Amino Acids
Prodrugs
Nucleosides
40 Citations (Scopus)

Catalytic mechanism of hamster arylamine N-acetyltransferase 2

Wang, H., Liu, L., Hanna, P. E. & Wagner, C. R., Aug 23 2005, In : Biochemistry. 44, 33, p. 11295-11306 12 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Acetyl Coenzyme A
Isotopes
Cricetinae
29 Citations (Scopus)

Dissociation of I domain and global conformational changes in LFA-1: Refinement of small molecule-I domain structure-activity relationships

Larson, R. S., Davis, T., Bologa, C., Semenuk, G., Vijayan, S., Li, Y., Oprea, T., Chigaev, A., Buranda, T., Wagner, C. R. & Sklar, L. A., Mar 22 2005, In : Biochemistry. 44, 11, p. 4322-4331 10 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
Structure-Activity Relationship
Molecules
Dithiothreitol
Divalent Cations

Erratum: Catalytic mechanism of hamster arylamine N-acetyltransferase 2 (Biochemistry (August 23, 2005) 44, 3 (11295-11306))

Wang, H., Liu, L., Hanna, P. E. & Wagner, C. R., Dec 6 2005, In : Biochemistry. 44, 48, 1 p.

Research output: Contribution to journalComment/debate

Arylamine N-Acetyltransferase
Cricetinae
Biochemistry
75 Citations (Scopus)

Eukaryotic arylamine N-acetyltransferase investigation of substrate specificity by high-throughput screening

Kawamura, A., Graham, J., Mushtaq, A., Tsiftsoglou, S. A., Vath, G. M., Hanna, P. E., Wagner, C. R. & Sim, E., Jan 15 2005, In : Biochemical Pharmacology. 69, 2, p. 347-359 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Mesocricetus
Substrate Specificity
Screening
Throughput
20 Citations (Scopus)
N-hydroxy-4-acetylaminobiphenyl
Arylamine N-Acetyltransferase
Acetyltransferases
Cricetinae
Enzymes
19 Citations (Scopus)

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1

Wang, H., Vath, G. M., Kawamura, A., Bates, C. A., Sim, E., Hanna, P. E. & Wagner, C. R., Feb 1 2005, In : Protein Journal. 24, 2, p. 65-77 13 p.

Research output: Contribution to journalArticle

Purification
Cricetinae
Fusion reactions
Acids
Substrates
30 Citations (Scopus)

Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP

Ghosh, P., Park, C., Peterson, M. S., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Apr 15 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 8, p. 2177-2180 4 p.

Research output: Contribution to journalArticle

Organophosphonates
Messenger RNA
Competitive Binding
Guanosine
Nucleosides
2004

A dogma in need of a reformation.

Wagner, C. R., Jul 1 2004, In : Mol Pharm. 1, 4, 1 p.

Research output: Contribution to journalEditorial

Drug Design
Drug Delivery Systems
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
83 Citations (Scopus)

An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries: Discovery of a novel antagonist of E. coli dihydrofolate reductase

Annis, D. A., Athanasopoulos, J., Curran, P. J., Felsch, J. S., Kalghatgi, K., Lee, W. H., Nash, H. M., Orminati, J. P. A., Rosner, K. E., Shipps, G. W., Thaddupathy, G. R. A., Tyler, A. N., Vilenchik, L., Wagner, C. R. & Wintner, E. A., Nov 1 2004, In : International Journal of Mass Spectrometry. 238, 2, p. 77-83 7 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Escherichia coli
Mass spectrometry
affinity
mass spectroscopy
7 Citations (Scopus)

Chemical modification of hamster arylamine N-acetyltransferase 2 with isozyme-selective and nonselective N-arylbromoacetamido reagents

Wang, H., Guo, Z., Vath, G. M., Wagner, C. R. & Hanna, P. E., Dec 1 2004, In : Protein Journal. 23, 2, p. 153-166 14 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Alkylation
Chemical modification
Cricetinae
Isoenzymes
65 Citations (Scopus)

Designing a pronucleotide stratagem: Lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines

Drontle, D. P. & Wagner, C. R., Jan 1 2004, In : Mini-Reviews in Medicinal Chemistry. 4, 4, p. 409-419 11 p.

Research output: Contribution to journalReview article

Pyrimidines
Antiviral Agents
Amino Acids
Zidovudine
Nucleosides
25 Citations (Scopus)

Direct measurement of nucleoside monophosphate delivery from a phosphoramidate pronucleotide by stable isotope labeling and LC-ESI(-)-MS/MS.

Kim, J., Chou, T. F., Griesgraber, G. W. & Wagner, C. R., Jan 1 2004, In : Molecular Pharmaceutics. 1, 2, p. 102-111 10 p.

Research output: Contribution to journalArticle

Isotope Labeling
Nucleosides
Blood Cells
Amino Acids
5'-Nucleotidase
24 Citations (Scopus)
2-Acetylaminofluorene
Cricetinae
Acetylation
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Arylamine N-Acetyltransferase
6 Citations (Scopus)

Monitoring the Intracellular Metabolism of Nucleoside Phosphoramidate Pronucleotides by 31P NMR

Kim, J., Drontle, D. P. & Wagner, C. R., Mar 26 2004, In : Nucleosides, Nucleotides and Nucleic Acids. 23, 1-2, p. 483-493 11 p.

