1986 …2025

Research output per year

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Research Output

Fluorescent tumour imaging of type I IGF receptor in vivo: comparison of antibody-conjugated quantum dots and small-molecule fluorophore

Zhang, H., Zeng, X., Li, Q., Gaillard-Kelly, M., Wagner, C. R. & Yee, D., Jul 7 2009, In : British Journal of Cancer. 101, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection

Cheng, J., Zhou, X., Chou, T. F., Ghosh, B., Liu, B. & Wagner, C. R., Dec 8 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 22, p. 6379-6381 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines

Liu, L., Wagner, C. R. & Hanna, P. E., Dec 21 2009, In : Chemical research in toxicology. 22, 12, p. 1962-1974 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

Ghosh, B., Benyumov, A., Ghosh, P., Jia, Y., Avdulov, S. V., Dahlberg, P. S., Peterson, M., Smith, K., Polunovsky, V. A., Bitterman, P. B. & Wagner, C. R., May 15 2009, In : ACS Chemical Biology. 4, 5, p. 367-377 11 p.

Research output: Contribution to journalArticle

57 Scopus citations

Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190

Zhou, X., Zhang, N., Liu, L., Walters, K. J., Hanna, P. E. & Wagner, C. R., Dec 1 2009, In : FEBS Journal. 276, 23, p. 6928-6941 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2008

A letter from the editors. RE: Impact factors

Amidon, G. L., Wagner, C. R. & Lee, K. D., Jul 1 2008, In : Molecular Pharmaceutics. 5, 4, 1 p.

Research output: Contribution to journalEditorial

Enzyme nanorings

Chou, T. F., So, C., White, B. R., Carlson, J. C. T., Sarikaya, M. & Wagner, C. R., Dec 23 2008, In : ACS nano. 2, 12, p. 2519-2525 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein

Ghosh, P., Cheng, J., Chou, T. F., Jia, Y., Avdulov, S., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Aug 1 2008, In : Protein Expression and Purification. 60, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
23 Scopus citations
10 Scopus citations

Self-assembly of antibodies by chemical induction

Li, Q., Hapka, D., Chen, H., Vallera, D. A. & Wagner, C. R., Dec 15 2008, In : Angewandte Chemie - International Edition. 47, 52, p. 10179-10182 4 p.

Research output: Contribution to journalArticle

20 Scopus citations
2007

Arylamine N-acetyltransferase I

Minchin, R. F., Hanna, P. E., Dupret, J. M., Wagner, C. R., Rodrigues-Lima, F. & Butcher, N. J., Sep 11 2007, In : International Journal of Biochemistry and Cell Biology. 39, 11, p. 1999-2005 7 p.

Research output: Contribution to journalShort survey

58 Scopus citations

Arylamine N-acetyltransferases: Characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2

Liu, L., Von Vett, A., Zhang, N., Walters, K. J., Wagner, C. R. & Hanna, P. E., Sep 1 2007, In : Chemical research in toxicology. 20, 9, p. 1300-1308 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate

Chou, T. F., Tikh, I. B., Horta, B. A. C., Ghosh, B., De Alencastro, R. B. & Wagner, C. R., May 18 2007, In : Journal of Biological Chemistry. 282, 20, p. 15137-15147 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Evidence that Human Histidine Triad Nucleotide Binding Protein 3 (Hint3) is a Distinct Branch of the Histidine Triad (HIT) Superfamily

Chou, T. F., Cheng, J., Tikh, I. B. & Wagner, C. R., Nov 2 2007, In : Journal of Molecular Biology. 373, 4, p. 978-989 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Impact of the C-terminal loop of histidine triad nucleotide binding protein 1 (Hint1) on substrate specificity

Chou, T. F., Sham, Y. Y. & Wagner, C. R., Nov 13 2007, In : Biochemistry. 46, 45, p. 13074-13079 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins

Chou, T. F. & Wagner, C. R., Feb 16 2007, In : Journal of Biological Chemistry. 282, 7, p. 4719-4727 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Phosphoramidate pronucleotides: A comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins

