1986 …2020

Research output per year

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Research Output

1986

Phospholipid autoxidation

Porter, N. A. & Wagner, C. R., 1986, In : Advances in Free Radical Biology and Medicine. 2, 2, p. 283-323 41 p.

Research output: Contribution to journalArticle

32 Scopus citations
1988

A Phospholipase C Protocol for Phospholipid Peroxidation Analysis

Wagner, C. R. & Porter, N. A., Sep 1 1988, In : Chemical Research in Toxicology. 1, 5, p. 274-280 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
1990

Site directed mutagenesis: a tool for enzyme mechanism dissection

Wagner, C. R. & Benkovic, S. J., 1990, In : Trends in biotechnology. 8, C, p. 263-270 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
1992

Complementary Perturbation of the Kinetic Mechanism and Catalytic Effectiveness of Dihydrofolate Reductase by Side-Chain Interchange

Wagner, C. R., Thillet, J. & Benkovic, S. J., Feb 1 1992, In : Biochemistry. 31, 34, p. 7834-7840 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Probing the Molecular Basis of Resistance to Pyrimethamine by Site-Directed Mutagenesis

Wagner, C. R. & Benkovic, S. J., Jul 1 1992, In : Journal of medicinal chemistry. 35, 15, p. 2912-2915 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
1994

A phosphoramidite-based synthesis of phosphoramidate amino acid diesters of antiviral nucleosides

Abraham, T. W. & Wagner, C. R., Sep 1 1994, In : Nucleosides and Nucleotides. 13, 9, p. 1891-1903 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Nonadditivity of Mutational Effects at the Folate Binding Site of Escherichia coli Dihydrofolate Reductase

Huang, Z., Wagner, C. R. & Benkovic, S. J., Sep 1 1994, In : Biochemistry. 33, 38, p. 11576-11585 10 p.

Research output: Contribution to journalArticle

44 Scopus citations
1995

Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication

Wagner, C. R., McIntee, E. J., Schinazi, R. F. & Abraham, T. W., Aug 17 1995, In : Bioorganic and Medicinal Chemistry Letters. 5, 16, p. 1819-1824 6 p.

Research output: Contribution to journalArticle

52 Scopus citations

Hamster Monomorphic Arylamine N-Acetyltransferase: Expression in Escherichia coli and Purification

Bergstrom, C. P., Wagner, C. R., Ann, D. K. & Hanna, P. E., Feb 1 1995, In : Protein Expression and Purification. 6, 1, p. 45-55 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Molecular Basis for Nonadditive Mutational Effects in Escherichia coli Dihydrofolate Reductase

Wagner, C. R., Huang, Z., Singleton, S. F. & Benkovic, S. J., Dec 1995, In : Biochemistry. 34, 48, p. 15671-15680 10 p.

Research output: Contribution to journalArticle

41 Scopus citations
1996

Arylamine N-acetyltransferases: Expression in Escherichia coli, purification, and substrate specificities of recombinant hamster monomorphic and polymorphic isozymes

Wagner, C. R., Bergstrom, C. P., Koning, K. R. & Hanna, P. E., Feb 27 1996, In : Drug Metabolism and Disposition. 24, 2, p. 245-253 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Methotrexate resistance of mouse dihydrofolate reductase: Effect of substitution of phenylalanine-31 by serine or tryptophan

Evenson, D. A., Adams, J., McIvor, R. S. & Wagner, C. R., Apr 26 1996, In : Journal of Medicinal Chemistry. 39, 9, p. 1763-1766 4 p.

Research output: Contribution to journalReview article

6 Scopus citations

Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-β- arabinofuranosylcytosine: Evidence of phosphoramidase activity

Abraham, T. W., Kalman, T. I., McIntee, E. J. & Wagner, C. R., Nov 26 1996, In : Journal of medicinal chemistry. 39, 23, p. 4569-4575 7 p.

Research output: Contribution to journalArticle

83 Scopus citations
1997

Antiviral nucleotide drug delivery via amino acid phosphoramidates

Wagner, C. R., McIntee, E. J., Chang, S. L. & Zimmerman, C., Dec 1 1997, In : FASEB Journal. 11, 9, p. A836

Research output: Contribution to journalArticle

Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein

Sticha, K. R. K., Sieg, C. A., Bergstrom, C. P., Hanna, P. E. & Wagner, C. R., Jun 1997, In : Protein Expression and Purification. 10, 1, p. 141-153 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors

Wagner, C. R., Ballato, G., Akanni, A. O., McIntee, E. J., Larson, R. S., Chang, S. L. & Abul-Hajj, Y. J., Jun 15 1997, In : Cancer Research. 57, 12, p. 2341-2345 5 p.

