1986 …2020
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Research Output 1986 2019

8 Citations (Scopus)

E. coli Histidine triad nucleotide binding protein 1 (echint) is a catalytic regulator of d-alanine dehydrogenase (dada) activity in vivo

Bardaweel, S., Ghosh, B., Chou, T. F., Sadowsky, M. J. & Wagner, C. R., Jul 11 2011, In : PloS one. 6, 7, e20897.

Research output: Contribution to journalArticle

alanine dehydrogenase
Alanine Dehydrogenase
histidine
Histidine
Escherichia coli
26 Citations (Scopus)

Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate

Chou, T. F., Tikh, I. B., Horta, B. A. C., Ghosh, B., De Alencastro, R. B. & Wagner, C. R., May 18 2007, In : Journal of Biological Chemistry. 282, 20, p. 15137-15147 11 p.

Research output: Contribution to journalArticle

Lysine-tRNA Ligase
Hydrolysis
Adenosine Monophosphate
Adenosine
Monomers
8 Citations (Scopus)

Engineering Reversible Cell-Cell Interactions with Lipid Anchored Prosthetic Receptors

Csizmar, C. M., Petersburg, J. R., Hendricks, A., Stern, L. A., Hackel, B. J. & Wagner, C. R., Apr 18 2018, In : Bioconjugate Chemistry. 29, 4, p. 1291-1301 11 p.

Research output: Contribution to journalArticle

Open Access
Nanorings
Cell Engineering
Cell membranes
Prosthetics
Cell Communication
30 Citations (Scopus)

Enzyme nanorings

Chou, T. F., So, C., White, B. R., Carlson, J. C. T., Sarikaya, M. & Wagner, C. R., Dec 23 2008, In : ACS Nano. 2, 12, p. 2519-2525 7 p.

Research output: Contribution to journalArticle

Nanorings
enzymes
Enzymes
fusion
proteins
2 Citations (Scopus)

Eradication of Established Tumors by Chemically Self-Assembled Nanoring Labeled T Cells

Petersburg, J. R., Shen, J., Csizmar, C. M., Murphy, K. A., Spanier, J. A., Gabrielse, K., Griffith, T. S., Fife, B. T. & Wagner, C. R., Jul 24 2018, In : ACS Nano. 12, 7, p. 6563-6576 14 p.

Research output: Contribution to journalArticle

Nanorings
T-cells
Antigen Receptors
Antigens
Prosthetics

Erratum: Catalytic mechanism of hamster arylamine N-acetyltransferase 2 (Biochemistry (August 23, 2005) 44, 3 (11295-11306))

Wang, H., Liu, L., Hanna, P. E. & Wagner, C. R., Dec 6 2005, In : Biochemistry. 44, 48, 1 p.

Research output: Contribution to journalComment/debate

Arylamine N-Acetyltransferase
Cricetinae
Biochemistry
1 Citation (Scopus)
Pharmaceutical Chemistry
7-methylguanosine triphosphate
76 Citations (Scopus)

Eukaryotic arylamine N-acetyltransferase investigation of substrate specificity by high-throughput screening

Kawamura, A., Graham, J., Mushtaq, A., Tsiftsoglou, S. A., Vath, G. M., Hanna, P. E., Wagner, C. R. & Sim, E., Jan 15 2005, In : Biochemical Pharmacology. 69, 2, p. 347-359 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Mesocricetus
Substrate Specificity
Screening
Throughput
6 Citations (Scopus)

Evidence that Human Histidine Triad Nucleotide Binding Protein 3 (Hint3) is a Distinct Branch of the Histidine Triad (HIT) Superfamily

Chou, T. F., Cheng, J., Tikh, I. B. & Wagner, C. R., Nov 2 2007, In : Journal of Molecular Biology. 373, 4, p. 978-989 12 p.

Research output: Contribution to journalArticle

Histidine
Carrier Proteins
Nucleotides
Lysine-tRNA Ligase
Catalytic Domain
7 Citations (Scopus)

Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein

Ghosh, P., Cheng, J., Chou, T. F., Jia, Y., Avdulov, S. V., Bitterman, P. B., Polunovsky, V. A. & Wagner, C. R., Aug 1 2008, In : Protein Expression and Purification. 60, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Tetrahydrofolate Dehydrogenase
Proteins
Trimethoprim
Anions
43 Citations (Scopus)

Fluorescent tumour imaging of type I IGF receptor in vivo: comparison of antibody-conjugated quantum dots and small-molecule fluorophore

Zhang, H., Zeng, X., Li, Q., Gaillard-Kelly, M., Wagner, C. R. & Yee, D., Jul 7 2009, In : British Journal of Cancer. 101, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

Quantum Dots
IGF Type 1 Receptor
Down-Regulation
Heterografts
Antibodies
151 Citations (Scopus)

Future research directions in idiopathic pulmonary fibrosis: Summary of a National Heart, Lung, and Blood Institute Working Group

Crystal, R. G., Bitterman, P. B., Mossman, B., Schwarz, M. I., Sheppard, D., Almasy, L., Chapman, H. A., Friedman, S. L., King, T. E., Leinwand, L. A., Liotta, L., Martin, G. R., Schwartz, D. A., Schultz, G. S., Wagner, C. R. & Musson, R. A., Jul 15 2002, In : American journal of respiratory and critical care medicine. 166, 2, p. 236-246 11 p.

