1986 …2025

Research output per year

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Research Output

2020

Repression of oncogenic cap-mediated translation by 4Ei-10 diminishes proliferation, enhances chemosensitivity and alters expression of malignancy-related proteins in mesothelioma

Ahmad, Z., Jacobson, B. A., McDonald, M. W., Vattendahl Vidal, N., Vattendahl Vidal, G., Chen, S., Dillenburg, M., Okon, A. M., Patel, M. R., Wagner, C. R. & Kratzke, R. A., Feb 1 2020, In : Cancer chemotherapy and pharmacology. 85, 2, p. 425-432 8 p.

Research output: Contribution to journalArticle

The LFA-1 antagonist BIRT377 reverses neuropathic pain in prenatal alcohol-exposed female rats via actions on peripheral and central neuroimmune function in discrete pain-relevant tissue regions

Noor, S., Sanchez, J. J., Sun, M. S., Pervin, Z., Sanchez, J. E., Havard, M. A., Epler, L. T., Nysus, M. V., Norenberg, J. P., Wagner, C. R., Davies, S., Wagner, J. L., Savage, D. D., Jantzie, L. L., Mellios, N. & Milligan, E. D., Jan 1 2020, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Open Access
2019

Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice

Shah, R. M., Peterson, C., Strom, A., Dillenburg, M., Finzel, B., Kitto, K. F., Fairbanks, C., Wilcox, G. & Wagner, C. R., Oct 16 2019, In : ACS Chemical Neuroscience. 10, 10, p. 4385-4393 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

Csizmar, C. M., Petersburg, J. R., Perry, T. J., Rozumalski, L., Hackel, B. J. & Wagner, C. R., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 251-261 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Sanchez, J. J., Sanchez, J. E., Noor, S., Ruffaner-Hanson, C. D., Davies, S., Wagner, C. R., Jantzie, L. L., Mellios, N., Savage, D. D. & Milligan, E. D., Apr 8 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

111 In-DANBIRT in Vivo Molecular Imaging of Inflammatory Cells in Atherosclerosis

Mota, R., Campen, M. J., Cuellar, M. E., Garver, W. S., Hesterman, J., Qutaish, M., Daniels, T., Nysus, M., Wagner, C. R. & Norenberg, J. P., Jan 1 2018, In : Contrast Media and Molecular Imaging. 2018, 6508724.

Research output: Contribution to journalArticle

Open Access

A Great Ride

Wagner, C. R., Dec 3 2018, In : Molecular Pharmaceutics. 15, 12, 1 p.

Research output: Contribution to journalEditorial

Engineering Reversible Cell-Cell Interactions with Lipid Anchored Prosthetic Receptors

Csizmar, C. M., Petersburg, J. R., Hendricks, A., Stern, L. A., Hackel, B. J. & Wagner, C. R., Apr 18 2018, In : Bioconjugate Chemistry. 29, 4, p. 1291-1301 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Eradication of Established Tumors by Chemically Self-Assembled Nanoring Labeled T Cells

Petersburg, J. R., Shen, J., Csizmar, C. M., Murphy, K. A., Spanier, J., Gabrielse, K., Griffith, T. S., Fife, B. & Wagner, C. R., Jul 24 2018, In : ACS nano. 12, 7, p. 6563-6576 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Induction of the p53 tumor suppressor in cancer cells through inhibition of cap-dependent translation

Harris, B. R. E., Wang, D., Zhang, Y., Ferrari, M., Okon, A., Cleary, M. P., Wagner, C. R. & Yang, D., May 1 2018, In : Molecular and cellular biology. 38, 10, e00367.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Programming Cell-Cell Interactions through Non-genetic Membrane Engineering

Csizmar, C. M., Petersburg, J. R. & Wagner, C. R., Aug 16 2018, In : Cell Chemical Biology. 25, 8, p. 931-940 10 p.

