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Research Output 1986 2019

Article

111 In-DANBIRT in Vivo Molecular Imaging of Inflammatory Cells in Atherosclerosis

Mota, R., Campen, M. J., Cuellar, M. E., Garver, W. S., Hesterman, J., Qutaish, M., Daniels, T., Nysus, M., Wagner, C. R. & Norenberg, J. P., Jan 1 2018, In : Contrast Media and Molecular Imaging. 2018, 6508724.

Research output: Contribution to journalArticle

Molecular Imaging
High Fat Diet
Atherosclerotic Plaques
Atherosclerosis
Ozone
41 Citations (Scopus)

31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions

Chou, T. F., Bieganowski, P., Shilinski, K., Cheng, J., Brenner, C. & Wagner, C. R., Apr 15 2005, In : Journal of Biological Chemistry. 280, 15, p. 15356-15361 6 p.

Research output: Contribution to journalArticle

Purine Nucleosides
Adenosine Monophosphate
Salts
Escherichia coli
Nuclear magnetic resonance
2 Citations (Scopus)

A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides

Maize, K. M., Shah, R., Strom, A., Kumarapperuma, S., Zhou, A., Wagner, C. R. & Finzel, B. C., Nov 6 2017, In : Molecular pharmaceutics. 14, 11, p. 3987-3997 11 p.

Research output: Contribution to journalArticle

Nucleosides
nucleoside phosphotransferase
Prodrugs
Nucleotides
Calorimetry
76 Citations (Scopus)

A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation

Rashidian, M., Mahmoodi, M. M., Shah, R., Dozier, J. K., Wagner, C. R. & Distefano, M. D., Mar 20 2013, In : Bioconjugate Chemistry. 24, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

Hydrazones
Oximes
Ligation
Aniline
Catalysts
14 Citations (Scopus)
Electrospray Ionization Mass Spectrometry
High Pressure Liquid Chromatography
Amino Acids
Prodrugs
Nucleosides
62 Citations (Scopus)

Amino acid phosphoramidate monoesters of 3′-azido-3′-deoxythymidine: Relationship between antiviral potency and intracellular metabolism

Chang, S. L., Griesgraber, G. W., Southern, P. & Wagner, C. R., Jan 18 2001, In : Journal of Medicinal Chemistry. 44, 2, p. 223-231 9 p.

Research output: Contribution to journalArticle

Zidovudine
Metabolism
Antiviral Agents
Amino Acids
Blood Cells
6 Citations (Scopus)

Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.

McIntee, E. J. & Wagner, C. R., Jan 1 2001, In : Bioorganic & medicinal chemistry letters. 11, 21, p. 2803-2805 3 p.

Research output: Contribution to journalArticle

Cytarabine
Nucleosides
Amino Acids
Substrates
Leukemia

Amino acid phosphoramidates of antiviral 3-deazaadenosine analogs exhibit high potency and low cytotoxicity

McIntee, E. J., Wagner, C. R., Giordano, V., Jeang, K. T. & Chiang, P. K., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

Cytotoxicity
Human immunodeficiency virus 1
Antiviral Agents
cytotoxicity
Amino Acids
83 Citations (Scopus)

An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries: Discovery of a novel antagonist of E. coli dihydrofolate reductase

Annis, D. A., Athanasopoulos, J., Curran, P. J., Felsch, J. S., Kalghatgi, K., Lee, W. H., Nash, H. M., Orminati, J. P. A., Rosner, K. E., Shipps, G. W., Thaddupathy, G. R. A., Tyler, A. N., Vilenchik, L., Wagner, C. R. & Wintner, E. A., Nov 1 2004, In : International Journal of Mass Spectrometry. 238, 2, p. 77-83 7 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Escherichia coli
Mass spectrometry
affinity
mass spectroscopy
3 Citations (Scopus)

Anchimerically Activatable Antiviral ProTides

Okon, A., Matos De Souza, M. R., Shah, R., Amorim, R., Da Costa, L. J. & Wagner, C. R., Jan 1 2017, In : ACS Medicinal Chemistry Letters. 8, 9, p. 958-962 5 p.