Research output: Contribution to journalArticle

Nucleosides
Metabolism
Nuclear magnetic resonance
Monitoring
Cells
57 Citations (Scopus)

Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies

Wang, H., Vath, G. M., Gleason, K. J., Hanna, P. E. & Wagner, C. R., Jun 29 2004, In : Biochemistry. 43, 25, p. 8234-8246 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Mutagenesis
Site-Directed Mutagenesis
Iodoacetamide
2003

Arylamine N-acetyltransferases: Covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene

Guo, Z., Vath, G. M., Wagner, C. R. & Hanna, P. E., Dec 1 2003, In : Protein Journal. 22, 7-8, p. 631-642 12 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Proteolysis
Aniline
Cricetinae
Peptides
9 Citations (Scopus)
Arylamine N-Acetyltransferase
Proteolysis
Aniline
Cricetinae
Peptides
26 Citations (Scopus)

Designing protein dimerizers: The importance of ligand conformational equilibria

Carlson, J. C. T., Kanter, A., Thuduppathy, G. R., Cody, V., Pineda, P. E., Mc Ivor, R. S. & Wagner, C. R., Feb 12 2003, In : Journal of the American Chemical Society. 125, 6, p. 1501-1507 7 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Dimerization
Ligands
Methotrexate
Proteins
10 Citations (Scopus)

Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate

Pineda, P., Kanter, A., Mc Ivor, R. S., Benkovic, S. J., Rosowsky, A. & Wagner, C. R., Jul 3 2003, In : Journal of Medicinal Chemistry. 46, 14, p. 2816-2818 3 p.

Research output: Contribution to journalArticle

Trimetrexate
Tetrahydrofolate Dehydrogenase
Methotrexate
Folic Acid Antagonists
Genetic Therapy
12 Citations (Scopus)

Disposition and oral bioavailability in rats of an antiviral and antitumor amino acid phosphoramidate prodrug of AZT-monophosphate

Song, H., Johns, R., Griesgraber, G. W., Wagner, C. R. & Zimmerman, C. L., Mar 1 2003, In : Pharmaceutical research. 20, 3, p. 448-451 4 p.

Research output: Contribution to journalArticle

Prodrugs
Biological Availability
Antiviral Agents
Rats
Amino Acids
2002
150 Citations (Scopus)

Future research directions in idiopathic pulmonary fibrosis: Summary of a National Heart, Lung, and Blood Institute Working Group

Crystal, R. G., Bitterman, P. B., Mossman, B., Schwarz, M. I., Sheppard, D., Almasy, L., Chapman, H. A., Friedman, S. L., King, T. E., Leinwand, L. A., Liotta, L., Martin, G. R., Schwartz, D. A., Schultz, G. S., Wagner, C. R. & Musson, R. A., Jul 15 2002, In : American journal of respiratory and critical care medicine. 166, 2, p. 236-246 11 p.

Research output: Contribution to journalArticle

National Heart, Lung, and Blood Institute (U.S.)
Idiopathic Pulmonary Fibrosis
Molecular Diagnostic Techniques
Laser Capture Microdissection
Human Genome Project
18 Citations (Scopus)

Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats

Song, H., Griesgraber, G. W., Wagner, C. R. & Zimmerman, C. L., May 2 2002, In : Antimicrobial Agents and Chemotherapy. 46, 5, p. 1357-1363 7 p.

Research output: Contribution to journalArticle

Zidovudine
Pharmacokinetics
Amino Acids
phosphoramidic acid
Urine
2001
62 Citations (Scopus)

Amino acid phosphoramidate monoesters of 3′-azido-3′-deoxythymidine: Relationship between antiviral potency and intracellular metabolism

Chang, S. L., Griesgraber, G. W., Southern, P. & Wagner, C. R., Jan 18 2001, In : Journal of Medicinal Chemistry. 44, 2, p. 223-231 9 p.

Research output: Contribution to journalArticle

Zidovudine
Metabolism
Antiviral Agents
Amino Acids
Blood Cells
6 Citations (Scopus)

Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.

McIntee, E. J. & Wagner, C. R., Jan 1 2001, In : Bioorganic & medicinal chemistry letters. 11, 21, p. 2803-2805 3 p.

Research output: Contribution to journalArticle

Cytarabine
Nucleosides
Amino Acids
Substrates
Leukemia
10 Citations (Scopus)
Dideoxyadenosine
Zidovudine
Antiviral Agents
Amino Acids
Derivatives
14 Citations (Scopus)

Inhibition of CMP-sialic acid transport into golgi vesicles by nucleoside monophosphates

Chiaramonte, M., Koviach, J. L., Moore, C., Iyer, V. V., Wagner, C. R., Halcomb, R. L., Miller, W., Melançon, P. & Kuchta, R. D., Nov 27 2001, In : Biochemistry. 40, 47, p. 14260-14267 8 p.

Research output: Contribution to journalArticle

Cytidine Monophosphate N-Acetylneuraminic Acid
Nucleosides
Sugars
Nucleotides
Glycosylation
2000
242 Citations (Scopus)

Pronucleotides: Toward the in vivo delivery of antiviral and anticancer nucleotides

Wagner, C. R., Iyer, V. V. & McIntee, E. J., Nov 9 2000, In : Medicinal Research Reviews. 20, 6, p. 417-451 35 p.

Research output: Contribution to journalArticle

Antiviral Agents
Nucleotides
Prodrugs
Nucleosides
Pharmacology