Chou, T. F., Baraniak, J., Kaczmarek, R., Zhou, X., Cheng, J., Ghosh, B. & Wagner, C. R., Mar 1 2007, In : Molecular Pharmaceutics. 4, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

58 Scopus citations
2006

Arylamine N-acetyltransferase Aggregation and Constitutive Ubiquitylation

Liu, F., Zhang, N., Zhou, X., Hanna, P. E., Wagner, C. R., Koepp, D. M. & Walters, K. J., Aug 18 2006, In : Journal of Molecular Biology. 361, 3, p. 482-492 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Characterization of a radiolabeled small molecule targeting leukocyte function-associated antigen-1 expression in lymphoma and leukemia

Poria, R. B., Norenberg, J. P., Anderson, T. L., Erion, J., Wagner, C. R., Arterburn, J. B. & Larson, R. S., Nov 20 2006, In : Cancer Biotherapy and Radiopharmaceuticals. 21, 5, p. 418-426 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Chemically controlled self-assembly of protein nanorings

Carlson, J. C. T., Jena, S. S., Flenniken, M., Chou, T. F., Siegel, R. A. & Wagner, C. R., Jun 14 2006, In : Journal of the American Chemical Society. 128, 23, p. 7630-7638 9 p.

Research output: Contribution to journalArticle

111 Scopus citations

NMR-based Model Reveals the Structural Determinants of Mammalian Arylamine N-Acetyltransferase Substrate Specificity

Zhang, N., Liu, L., Liu, F., Wagner, C. R., Hanna, P. E. & Walters, K. J., Oct 13 2006, In : Journal of Molecular Biology. 363, 1, p. 188-200 13 p.

Research output: Contribution to journalArticle

38 Scopus citations
2005

31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions

Chou, T. F., Bieganowski, P., Shilinski, K., Cheng, J., Brenner, C. & Wagner, C. R., Apr 15 2005, In : Journal of Biological Chemistry. 280, 15, p. 15356-15361 6 p.

Research output: Contribution to journalArticle

41 Scopus citations
14 Scopus citations

Catalytic mechanism of hamster arylamine N-acetyltransferase 2

Wang, H., Liu, L., Hanna, P. E. & Wagner, C. R., Aug 23 2005, In : Biochemistry. 44, 33, p. 11295-11306 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Dissociation of I domain and global conformational changes in LFA-1: Refinement of small molecule-I domain structure-activity relationships

Larson, R. S., Davis, T., Bologa, C., Semenuk, G., Vijayan, S., Li, Y., Oprea, T., Chigaev, A., Buranda, T., Wagner, C. R. & Sklar, L. A., Mar 22 2005, In : Biochemistry. 44, 11, p. 4322-4331 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Erratum: Catalytic mechanism of hamster arylamine N-acetyltransferase 2 (Biochemistry (August 23, 2005) 44, 3 (11295-11306))

Wang, H., Liu, L., Hanna, P. E. & Wagner, C. R., Dec 6 2005, In : Biochemistry. 44, 48, 1 p.

Research output: Contribution to journalComment/debate

Eukaryotic arylamine N-acetyltransferase investigation of substrate specificity by high-throughput screening

Kawamura, A., Graham, J., Mushtaq, A., Tsiftsoglou, S. A., Vath, G. M., Hanna, P. E., Wagner, C. R. & Sim, E., Jan 15 2005, In : Biochemical Pharmacology. 69, 2, p. 347-359 13 p.

Research output: Contribution to journalArticle

77 Scopus citations
20 Scopus citations

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1

Wang, H., Vath, G. M., Kawamura, A., Bates, C. A., Sim, E., Hanna, P. E. & Wagner, C. R., Feb 1 2005, In : Protein Journal. 24, 2, p. 65-77 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP

Ghosh, P., Park, C., Peterson, M. S., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Apr 15 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 8, p. 2177-2180 4 p.

Research output: Contribution to journalArticle

30 Scopus citations
2004

A dogma in need of a reformation.

Wagner, C. R., Jul 1 2004, In : Mol Pharm. 1, 4, 1 p.