Research output: Contribution to journalArticle

40 Scopus citations

Synthesis, biological activity and decomposition studies of amino acid phosphomonoester amidates of acyclovir

Abraham, T. W., McIntee, E. J., Iyer, V. V., Schinazi, R. F. & Wagner, C. R., Jan 1 1997, In : Nucleosides and Nucleotides. 16, 10-11, p. 2079-2092 14 p.

Research output: Contribution to journalReview article

15 Scopus citations
1998

Amino acid phosphoramidates of antiviral 3-deazaadenosine analogs exhibit high potency and low cytotoxicity

McIntee, E. J., Wagner, C. R., Giordano, V., Jeang, K. T. & Chiang, P. K., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

17 Scopus citations
1999

Antiviral nucleoside drug delivery via amino acid phosphoramidates

Wagner, C. R., Chang, S. L., Griesgraber, G. W., Song, H., McIntee, E. J. & Zimmerman, C. L., Jan 1 1999, In : Nucleosides and Nucleotides. 18, 4-5, p. 913-919 7 p.

Research output: Contribution to journalArticle

28 Scopus citations
2000

Pronucleotides: Toward the in vivo delivery of antiviral and anticancer nucleotides

Wagner, C. R., Iyer, V. V. & McIntee, E. J., Nov 9 2000, In : Medicinal Research Reviews. 20, 6, p. 417-451 35 p.

Research output: Contribution to journalArticle

244 Scopus citations

Synthesis, in vitro anti-breast cancer activity, and intracellular decomposition of amino acid methyl ester and alkyl amide phosphoramidate monoesters of 3'-azido-3'-deoxythymidine (AZT)

Iyer, V. V., Griesgraber, G. W., Radmer, M. R., McIntee, E. J. & Wagner, C. R., Jun 1 2000, In : Journal of medicinal chemistry. 43, 11, p. 2266-2274 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Synthesis and antiviral activity of amino acid carbamate derivatives of AZT

Chang, S. L., Griesgraber, G., Abraham, T. W., Garg, T., Song, H., Zimmerman, C. L. & Wagner, C. R., Jan 1 2000, In : Nucleosides, Nucleotides and Nucleic Acids. 19, 1-2, p. 87-100 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
2001
64 Scopus citations

Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.

McIntee, E. J. & Wagner, C. R., Nov 5 2001, In : Bioorganic & medicinal chemistry letters. 11, 21, p. 2803-2805 3 p.

Research output: Contribution to journalArticle

6 Scopus citations
10 Scopus citations

Inhibition of CMP-sialic acid transport into golgi vesicles by nucleoside monophosphates

Chiaramonte, M., Koviach, J. L., Moore, C., Iyer, V. V., Wagner, C. R., Halcomb, R. L., Miller, W., Melançon, P. & Kuchta, R. D., Nov 27 2001, In : Biochemistry. 40, 47, p. 14260-14267 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2002

Future research directions in idiopathic pulmonary fibrosis: Summary of a National Heart, Lung, and Blood Institute Working Group

Crystal, R. G., Bitterman, P. B., Mossman, B., Schwarz, M. I., Sheppard, D., Almasy, L., Chapman, H. A., Friedman, S. L., King, T. E., Leinwand, L. A., Liotta, L., Martin, G. R., Schwartz, D. A., Schultz, G. S., Wagner, C. R. & Musson, R. A., Jul 15 2002, In : American journal of respiratory and critical care medicine. 166, 2, p. 236-246 11 p.

Research output: Contribution to journalArticle

153 Scopus citations

Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats

Song, H., Griesgraber, G. W., Wagner, C. R. & Zimmerman, C. L., May 2 2002, In : Antimicrobial agents and chemotherapy. 46, 5, p. 1357-1363 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2003

Arylamine N-acetyltransferases: Covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene

Guo, Z., Vath, G. M., Wagner, C. R. & Hanna, P. E., Dec 1 2003, In : Protein Journal. 22, 7-8, p. 631-642 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Designing protein dimerizers: The importance of ligand conformational equilibria

Carlson, J. C. T., Kanter, A., Thuduppathy, G. R., Cody, V., Pineda, P. E., Mc Ivor, R. S. & Wagner, C. R., Feb 12 2003, In : Journal of the American Chemical Society. 125, 6, p. 1501-1507 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate

Pineda, P., Kanter, A., Mc Ivor, R. S., Benkovic, S. J., Rosowsky, A. & Wagner, C. R., Jul 3 2003, In : Journal of Medicinal Chemistry. 46, 14, p. 2816-2818 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Disposition and oral bioavailability in rats of an antiviral and antitumor amino acid phosphoramidate prodrug of AZT-monophosphate

Song, H., Johns, R., Griesgraber, G. W., Wagner, C. R. & Zimmerman, C. L., Mar 1 2003, In : Pharmaceutical research. 20, 3, p. 448-451 4 p.

