1986 …2020
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Research Output 1986 2019

Tunable Supramolecular Assemblies from Amphiphilic Nucleoside Phosphoramidate Nanofibers by Enzyme Activation

West, H. T., Csizmar, C. M. & Wagner, C. R., Jul 9 2018, In : Biomacromolecules. 19, 7, p. 2650-2656 7 p.

Research output: Contribution to journalArticle

Nanofibers
Nucleosides
Enzymes
Chemical activation
Hydrogel
38 Citations (Scopus)
gemcitabine
Guanosine Monophosphate
Lung Neoplasms
Breast Neoplasms
Prodrugs
16 Citations (Scopus)

Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E

Smith, K. A., Zhou, B., Avdulov, S. V., Benyumov, A., Peterson, M., Liu, Y., Okon, A., Hergert, P., Braziunas, J., Wagner, C. R., Borok, Z. & Bitterman, P. B., Dec 18 2015, In : Scientific reports. 5, 18233.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Transforming Growth Factors
Transforming Growth Factor beta
Fibrosis
Epithelial Cells
6 Citations (Scopus)

Titratable Avidity Reduction Enhances Affinity Discrimination in Mammalian Cellular Selections of Yeast-Displayed Ligands

Stern, L. A., Csizmar, C. M., Woldring, D. R., Wagner, C. R. & Hackel, B. J., May 8 2017, In : ACS Combinatorial Science. 19, 5, p. 315-323 9 p.

Research output: Contribution to journalArticle

Yeast
Ligands
Cells
Fibronectins
Binders

Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Sanchez, J. J., Sanchez, J. E., Noor, S., Ruffaner-Hanson, C. D., Davies, S., Wagner, C. R., Jantzie, L. L., Mellios, N., Savage, D. D. & Milligan, E. D., Apr 8 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Lymphocyte Function-Associated Antigen-1
Integrins
Alcohols
Interleukin-1
Spinal Ganglia
6 Citations (Scopus)

Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures

Gangar, A., Fegan, A., Kumarapperuma, S. C., Huynh, P., Benyumov, A. & Wagner, C. R., Sep 3 2013, In : Molecular Pharmaceutics. 10, 9, p. 3514-3518 5 p.

Research output: Contribution to journalArticle

Nanostructures
Antisense Oligonucleotides
Nucleic Acids
Methotrexate
Eukaryotic Initiation Factor-4E
Organophosphonates
Amino Acids
Nucleosides
Iodine
phosphoramidic acid
2 Citations (Scopus)

Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins

Bardaweel, S. K., Ghosh, B. & Wagner, C. R., Jan 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 1, p. 558-560 3 p.

Research output: Contribution to journalArticle

Carbamates
Histidine
Escherichia coli
Carrier Proteins
Nucleotides
30 Citations (Scopus)

Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP

Ghosh, P., Park, C., Peterson, M. S., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Apr 15 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 8, p. 2177-2180 4 p.

Research output: Contribution to journalArticle

Organophosphonates
Messenger RNA
Competitive Binding
Guanosine
Nucleosides
82 Citations (Scopus)

Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-β- arabinofuranosylcytosine: Evidence of phosphoramidase activity

Abraham, T. W., Kalman, T. I., McIntee, E. J. & Wagner, C. R., Nov 26 1996, In : Journal of Medicinal Chemistry. 39, 23, p. 4569-4575 7 p.

Research output: Contribution to journalArticle

Aromatic Amino Acids
Cytarabine
Floxuridine
Thymidylate Synthase
T-Cell Leukemia
8 Citations (Scopus)

Synthesis and antiviral activity of amino acid carbamate derivatives of AZT

Chang, S. L., Griesgraber, G., Abraham, T. W., Garg, T., Song, H., Zimmerman, C. L. & Wagner, C. R., Jan 1 2000, In : Nucleosides, Nucleotides and Nucleic Acids. 19, 1-2, p. 87-100 14 p.

Research output: Contribution to journalArticle

Carbamates
Amides
Antiviral Agents
Esters
Derivatives
63 Citations (Scopus)

Synthesis, in vitro anti-breast cancer activity, and intracellular decomposition of amino acid methyl ester and alkyl amide phosphoramidate monoesters of 3'-azido-3'-deoxythymidine (AZT)

Iyer, V. V., Griesgraber, G. W., Radmer, M. R., McIntee, E. J. & Wagner, C. R., Jun 1 2000, In : Journal of Medicinal Chemistry. 43, 11, p. 2266-2274 9 p.

