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Research Output 1997 2019

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2019
4 Citations (Scopus)

Phosphorylated progesterone receptor isoforms mediate opposing stem cell and proliferative breast cancer cell fates

Truong, T. H., Dwyer, A. R., Diep, C. H., Hu, H., Hagen, K. M. & Lange, C. A., Jan 1 2019, In : Endocrinology. 160, 2, p. 430-446 17 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Protein Isoforms
Stem Cells
Breast Neoplasms
Neoplastic Stem Cells
2018
2 Citations (Scopus)

Cancer stem cell phenotypes in ER+ breast cancer models are promoted by PELP1/AIB1 complexes

Truong, T. H., Hu, H., Temiz, N. A., Hagen, K. M., Girard, B. J., Brady, N. J., Schwertfeger, K. L., Lange, C. A. & Ostrander, J. H., Apr 1 2018, In : Molecular Cancer Research. 16, 4, p. 707-719 13 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Breast Neoplasms
Phenotype
human PELP1 protein
Neoplasms
5 Citations (Scopus)

Deciphering Steroid Receptor Crosstalk in Hormone-Driven Cancers

Truong, T. H. & Lange, C. A., Dec 1 2018, In : Endocrinology. 159, 12, p. 3897-3907 11 p.

Research output: Contribution to journalArticle

Steroid Receptors
Hormones
Neoplasms
Estrogen Receptors
Ligands
7 Citations (Scopus)

NOTCH3 expression is linked to breast cancer seeding and distant metastasis

Leontovich, A. A., Jalalirad, M., Salisbury, J. L., Mills, L., Haddox, C., Schroeder, M., Tuma, A., Guicciardi, M. E., Zammataro, L., Gambino, M. W., Amato, A., Di Leonardo, A., McCubrey, J., Lange, C. A., Liu, M., Haddad, T., Goetz, M., Boughey, J., Sarkaria, J., Wang, L. & 3 others, Ingle, J. N., Galanis, E. & D'Assoro, A. B., Sep 4 2018, In : Breast Cancer Research. 20, 1, 105.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Phenotype

Taxol induces brk-dependent prosurvival phenotypes in TNBC cells through an AhR/GR/HIF-driven signaling axis

Anderson, T. M. R., Ma, S., Kerkvliet, C. P., Peng, Y., Helle, T. M., Krutilina, R. I., Raj, G. V., Cidlowski, J. A., Ostrander, J. H., Schwertfeger, K. L., Seagroves, T. N. & Lange, C. A., Nov 2018, In : Molecular Cancer Research. 16, 11, p. 1761-1772 12 p.

Research output: Contribution to journalArticle

Open Access
Aryl Hydrocarbon Receptors
Glucocorticoid Receptors
Paclitaxel
Breast Neoplasms
Phenotype
2017
5 Citations (Scopus)

Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells

Huang, Y., Burns, D. J., Rich, B. E., MacNeil, I. A., Dandapat, A., Soltani, S. M., Myhre, S., Sullivan, B. F., Lange, C. A., Furcht, L. T. & Laing, L. G., Mar 16 2017, In : BMC Cancer. 17, 1, 199.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
Cell Line
human ERBB2 protein
Biosensing Techniques
Neoplasms
11 Citations (Scopus)

Pathway-based discovery of genetic interactions in breast cancer

Wang, W., Xu, Z. Z., Costanzo, M., Boone, C., Lange, C. A. & Myers, C. L., Sep 2017, In : PLoS genetics. 13, 9, e1006973.

Research output: Contribution to journalArticle

breast neoplasms
cancer
Breast Neoplasms
Genome-Wide Association Study
Single Nucleotide Polymorphism
17 Citations (Scopus)

Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs

Knutson, T. P., Truong, T. H., Ma, S., Brady, N. J., Sullivan, M. E., Raj, G., Schwertfeger, K. & Lange, C. A., Apr 17 2017, In : Journal of Hematology and Oncology. 10, 1, 89.