Research output: Contribution to journalArticle

National Heart, Lung, and Blood Institute (U.S.)
Idiopathic Pulmonary Fibrosis
Molecular Diagnostic Techniques
Laser Capture Microdissection
Human Genome Project
13 Citations (Scopus)

Hamster Monomorphic Arylamine N-Acetyltransferase: Expression in Escherichia coli and Purification

Bergstrom, C. P., Wagner, C. R., Ann, D. K. & Hanna, P. E., Feb 1 1995, In : Protein Expression and Purification. 6, 1, p. 45-55 11 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetyltransferases
Cricetinae
hydrazine
Escherichia coli
24 Citations (Scopus)

HINT1 protein: A new therapeutic target to enhance opioid antinociception and block mechanical allodynia

Garzón, J., Herrero-Labrador, R., Rodríguez-Muñoz, M., Shah, R., Vicente-Sánchez, A., Wagner, C. R. & Sánchez-Blázquez, P., Jan 1 2015, In : Neuropharmacology. 89, p. 412-423 12 p.

Research output: Contribution to journalArticle

Hyperalgesia
Staphylococcal Protein A
N-Methyl-D-Aspartate Receptors
Opioid Analgesics
mu Opioid Receptor
23 Citations (Scopus)
Poisons
Metabolites
HeLa Cells
Acetylation
Detoxification
10 Citations (Scopus)

Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection

Cheng, J., Zhou, X., Chou, T. F., Ghosh, B., Liu, B. & Wagner, C. R., Dec 8 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 22, p. 6379-6381 3 p.

Research output: Contribution to journalArticle

Bacteriophage T7
Bacteriophages
Display devices
Ribonucleotides
Amino Acids
11 Citations (Scopus)

Impact of the C-terminal loop of histidine triad nucleotide binding protein 1 (Hint1) on substrate specificity

Chou, T. F., Sham, Y. Y. & Wagner, C. R., Nov 13 2007, In : Biochemistry. 46, 45, p. 13074-13079 6 p.

Research output: Contribution to journalArticle

Substrate Specificity
Histidine
Escherichia coli
Carrier Proteins
Nucleotides
2 Citations (Scopus)

Induction of the p53 tumor suppressor in cancer cells through inhibition of cap-dependent translation

Harris, B. R. E., Wang, D., Zhang, Y., Ferrari, M., Okon, A., Cleary, M. P., Wagner, C. R. & Yang, D., May 1 2018, In : Molecular and cellular biology. 38, 10, e00367.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Protein Biosynthesis
Apoptosis
Double-Stranded DNA Breaks
5' Untranslated Regions
3 Citations (Scopus)
Neuralgia
Histidine
Analgesia
Opioid Analgesics
Metal ions
15 Citations (Scopus)

Inhibition of CMP-sialic acid transport into golgi vesicles by nucleoside monophosphates

Chiaramonte, M., Koviach, J. L., Moore, C., Iyer, V. V., Wagner, C. R., Halcomb, R. L., Miller, W., Melançon, P. & Kuchta, R. D., Nov 27 2001, In : Biochemistry. 40, 47, p. 14260-14267 8 p.

Research output: Contribution to journalArticle

Cytidine Monophosphate N-Acetylneuraminic Acid
Nucleosides
Sugars
Nucleotides
Glycosylation
8 Citations (Scopus)

In vivo evaluation of site-specifically PEGylated chemically self-assembled protein nanostructures

Shah, R., Petersburg, J., Gangar, A. C., Fegan, A., Wagner, C. R. & Kumarapperuma, S. C., Jul 5 2016, In : Molecular Pharmaceutics. 13, 7, p. 2193-2203 11 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Nanostructures
Epidermal Growth Factor Receptor
leucyl-alanyl-arginyl-leucyl-leucyl-threonine
Proteins
20 Citations (Scopus)
N-hydroxy-4-acetylaminobiphenyl
Arylamine N-Acetyltransferase
Acetyltransferases
Cricetinae
Enzymes
24 Citations (Scopus)

Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines

Liu, L., Wagner, C. R. & Hanna, P. E., Dec 21 2009, In : Chemical research in toxicology. 22, 12, p. 1962-1974 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Metabolites
Protein Isoforms
Acetylation
HeLa Cells
14 Citations (Scopus)

Kinetic mechanism of human histidine triad nucleotide binding protein 1

Zhou, X., Chou, T. F., Aubol, B. E., Park, C. J., Wolfenden, R., Adams, J. & Wagner, C. R., May 21 2013, In : Biochemistry. 52, 20, p. 3588-3600 13 p.

