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Research Output 1988 2019

2019
2 Citations (Scopus)

Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway

Koehn, E. M., Latham, J. A., Armand, T., Evans, R. L., Tu, X., Wilmot, C. M., Iavarone, A. T. & Klinman, J. P., Mar 13 2019, In : Journal of the American Chemical Society. 141, 10, p. 4398-4405 8 p.

Research output: Contribution to journalArticle

PQQ Cofactor
Biosynthesis
Biosynthetic Pathways
Mixed Function Oxygenases
Iron
2018

The role of OleA His285 in orchestration of long-chain acyl-coenzyme A substrates

Jensen, M. R., Goblirsch, B. R., Esler, M. A., Christenson, J. K., Mohamed, F. A., Wackett, L. P. & Wilmot, C. M., Mar 1 2018, In : FEBS Letters. 592, 6, p. 987-998 12 p.

Research output: Contribution to journalLetter

Acyl Coenzyme A
Olea
Keto Acids
Mutagenesis
Nucleophiles
3 Citations (Scopus)

X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE

Barr, I., Stich, T. A., Gizzi, A. S., Grove, T. L., Bonanno, J. B., Latham, J. A., Chung, T., Wilmot, C. M., Britt, R. D., Almo, S. C. & Klinman, J. P., Feb 27 2018, In : Biochemistry. 57, 8, p. 1306-1315 10 p.

Research output: Contribution to journalArticle

Electron Spin Resonance Spectroscopy
Paramagnetic resonance
Spectrum Analysis
X ray crystallography
X Ray Crystallography
2017
5 Citations (Scopus)

Active multienzyme assemblies for long-chain olefinic hydrocarbon biosynthesis

Christenson, J. K., Jensen, M. R., Goblirsch, B. R., Mohamed, F., Zhang, W., Wilmot, C. M. & Wackett, L. P., May 1 2017, In : Journal of bacteriology. 199, 9, e00890-16.

Research output: Contribution to journalArticle

Open Access
Hydrocarbons
Olea
Xanthomonas campestris
Proteins
Acyl Coenzyme A
3 Citations (Scopus)

Crystal structures reveal metal-binding plasticity at the metallo-β-lactamase active site of PqqB from Pseudomonas putida

Tu, X., Latham, J. A., Klema, V. J., Evans, R. L., Li, C., Klinman, J. P. & Wilmot, C. M., Oct 1 2017, In : Journal of Biological Inorganic Chemistry. 22, 7, p. 1089-1097 9 p.

Research output: Contribution to journalArticle

Pseudomonas putida
Metal ions
Plasticity
Catalytic Domain
Crystal structure
6 Citations (Scopus)

Nuclear Magnetic Resonance Structure and Binding Studies of PqqD, a Chaperone Required in the Biosynthesis of the Bacterial Dehydrogenase Cofactor Pyrroloquinoline Quinone

Evans, R. L., Latham, J. A., Xia, Y., Klinman, J. P. & Wilmot, C. M., May 30 2017, In : Biochemistry. 56, 21, p. 2735-2746 12 p.

Research output: Contribution to journalArticle

Open Access
PQQ Cofactor
Biosynthesis
Oxidoreductases
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
1 Citation (Scopus)

OleA Glu117 is key to condensation of two fatty-acyl coenzyme A substrates in long-chain olefin biosynthesis

Jensen, M. R., Goblirsch, B. R., Christenson, J. K., Esler, M. A., Mohamed, F. A., Wackett, L. P. & Wilmot, C. M., Dec 1 2017, In : Biochemical Journal. 474, 23, p. 3871-3886 16 p.

Research output: Contribution to journalArticle

Acyl Coenzyme A
Biosynthesis
Alkenes
Olea
Condensation
16 Citations (Scopus)

β-Lactone synthetase found in the olefin biosynthesis pathway

Christenson, J. K., Richman, J. E., Jensen, M. R., Neufeld, J. Y., Wilmot, C. M. & Wackett, L. P., Jan 1 2017, In : Biochemistry. 56, 2, p. 348-351 4 p.