Research output: Contribution to journalArticle

Open Access
Neoplastic Stem Cells
Progesterone Receptors
Breast Neoplasms
Ligands
Genes
2016
9 Citations (Scopus)
Progesterone Receptors
Transcriptional Activation
Protein Isoforms
Progestins
Cell Aging
1 Citation (Scopus)

A functional signal profiling test for identifying a subset of HER2-negative breast cancers with abnormally amplified HER2 signaling activity

Huang, Y., Burns, D. J., Rich, B. E., MacNeil, I. A., Dandapat, A., Soltani, S. M., Myhre, S., Sullivan, B. F., Furcht, L. T., Lange, C. A., Hurvitz, S. A. & Laing, L. G., Jan 1 2016, In : Oncotarget. 7, 48, p. 78577-78590 14 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Drug Delivery Systems
Routine Diagnostic Tests
Epidermal Growth Factor
Estrogen Receptors
12 Citations (Scopus)

Breast tumor kinase (Brk/PTK6) is induced by HIF, glucocorticoid receptor, and PELP1-mediated stress signaling in triple-negative breast cancer

Regan Anderson, T. M., Ma, S. H., Raj, G. V., Cidlowski, J. A., Helle, T. M., Knutson, T. P., Krutilina, R. I., Seagroves, T. N. & Lange, C. A., Mar 15 2016, In : Cancer Research. 76, 6, p. 1653-1663 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Glucocorticoid Receptors
Phosphotransferases
Breast Neoplasms
Dexamethasone
11 Citations (Scopus)
Estrogen Receptor alpha
Progesterone Receptors
Gene expression
Protein Kinases
Progesterone
5 Citations (Scopus)

Tumour and cellular distribution of activated forms of PR in breast cancers: A novel immunohistochemical analysis of a large clinical cohort

Bonneterre, J., Bosq, J., Jamme, P., Valent, A., Gilles, E. M., Zukiwski, A. A., Fuqua, S. A. W., Lange, C. A. & O'Shaughnessy, J., Jul 2016, In : ESMO Open. 1, 4, e000072.

Research output: Contribution to journalArticle

Progesterone Receptors
Breast Neoplasms
Neoplasms
Epidermal Growth Factor
Estrogen Receptors
2015
60 Citations (Scopus)

Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1-and estrogen receptor-containing transcription complexes

Daniel, A. R., Gaviglio, A. L., Knutson, T. P., Ostrander, J. H., D'Assoro, A. B., Ravindranathan, P., Peng, Y., Raj, G. V., Yee, D. & Lange, C. A., Jan 22 2015, In : Oncogene. 34, 4, p. 506-515 10 p.

Research output: Contribution to journalArticle

Proline
Leucine
Estrogen Receptors
Glutamic Acid
Progesterone Receptors
2014
13 Citations (Scopus)

Aurora-A mitotic kinase induces endocrine resistance through down-regulation of ERα expression in initially ERα+ breast cancer cells

Opyrchal, M., Salisbury, J. L., Zhang, S., McCubrey, J., Hawse, J., Goetz, M. P., Lomberk, G. A., Haddad, T., Degnim, A., Lange, C., Ingle, J. N., Galanis, E. & D'Assoro, A. B., May 9 2014, In : PloS one. 9, 5, e96995.

Research output: Contribution to journalArticle

Aurora Kinase A
Estrogen Receptor alpha
breast neoplasms
phosphotransferases (kinases)
Phosphotransferases
21 Citations (Scopus)

Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells

Dressing, G. E., Knutson, T. P., Schiewer, M. J., Daniel, A. R., Hagan, C. R., Diep, C. H., Knudsen, K. E. & Lange, C. A., 2014, In : Molecular Endocrinology. 28, 4, p. 442-457 16 p.