Research output: Contribution to journalArticle

Dengue Virus
Viruses
Antiviral Agents
Cytotoxicity
Virus Replication
6 Citations (Scopus)

Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma

Okon, A., Han, J., Dawadi, S., Demosthenous, C., Aldrich, C., Gupta, M. & Wagner, C. R., Oct 12 2017, In : Journal of Medicinal Chemistry. 60, 19, p. 8131-8144 14 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Nucleotides
Chemical Phenomena
Nucleosides
Sulfur
28 Citations (Scopus)

Antiviral nucleoside drug delivery via amino acid phosphoramidates

Wagner, C. R., Chang, S. L., Griesgraber, G. W., Song, H., McIntee, E. J. & Zimmerman, C. L., Jan 1 1999, In : Nucleosides and Nucleotides. 18, 4-5, p. 913-919 7 p.

Research output: Contribution to journalArticle

Tissue Distribution
Cell Extracts
Drug delivery
Nucleosides
Metabolism

Antiviral nucleotide drug delivery via amino acid phosphoramidates

Wagner, C. R., McIntee, E. J., Chang, S. L. & Zimmerman, C., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

nucleosides
Drug delivery
Nucleosides
Antiviral Agents
Nucleotides
5 Citations (Scopus)

A Phospholipase C Protocol for Phospholipid Peroxidation Analysis

Wagner, C. R. & Porter, N. A., Sep 1 1988, In : Chemical Research in Toxicology. 1, 5, p. 274-280 7 p.

Research output: Contribution to journalArticle

High pressure liquid chromatography
Diglycerides
Type C Phospholipases
Phospholipids
Hydroxides
44 Citations (Scopus)

A phosphoramidite-based synthesis of phosphoramidate amino acid diesters of antiviral nucleosides

Abraham, T. W. & Wagner, C. R., Sep 1 1994, In : Nucleosides and Nucleotides. 13, 9, p. 1891-1903 13 p.

Research output: Contribution to journalArticle

Nucleosides
Antiviral Agents
Stavudine
Amino Acids
Zidovudine
52 Citations (Scopus)

Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication

Wagner, C. R., McIntee, E. J., Schinazi, R. F. & Abraham, T. W., Aug 17 1995, In : Bioorganic and Medicinal Chemistry Letters. 5, 16, p. 1819-1824 6 p.

Research output: Contribution to journalArticle

Aromatic Amino Acids
Zidovudine
HIV-1
Blood Cells
Blood
30 Citations (Scopus)

Arylamine N-acetyltransferase Aggregation and Constitutive Ubiquitylation

Liu, F., Zhang, N., Zhou, X., Hanna, P. E., Wagner, C. R., Koepp, D. M. & Walters, K. J., Aug 18 2006, In : Journal of Molecular Biology. 361, 3, p. 482-492 11 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Ubiquitination
Cricetinae
Mutation
Tryptophan
13 Citations (Scopus)

Arylamine N-acetyltransferases: Expression in Escherichia coli, purification, and substrate specificities of recombinant hamster monomorphic and polymorphic isozymes

Wagner, C. R., Bergstrom, C. P., Koning, K. R. & Hanna, P. E., Feb 27 1996, In : Drug Metabolism and Disposition. 24, 2, p. 245-253 9 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Enteropeptidase
Substrate Specificity
Cricetinae
Isoenzymes
30 Citations (Scopus)

Arylamine N-acetyltransferases: Characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2

Liu, L., Von Vett, A., Zhang, N., Walters, K. J., Wagner, C. R. & Hanna, P. E., Sep 1 2007, In : Chemical Research in Toxicology. 20, 9, p. 1300-1308 9 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Molecular interactions
Substrate Specificity
Acetyltransferases

Arylamine N-acetyltransferases: Covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene

Guo, Z., Vath, G. M., Wagner, C. R. & Hanna, P. E., Dec 1 2003, In : Protein Journal. 22, 7-8, p. 631-642 12 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Proteolysis
Aniline
Cricetinae
Peptides
9 Citations (Scopus)
Arylamine N-Acetyltransferase
Proteolysis
Aniline
Cricetinae
Peptides
72 Citations (Scopus)

