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Substrates Chemical Compounds

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Projects 1994 2022

Metals

DRUG DISCOVERY RESEARCH, DEVELOPMENT AND COMMERCIALIZATI

Ashe, K. H., Cleary, J. P., Walters, M. A. & Wilmot, C.

Eli Lilly and Company

3/7/133/5/16

Project: Research project

Technology Transfer
Drug Discovery
Research
Calorimeters
Titration
Ligands
Proteins
Nucleic Acids
Protein
Fundamental

Research Output 1988 2019

3 Citations (Scopus)

Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway

Koehn, E. M., Latham, J. A., Armand, T., Evans, R. L., Tu, X., Wilmot, C. M., Iavarone, A. T. & Klinman, J. P., Mar 13 2019, In : Journal of the American Chemical Society. 141, 10, p. 4398-4405 8 p.

Research output: Contribution to journalArticle

PQQ Cofactor
Biosynthesis
Biosynthetic Pathways
Mixed Function Oxygenases
Iron

The role of OleA His285 in orchestration of long-chain acyl-coenzyme A substrates

Jensen, M. R., Goblirsch, B. R., Esler, M. A., Christenson, J. K., Mohamed, F. A., Wackett, L. P. & Wilmot, C. M., Mar 1 2018, In : FEBS Letters. 592, 6, p. 987-998 12 p.

Research output: Contribution to journalLetter

Acyl Coenzyme A
Olea
Keto Acids
Mutagenesis
Nucleophiles
3 Citations (Scopus)

X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE

Barr, I., Stich, T. A., Gizzi, A. S., Grove, T. L., Bonanno, J. B., Latham, J. A., Chung, T., Wilmot, C. M., Britt, R. D., Almo, S. C. & Klinman, J. P., Feb 27 2018, In : Biochemistry. 57, 8, p. 1306-1315 10 p.

Research output: Contribution to journalArticle

Electron Spin Resonance Spectroscopy
Paramagnetic resonance
Spectrum Analysis
X ray crystallography
X Ray Crystallography
5 Citations (Scopus)

Active multienzyme assemblies for long-chain olefinic hydrocarbon biosynthesis

Christenson, J. K., Jensen, M. R., Goblirsch, B. R., Mohamed, F., Zhang, W., Wilmot, C. M. & Wackett, L. P., May 1 2017, In : Journal of bacteriology. 199, 9, e00890-16.

Research output: Contribution to journalArticle

Open Access
Hydrocarbons
Olea
Xanthomonas campestris
Proteins
Acyl Coenzyme A
3 Citations (Scopus)

Crystal structures reveal metal-binding plasticity at the metallo-β-lactamase active site of PqqB from Pseudomonas putida

Tu, X., Latham, J. A., Klema, V. J., Evans, R. L., Li, C., Klinman, J. P. & Wilmot, C. M., Oct 1 2017, In : Journal of Biological Inorganic Chemistry. 22, 7, p. 1089-1097 9 p.

Research output: Contribution to journalArticle

Pseudomonas putida
Metal ions
Plasticity
Catalytic Domain
Crystal structure