Research output: Contribution to journalArticle

Cyclin D1
Progesterone Receptors
Cell Cycle
Breast Neoplasms
Progestins
4 Citations (Scopus)

Progesterone regulation of tissue factor depends on MEK1/2 activation and requires the proline-rich site on progesterone receptor

Bravo, M. L., Pinto, M. P., Gonzalez, I., Oliva, B., Kato, S., Cuello, M. A., Lange, C. A. & Owen, G. I., Jan 1 2014, In : Endocrine. 48, 1, p. 309-320 12 p.

Research output: Contribution to journalArticle

Thromboplastin
Progesterone Receptors
Proline
Progesterone
Up-Regulation
2013
29 Citations (Scopus)
Dual Specificity Phosphatase 6
Breast Neoplasms
Progestins
Phosphorylation
Genes
26 Citations (Scopus)

Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia- associated breast cancer progression

Anderson, T. M. R., Peacock, D. L., Daniel, A. R., Hubbard, G. K., Lofgren, K. A., Girard, B. J., Schorg, A., Hoogewijs, D., Wenger, R. H., Seagroves, T. N. & Lange, C. A., Sep 15 2013, In : Cancer Research. 73, 18, p. 5810-5820 11 p.

Research output: Contribution to journalArticle

Phosphotransferases
Triple Negative Breast Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
44 Citations (Scopus)

Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells

Diep, C. H., Charles, N. J., Gilks, C. B., Kalloger, S. E., Argenta, P. A. & Lange, C. A., May 1 2013, In : Cell Cycle. 12, 9, p. 1433-1449 17 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Ovarian Neoplasms
Progestins
Cell Aging
Neoplasms
2012
67 Citations (Scopus)

Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

Knutson, T. P., Daniel, A. R., Fan, D., Silverstein, K. A. T., Covington, K. R., Fuqua, S. A. W. & Lange, C. A., Jun 14 2012, In : Breast Cancer Research. 14, 3, R95.

Research output: Contribution to journalArticle

Sumoylation
Progesterone Receptors
Breast Neoplasms
Genes
Ubiquitin
19 Citations (Scopus)

Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1

Diaz, J., Aranda, E., Henriquez, S., Quezada, M., Espinoza, E., Bravo, M. L., Oliva, B., Lange, S., Villalon, M., Jones, M., Brosens, J. J., Kato, S., Cuello, M. A., Knutson, T. P., Lange, C. A., Leyton, L. & Owen, G. I., Aug 1 2012, In : Journal of Endocrinology. 214, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Focal Adhesions
Progesterone
Progesterone Receptors
Breast Neoplasms
2011
46 Citations (Scopus)

ck2-dependent phosphorylation of progesterone receptors (PR) on ser81 regulates PR-B isoform-specific target gene expression in breast cancer cells

Hagan, C. R., Regan, T. M., Dressing, G. E. & Lange, C. A., Jun 1 2011, In : Molecular and cellular biology. 31, 12, p. 2439-2452 14 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Protein Isoforms
Phosphorylation
Breast Neoplasms
Gene Expression
21 Citations (Scopus)

Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK

Lofgren, K. A., Ostrander, J. H., Housa, D., Hubbard, G. K., Locatelli, A., Bliss, R. L., Schwertfeger, K. L. & Lange, C. A., Sep 17 2011, In : Breast Cancer Research. 13, 5, R89.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Human Mammary Glands
Breast Neoplasms
Breast
Epithelial Cells
13 Citations (Scopus)

Met receptors induce Sam68-dependent cell migration by activation of alternate extracellular signal-regulated kinase family members

Locatelli, A. & Lange, C. A., Jun 17 2011, In : Journal of Biological Chemistry. 286, 24, p. 21062-21072 11 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Extracellular Signal-Regulated MAP Kinases
Cell Movement
Chemical activation
Neoplasms
2010
7 Citations (Scopus)

2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells

Quezada, M., Diaz, J., Henriquez, S., Bravo, M. L., Aranda, E., Oliva, B., Villalon, M., Kato, S., Cuello, M. A., Brosens, J. J., Lange, C. A. & Owen, G. I., Jul 23 2010, In : Hormones and Cancer. 1, 3, p. 117-126 10 p.