Research output: Contribution to journalReview article

6 Scopus citations
Open Access
1 Scopus citations

Tunable Supramolecular Assemblies from Amphiphilic Nucleoside Phosphoramidate Nanofibers by Enzyme Activation

West, H. T., Csizmar, C. M. & Wagner, C. R., Jul 9 2018, In : Biomacromolecules. 19, 7, p. 2650-2656 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides

Maize, K. M., Shah, R., Strom, A., Kumarapperuma, S., Zhou, A., Wagner, C. R. & Finzel, B. C., Nov 6 2017, In : Molecular pharmaceutics. 14, 11, p. 3987-3997 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Anchimerically Activatable Antiviral ProTides

Okon, A., Matos De Souza, M. R., Shah, R., Amorim, R., Da Costa, L. J. & Wagner, C. R., Jan 1 2017, In : ACS Medicinal Chemistry Letters. 8, 9, p. 958-962 5 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma

Okon, A., Han, J., Dawadi, S., Demosthenous, C., Aldrich, C., Gupta, M. & Wagner, C. R., Oct 12 2017, In : Journal of Medicinal Chemistry. 60, 19, p. 8131-8144 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
8 Scopus citations
4 Scopus citations
4 Scopus citations

Titratable Avidity Reduction Enhances Affinity Discrimination in Mammalian Cellular Selections of Yeast-Displayed Ligands

Stern, L. A., Csizmar, C. M., Woldring, D. R., Wagner, C. R. & Hackel, B. J., May 8 2017, In : ACS Combinatorial Science. 19, 5, p. 315-323 9 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2016

Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1

Shah, R., Strom, A., Zhou, A., Maize, K. M., Finzel, B. C. & Wagner, C. R., Aug 11 2016, In : ACS Medicinal Chemistry Letters. 7, 8, p. 780-784 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

In vivo evaluation of site-specifically PEGylated chemically self-assembled protein nanostructures

Shah, R., Petersburg, J., Gangar, A. C., Fegan, A., Wagner, C. R. & Kumarapperuma, S. C., Jul 5 2016, In : Molecular Pharmaceutics. 13, 7, p. 2193-2203 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

HINT1 protein: A new therapeutic target to enhance opioid antinociception and block mechanical allodynia

Garzón, J., Herrero-Labrador, R., Rodríguez-Muñoz, M., Shah, R., Vicente-Sánchez, A., Wagner, C. R. & Sánchez-Blázquez, P., Feb 2015, In : Neuropharmacology. 89, p. 412-423 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Prosthetic antigen receptors

Shen, J., Vallera, D. A. & Wagner, C. R., Aug 19 2015, In : Journal of the American Chemical Society. 137, 32, p. 10108-10111 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E

Smith, K. A., Zhou, B., Avdulov, S., Benyumov, A., Peterson, M., Liu, Y., Okon, A., Hergert, P., Braziunas, J., Wagner, C. R., Borok, Z. & Bitterman, P. B., Dec 18 2015, In : Scientific reports. 5, 18233.

Research output: Contribution to journalArticle

19 Scopus citations
2014

Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α

Cao, J., He, L., Lin, G., Hu, C., Dong, R., Zhang, J., Zhu, H., Hu, Y., Wagner, C. R., He, Q. & Yang, B., May 1 2014, In : Biochemical Pharmacology. 89, 1, p. 20-30 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Reversible Re-programing of Cell-Cell Interactions

Gabrielse, K., Gangar, A., Kumar, N., Lee, J. C., Fegan, A., Shen, J. J., Li, Q., Vallera, D. & Wagner, C. R., May 12 2014, In : Angewandte Chemie - International Edition. 53, 20, p. 5112-5116 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells

Chen, E. Z., Jacobson, B. A., Patel, M. R., Okon, A. M., Li, S., Xiong, K., Vaidya, A. J., Bitterman, P. B., Wagner, C. R. & Kratzke, R. A., Aug 2014, In : Investigational New Drugs. 32, 4, p. 598-603 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation

Rashidian, M., Mahmoodi, M. M., Shah, R., Dozier, J. K., Wagner, C. R. & Distefano, M. D., Mar 20 2013, In : Bioconjugate Chemistry. 24, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

Distinct Translational Control in CD4+ T Cell Subsets

Bjur, E., Larsson, O., Yurchenko, E., Zheng, L., Gandin, V., Topisirovic, I., Li, S., Wagner, C. R., Sonenberg, N. & Piccirillo, C. A., May 1 2013, In : PLoS genetics. 9, 5, e1003494.

