1986 …2020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1986 2019

13 Citations (Scopus)

Reversible Re-programing of Cell-Cell Interactions

Gabrielse, K., Gangar, A., Kumar, N., Lee, J. C., Fegan, A., Shen, J. J., Li, Q., Vallera, D. & Wagner, C. R., May 12 2014, In : Angewandte Chemie - International Edition. 53, 20, p. 5112-5116 5 p.

Research output: Contribution to journalArticle

Nanorings
Lipids
Antigens
Ligands
Antigen Receptors
13 Citations (Scopus)

Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191

Birkus, G., Kutty, N., Frey, C. R., Shribata, R., Chou, T., Wagner, C. R., McDermott, M. & Cihlar, T., May 1 2011, In : Antimicrobial agents and chemotherapy. 55, 5, p. 2166-2173 8 p.

Research output: Contribution to journalArticle

Cathepsin A
Lysosomes
Phenylalanine
Esters
Hydrolysis
20 Citations (Scopus)

Self-assembly of antibodies by chemical induction

Li, Q., Hapka, D., Chen, H., Vallera, D. A. & Wagner, C. R., Dec 15 2008, In : Angewandte Chemie - International Edition. 47, 52, p. 10179-10182 4 p.

Research output: Contribution to journalArticle

Antibodies
Self assembly
Proteins
Tetrahydrofolate Dehydrogenase
Trimethoprim
24 Citations (Scopus)

Simultaneous dual protein labeling using a triorthogonal reagent

Rashidian, M., Kumarapperuma, S. C., Gabrielse, K., Fegan, A., Wagner, C. R. & Distefano, M. D., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16388-16396 9 p.

Research output: Contribution to journalArticle

Labeling
Proteins
Tetrahydrofolate Dehydrogenase
Fluorophores
Polyethylene glycols
35 Citations (Scopus)

Site directed mutagenesis: a tool for enzyme mechanism dissection

Wagner, C. R. & Benkovic, S. J., Jan 1 1990, In : Trends in Biotechnology. 8, C, p. 263-270 8 p.

Research output: Contribution to journalArticle

Dissection
Mutagenesis
Site-Directed Mutagenesis
Catalytic Domain
Enzymes
10 Citations (Scopus)

Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells

Chen, E. Z., Jacobson, B. A., Patel, M. R., Okon, A. M., Li, S., Xiong, K., Vaidya, A. J., Bitterman, P. B., Wagner, C. R. & Kratzke, R. A., Jan 1 2014, In : Investigational New Drugs. 32, 4, p. 598-603 6 p.

Research output: Contribution to journalArticle

Mesothelioma
Protein Biosynthesis
Pemetrexed
Prodrugs
Messenger RNA
14 Citations (Scopus)

Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily

Maize, K. M., Wagner, C. R. & Finzel, B. C., Jul 1 2013, In : FEBS Journal. 280, 14, p. 3389-3398 10 p.

Research output: Contribution to journalArticle

Hydrolases
Adenosine Monophosphate
Histidine
Carrier Proteins
Nucleotides
1 Citation (Scopus)

Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia

Shah, R. M., Maize, K. M., West, H. T., Strom, A. M., Finzel, B. C. & Wagner, C. R., Aug 17 2018, In : Journal of Molecular Biology. 430, 17, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

Isaacs Syndrome
Mutation
Enzymes
Adenosine Monophosphate
Histidine
1 Citation (Scopus)
pain
histidine
nucleotides
Neuralgia
Fluorescent Dyes
15 Citations (Scopus)

Synthesis, biological activity and decomposition studies of amino acid phosphomonoester amidates of acyclovir

Abraham, T. W., McIntee, E. J., Iyer, V. V., Schinazi, R. F. & Wagner, C. R., Jan 1 1997, In : Nucleosides and Nucleotides. 16, 10-11, p. 2079-2092 14 p.

Research output: Contribution to journalReview article

Acyclovir
Bioactivity
Decomposition
Amino Acids
valacyclovir
63 Citations (Scopus)

Synthesis, in vitro anti-breast cancer activity, and intracellular decomposition of amino acid methyl ester and alkyl amide phosphoramidate monoesters of 3'-azido-3'-deoxythymidine (AZT)

Iyer, V. V., Griesgraber, G. W., Radmer, M. R., McIntee, E. J. & Wagner, C. R., Jun 1 2000, In : Journal of Medicinal Chemistry. 43, 11, p. 2266-2274 9 p.