Research output: Contribution to journalArticle

Thromboplastin
Progesterone
Progesterone Receptors
Breast Neoplasms
STAT5 Transcription Factor
43 Citations (Scopus)
Mitogen-Activated Protein Kinase 7
Cell Movement
Phosphotransferases
Breast Neoplasms
Hepatocyte Growth Factor
31 Citations (Scopus)

Expression of Membrane Progesterone Receptors (mPR/PAQR) in Ovarian Cancer Cells: Implications for Progesterone-Induced Signaling Events

Charles, N. J., Thomas, P. & Lange, C. A., Aug 1 2010, In : Hormones and Cancer. 1, 4, p. 167-176 10 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Ovarian Neoplasms
Progesterone
Membranes
Cyclic AMP
45 Citations (Scopus)

The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention

Daniel, A. R., Gaviglio, A. L., Czaplicki, L. M., Hillard, C. J., Housa, D. & Lange, C. A., Nov 1 2010, In : Molecular Endocrinology. 24, 11, p. 2126-2138 13 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Acetylation
Phosphorylation
Progestins
Hormones
2009
18 Citations (Scopus)

Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferation

Dressing, G. E. & Lange, C. A., Jul 1 2009, In : Steroids. 74, 7, p. 573-576 4 p.

Research output: Contribution to journalArticle

Cell proliferation
Progesterone Receptors
Machinery
Cell Cycle
Cells

Meeting review: Extra-nuclear steroid receptors-Integration with multiple signaling pathways

Carbajal, L., Deng, J., Dressing, G. E., Hagan, C. R., Lange, C. A. & Hammes, S. R., Jul 1 2009, In : Steroids. 74, 7, p. 551-554 4 p.

Research output: Contribution to journalArticle

Signal transduction
Steroid Receptors
Animals
Phosphotransferases
47 Citations (Scopus)
Progesterone Receptors
Protein Kinases
Breast Neoplasms
Ligands
Progestins
2008
44 Citations (Scopus)

Challenges to defining a role for progesterone in breast cancer

Lange, C. A., Oct 1 2008, In : Steroids. 73, 9-10, p. 914-921 8 p.

Research output: Contribution to journalArticle

Progesterone
Estrogens
Breast Neoplasms
Breast
Progestins
101 Citations (Scopus)

Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors

Faivre, E. J., Daniel, A. R., Hillard, C. J. & Lange, C. A., Apr 1 2008, In : Molecular Endocrinology. 22, 4, p. 823-837 15 p.

Research output: Contribution to journalArticle

Sp1 Transcription Factor
Progesterone Receptors
Serine
Progestins
Phosphorylation
2007
98 Citations (Scopus)

Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells

Ostrander, J. H., Daniel, A. R., Lofgren, K., Kleer, C. G. & Lange, C. A., May 1 2007, In : Cancer Research. 67, 9, p. 4199-4209 11 p.

Research output: Contribution to journalArticle

Neuregulin-1
p38 Mitogen-Activated Protein Kinases
Protein-Tyrosine Kinases
Phosphotransferases
Breast Neoplasms
62 Citations (Scopus)
Phosphorylation
Cell growth
Progestins
Progesterone Receptors
Epidermal Growth Factor
81 Citations (Scopus)

Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells

Daniel, A. R., Faivre, E. J. & Lange, C. A., Dec 1 2007, In : Molecular Endocrinology. 21, 12, p. 2890-2906 17 p.