Research output: Contribution to journalArticle

Hydrolysis
Adenosine Monophosphate
Kinetics
Nucleophiles
Catalytic Domain
41 Citations (Scopus)

Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins

Chou, T. F. & Wagner, C. R., Feb 16 2007, In : Journal of Biological Chemistry. 282, 7, p. 4719-4727 9 p.

Research output: Contribution to journalArticle

Lysine-tRNA Ligase
Histidine
Adenosine Monophosphate
Carrier Proteins
Nucleotides
24 Citations (Scopus)
2-Acetylaminofluorene
Cricetinae
Acetylation
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Arylamine N-Acetyltransferase
6 Citations (Scopus)

Methotrexate resistance of mouse dihydrofolate reductase: Effect of substitution of phenylalanine-31 by serine or tryptophan

Evenson, D. A., Adams, J., McIvor, R. S. & Wagner, C. R., Apr 26 1996, In : Journal of Medicinal Chemistry. 39, 9, p. 1763-1766 4 p.

Research output: Contribution to journalReview article

Tetrahydrofolate Dehydrogenase
Phenylalanine
Methotrexate
Tryptophan
Serine
41 Citations (Scopus)

Molecular Basis for Nonadditive Mutational Effects in Escherichia coli Dihydrofolate Reductase

Wagner, C. R., Huang, Z., Singleton, S. F. & Benkovic, S. J., Jan 1 1995, In : Biochemistry. 34, 48, p. 15671-15680 10 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Escherichia coli
Hydrides
Free energy
Conformations
9 Citations (Scopus)
Molecular modeling
Charge distribution
Binding energy
charge distribution
field theory (physics)
6 Citations (Scopus)

Monitoring the Intracellular Metabolism of Nucleoside Phosphoramidate Pronucleotides by 31P NMR

Kim, J., Drontle, D. P. & Wagner, C. R., Mar 26 2004, In : Nucleosides, Nucleotides and Nucleic Acids. 23, 1-2, p. 483-493 11 p.

Research output: Contribution to journalArticle

Nucleosides
Metabolism
Nuclear magnetic resonance
Monitoring
Cells

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

Csizmar, C. M., Petersburg, J. R., Perry, T. J., Rozumalski, L., Hackel, B. J. & Wagner, C. R., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 251-261 11 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Cell membranes
Antigens
Ligands
Cell Membrane
38 Citations (Scopus)

NMR-based Model Reveals the Structural Determinants of Mammalian Arylamine N-Acetyltransferase Substrate Specificity

Zhang, N., Liu, L., Liu, F., Wagner, C. R., Hanna, P. E. & Walters, K. J., Oct 13 2006, In : Journal of Molecular Biology. 363, 1, p. 188-200 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetyltransferases
Structural Models
Substrate Specificity
2-toluidine
44 Citations (Scopus)

Nonadditivity of Mutational Effects at the Folate Binding Site of Escherichia coli Dihydrofolate Reductase

Huang, Z., Wagner, C. R. & Benkovic, S. J., Sep 1 1994, In : Biochemistry. 33, 38, p. 11576-11585 10 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Folic Acid
Escherichia coli
Binding Sites
Mutant Proteins
55 Citations (Scopus)

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

Ghosh, B., Benyumov, A., Ghosh, P., Jia, Y., Avdulov, S. V., Dahlberg, P. S., Peterson, M., Smith, K., Polunovsky, V. A., Bitterman, P. B. & Wagner, C. R., May 15 2009, In : ACS Chemical Biology. 4, 5, p. 367-377 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Tissue
Messenger RNA
Prodrugs
Zebrafish
20 Citations (Scopus)

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1

Wang, H., Vath, G. M., Kawamura, A., Bates, C. A., Sim, E., Hanna, P. E. & Wagner, C. R., Feb 1 2005, In : Protein Journal. 24, 2, p. 65-77 13 p.

Research output: Contribution to journalArticle

Purification
Cricetinae
Fusion reactions
Acids
Substrates
39 Citations (Scopus)

Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein

Sticha, K. R. K., Sieg, C. A., Bergstrom, C. P., Hanna, P. E. & Wagner, C. R., Jan 1 1997, In : Protein Expression and Purification. 10, 1, p. 141-153 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Tetrahydrofolate Dehydrogenase
Cricetinae
Acetyltransferases
Thrombin
18 Citations (Scopus)

Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats

Song, H., Griesgraber, G. W., Wagner, C. R. & Zimmerman, C. L., May 2 2002, In : Antimicrobial Agents and Chemotherapy. 46, 5, p. 1357-1363 7 p.