Research output: Contribution to journalArticle

12 Scopus citations
2004

A dogma in need of a reformation.

Wagner, C. R., Jul 1 2004, In : Mol Pharm. 1, 4, 1 p.

Research output: Contribution to journalEditorial

An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries: Discovery of a novel antagonist of E. coli dihydrofolate reductase

Annis, D. A., Athanasopoulos, J., Curran, P. J., Felsch, J. S., Kalghatgi, K., Lee, W. H., Nash, H. M., Orminati, J. P. A., Rosner, K. E., Shipps, G. W., Thaddupathy, G. R. A., Tyler, A. N., Vilenchik, L., Wagner, C. R. & Wintner, E. A., Nov 1 2004, In : International Journal of Mass Spectrometry. 238, 2, p. 77-83 7 p.

Research output: Contribution to journalArticle

89 Scopus citations

Chemical modification of hamster arylamine N-acetyltransferase 2 with isozyme-selective and nonselective N-arylbromoacetamido reagents

Wang, H., Guo, Z., Vath, G. M., Wagner, C. R. & Hanna, P. E., Dec 1 2004, In : Protein Journal. 23, 2, p. 153-166 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Designing a pronucleotide stratagem: Lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines

Drontle, D. P. & Wagner, C. R., May 2004, In : Mini-Reviews in Medicinal Chemistry. 4, 4, p. 409-419 11 p.

Research output: Contribution to journalReview article

66 Scopus citations

Direct measurement of nucleoside monophosphate delivery from a phosphoramidate pronucleotide by stable isotope labeling and LC-ESI(-)-MS/MS.

Kim, J., Chou, T. F., Griesgraber, G. W. & Wagner, C. R., Jan 1 2004, In : Molecular pharmaceutics. 1, 2, p. 102-111 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
24 Scopus citations

Monitoring the Intracellular Metabolism of Nucleoside Phosphoramidate Pronucleotides by 31P NMR

Kim, J., Drontle, D. P. & Wagner, C. R., Mar 26 2004, In : Nucleosides, Nucleotides and Nucleic Acids. 23, 1-2, p. 483-493 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies

Wang, H., Vath, G. M., Gleason, K. J., Hanna, P. E. & Wagner, C. R., Jun 29 2004, In : Biochemistry. 43, 25, p. 8234-8246 13 p.

Research output: Contribution to journalArticle

59 Scopus citations
2005

31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions

Chou, T. F., Bieganowski, P., Shilinski, K., Cheng, J., Brenner, C. & Wagner, C. R., Apr 15 2005, In : Journal of Biological Chemistry. 280, 15, p. 15356-15361 6 p.

Research output: Contribution to journalArticle

42 Scopus citations
14 Scopus citations

Catalytic mechanism of hamster arylamine N-acetyltransferase 2

Wang, H., Liu, L., Hanna, P. E. & Wagner, C. R., Aug 23 2005, In : Biochemistry. 44, 33, p. 11295-11306 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Dissociation of I domain and global conformational changes in LFA-1: Refinement of small molecule-I domain structure-activity relationships

Larson, R. S., Davis, T., Bologa, C., Semenuk, G., Vijayan, S., Li, Y., Oprea, T., Chigaev, A., Buranda, T., Wagner, C. R. & Sklar, L. A., Mar 22 2005, In : Biochemistry. 44, 11, p. 4322-4331 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Erratum: Catalytic mechanism of hamster arylamine N-acetyltransferase 2 (Biochemistry (August 23, 2005) 44, 3 (11295-11306))

Wang, H., Liu, L., Hanna, P. E. & Wagner, C. R., Dec 6 2005, In : Biochemistry. 44, 48, 1 p.

Research output: Contribution to journalComment/debate

Eukaryotic arylamine N-acetyltransferase investigation of substrate specificity by high-throughput screening

Kawamura, A., Graham, J., Mushtaq, A., Tsiftsoglou, S. A., Vath, G. M., Hanna, P. E., Wagner, C. R. & Sim, E., Jan 15 2005, In : Biochemical Pharmacology. 69, 2, p. 347-359 13 p.

Research output: Contribution to journalArticle

77 Scopus citations
20 Scopus citations

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1

Wang, H., Vath, G. M., Kawamura, A., Bates, C. A., Sim, E., Hanna, P. E. & Wagner, C. R., Feb 1 2005, In : Protein Journal. 24, 2, p. 65-77 13 p.

Research output: Contribution to journalArticle

20 Scopus citations