Blood-nanoparticle interactions and in Vivo biodistribution: Impact of surface peg and ligand properties

Shah, N. B., Vercellotti, G. M., White, J. G., Fegan, A., Wagner, C. R. & Bischof, J. C., Aug 6 2012, In : Molecular pharmaceutics. 9, 8, p. 2146-2155 10 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Ligands
Surface Properties
Blood Proteins
12 Citations (Scopus)

Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α

Cao, J., He, L., Lin, G., Hu, C., Dong, R., Zhang, J., Zhu, H., Hu, Y., Wagner, C. R., He, Q. & Yang, B., May 1 2014, In : Biochemical Pharmacology. 89, 1, p. 20-30 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Peptide Initiation Factors
Ouabain
Cardiac Glycosides
Heart Neoplasms
40 Citations (Scopus)

Catalytic mechanism of hamster arylamine N-acetyltransferase 2

Wang, H., Liu, L., Hanna, P. E. & Wagner, C. R., Aug 23 2005, In : Biochemistry. 44, 33, p. 11295-11306 12 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Acetyl Coenzyme A
Isotopes
Cricetinae
8 Citations (Scopus)
Protons
Trajectories
Catalysis
Proton transfer
Enzymes
4 Citations (Scopus)

Characterization of a radiolabeled small molecule targeting leukocyte function-associated antigen-1 expression in lymphoma and leukemia

Poria, R. B., Norenberg, J. P., Anderson, T. L., Erion, J., Wagner, C. R., Arterburn, J. B. & Larson, R. S., Nov 20 2006, In : Cancer Biotherapy and Radiopharmaceuticals. 21, 5, p. 418-426 9 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
Lymphoma
Leukemia
Lutetium
Fluorescein
17 Citations (Scopus)
Arylamine N-Acetyltransferase
2-Acetylaminofluorene
Cricetinae
Acetyltransferases
DNA Adducts
137 Citations (Scopus)

Chemically controlled protein assembly: Techniques and applications

Fegan, A., White, B., Carlson, J. C. T. & Wagner, C. R., Jun 9 2010, In : Chemical Reviews. 110, 6, p. 3315-3336 22 p.

Research output: Contribution to journalArticle

Dimerization
Proteins
DNA Gyrase
Ligands
Bacterial DNA
104 Citations (Scopus)

Chemically controlled self-assembly of protein nanorings

Carlson, J. C. T., Jena, S. S., Flenniken, M., Chou, T. F., Siegel, R. A. & Wagner, C. R., Jun 14 2006, In : Journal of the American Chemical Society. 128, 23, p. 7630-7638 9 p.

Research output: Contribution to journalArticle

Nanorings
Self assembly
Proteins
Peptides
Tetrahydrofolate Dehydrogenase

Chemically induced self-assembly of enzyme nanorings.

White, B. R., Li, Q. & Wagner, C. R., Sep 15 2011, In : Methods in molecular biology (Clifton, N.J.). 743, p. 17-26 10 p.

Research output: Contribution to journalArticle

Dimerization
Enzymes
Technology
Tetrahydrofolate Dehydrogenase
Proteins
47 Citations (Scopus)

Chemically self-assembled antibody nanorings (CSANs): Design and characterization of an anti-CD3 IgM biomimetic

Li, Q., So, C. R., Fegan, A., Cody, V., Sarikaya, M., Vallera, D. A. & Wagner, C. R., Dec 8 2010, In : Journal of the American Chemical Society. 132, 48, p. 17247-17257 11 p.

Research output: Contribution to journalArticle

Nanorings
Biomimetics
Antibodies
Immunoglobulin M
Monoclonal antibodies
15 Citations (Scopus)

Chemically self-assembled antibody nanostructures as potential drug carriers

Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Nov 5 2012, In : Molecular Pharmaceutics. 9, 11, p. 3218-3227 10 p.