Research output: Contribution to journalArticle

Zidovudine
MCF-7 Cells
Amides
Esters
Thermodynamic properties
8 Citations (Scopus)

Synthesis and antiviral activity of amino acid carbamate derivatives of AZT

Chang, S. L., Griesgraber, G., Abraham, T. W., Garg, T., Song, H., Zimmerman, C. L. & Wagner, C. R., Jan 1 2000, In : Nucleosides, Nucleotides and Nucleic Acids. 19, 1-2, p. 87-100 14 p.

Research output: Contribution to journalArticle

Carbamates
Amides
Antiviral Agents
Esters
Derivatives
82 Citations (Scopus)

Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-β- arabinofuranosylcytosine: Evidence of phosphoramidase activity

Abraham, T. W., Kalman, T. I., McIntee, E. J. & Wagner, C. R., Nov 26 1996, In : Journal of Medicinal Chemistry. 39, 23, p. 4569-4575 7 p.

Research output: Contribution to journalArticle

Aromatic Amino Acids
Cytarabine
Floxuridine
Thymidylate Synthase
T-Cell Leukemia
30 Citations (Scopus)

Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP

Ghosh, P., Park, C., Peterson, M. S., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Apr 15 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 8, p. 2177-2180 4 p.

Research output: Contribution to journalArticle

Organophosphonates
Messenger RNA
Competitive Binding
Guanosine
Nucleosides
2 Citations (Scopus)

Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins

Bardaweel, S. K., Ghosh, B. & Wagner, C. R., Jan 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 1, p. 558-560 3 p.

Research output: Contribution to journalArticle

Carbamates
Histidine
Escherichia coli
Carrier Proteins
Nucleotides
Organophosphonates
Amino Acids
Nucleosides
Iodine
phosphoramidic acid
6 Citations (Scopus)

Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures

Gangar, A., Fegan, A., Kumarapperuma, S. C., Huynh, P., Benyumov, A. & Wagner, C. R., Sep 3 2013, In : Molecular Pharmaceutics. 10, 9, p. 3514-3518 5 p.

Research output: Contribution to journalArticle

Nanostructures
Antisense Oligonucleotides
Nucleic Acids
Methotrexate
Eukaryotic Initiation Factor-4E

Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Sanchez, J. J., Sanchez, J. E., Noor, S., Ruffaner-Hanson, C. D., Davies, S., Wagner, C. R., Jantzie, L. L., Mellios, N., Savage, D. D. & Milligan, E. D., Apr 8 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Lymphocyte Function-Associated Antigen-1
Integrins
Alcohols
Interleukin-1
Spinal Ganglia
6 Citations (Scopus)

Titratable Avidity Reduction Enhances Affinity Discrimination in Mammalian Cellular Selections of Yeast-Displayed Ligands

Stern, L. A., Csizmar, C. M., Woldring, D. R., Wagner, C. R. & Hackel, B. J., May 8 2017, In : ACS Combinatorial Science. 19, 5, p. 315-323 9 p.

Research output: Contribution to journalArticle

Yeast
Ligands
Cells
Fibronectins
Binders
16 Citations (Scopus)

Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E

Smith, K. A., Zhou, B., Avdulov, S. V., Benyumov, A., Peterson, M., Liu, Y., Okon, A., Hergert, P., Braziunas, J., Wagner, C. R., Borok, Z. & Bitterman, P. B., Dec 18 2015, In : Scientific reports. 5, 18233.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Transforming Growth Factors
Transforming Growth Factor beta
Fibrosis
Epithelial Cells
38 Citations (Scopus)
gemcitabine
Guanosine Monophosphate
Lung Neoplasms
Breast Neoplasms
Prodrugs

Tunable Supramolecular Assemblies from Amphiphilic Nucleoside Phosphoramidate Nanofibers by Enzyme Activation

West, H. T., Csizmar, C. M. & Wagner, C. R., Jul 9 2018, In : Biomacromolecules. 19, 7, p. 2650-2656 7 p.

Research output: Contribution to journalArticle

Nanofibers
Nucleosides
Enzymes
Chemical activation
Hydrogel