Research output: Contribution to journalArticle

Biosynthesis
Alkenes
Lactones
Ligases
Hydrocarbons
2016
2 Citations (Scopus)

1H, 13C, and 15N resonance assignments and secondary structure information for Methylobacterium extorquens PqqD and the complex of PqqD with PqqA

Evans, R. L., Latham, J. A., Klinman, J. P., Wilmot, C. M. & Xia, Y., Oct 1 2016, In : Biomolecular NMR Assignments. 10, 2, p. 385-389 5 p.

Research output: Contribution to journalArticle

Methylobacterium extorquens
PQQ Cofactor
Biosynthesis
Peptides
Xanthomonas campestris
37 Citations (Scopus)

Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography

Roessler, C. G., Agarwal, R., Allaire, M., Alonso-Mori, R., Andi, B., Bachega, J. F. R., Bommer, M., Brewster, A. S., Browne, M. C., Chatterjee, R., Cho, E., Cohen, A. E., Cowan, M., Datwani, S., Davidson, V. L., Defever, J., Eaton, B., Ellson, R., Feng, Y., Ghislain, L. P. & 30 others, Glownia, J. M., Han, G., Hattne, J., Hellmich, J., Héroux, A., Ibrahim, M., Kern, J., Kuczewski, A., Lemke, H. T., Liu, P., Majlof, L., McClintock, W. M., Myers, S., Nelsen, S., Olechno, J., Orville, A. M., Sauter, N. K., Soares, A. S., Soltis, S. M., Song, H., Stearns, R. G., Tran, R., Tsai, Y., Uervirojnangkoorn, M., Wilmot, C. M., Yachandra, V., Yano, J., Yukl, E. T., Zhu, D. & Zouni, A., Apr 5 2016, In : Structure. 24, 4, p. 631-640 10 p.

Research output: Contribution to journalArticle

Crystallography
Acoustics
X-Rays
Lasers
Electrons
8 Citations (Scopus)

Substrate trapping in crystals of the thiolase olea identifies three channels that enable long chain olefin biosynthesis

Goblirsch, B. R., Jensen, M. R., Mohamed, F. A., Wackett, L. P. & Wilmot, C. M., Dec 23 2016, In : Journal of Biological Chemistry. 291, 52, p. 26698-26706 9 p.

Research output: Contribution to journalArticle

Biosynthesis
Alkenes
Olea
Acyl Coenzyme A
Carbon
2015
2 Citations (Scopus)

A T67A mutation in the proximal pocket of the high-spin heme of MauG stabilizes formation of a mixed-valent FeII/FeIII state and enhances charge resonance stabilization of the bis-FeIV state

Shin, S., Feng, M., Li, C., Williamson, H. R., Choi, M., Wilmot, C. M. & Davidson, V. L., Apr 25 2015, In : Biochimica et Biophysica Acta - Bioenergetics. 1847, 8, p. 709-716 8 p.

Research output: Contribution to journalArticle

Heme
Stabilization
Mutation
Ligands
Electrons
2 Citations (Scopus)

Hydrocarbon Biosynthesis in Microorganisms

Wackett, L. P. & Wilmot, C. M., May 29 2015, Direct Microbial Conversion of Biomass to Advanced Biofuels. Elsevier, p. 13-31 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biosynthesis
Microorganisms
Hydrocarbons
Olefins
Biofuels
68 Citations (Scopus)

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

Liu, P., Reed, M. N., Kotilinek, L. A., Grant, M. K. O., Forster, C. L., Qiang, W., Shapiro, S. L., Reichl, J. H., Chiang, A. C. A., Jankowsky, J. L., Wilmot, C. M., Cleary, J. P., Zahs, K. R. & Ashe, K. H., Jun 23 2015, In : Cell Reports. 11, 11, p. 1760-1771 12 p.