Research output: Contribution to journalArticle

Drug Carriers
Nanostructures
Methotrexate
Antibodies
Trimethoprim
7 Citations (Scopus)

Chemical modification of hamster arylamine N-acetyltransferase 2 with isozyme-selective and nonselective N-arylbromoacetamido reagents

Wang, H., Guo, Z., Vath, G. M., Wagner, C. R. & Hanna, P. E., Dec 1 2004, In : Protein Journal. 23, 2, p. 153-166 14 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Alkylation
Chemical modification
Cricetinae
Isoenzymes
10 Citations (Scopus)
Dideoxyadenosine
Zidovudine
Antiviral Agents
Amino Acids
Derivatives
25 Citations (Scopus)

Complementary Perturbation of the Kinetic Mechanism and Catalytic Effectiveness of Dihydrofolate Reductase by Side-Chain Interchange

Wagner, C. R., Thillet, J. & Benkovic, S. J., Feb 1 1992, In : Biochemistry. 31, 34, p. 7834-7840 7 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Interchanges
Escherichia coli
Rate constants
NADP
6 Citations (Scopus)

Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1

Shah, R., Strom, A., Zhou, A., Maize, K. M., Finzel, B. C. & Wagner, C. R., Aug 11 2016, In : ACS Medicinal Chemistry Letters. 7, 8, p. 780-784 5 p.

Research output: Contribution to journalArticle

Molecular Probes
Tobacco Use Disorder
Calorimetry
Neuralgia
Thermodynamics
29 Citations (Scopus)

Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP

Jia, Y., Chiu, T. L., Amin, E. A., Polunovsky, V., Bitterman, P. B. & Wagner, C. R., Apr 1 2010, In : European Journal of Medicinal Chemistry. 45, 4, p. 1304-1313 10 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Guanosine Monophosphate
Quantitative Structure-Activity Relationship
Libraries
RNA Cap-Binding Proteins
26 Citations (Scopus)

Designing protein dimerizers: The importance of ligand conformational equilibria

Carlson, J. C. T., Kanter, A., Thuduppathy, G. R., Cody, V., Pineda, P. E., Mc Ivor, R. S. & Wagner, C. R., Feb 12 2003, In : Journal of the American Chemical Society. 125, 6, p. 1501-1507 7 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Dimerization
Ligands
Methotrexate
Proteins
10 Citations (Scopus)

Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate

Pineda, P., Kanter, A., Mc Ivor, R. S., Benkovic, S. J., Rosowsky, A. & Wagner, C. R., Jul 3 2003, In : Journal of Medicinal Chemistry. 46, 14, p. 2816-2818 3 p.

Research output: Contribution to journalArticle

Trimetrexate
Tetrahydrofolate Dehydrogenase
Methotrexate
Folic Acid Antagonists
Genetic Therapy
25 Citations (Scopus)

Direct measurement of nucleoside monophosphate delivery from a phosphoramidate pronucleotide by stable isotope labeling and LC-ESI(-)-MS/MS.

Kim, J., Chou, T. F., Griesgraber, G. W. & Wagner, C. R., Jan 1 2004, In : Molecular Pharmaceutics. 1, 2, p. 102-111 10 p.

Research output: Contribution to journalArticle

Isotope Labeling
Nucleosides
Blood Cells
Amino Acids
5'-Nucleotidase
12 Citations (Scopus)

Disposition and oral bioavailability in rats of an antiviral and antitumor amino acid phosphoramidate prodrug of AZT-monophosphate

Song, H., Johns, R., Griesgraber, G. W., Wagner, C. R. & Zimmerman, C. L., Mar 1 2003, In : Pharmaceutical research. 20, 3, p. 448-451 4 p.