Research output: Contribution to journalArticle

Sumoylation
Progesterone Receptors
Phosphorylation
Breast Neoplasms
Progestins
158 Citations (Scopus)
Mitogen-Activated Protein Kinase 1
Progesterone Receptors
Epidermal Growth Factor Receptor
Transcriptional Activation
Up-Regulation
2006
91 Citations (Scopus)

Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells

Byron, S. A., Horwitz, K. B., Richer, J. K., Lange, C. A., Zhang, X. & Yee, D., Nov 6 2006, In : British Journal of Cancer. 95, 9, p. 1220-1228 9 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Insulin Receptor
Insulin Receptor Substrate Proteins
Breast Neoplasms
Phenotype
2005
69 Citations (Scopus)

Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: Role of mitogen-activated protein kinases and cell cycle regulators

Faivre, E., Skildum, A. J., Pierson-Mullany, L. & Lange, C. A., Jan 1 2005, In : Steroids. 70, 5-7 SPEC. ISS., p. 418-426 9 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Mitogen-Activated Protein Kinases
Cell Cycle
Cells
Breast Neoplasms
96 Citations (Scopus)

Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases

Skildum, A. J., Faivre, E. & Lange, C. A., Feb 1 2005, In : Molecular Endocrinology. 19, 2, p. 327-339 13 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Mitogen-Activated Protein Kinases
Progestins
Cell Cycle
Mitogen-Activated Protein Kinase 3
54 Citations (Scopus)

Regulated association of protein kinase B/Akt with breast tumor kinase

Zhang, P., Ostrander, J. H., Faivre, E. J., Olsen, A., Fitzsimmons, D. & Lange, C. A., Jan 21 2005, In : Journal of Biological Chemistry. 280, 3, p. 1982-1991 10 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Tumors
Phosphotransferases
Association reactions
Breast Neoplasms
17 Citations (Scopus)

Steadying the boat: Integrating mechanisms of membrane and nuclear-steroid-receptor signalling

Watson, C. S. & Lange, C. A., Mar 15 2005, In : EMBO Reports. 6, 2, p. 116-119 4 p.

Research output: Contribution to journalArticle

Signal transduction
Steroid Receptors
Gonadal Steroid Hormones
Cell Surface Receptors
Boats
2004
95 Citations (Scopus)
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinases
Progesterone Receptors
Serine
Phosphorylation
2003
74 Citations (Scopus)
Progesterone Receptors
Steroid hormones
Phosphotransferases
Association reactions
Degradation
111 Citations (Scopus)

Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors

Qiu, M., Olsen, A., Faivre, E., Horwitz, K. B. & Lange, C. A., Apr 1 2003, In : Molecular Endocrinology. 17, 4, p. 628-642 15 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Mitogen-Activated Protein Kinases
Progestins
Cell Nucleus Active Transport
Steroid Receptors
2001
169 Citations (Scopus)
Progesterone Receptors
Mitogen-Activated Protein Kinases
Serine
Down-Regulation
Phosphorylation
2000
356 Citations (Scopus)
Progesterone Receptors
Mitogen-Activated Protein Kinases
Serine
Phosphorylation
Down-Regulation
1998
161 Citations (Scopus)

Convergence of progesterone and epidermal growth factor signaling in breast cancer: Potentiation of mitogen-activated protein kinase pathways

Lange, C. A., Richer, J. K., Shen, T. & Horwitz, K. B., Nov 20 1998, In : Journal of Biological Chemistry. 273, 47, p. 31308-31316 9 p.

Research output: Contribution to journalArticle

Promegestone
Mitogen-Activated Protein Kinases
Epidermal Growth Factor
Progesterone
Breast Neoplasms
164 Citations (Scopus)

Convergence of progesterone with growth factor and cytokine signaling in breast cancer: Progesterone receptors regulate signal transducers and activators of transcription expression and activity

Richer, J. K., Lange, C. A., Manning, N. G., Owen, G., Powell, R. & Horwitz, K. B., Nov 20 1998, In : Journal of Biological Chemistry. 273, 47, p. 31317-31326 10 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Transcription
Transducers
Progesterone
Intercellular Signaling Peptides and Proteins