Research output: Contribution to journalArticle

Oligomers
Amyloid
Alzheimer Disease
Poisons
Amyloid Plaques
2014
33 Citations (Scopus)

A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36

Cheng, Z., Cheung, P., Kuo, A. J., Yukl, E. T., Wilmot, C. M., Gozani, O. & Patel, D. J., Aug 15 2014, In : Genes and Development. 28, 16, p. 1758-1771 14 p.

Research output: Contribution to journalArticle

Histones
Methylation
Lysine
Histone Demethylases
Peptides
8 Citations (Scopus)

Site-directed mutagenesis of Gln103 reveals the influence of this residue on the redox properties and stability of MauG

Shin, S., Yukl, E. T., Sehanobish, E., Wilmot, C. M. & Davidson, V. L., Mar 4 2014, In : Biochemistry. 53, 8, p. 1342-1349 8 p.

Research output: Contribution to journalArticle

Mutagenesis
Site-Directed Mutagenesis
Oxidation-Reduction
Biosynthesis
Hydrogen Bonding
4 Citations (Scopus)

Standardization of α-L-iduronidase enzyme assay with Michaelis-Menten kinetics

Ou, L., Herzog, T. L., Wilmot, C. M. & Whitley, C. B., 2014, In : Molecular Genetics and Metabolism. 111, 2, p. 113-115 3 p.

Research output: Contribution to journalArticle

Iduronidase
Enzyme Assays
Standardization
Assays
Kinetics
2013
2 Citations (Scopus)

A Trp199Glu MauG variant reveals a role for Trp199 interactions with pre-methylamine dehydrogenase during tryptophan tryptophylquinone biosynthesis

Abu Tarboush, N., Jensen, L. M. R., Wilmot, C. M. & Davidson, V. L., Jun 19 2013, In : FEBS Letters. 587, 12, p. 1736-1741 6 p.

Research output: Contribution to journalArticle

Biosynthesis
Protein Biosynthesis
Post Translational Protein Processing
Catalysis
Electrons
12 Citations (Scopus)

Carboxyl group of glu113 is required for stabilization of the diferrous and bis-FeIV states of MauG

Abu Tarboush, N., Yukl, E. T., Shin, S., Feng, M., Wilmot, C. M. & Davidson, V. L., Sep 17 2013, In : Biochemistry. 52, 37, p. 6358-6367 10 p.

Research output: Contribution to journalArticle

Heme
Oxidation-Reduction
Stabilization
Biosynthesis
Hydroquinones
34 Citations (Scopus)

Diradical intermediate within the context of tryptophan tryptophylquinone biosynthesis

Yukl, E. T., Liu, F., Krzystek, J., Shin, S., Jensen, L. M. R., Davidson, V. L., Wilmot, C. M. & Liu, A., Mar 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 12, p. 4569-4573 5 p.

Research output: Contribution to journalArticle

Tryptophan
Electrons
Spectrum Analysis
Oxidoreductases
Biocatalysis
9 Citations (Scopus)

MauG: A di-heme enzyme required for methylamine dehydrogenase maturation

Wilmot, C. M. & Yukl, E. T., Mar 7 2013, In : Dalton Transactions. 42, 9, p. 3127-3135 9 p.

Research output: Contribution to journalReview article

Heme
Electrons
Enzymes
Oxidation
Oxidants
18 Citations (Scopus)

Oxidative damage in MauG: Implications for the control of high-valent iron species and radical propagation pathways

Yukl, E. T., Williamson, H. R., Higgins, L., Davidson, V. L. & Wilmot, C. M., Dec 31 2013, In : Biochemistry. 52, 52, p. 9447-9455 9 p.

Research output: Contribution to journalArticle

Heme
Iron
Enzyme Precursors
Oxidation
Biosynthesis
27 Citations (Scopus)

Posttranslational biosynthesis of the protein-derived cofactor tryptophan tryptophylquinone

Davidson, V. L. & Wilmot, C. M., Jun 1 2013, In : Annual Review of Biochemistry. 82, p. 531-550 20 p.