Research output: Contribution to journalArticle

Prodrugs
Biological Availability
Antiviral Agents
Rats
Amino Acids
29 Citations (Scopus)

Dissociation of I domain and global conformational changes in LFA-1: Refinement of small molecule-I domain structure-activity relationships

Larson, R. S., Davis, T., Bologa, C., Semenuk, G., Vijayan, S., Li, Y., Oprea, T., Chigaev, A., Buranda, T., Wagner, C. R. & Sklar, L. A., Mar 22 2005, In : Biochemistry. 44, 11, p. 4322-4331 10 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
Structure-Activity Relationship
Molecules
Dithiothreitol
Divalent Cations
26 Citations (Scopus)

Distinct Translational Control in CD4+ T Cell Subsets

Bjur, E., Larsson, O., Yurchenko, E., Zheng, L., Gandin, V., Topisirovic, I., Li, S., Wagner, C. R., Sonenberg, N. & Piccirillo, C. A., May 1 2013, In : PLoS genetics. 9, 5, e1003494.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
translation (genetics)
T-lymphocytes
Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
7 Citations (Scopus)

E. coli Histidine triad nucleotide binding protein 1 (echint) is a catalytic regulator of d-alanine dehydrogenase (dada) activity in vivo

Bardaweel, S., Ghosh, B., Chou, T. F., Sadowsky, M. J. & Wagner, C. R., Jul 11 2011, In : PLoS One. 6, 7, e20897.

Research output: Contribution to journalArticle

alanine dehydrogenase
Alanine Dehydrogenase
histidine
Histidine
Escherichia coli
26 Citations (Scopus)

Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate

Chou, T. F., Tikh, I. B., Horta, B. A. C., Ghosh, B., De Alencastro, R. B. & Wagner, C. R., May 18 2007, In : Journal of Biological Chemistry. 282, 20, p. 15137-15147 11 p.

Research output: Contribution to journalArticle

Lysine-tRNA Ligase
Hydrolysis
Adenosine Monophosphate
Adenosine
Monomers
7 Citations (Scopus)

Engineering Reversible Cell-Cell Interactions with Lipid Anchored Prosthetic Receptors

Csizmar, C. M., Petersburg, J. R., Hendricks, A., Stern, L. A., Hackel, B. J. & Wagner, C. R., Apr 18 2018, In : Bioconjugate Chemistry. 29, 4, p. 1291-1301 11 p.

Research output: Contribution to journalArticle

Open Access
Nanorings
Cell Engineering
Cell membranes
Prosthetics
Cell Communication
30 Citations (Scopus)

Enzyme nanorings

Chou, T. F., So, C., White, B. R., Carlson, J. C. T., Sarikaya, M. & Wagner, C. R., Dec 23 2008, In : ACS Nano. 2, 12, p. 2519-2525 7 p.

Research output: Contribution to journalArticle

Nanorings
enzymes
Enzymes
fusion
proteins
2 Citations (Scopus)

Eradication of Established Tumors by Chemically Self-Assembled Nanoring Labeled T Cells

Petersburg, J. R., Shen, J., Csizmar, C. M., Murphy, K. A., Spanier, J. A., Gabrielse, K., Griffith, T. S., Fife, B. T. & Wagner, C. R., Jul 24 2018, In : ACS Nano. 12, 7, p. 6563-6576 14 p.

Research output: Contribution to journalArticle

Nanorings
T-cells
Antigen Receptors
Antigens
Prosthetics
75 Citations (Scopus)

Eukaryotic arylamine N-acetyltransferase investigation of substrate specificity by high-throughput screening

Kawamura, A., Graham, J., Mushtaq, A., Tsiftsoglou, S. A., Vath, G. M., Hanna, P. E., Wagner, C. R. & Sim, E., Jan 15 2005, In : Biochemical Pharmacology. 69, 2, p. 347-359 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Mesocricetus
Substrate Specificity
Screening
Throughput
6 Citations (Scopus)

Evidence that Human Histidine Triad Nucleotide Binding Protein 3 (Hint3) is a Distinct Branch of the Histidine Triad (HIT) Superfamily

Chou, T. F., Cheng, J., Tikh, I. B. & Wagner, C. R., Nov 2 2007, In : Journal of Molecular Biology. 373, 4, p. 978-989 12 p.

Research output: Contribution to journalArticle

Histidine
Carrier Proteins
Nucleotides
Lysine-tRNA Ligase
Catalytic Domain