Research output: Contribution to journalArticle

34 Scopus citations

Kinetic mechanism of human histidine triad nucleotide binding protein 1

Zhou, X., Chou, T. F., Aubol, B. E., Park, C. J., Wolfenden, R., Adams, J. & Wagner, C. R., May 21 2013, In : Biochemistry. 52, 20, p. 3588-3600 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Simultaneous dual protein labeling using a triorthogonal reagent

Rashidian, M., Kumarapperuma, S. C., Gabrielse, K., Fegan, A., Wagner, C. R. & Distefano, M. D., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16388-16396 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily

Maize, K. M., Wagner, C. R. & Finzel, B. C., Jul 1 2013, In : FEBS Journal. 280, 14, p. 3389-3398 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures

Gangar, A., Fegan, A., Kumarapperuma, S. C., Huynh, P., Benyumov, A. & Wagner, C. R., Sep 3 2013, In : Molecular Pharmaceutics. 10, 9, p. 3514-3518 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
40 Scopus citations
2012

Blood-nanoparticle interactions and in Vivo biodistribution: Impact of surface peg and ligand properties

Shah, N. B., Vercellotti, G. M., White, J. G., Fegan, A., Wagner, C. R. & Bischof, J. C., Aug 6 2012, In : Molecular pharmaceutics. 9, 8, p. 2146-2155 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

Cap-Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target

Jia, Y., Polunovsky, V., Bitterman, P. B. & Wagner, C. R., Jul 1 2012, In : Medicinal Research Reviews. 32, 4, p. 786-814 29 p.

Research output: Contribution to journalReview article

65 Scopus citations

Chemically self-assembled antibody nanostructures as potential drug carriers

Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Nov 5 2012, In : Molecular pharmaceutics. 9, 11, p. 3218-3227 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers

Gangar, A., Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Feb 15 2012, In : Journal of the American Chemical Society. 134, 6, p. 2895-2897 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Protein interface remodeling in a chemically induced protein dimer

White, B. R., Carlson, J. C. T., Kerns, J. L. & Wagner, C. R., Jul 1 2012, In : Journal of Molecular Recognition. 25, 7, p. 393-403 11 p.

Research output: Contribution to journalArticle

Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins

Bardaweel, S. K., Ghosh, B. & Wagner, C. R., Jan 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 1, p. 558-560 3 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

Chemically induced self-assembly of enzyme nanorings.

White, B. R., Li, Q. & Wagner, C. R., Sep 15 2011, In : Methods in molecular biology (Clifton, N.J.). 743, p. 17-26 10 p.

Research output: Contribution to journalArticle

E. coli Histidine triad nucleotide binding protein 1 (echint) is a catalytic regulator of d-alanine dehydrogenase (dada) activity in vivo

Bardaweel, S., Ghosh, B., Chou, T. F., Sadowsky, M. J. & Wagner, C. R., Jul 11 2011, In : PloS one. 6, 7, e20897.

Research output: Contribution to journalArticle

8 Scopus citations

Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191

Birkus, G., Kutty, N., Frey, C. R., Shribata, R., Chou, T., Wagner, C., McDermott, M. & Cihlar, T., May 1 2011, In : Antimicrobial agents and chemotherapy. 55, 5, p. 2166-2173 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2010

Chemically controlled protein assembly: Techniques and applications

Fegan, A., White, B., Carlson, J. C. T. & Wagner, C. R., Jun 9 2010, In : Chemical Reviews. 110, 6, p. 3315-3336 22 p.

Research output: Contribution to journalArticle

152 Scopus citations

Chemically self-assembled antibody nanorings (CSANs): Design and characterization of an anti-CD3 IgM biomimetic

Li, Q., So, C. R., Fegan, A., Cody, V., Sarikaya, M., Vallera, D. A. & Wagner, C. R., Dec 8 2010, In : Journal of the American Chemical Society. 132, 48, p. 17247-17257 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP

Jia, Y., Chiu, T. L., Amin, E. A., Polunovsky, V., Bitterman, P. B. & Wagner, C. R., Apr 1 2010, In : European Journal of Medicinal Chemistry. 45, 4, p. 1304-1313 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

DHFR Fusion proteins for the cellular delivery of methotrexate labeled oligonucleotides

Fegan, A., Kumarapperuma, S. C. & Wagner, C. R., Dec 1 2010, 7th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2010. p. 27-28 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Probing the Impact of the echinT C-Terminal Domain on Structure and Catalysis

Bardaweel, S., Pace, J., Chou, T. F., Cody, V. & Wagner, C. R., Dec 10 2010, In : Journal of Molecular Biology. 404, 4, p. 627-638 12 p.

Research output: Contribution to journalArticle

12 Scopus citations