Research output: Contribution to journalReview article

Biosynthesis
Protein Biosynthesis
Electrons
Tryptophan
Catalyst activity
7 Citations (Scopus)

Structural analysis of aliphatic versus aromatic substrate specificity in a copper amine oxidase from hansenula polymorpha

Klema, V. J., Solheid, C. J., Klinman, J. P. & Wilmot, C. M., Apr 2 2013, In : Biochemistry. 52, 13, p. 2291-2301 11 p.

Research output: Contribution to journalArticle

Amine Oxidase (Copper-Containing)
Pichia
Substrate Specificity
Structural analysis
Amines
14 Citations (Scopus)

Structural snapshots from the oxidative half-reaction of a copper amine oxidase: Implications for O2 activation

Johnson, B. J., Yukl, E. T., Klema, V. J., Klinman, J. P. & Wilmot, C. M., Sep 27 2013, In : Journal of Biological Chemistry. 288, 39, p. 28409-28417 9 p.

Research output: Contribution to journalArticle

Amine Oxidase (Copper-Containing)
Chemical activation
Copper
benzoquinone
26 Citations (Scopus)

Structural studies of hydroxylamine oxidoreductase reveal a unique heme cofactor and a previously unidentified interaction partner

Cedervall, P., Hooper, A. B. & Wilmot, C. M., Sep 10 2013, In : Biochemistry. 52, 36, p. 6211-6218 8 p.

Research output: Contribution to journalArticle

hydroxylamine dehydrogenase
Heme
Porphyrins
Nitrosomonas europaea
Nitrogen Cycle
19 Citations (Scopus)

Structure of a dinuclear iron cluster-containing β-hydroxylase active in antibiotic biosynthesis

Makris, T. M., Knoot, C. J., Wilmot, C. M. & Lipscomb, J. D., Sep 24 2013, In : Biochemistry. 52, 38, p. 6662-6671 10 p.

Research output: Contribution to journalArticle

Peptide Synthases
Hydroxylation
Biosynthesis
Viperidae
Mixed Function Oxygenases
7 Citations (Scopus)

Structures of MauG in complex with quinol and quinone MADH

Yukl, E. T., Jensen, L. M. R., Davidson, V. L. & Wilmot, C. M., Jul 1 2013, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 7, p. 738-743 6 p.

Research output: Contribution to journalReview article

Hydroquinones
dehydrogenases
quinones
Bearings (structural)
proteins
2012
11 Citations (Scopus)

Cofactor biosynthesis through protein post-translational modification

Yukl, E. T. & Wilmot, C. M., Apr 1 2012, In : Current opinion in chemical biology. 16, 1-2, p. 54-59 6 p.

Research output: Contribution to journalReview article

Biosynthesis
Accessories
Post Translational Protein Processing
PQQ Cofactor
Amino Acids
14 Citations (Scopus)

Crystal structures of xanthomonas campestris OleA reveal features that promote head-to-head condensation of two long-chain fatty acids

Goblirsch, B. R., Frias, J. A., Wackett, L. P. & Wilmot, C. M., May 22 2012, In : Biochemistry. 51, 20, p. 4138-4146 9 p.

Research output: Contribution to journalArticle

Xanthomonas campestris
Olea
Condensation
Fatty Acids
Crystal structure
20 Citations (Scopus)

Geometric and electronic structures of the His-Fe(IV)=O and His-Fe(IV)-Tyr hemes of MauG

Jensen, L. M. R., Meharenna, Y. T., Davidson, V. L., Poulos, T. L., Hedman, B., Wilmot, C. M. & Sarangi, R., Dec 1 2012, In : Journal of Biological Inorganic Chemistry. 17, 8, p. 1241-1255 15 p.