Research output: Contribution to journalArticle

Zidovudine
MCF-7 Cells
Amides
Esters
Thermodynamic properties
15 Citations (Scopus)

Synthesis, biological activity and decomposition studies of amino acid phosphomonoester amidates of acyclovir

Abraham, T. W., McIntee, E. J., Iyer, V. V., Schinazi, R. F. & Wagner, C. R., Jan 1 1997, In : Nucleosides and Nucleotides. 16, 10-11, p. 2079-2092 14 p.

Research output: Contribution to journalReview article

Acyclovir
Bioactivity
Decomposition
Amino Acids
valacyclovir
1 Citation (Scopus)
pain
histidine
nucleotides
Neuralgia
Fluorescent Dyes
1 Citation (Scopus)

Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia

Shah, R. M., Maize, K. M., West, H. T., Strom, A. M., Finzel, B. C. & Wagner, C. R., Aug 17 2018, In : Journal of Molecular Biology. 430, 17, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

Isaacs Syndrome
Mutation
Enzymes
Adenosine Monophosphate
Histidine
14 Citations (Scopus)

Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily

Maize, K. M., Wagner, C. R. & Finzel, B. C., Jul 1 2013, In : FEBS Journal. 280, 14, p. 3389-3398 10 p.

Research output: Contribution to journalArticle

Hydrolases
Adenosine Monophosphate
Histidine
Carrier Proteins
Nucleotides
10 Citations (Scopus)

Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells

Chen, E. Z., Jacobson, B. A., Patel, M. R., Okon, A. M., Li, S., Xiong, K., Vaidya, A. J., Bitterman, P. B., Wagner, C. R. & Kratzke, R. A., Jan 1 2014, In : Investigational New Drugs. 32, 4, p. 598-603 6 p.

Research output: Contribution to journalArticle

Mesothelioma
Protein Biosynthesis
Pemetrexed
Prodrugs
Messenger RNA
35 Citations (Scopus)

Site directed mutagenesis: a tool for enzyme mechanism dissection

Wagner, C. R. & Benkovic, S. J., Jan 1 1990, In : Trends in Biotechnology. 8, C, p. 263-270 8 p.

Research output: Contribution to journalArticle

Dissection
Mutagenesis
Site-Directed Mutagenesis
Catalytic Domain
Enzymes
24 Citations (Scopus)

Simultaneous dual protein labeling using a triorthogonal reagent

Rashidian, M., Kumarapperuma, S. C., Gabrielse, K., Fegan, A., Wagner, C. R. & Distefano, M. D., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16388-16396 9 p.

Research output: Contribution to journalArticle

Labeling
Proteins
Tetrahydrofolate Dehydrogenase
Fluorophores
Polyethylene glycols
20 Citations (Scopus)

Self-assembly of antibodies by chemical induction

Li, Q., Hapka, D., Chen, H., Vallera, D. A. & Wagner, C. R., Dec 15 2008, In : Angewandte Chemie - International Edition. 47, 52, p. 10179-10182 4 p.

Research output: Contribution to journalArticle

Antibodies
Self assembly
Proteins
Tetrahydrofolate Dehydrogenase
Trimethoprim
13 Citations (Scopus)

Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191

Birkus, G., Kutty, N., Frey, C. R., Shribata, R., Chou, T., Wagner, C. R., McDermott, M. & Cihlar, T., May 1 2011, In : Antimicrobial agents and chemotherapy. 55, 5, p. 2166-2173 8 p.

Research output: Contribution to journalArticle

Cathepsin A
Lysosomes
Phenylalanine
Esters
Hydrolysis
13 Citations (Scopus)

Reversible Re-programing of Cell-Cell Interactions

Gabrielse, K., Gangar, A., Kumar, N., Lee, J. C., Fegan, A., Shen, J. J., Li, Q., Vallera, D. & Wagner, C. R., May 12 2014, In : Angewandte Chemie - International Edition. 53, 20, p. 5112-5116 5 p.

Research output: Contribution to journalArticle

Nanorings
Lipids
Antigens
Ligands
Antigen Receptors

Protein interface remodeling in a chemically induced protein dimer

White, B. R., Carlson, J. C. T., Kerns, J. L. & Wagner, C. R., Jul 1 2012, In : Journal of Molecular Recognition. 25, 7, p. 393-403 11 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Proteins
Nanostructures
Population Characteristics
Methotrexate
6 Citations (Scopus)

Prosthetic antigen receptors

Shen, J., Vallera, D. A. & Wagner, C. R., Aug 19 2015, In : Journal of the American Chemical Society. 137, 32, p. 10108-10111 4 p.