Research output: Contribution to journalArticle

Zidovudine
Pharmacokinetics
Amino Acids
phosphoramidic acid
Urine
31 Citations (Scopus)

Phospholipid autoxidation

Porter, N. A. & Wagner, C. R., Jan 1 1986, In : Advances in Free Radical Biology and Medicine. 2, 2, p. 283-323 41 p.

Research output: Contribution to journalArticle

Phospholipids
Complex Mixtures
Organic solvents
High pressure liquid chromatography
Biological membranes
56 Citations (Scopus)

Phosphoramidate pronucleotides: A comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins

Chou, T. F., Baraniak, J., Kaczmarek, R., Zhou, X., Cheng, J., Ghosh, B. & Wagner, C. R., Mar 1 2007, In : Molecular pharmaceutics. 4, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

Substrate Specificity
Histidine
Carrier Proteins
Nucleotides
Escherichia coli
37 Citations (Scopus)

Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors

Wagner, C. R., Ballato, G., Akanni, A. O., McIntee, E. J., Larson, R. S., Chang, S. L. & Abul-Hajj, Y. J., Jun 15 1997, In : Cancer Research. 57, 12, p. 2341-2345 5 p.

Research output: Contribution to journalArticle

Zidovudine
Breast Neoplasms
Growth
Inhibitory Concentration 50
T-Cell Leukemia
3 Citations (Scopus)

Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190

Zhou, X., Zhang, N., Liu, L., Walters, K. J., Hanna, P. E. & Wagner, C. R., Dec 1 2009, In : FEBS Journal. 276, 23, p. 6928-6941 14 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Mutagenesis
hydrazine
Site-Directed Mutagenesis
12 Citations (Scopus)

Probing the Impact of the echinT C-Terminal Domain on Structure and Catalysis

Bardaweel, S., Pace, J., Chou, T. F., Cody, V. & Wagner, C. R., Dec 10 2010, In : Journal of Molecular Biology. 404, 4, p. 627-638 12 p.

Research output: Contribution to journalArticle

Catalysis
Escherichia coli
Bacteria
Gram-Positive Bacteria
Adenosine Monophosphate
57 Citations (Scopus)

Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies

Wang, H., Vath, G. M., Gleason, K. J., Hanna, P. E. & Wagner, C. R., Jun 29 2004, In : Biochemistry. 43, 25, p. 8234-8246 13 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetylation
Mutagenesis
Site-Directed Mutagenesis
Iodoacetamide
2 Citations (Scopus)

Probing the Molecular Basis of Resistance to Pyrimethamine by Site-Directed Mutagenesis

Wagner, C. R. & Benkovic, S. J., Jul 1 1992, In : Journal of Medicinal Chemistry. 35, 15, p. 2912-2915 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers

Gangar, A., Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Feb 15 2012, In : Journal of the American Chemical Society. 134, 6, p. 2895-2897 3 p.

Research output: Contribution to journalArticle

Oligonucleotides
Antibodies
Self assembly
Carrier Proteins
Proteins
3 Citations (Scopus)

Programming Cell-Cell Interactions through Non-genetic Membrane Engineering

Csizmar, C. M., Petersburg, J. R. & Wagner, C. R., Aug 16 2018, In : Cell Chemical Biology. 25, 8, p. 931-940 10 p.

Research output: Contribution to journalReview article

Cell Communication
Cell membranes
Membranes
Cell Membrane
Metabolic engineering
242 Citations (Scopus)

Pronucleotides: Toward the in vivo delivery of antiviral and anticancer nucleotides

Wagner, C. R., Iyer, V. V. & McIntee, E. J., Nov 9 2000, In : Medicinal Research Reviews. 20, 6, p. 417-451 35 p.

Research output: Contribution to journalArticle

Antiviral Agents
Nucleotides
Prodrugs
Nucleosides
Pharmacology
6 Citations (Scopus)

Prosthetic antigen receptors

Shen, J., Vallera, D. A. & Wagner, C. R., Aug 19 2015, In : Journal of the American Chemical Society. 137, 32, p. 10108-10111 4 p.

Research output: Contribution to journalArticle

Nanorings
Antigen Receptors
T-cells
Antigens
Prosthetics

Protein interface remodeling in a chemically induced protein dimer

White, B. R., Carlson, J. C. T., Kerns, J. L. & Wagner, C. R., Jul 1 2012, In : Journal of Molecular Recognition. 25, 7, p. 393-403 11 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Proteins
Nanostructures
Population Characteristics
Methotrexate