Research output: Contribution to journalArticle

Heme
Electronic structure
Density functional theory
Oxidation-Reduction
X-Ray Absorption Spectroscopy
1 Citation (Scopus)

Polysaccharide monoxygenases: Giving a boost to biofuel production

Wilmot, C. M., Jun 6 2012, In : Structure. 20, 6, p. 938-940 3 p.

Research output: Contribution to journalShort survey

Fungal Polysaccharides
Aromatic Amino Acids
Biofuels
Glycosylation
Cellulose
27 Citations (Scopus)

Proline 107 is a major determinant in maintaining the structure of the distal pocket and reactivity of the high-spin heme of MauG

Feng, M., Jensen, L. M. R., Yukl, E. T., Wei, X., Liu, A., Wilmot, C. M. & Davidson, V. L., Feb 28 2012, In : Biochemistry. 51, 8, p. 1598-1606 9 p.

Research output: Contribution to journalArticle

Heme
Proline
Biosynthesis
Sulfinic Acids
Ligands
3 Citations (Scopus)

The precursor form of Hansenula polymorpha copper amine oxidase 1 in complex with Cu I and Co II

Klema, V. J., Johnson, B. J., Klinman, J. P. & Wilmot, C. M., May 1 2012, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 68, 5, p. 501-510 10 p.

Research output: Contribution to journalArticle

Amine Oxidase (Copper-Containing)
Pichia
oxidase
quinones
biological evolution
20 Citations (Scopus)

The role of protein crystallography in defining the mechanisms of biogenesis and catalysis in copper amine oxidase

Klema, V. J. & Wilmot, C. M., May 1 2012, In : International journal of molecular sciences. 13, 5, p. 5375-5405 31 p.

Research output: Contribution to journalReview article

biological evolution
Amine Oxidase (Copper-Containing)
Crystallography
oxidase
Catalysis
2011
57 Citations (Scopus)

Chlorite dismutases, DyPs, and EfeB: 3 microbial heme enzyme families comprise the CDE structural superfamily

Goblirsch, B., Kurker, R. C., Streit, B. R., Wilmot, C. M. & Dubois, J. L., May 6 2011, In : Journal of Molecular Biology. 408, 3, p. 379-398 20 p.

Research output: Contribution to journalReview article

chlorite dismutase
Heme
Hemeproteins
Enzymes
Aptitude
18 Citations (Scopus)

Crystal structures of CO and NO adducts of MauG in complex with pre-methylamine dehydrogenase: Implications for the mechanism of dioxygen activation

Yukl, E. T., Goblirsch, B. R., Davidson, V. L. & Wilmot, C. M., Apr 12 2011, In : Biochemistry. 50, 14, p. 2931-2938 8 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Heme
Crystal structure
Chemical activation
Oxygen
47 Citations (Scopus)

Mutagenesis of tryptophan199 suggests that hopping is required for MauG-dependent tryptophan tryptophylquinone biosynthesis

Tarboush, N. A., Jensen, L. M. R., Yukl, E. T., Geng, J., Liu, A., Wilmot, C. M. & Davidson, V. L., Oct 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 16956-16961 6 p.

Research output: Contribution to journalArticle

Mutagenesis
Electrons
Proteins
Heme
Mutation
22 Citations (Scopus)

Structural analysis of a Ni-methyl species in methyl-coenzyme M reductase from methanothermobacter marburgensis

Cedervall, P. E., Dey, M., Li, X., Sarangi, R., Hedman, B., Ragsdale, S. W. & Wilmot, C. M., Apr 20 2011, In : Journal of the American Chemical Society. 133, 15, p. 5626-5628 3 p.

Research output: Contribution to journalArticle

Methanobacteriaceae
Coenzymes
Structural analysis
Methane
Substrates
15 Citations (Scopus)

The tightly bound calcium of MauG is required for tryptophan tryptophylquinone cofactor biosynthesis

Shin, S., Feng, M., Chen, Y., Jensen, L. M. R., Tachikawa, H., Wilmot, C. M., Liu, A. & Davidson, V. L., Jan 11 2011, In : Biochemistry. 50, 1, p. 144-150 7 p.