Research output: Contribution to journalArticle

Nanorings
Antigen Receptors
T-cells
Antigens
Prosthetics
242 Citations (Scopus)

Pronucleotides: Toward the in vivo delivery of antiviral and anticancer nucleotides

Wagner, C. R., Iyer, V. V. & McIntee, E. J., Nov 9 2000, In : Medicinal Research Reviews. 20, 6, p. 417-451 35 p.

Research output: Contribution to journalArticle

Antiviral Agents
Nucleotides
Prodrugs
Nucleosides
Pharmacology
3 Citations (Scopus)

Programming Cell-Cell Interactions through Non-genetic Membrane Engineering

Csizmar, C. M., Petersburg, J. R. & Wagner, C. R., Aug 16 2018, In : Cell Chemical Biology. 25, 8, p. 931-940 10 p.

Research output: Contribution to journalReview article

Cell Communication
Cell membranes
Membranes
Cell Membrane
Metabolic engineering
10 Citations (Scopus)

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers

Gangar, A., Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Feb 15 2012, In : Journal of the American Chemical Society. 134, 6, p. 2895-2897 3 p.

Research output: Contribution to journalArticle

Oligonucleotides
Antibodies
Self assembly
Carrier Proteins
Proteins
2 Citations (Scopus)

Probing the Molecular Basis of Resistance to Pyrimethamine by Site-Directed Mutagenesis

Wagner, C. R. & Benkovic, S. J., Jul 1 1992, In : Journal of Medicinal Chemistry. 35, 15, p. 2912-2915 4 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies

Wang, H., Vath, G. M., Gleason, K. J., Hanna, P. E. & Wagner, C. R., Jun 29 2004, In : Biochemistry. 43, 25, p. 8234-8246 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Mutagenesis
Site-Directed Mutagenesis
Iodoacetamide
12 Citations (Scopus)

Probing the Impact of the echinT C-Terminal Domain on Structure and Catalysis

Bardaweel, S., Pace, J., Chou, T. F., Cody, V. & Wagner, C. R., Dec 10 2010, In : Journal of Molecular Biology. 404, 4, p. 627-638 12 p.

Research output: Contribution to journalArticle

Catalysis
Escherichia coli
Bacteria
Gram-Positive Bacteria
Adenosine Monophosphate
3 Citations (Scopus)

Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190

Zhou, X., Zhang, N., Liu, L., Walters, K. J., Hanna, P. E. & Wagner, C. R., Dec 1 2009, In : FEBS Journal. 276, 23, p. 6928-6941 14 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Mutagenesis
hydrazine
Site-Directed Mutagenesis
37 Citations (Scopus)

Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors

Wagner, C. R., Ballato, G., Akanni, A. O., McIntee, E. J., Larson, R. S., Chang, S. L. & Abul-Hajj, Y. J., Jun 15 1997, In : Cancer Research. 57, 12, p. 2341-2345 5 p.

Research output: Contribution to journalArticle

Zidovudine
Breast Neoplasms
Growth
Inhibitory Concentration 50
T-Cell Leukemia
56 Citations (Scopus)

Phosphoramidate pronucleotides: A comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins

Chou, T. F., Baraniak, J., Kaczmarek, R., Zhou, X., Cheng, J., Ghosh, B. & Wagner, C. R., Mar 1 2007, In : Molecular pharmaceutics. 4, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

Substrate Specificity
Histidine
Carrier Proteins
Nucleotides
Escherichia coli
31 Citations (Scopus)

Phospholipid autoxidation

Porter, N. A. & Wagner, C. R., Jan 1 1986, In : Advances in Free Radical Biology and Medicine. 2, 2, p. 283-323 41 p.

Research output: Contribution to journalArticle

Phospholipids
Complex Mixtures
Organic solvents
High pressure liquid chromatography
Biological membranes
18 Citations (Scopus)

Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats

Song, H., Griesgraber, G. W., Wagner, C. R. & Zimmerman, C. L., May 2 2002, In : Antimicrobial Agents and Chemotherapy. 46, 5, p. 1357-1363 7 p.

Research output: Contribution to journalArticle

Zidovudine
Pharmacokinetics
Amino Acids
phosphoramidic acid
Urine
39 Citations (Scopus)

Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein

Sticha, K. R. K., Sieg, C. A., Bergstrom, C. P., Hanna, P. E. & Wagner, C. R., Jan 1 1997, In : Protein Expression and Purification. 10, 1, p. 141-153 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Tetrahydrofolate Dehydrogenase
Cricetinae
Acetyltransferases
Thrombin
20 Citations (Scopus)

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1

Wang, H., Vath, G. M., Kawamura, A., Bates, C. A., Sim, E., Hanna, P. E. & Wagner, C. R., Feb 1 2005, In : Protein Journal. 24, 2, p. 65-77 13 p.