Research output: Contribution to journalEditorial

An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries: Discovery of a novel antagonist of E. coli dihydrofolate reductase

Annis, D. A., Athanasopoulos, J., Curran, P. J., Felsch, J. S., Kalghatgi, K., Lee, W. H., Nash, H. M., Orminati, J. P. A., Rosner, K. E., Shipps, G. W., Thaddupathy, G. R. A., Tyler, A. N., Vilenchik, L., Wagner, C. R. & Wintner, E. A., Nov 1 2004, In : International Journal of Mass Spectrometry. 238, 2, p. 77-83 7 p.

Research output: Contribution to journalArticle

88 Scopus citations

Chemical modification of hamster arylamine N-acetyltransferase 2 with isozyme-selective and nonselective N-arylbromoacetamido reagents

Wang, H., Guo, Z., Vath, G. M., Wagner, C. R. & Hanna, P. E., Dec 1 2004, In : Protein Journal. 23, 2, p. 153-166 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Designing a pronucleotide stratagem: Lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines

Drontle, D. P. & Wagner, C. R., May 2004, In : Mini-Reviews in Medicinal Chemistry. 4, 4, p. 409-419 11 p.

Research output: Contribution to journalReview article

66 Scopus citations

Direct measurement of nucleoside monophosphate delivery from a phosphoramidate pronucleotide by stable isotope labeling and LC-ESI(-)-MS/MS.

Kim, J., Chou, T. F., Griesgraber, G. W. & Wagner, C. R., Jan 1 2004, In : Molecular pharmaceutics. 1, 2, p. 102-111 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
24 Scopus citations

Monitoring the Intracellular Metabolism of Nucleoside Phosphoramidate Pronucleotides by 31P NMR

Kim, J., Drontle, D. P. & Wagner, C. R., Mar 26 2004, In : Nucleosides, Nucleotides and Nucleic Acids. 23, 1-2, p. 483-493 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies

Wang, H., Vath, G. M., Gleason, K. J., Hanna, P. E. & Wagner, C. R., Jun 29 2004, In : Biochemistry. 43, 25, p. 8234-8246 13 p.

Research output: Contribution to journalArticle

57 Scopus citations
2003

Arylamine N-acetyltransferases: Covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene

Guo, Z., Vath, G. M., Wagner, C. R. & Hanna, P. E., Dec 1 2003, In : Protein Journal. 22, 7-8, p. 631-642 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Designing protein dimerizers: The importance of ligand conformational equilibria

Carlson, J. C. T., Kanter, A., Thuduppathy, G. R., Cody, V., Pineda, P. E., Mc Ivor, R. S. & Wagner, C. R., Feb 12 2003, In : Journal of the American Chemical Society. 125, 6, p. 1501-1507 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate

Pineda, P., Kanter, A., Mc Ivor, R. S., Benkovic, S. J., Rosowsky, A. & Wagner, C. R., Jul 3 2003, In : Journal of Medicinal Chemistry. 46, 14, p. 2816-2818 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Disposition and oral bioavailability in rats of an antiviral and antitumor amino acid phosphoramidate prodrug of AZT-monophosphate

Song, H., Johns, R., Griesgraber, G. W., Wagner, C. R. & Zimmerman, C. L., Mar 1 2003, In : Pharmaceutical research. 20, 3, p. 448-451 4 p.

Research output: Contribution to journalArticle

12 Scopus citations
2002

Future research directions in idiopathic pulmonary fibrosis: Summary of a National Heart, Lung, and Blood Institute Working Group

Crystal, R. G., Bitterman, P. B., Mossman, B., Schwarz, M. I., Sheppard, D., Almasy, L., Chapman, H. A., Friedman, S. L., King, T. E., Leinwand, L. A., Liotta, L., Martin, G. R., Schwartz, D. A., Schultz, G. S., Wagner, C. R. & Musson, R. A., Jul 15 2002, In : American journal of respiratory and critical care medicine. 166, 2, p. 236-246 11 p.

Research output: Contribution to journalArticle

152 Scopus citations

Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats

Song, H., Griesgraber, G. W., Wagner, C. R. & Zimmerman, C. L., May 2 2002, In : Antimicrobial agents and chemotherapy. 46, 5, p. 1357-1363 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2001
62 Scopus citations