Research output: Contribution to journalArticle

Biosynthesis
Heme
Calcium
Peroxidases
Potassium Chloride
2010
7 Citations (Scopus)
Stenotrophomonas maltophilia
Synchrotrons
biosynthesis
Cloning
Biosynthesis
32 Citations (Scopus)

Functional importance of tyrosine 294 and the catalytic selectivity for the Bis-Fe(IV) state of MauG revealed by replacement of this axial heme ligand with histidine

Abu Tarboush, N., Jensen, L. M. R., Feng, M., Tachikawa, H., Wilmot, C. M. & Davidson, V. L., Nov 16 2010, In : Biochemistry. 49, 45, p. 9783-9791 9 p.

Research output: Contribution to journalArticle

Heme
Histidine
Tyrosine
Ligands
Oxidation-Reduction
89 Citations (Scopus)

In crystallo posttranslational modification within a MauG/Pre-methylamine dehydrogenase complex

Jensen, L. M. R., Sanishvili, R., Davidson, V. L. & Wilmot, C. M., Mar 12 2010, In : Science. 327, 5971, p. 1392-1394 3 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Heme
Catalysis
Tryptophan
Hydrogen Peroxide
30 Citations (Scopus)

Kinetic and structural analysis of substrate specificity in two copper amine oxidases from Hansenula polymorpha

Chang, C. M., Klema, V. J., Johnson, B. J., Mure, M., Klinman, J. P. & Wilmot, C. M., Mar 23 2010, In : Biochemistry. 49, 11, p. 2540-2550 11 p.

Research output: Contribution to journalArticle

Amine Oxidase (Copper-Containing)
Pichia
Substrate Specificity
Structural analysis
Protons
43 Citations (Scopus)

Structural features promoting dioxygen production by Dechloromonas aromatica chlorite dismutase

Goblirsch, B. R., Streit, B. R., DuBois, J. L. & Wilmot, C. M., Aug 1 2010, In : Journal of Biological Inorganic Chemistry. 15, 6, p. 879-888 10 p.

Research output: Contribution to journalArticle

chlorite dismutase
Heme
Oxygen
Enzymes
Histidine
20 Citations (Scopus)

Structural insight into methyl-coenzyme M reductase chemistry using coenzyme B analogues

Cedervall, P. E., Dey, M., Pearson, A. R., Ragsdale, S. W. & Wilmot, C. M., Sep 7 2010, In : Biochemistry. 49, 35, p. 7683-7693 11 p.

Research output: Contribution to journalArticle

Nickel
Catalytic Domain
Methane
Substrates
Carbon
2009
6 Citations (Scopus)
hydroxylamine dehydrogenase
Nitrosomonas europaea
Crystallization
Heme
X-Rays
4 Citations (Scopus)

Crystallization and preliminary X-ray diffraction of chlorite dismutase from Dechloromonas aromatica RCB

Goblirsch, B. R., Streit, B. R., Dubois, J. L. & Wilmot, C. M., Aug 19 2009, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 65, 8, p. 818-821 4 p.

Research output: Contribution to journalArticle

chlorite dismutase
Synchrotrons
Crystallization
X-Ray Diffraction
synchrotrons
21 Citations (Scopus)

Uncovering novel biochemistry in the mechanism of tryptophan tryptophylquinone cofactor biosynthesis

Wilmot, C. M. & Davidson, V. L., Jan 1 2009, In : Current opinion in chemical biology. 13, 4, p. 469-474 6 p.

Research output: Contribution to journalReview article

Biochemistry
Biosynthesis
Post Translational Protein Processing
Heme
Biological Phenomena
2007
2 Citations (Scopus)

An ancient and intimate partnership

Wilmot, C. M., Apr 20 2007, In : Science. 316, 5823, p. 379-380 2 p.

Research output: Contribution to journalShort survey

Ferrous Compounds
Ferric Compounds
Molecular Conformation
Dioxygenases
Protein Conformation