Research output: Contribution to journalArticle

Purification
Cricetinae
Fusion reactions
Acids
Substrates
55 Citations (Scopus)

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

Ghosh, B., Benyumov, A., Ghosh, P., Jia, Y., Avdulov, S. V., Dahlberg, P. S., Peterson, M., Smith, K., Polunovsky, V. A., Bitterman, P. B. & Wagner, C. R., May 15 2009, In : ACS Chemical Biology. 4, 5, p. 367-377 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Tissue
Messenger RNA
Prodrugs
Zebrafish
44 Citations (Scopus)

Nonadditivity of Mutational Effects at the Folate Binding Site of Escherichia coli Dihydrofolate Reductase

Huang, Z., Wagner, C. R. & Benkovic, S. J., Sep 1 1994, In : Biochemistry. 33, 38, p. 11576-11585 10 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Folic Acid
Escherichia coli
Binding Sites
Mutant Proteins
38 Citations (Scopus)

NMR-based Model Reveals the Structural Determinants of Mammalian Arylamine N-Acetyltransferase Substrate Specificity

Zhang, N., Liu, L., Liu, F., Wagner, C. R., Hanna, P. E. & Walters, K. J., Oct 13 2006, In : Journal of Molecular Biology. 363, 1, p. 188-200 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetyltransferases
Structural Models
Substrate Specificity
2-toluidine

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

Csizmar, C. M., Petersburg, J. R., Perry, T. J., Rozumalski, L., Hackel, B. J. & Wagner, C. R., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 251-261 11 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Cell membranes
Antigens
Ligands
Cell Membrane
6 Citations (Scopus)

Monitoring the Intracellular Metabolism of Nucleoside Phosphoramidate Pronucleotides by 31P NMR

Kim, J., Drontle, D. P. & Wagner, C. R., Mar 26 2004, In : Nucleosides, Nucleotides and Nucleic Acids. 23, 1-2, p. 483-493 11 p.

Research output: Contribution to journalArticle

Nucleosides
Metabolism
Nuclear magnetic resonance
Monitoring
Cells
9 Citations (Scopus)
Molecular modeling
Charge distribution
Binding energy
charge distribution
field theory (physics)
41 Citations (Scopus)

Molecular Basis for Nonadditive Mutational Effects in Escherichia coli Dihydrofolate Reductase

Wagner, C. R., Huang, Z., Singleton, S. F. & Benkovic, S. J., Jan 1 1995, In : Biochemistry. 34, 48, p. 15671-15680 10 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Escherichia coli
Hydrides
Free energy
Conformations
6 Citations (Scopus)

Methotrexate resistance of mouse dihydrofolate reductase: Effect of substitution of phenylalanine-31 by serine or tryptophan

Evenson, D. A., Adams, J., McIvor, R. S. & Wagner, C. R., Apr 26 1996, In : Journal of Medicinal Chemistry. 39, 9, p. 1763-1766 4 p.

Research output: Contribution to journalReview article

Tetrahydrofolate Dehydrogenase
Phenylalanine
Methotrexate
Tryptophan
Serine
24 Citations (Scopus)
2-Acetylaminofluorene
Cricetinae
Acetylation
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Arylamine N-Acetyltransferase
41 Citations (Scopus)

Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins

Chou, T. F. & Wagner, C. R., Feb 16 2007, In : Journal of Biological Chemistry. 282, 7, p. 4719-4727 9 p.

Research output: Contribution to journalArticle

Lysine-tRNA Ligase
Histidine
Adenosine Monophosphate
Carrier Proteins
Nucleotides
14 Citations (Scopus)

Kinetic mechanism of human histidine triad nucleotide binding protein 1

Zhou, X., Chou, T. F., Aubol, B. E., Park, C. J., Wolfenden, R., Adams, J. & Wagner, C. R., May 21 2013, In : Biochemistry. 52, 20, p. 3588-3600 13 p.

Research output: Contribution to journalArticle

Hydrolysis
Adenosine Monophosphate
Kinetics
Nucleophiles
Catalytic Domain
24 Citations (Scopus)

Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines

Liu, L., Wagner, C. R. & Hanna, P. E., Dec 21 2009, In : Chemical research in toxicology. 22, 12, p. 1962-1974 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Metabolites
Protein Isoforms
Acetylation
HeLa Cells
20 Citations (Scopus)
N-hydroxy-4-acetylaminobiphenyl
Arylamine N-Acetyltransferase
Acetyltransferases
Cricetinae
Enzymes